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Coating for implants and implants with improved osteointegration, and manufacturing method

A technology for implants and coatings, applied in coatings, medical preparations containing active ingredients, drug delivery, etc. Osseointegration and increased circulation

Inactive Publication Date: 2008-10-15
NOLABS AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] Therefore, this article does not refer to the improvement of the prior art about NO-eluting polymers coated on implants to improve antibacterial, antifungal, and antiviral effects through the elution of nitric oxide NO, There is thus no mention of improved osseointegration
Also, the article is silent on regulating and / or controlling the elution of nitric oxide from the coating

Method used

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  • Coating for implants and implants with improved osteointegration, and manufacturing method

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Embodiment Construction

[0030] The following description focuses on embodiments of the present invention applicable to implant coatings that produce antiviral, antifungal, and antibacterial effects and promote osseointegration, bone healing, bone growth, and wound healing.

[0031] A patient in an embodiment may be a human or an animal, such as an animal selected from the group consisting of cats, dogs, horses, cows, and the like.

[0032] As for nitric oxide (nitric oxide, NO), its physiological and pharmacological effects have attracted widespread attention, and they have been studied. NO is synthesized from arginine by nitric oxide synthase (NOS). NOS is divided into the constitutive enzyme cNOS and the inducible enzyme iNOS. The former is present in living organisms in a normal state, and the latter is produced in large quantities in response to certain stimuli. It is known that compared with the concentration of NO produced by cNOS, the concentration of NO produced by iNOS is 2 to 3 orders of ...

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Abstract

A coating on an implant, said implant being intended for implantation in / on an implantation area, is provided. The coating comprises nitric oxide (NO) for obtaining an anti-viral, anti-fungal, and anti-bacterial effect, and for promotion of osteo-integration of the implant, bone healing, bone growth, and wound healing at said implantation area. A nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of a therapeutic dosage of nitric oxide (NO). An implant and a kit of implants, comprising said coating are also provided. Furthermore, a manufacturing method for the implant is disclosed.

Description

technical field [0001] The present invention relates generally to the field of coatings for implants configured for surgical treatment of fractures, deformities, neoplastic diseases, replacement of tissue such as bone, and promotion of osseointegration and wound healing of implants, The coating includes the use of nitric oxide. More specifically, the invention relates to a kit of implants having such a coating. Background technique [0002] In the field of implant surgery, surgeons implant many metallic, ceramic types, and polymeric materials into patients, such as humans and animals. Surgeons use these kinds of implants in orthopedic surgery, such as treatment of fractures, treatment of deformities, neoplastic diseases, and replacement of tissues such as bone, and also in other fields of transplantation, such as cosmetic surgery, reconstructive surgery, leads , cardiac surgery such as heart valve surgery, aneurysm clipping, and dental surgery. [0003] Problems associate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/48A61L27/54A61L29/12A61L29/16A61L31/12A61L31/16A61F2/00A61F2/04
CPCA61K33/00A61L27/34A61L27/54A61L31/10A61L31/16A61L2300/114A61L2300/404A61L2300/408A61L2300/412A61L2300/606A61L2300/622A61L2300/624
Inventor 托尔·彼得斯
Owner NOLABS AB
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