The present invention is one kind of nanometer hollow spherical granular hydroxyapatite and its preparation process. The nanometer hollow spherical granular hydroxyapatite has diameter of 130-170 nm, wall thickness of 40-50 nm, crystalline hydroxyapatite content of 40-60 % and amorphous calcium phosphate for the rest. The preparation process includes the following steps: dropping calcium salt solution slowly into solution containing phosphate radical and CTAB as template agent at certain temperature and in ultrasonic condition, dropping ammonia water solution to regulating the solution pH value to 9-10 and obtain milk white suspension, filtering, washing and low temperature vacuum drying. The nanometer hollow spherical granular hydroxyapatite has simple preparation process, light weight, great specific surface area and important application foreground in medicine release controlling carrier, medicated tissue engineering rack, etc.