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237results about How to "Promote osteogenic differentiation" patented technology

Calcium phosphate-based bone repair scaffold and preparation method thereof

The invention discloses a calcium phosphate-based bone repair scaffold and a preparation method thereof. Calcium phosphate bone cement is used as a raw material and is combined with a 3D printing technology to obtain a calcium phosphate bone cement scaffold with through macropores; a dopamine solution is used for modifying the surface of the scaffold; dopamine forms a polydopamine layer on the surface of the scaffold through self-oxidation under alkaline conditions; polydopamine has good viscosity and biocompatibility, can be used as an adhering coating layer of BMP-2, improves the content offixed BMP-2, and promotes cell adhesion and proliferation; the BMP-2 loaded on the scaffold can also effectively promote the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. The prepared calcium phosphate-based bone repair scaffold has through macropores, meets the mechanical strength requirements of cancellous bones, has excellent biocompatibility, can effectively promote bone tissue regeneration, and has potential application value in the field of bone tissue repair.
Owner:GUANGZHOU RAINHOME PHARM&TECH CO LTD

Preparation method of intra-fibrous biomimetic mineralized collagen membrane capable of promoting osteogenic differentiation of cells

The invention discloses a preparation method of an intra-fibrous biomimetic mineralized collagen membrane capable of promoting osteogenic differentiation of cells. According to the invention, the preparation method comprises the following steps: preparing a collagen solution; pouring the collagen solution into a prefabricated mold, putting the mold into a closed container containing ammonia water,carrying out neutralizing, moving the neutralized solution out and then putting the solution into a constant-temperature box to carry out culturing continuously, and completing self-assembling and forming a gel mode; carrying out cross-linking on the gel to obtain pure collagen gel; and putting the pure collagen gel into a biomimetic mineralization solution and carrying out culturing for a plurality of days to obtain collagen gel with different biomimetic mineralization degrees; and cooling the collagen gel and carrying out freeze-drying on the cooled gel in a freeze dryer to obtain the finalintra-fibrous biomimetic mineralized collagen membrane. According to the invention, intra-fibrous mineralization of the collagen fiber can be formed by biomimetic mineralization; the fiber network structure of the collagen membrane is reserved and utilized while the mechanical property and the biological property of the hydroxyapatite crystal are utilized.
Owner:THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE +1

Titanium metal material surface modifying method and modified titanium metal material

The invention discloses a titanium metal material surface modifying method and a modified titanium metal material obtained through the method. The method is characterized in that zinc ions and magnesium ions are co-implanted to the surface of a titanium metal material through a plasma immersion ion implantation technology in order to improve the biological activity of the medical titanium metal material. The modified titanium metal material has the characteristics of improved corrosion resistance, good cell spreading performance and increased cell proliferation rate, can promote ossification differentiation of rBMSCs, and has an ossification promotion effect.
Owner:SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI

3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof

The invention discloses a 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and a preparation method thereof. The 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold is prepared accordingto the following steps: adopting a fusion extruding forming type 3D printing technology for extruding PCL and forming fiber bundles and preparing a 3D printed PCL scaffold through a splicing frameworkof the fiber bundles; forming a PDA coating by automatically polymerizing dopamine on the fiber surface of the 3D printed PCL scaffold, thereby preparing a 3D printed PCL-PDA scaffold; lastly, soaking the acquired 3D printed PCL-PDA scaffold in a BMP2 solution, thereby acquiring the 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold. The scaffold prepared according to the invention has theadvantages of simple and reliable structure, controllable appearance and microstructure, reliable mechanical properties and controllable ion release property, and can be used for restorative treatmentof bone trauma, bone tumors and bone defect after bone infection.
Owner:NANJING FIRST HOSPITAL

PEEK false tooth composite and preparation method thereof

The invention discloses a PEEK false tooth composite. The PEEK false tooth composite is prepared from, by weight, 110-150 parts of polyether-ether-ketone, 10-20 parts of nano calcium silicate, 8-12 parts of hydroxyl hydroxyapatites, 4-8 parts of barium glass short fibers, 15-22 parts of organic solvent, 8-18 parts of refined paraffin, 1-4 parts of co-binding agent, 8-12 parts of binder, 2-6 parts of antibacterial agent, 6-10 parts of carbide and / or 8-15 parts of oxide. The invention further discloses a preparation method of the PEEK false tooth composite. The preparation method includes the steps that firstly, the raw materials of nano calcium silicate, hydroxyl hydroxyapatites, carbide and / or oxide are mixed, the mixture is heated to 150-220 DEG C, the situation is kept for 10-30 min, cooling is carried out, the refined paraffin is added, mixing and stirring are carried out, and after the mixture is crushed ultrasonically, the organic solvent, polyether-ether-ketone, the co-binding agent, the binder and the antibacterial agent are added to be stirred till uniform paste is obtained; finally the barium glass short fibers are added, ball-milling and drying are carried out, and the finished composite powder is obtained.
Owner:广西深雅医疗科技股份有限公司

Preparation method of bioactive glass-wrapping modified zirconium oxide dental ceramic material

The invention discloses a preparation method of a bioactive glass-wrapping modified zirconium oxide dental ceramic material. The method comprises the specific steps that a hydrolysable silicon-containing compound, triethyl phosphate and nitrate are dissolved in a solvent, the pH value is adjusted, the mixed solution is subjected to a hydrolytic condensation reaction, and bioactive glass precursorsol is obtained; a zirconium oxide suspension solution which is evenly dispersed in advance is added to the bioactive glass precursor sol and evenly dispersed, the sol is converted into gel through aging, a layer of extremely-thin bioactive glass wraps the peripheries of zirconium oxide particles, and after high-temperature sintering, the bioactive glass-wrapping modified zirconium oxide dental ceramic material is obtained. The zirconium oxide dental ceramic material has good biological activity and excellent mechanical properties, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells can also be promoted at the same time, and accordingly the material helps to improve the osseointegration capacity; the effect of repairing the dental material is improved, the wider clinical application of the material is promoted, and the material has high social economic value.
Owner:SOUTH CHINA UNIV OF TECH

Lipidosome-based method for modifying PEEK (polyetheretherketone) surface with hexadecadrol/minocycline and application

The invention discloses a lipidosome-based method for modifying a PEEK (polyetheretherketone) surface with hexadecadrol/minocycline and an application of the method. Lipidosome loaded with hexadecadrol and minocycline is prepared with a thin film dispersion method and then modifies the PEEK surface. The method comprises following steps: (1), hexadecadrol and lipids are dissolved in a methanol and chloroform mixture (1:1, v/v); (2), methanol and chloroform are removed by a rotary vacuum evaporator, and then a lipid membrane is hydrated by a hydration solution; lipidosome loaded with hexadecadrol is obtained by water bath ultrasonic treatment, and is extruded by a porous polycarbonate membrane; dialysis is performed overnight; (3), lipidosome is mixed with a minocycline storage solution, the mixture is shaken, and lipidosome loaded with hexadecadrol/minocycline is obtained, and is stored for standby application at 4 DEG C after being dialyzed overnight; (4), PEEK implant is put in a dopamine solution for reaction, and ultrasonic cleaning is performed; (5), the PEEK implant is added to a hexadecadrol/minocycline lipidosome solution for soaking and is slightly cleaned, and a product is obtained. The obtained product can promote bone repair, regeneration and integration.
Owner:BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY +1

Method for using Pickering emulsion method for producing GelMA macropore hydrogel and application

The invention discloses a method for using a Pickering emulsion method for producing GelMA macropore hydrogel and application. The method comprises the steps of dissolving GelMA and PEG-4SH in PBS buffer liquid, and stirring a mixture; adding MgO nano-particles after fully dissolving the GelMA and the PEG-4SH, stirring a mixture, and conducting ultrasonic treatment on the mixture; adding dodecaneand a photoinitiator, and using a high-speed homogenizer for intensively stirring a mixture to obtain stable Pickering emulsion; and making the emulsion subjected to UV illumination to form gel, and obtaining the GelMA macropore hydrogel by using ethyl alcohol and water for full wash dialysis. The produced GelMA macropore hydrogel has the advantage of the macropore structure, can promote transportation of nutrient substances, discharging of metabolic products and cell communication, entraps a component containing Mg, has effect of promoting adhesion and proliferation of bone marrow mesenchymalstem cells and promoting osteogenic differentiation, has excellent biocompatibility, can be used as a bone tissue engineering scaffold with excellent performance, and has large clinical application potential in the field of bone repair.
Owner:SOUTH CHINA UNIV OF TECH

Tissue engineering scaffold, preparation method thereof and 3D printing ink capable of being directly biologically mineralized

The invention provides a tissue engineering scaffold, a preparation method thereof and a 3D printing ink capable of being directly biologically mineralized. The tissue engineering scaffold comprises ahigh molecular hollow tubular structure, and the surface of the scaffold is uniformly covered with a nano-hydroxyapatite layer with controllable thickness. The tissue engineering scaffold can be widely applied to filling and reconstruction of bone tissues. The preparation method of the tissue engineering scaffold is carried out by virtue of shell-core coaxial spray head 3D printing under bio-safety conditions, and a three-dimensional scaffold stacked by hollow pipes can be efficiently prepared. The scaffold comprises an open macroporous structure and a controllable hollow pipe structure. Compared with straight-through hole scaffolds prepared by virtue of an existing template method, the tissue engineering scaffold has two types of hole structures, and the tubular orientation is controllable. The uniformly-distributed and thickness-controllable nano-hydroxyapatite layer is rapidly mineralized on the surface of a high molecular hollow tubular scaffold, so that the adhesion and multiplication of cells and the osteogenic differentiation can be remarkably improved.
Owner:SHENZHEN UNIV

Composition and reserve of bone filling material as well as preparation methods and applications of composition and reserve

InactiveCN106729972AAppropriate hardnessPromote osteogenic differentiation and osteoblast functionTissue regenerationProsthesisSolventChemistry
The invention belongs to the technical field of medical biomaterials and particularly relates to composition and a reserve of a bone filling material as well as preparation methods and applications of the composition and the reserve. The composition of the bone filling material comprises bone meal, gelatin and a crosslinking agent, and has the advantages of being inductive, elastic and good in shaping property. The reserve of the bone filling material is a product prepared from a solution of the composition of the bone filling material through freeze drying. A method for preparing the bone filling material comprises the step of mixing the composition or the reserve of the bone filling material with a medically acceptable solvent. The raw materials are widely sourced, the preparation is simple, and a fillable bone filling material can be provided timely during clinical application. The bone filling material can be widely applied to the field of scientific research, or serve as a medical material for use.
Owner:李倩 +1

Anti-inflammatory anti-infection bacitracin fixing titanium alloy prosthesis capable of promoting osteogenic differentiation and bone mineralization and preparation method of prosthesis

InactiveCN105288732AImprove the defect of single functionReduce infectionProsthesisOsseous DifferentiationInflammatory factors
The invention relates to an anti-inflammatory anti-infection bacitracin fixing titanium alloy prosthesis capable of promoting osteogenic differentiation and bone mineralization and a preparation method of the prosthesis. According to the preparation method of the prosthesis, bacitracin is fixed on titanium alloy through a covalent grafting method, and an obtained bacitracin modified titanium sheet can keep antibacterial biological activity and can promote mesenchymal stem cell osteogenic differentiation and bone mineralization, in addition, a function of inhibiting inflammatory factor secretion is also realized, and moreover, the preparation process is simple, the reaction condition is mild, the efficiency is high, the cost is low, and the repeatability is good. The anti-inflammatory anti-infection bacitracin fixing titanium alloy prosthesis capable of promoting osteogenic differentiation and bone mineralization provided by the invention can effectively improve the defect of the single biological function of the titanium alloy applied clinically at present, and reduce the related complications such as the infection after the titanium alloy is implanted into a body and the looseness caused by excessive inflammatory reaction in an early stage.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Scaffold material for in vitro osteogenesis induced differentiation of mesenchymal stem cells, and application of scaffold material

The invention discloses a scaffold material for in vitro osteogenesis induced differentiation of mesenchymal stem cells, and application of the scaffold material. The scaffold material is characterized in that a porous silk protein scaffold is taken as a main body, the scaffold is enveloped with organic silicon by means of biological silicification, and the porous silk protein scaffold enveloped with the organic silicon is taken as a culture carrier for the in vitro osteogenesis induced differentiation of human marrow mesenchymal stem cells; the human marrow mesenchymal stem cells are taken as seed cells and are inoculated onto the porous silk protein scaffold enveloped with the organic silicon according to certain cell density, and the porous silk protein scaffold enveloped with the organic silicon is placed in an osteogenesis induced differentiation micro-environment for culturing. A three-dimensional osteogenesis induced differentiation system established by using the scaffold material not only can be used for directionally inducing the human marrow mesenchymal stem cells to differentiate into osteoblasts in bone tissue engineering so as to enable the osteoblasts with stable traits to be more efficiently obtained, but also can provide important theoretical guidance for the research of the bone tissue engineering so as to provide new ideas for the clinical treatment of osteoporosis, bone injury and other orthopedic diseases.
Owner:DALIAN MEDICAL UNIVERSITY

Orthopaedic implantation instrument with osteogenesis promoting coating on surface and preparation method

The invention provides an orthopaedic implantation instrument with an osteogenesis promoting coating on the surface and further discloses a preparation method of the orthopaedic implantation instrument. A polydopamine coating is arranged on the surface of a smooth orthopaedic implantation instrument base body or an orthopaedic implantation instrument base body with a micro-nano structure, and salidroside is fixed on the surface of the polydopamine coating to form the osteogenesis promoting coating. The preparation method of the orthopaedic implantation instrument comprises the following steps:1) pretreating the orthopaedic implantation instrument base body to obtain a smooth or micro-nano structure surface appearance on the surface; (2) after the orthopaedic implantation instrument base body is pretreated, adding the orthopaedic implantation instrument into a dopamine solution to react for a period of time to form the polydopamine coating on the surface of the orthopaedic implantationinstrument, then putting the orthopaedic implantation instrument into a solution containing the salidroside, and fixing the salidroside on the surface of the orthopaedic implantation instrument by utilizing the excellent bonding performance of the polydopamine coating on the surface of the orthopaedic implantation instrument; and 3) rinsing the material with deionized water, and naturally dryingthe rinsed material.
Owner:SHANGHAI CITY JIADING DISTRICT CENT HOSPITAL
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