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Hollow ball shaped nanometer hydroxylapatite material and the preparing method

A technology of nano-hydroxyapatite and hydroxyapatite, which is applied in the fields of pharmaceutical formulations, medical preparations of non-active ingredients, medical science, etc., can solve the problems of not having very mature preparation methods, and achieve cheap and easy-to-obtain raw materials and preparation The method is simple and the effect of light specific gravity

Inactive Publication Date: 2007-09-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have successfully prepared CdS, ZrO2, TiO2, Si, SnO2 and other inorganic material nano-hollow spheres, but for bioceramics, there is no very mature and simple preparation method

Method used

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  • Hollow ball shaped nanometer hydroxylapatite material and the preparing method
  • Hollow ball shaped nanometer hydroxylapatite material and the preparing method
  • Hollow ball shaped nanometer hydroxylapatite material and the preparing method

Examples

Experimental program
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Embodiment 1

[0024] A hollow spherical nano-hydroxyapatite particle, the preparation process of which is as follows:

[0025] 1. At a concentration of 1.2 x 10 -3 Add the template agent CTAB to the 50mL disodium hydrogen phosphate solution of mol / L, and the concentration of CTAB in the mixed solution is 0.9×10 -3 mol / L, stir evenly with a magnetic stirrer, and the stirring speed is 200 rpm;

[0026] 2. After stirring the above first step solution for 10 minutes, measure the pH value of the mixed solution with precision alkaline test paper, and adjust the pH value of the solution to 9.5 with 0.1mol / L ammonia water;

[0027] 3. After stirring the solution in the second step above for 30 minutes, place it in a strong ultrasonic environment at 50°C for 5 minutes, and the ultrasonic input power is 40kHz, 150W;

[0028] 4. Slowly add 2 ml of calcium chloride solution with a concentration of 0.05 mol / L in the solution of the third step above, and the mol ratio of calcium and phosphate in the re...

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Abstract

The present invention is one kind of nanometer hollow spherical granular hydroxyapatite and its preparation process. The nanometer hollow spherical granular hydroxyapatite has diameter of 130-170 nm, wall thickness of 40-50 nm, crystalline hydroxyapatite content of 40-60 % and amorphous calcium phosphate for the rest. The preparation process includes the following steps: dropping calcium salt solution slowly into solution containing phosphate radical and CTAB as template agent at certain temperature and in ultrasonic condition, dropping ammonia water solution to regulating the solution pH value to 9-10 and obtain milk white suspension, filtering, washing and low temperature vacuum drying. The nanometer hollow spherical granular hydroxyapatite has simple preparation process, light weight, great specific surface area and important application foreground in medicine release controlling carrier, medicated tissue engineering rack, etc.

Description

technical field [0001] The invention relates to a nano-hydroxyapatite material, in particular to a nano-hollow spherical nano-hydroxyapatite material and a preparation method thereof. Background technique [0002] Due to traffic, sports injuries, the approaching aging society and the increasing demand for high-level quality of life, people's demand for medical devices and biomedical materials is increasing. Currently, medical biomaterials are used for human hard tissue repair and replacement. Among them, because hydroxyapatite is basically consistent with the inorganic components of human hard tissues, its biocompatibility and interface bioactivity are superior to various medical titanium, silicone rubber and carbon materials for bone grafting. Conductivity and the ability to combine with bone, plus no toxic side effects, no carcinogenic effect, so it is widely used as hard tissue repair materials and bone filling materials. Recently, in order to further improve the postope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L31/02A61K47/04
Inventor 唐睿康蔡玉荣
Owner ZHEJIANG UNIV
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