244 results about "Hydroxy apatite" patented technology

A process for preparing the bioactive porous structure on the surface of Ti explant for tooth includes such steps as blasting sand, double acid treating, treating with H2O2 and heat treating. Its surficial TiO2 layer can induce the crystallization of hydroxy apatite, and has high compatibility to bone tissue and high successful rate.

A composition of porous material and gel for preparing artificial bone is prepared from collagen and porous material chosen from alpha-tricalcium phosphate / hydroxy apatite, beta-tricalcium phosphate / hydroxy apatite-coral, calcium phosphate / hydroxy apatite, calcium carbonatel tricalcium phosphate, etc.

A process for synthesizing nano-class hydroxy apatite includes such steps as dissolving the organic compound containing carboxy, hydroxy and sulfonyl in the aqueous solution of Ca(NO3)2*4H2O at 40-100 deg.C, proportionally dripping H3PO4, regulating pH=10 or more, reaction for at least 4 hr, reaction at 40-200 deg.C for at least 8 hr, filter, washing and drying.

The invention relates to a macromolecule material / carbon material / hydroxyapatite hybridization fiber and the manufacture method. It includes the following steps: compounding carbon material / hydroxyapatite nm particle, making electric spinning suspension liquid, adopting electric spinning technology to make macromolecule material / carbon material / hydroxyapatite hybridization fiber and the carbon material and hydroxyapatite existing as nm compounding particle. The hybridization fiber has 3D multi-hole, and the porosity could be 30-99%, and the fiber diameter could be 20nm-2um. The invention has the excellent mechanical properties and good biocompatibility.

The porous bnoe prosthesis with good biological compatibility and biological activity is formed from nano hydroxyapatite and polyamide component with weight ratio of 1 / 1-0.3, and has mutual through pores whose pore size is 1-300 micrometers, and its total porosity is 30-70%. Its preparation method includes the following steps: according to the described ratio mixing fine hydroxyapatite powder and polyamide fine powder, then mixing them with ethyl alcohol solution containing calcium chloride to make solidifiation, and using water to dissolve the above-mentioned obtained material to remove water solubility component from solidified material and form porous structure in the bone prosthesis material.

A slowly-releasing artificial nerve canal for repairing nerve is prepared through dissolving the bio absorptive polylactic acid in organic solvent adding hydroxy apatite nanoparticles and freeze-dried nerve growth factor (NGF) powder, ultrasonic dispersing and volatilizing solvent to obtain milliporous canal.

The present invention relates to electrochemical deposition process of preparing nanometer ordered hydroxyapatite coating on the surface of medical metal material. Cathode electrochemical deposition onto surface of Ti or Ti alloy is performed with electrodeposition solution containing Ca ion of 1E(-4) to 1E(-3) mol / L and LH2PO4 ion of 0.5E(-4) to 1E(-3) mol / L and in voltage of 1-20 V and current of 0.1-10 mA / sq cm. By means of controlling the electrochemical deposition parameters for forming nanometer hydroxyapatite coating, nanometer hydroxyapatite crystal particles may have different aggregate forms to form different secondary microscopic structures, blossom cluster shaped, upstanding or microspore. The form controllable nanometer hydroxyapatite material is biological material with different topologic structure and homogeneous chemical property, and is expected to have raised biocompatibility and bioactivity in clinical application.

The invention discloses a degradable material for conducting hard tissue regeneration and renovation, and its preparation method which comprises, using degradable biomaterial collagen, chitosan or hydroxyl chitosan, tertiary calcium phosphate or hydroxyapatite as principal raw material, preparing acid solution and suspending liquid, mixing to prepare hard tissue filler, wherein the prepared biological material has good compatibility with the wound tissue.

The invention discloses a method for preparing a novel high-efficiency heavy metal ion sorbent-carbonic hydroxyl apatite: washing egg shells, drying, and crushing them into below 30 meshes, adding egg shell powder into phosphoric acid in the molar ratio of 1 to 1, calculated by CaCO3, controlling pH value at 1-3, controlling temperature at 30-40 deg.C, and reacting for 2-3 hours, where reaction equation: CaCO3+H3PO4=CaHPO4+CO2+H2O, filtering out nonsoluble matters, adding in urea and Ca(OH)2 powder in the molar ratio of 1 to 1, regulating the pH value to 9-12 with 1mol / L NaOH solution, preserving heat at 50-60 deg.C for 24 h, where chemical reaction formula: CaHPO4+(NH2)2CO+Ca(OH)2-Ca10{(PO4)6-x,(CO3 OH)x}(OH)2, cooling reaction product, and then washing with 1% NH4Cl solution to neutral, drying at 60 degrees centigrade, crushing and obtaining carbonic hydroxyl apatite powder.

Disclosed is a process for making hydroxy apatite / TiO2 biological ceramic coating on titanium based medical metallic material surface, which comprises, using titanium or titanium alloy as anode, stainless steel or titanium as cathode, oxidizing titanium or titanium alloy by using DC source or DC impulse source, then using the obtained titanium or titanium alloy with deposited oxidation film as cathode, using platinum wire or platinum sheets as anode, depositing ceramic film in Hap deposition solution.

PCT No. PCT / JP98 / 03523 Sec. 371 Date Apr. 29, 1999 Sec. 102(e) Date Apr. 29, 1999 PCT Filed Aug. 7, 1998 PCT Pub. No. WO99 / 15590 PCT Pub. Date Jan. 4, 1999A polyester composition, comprising a thermoplastic polyester resin and hydroxy apatite particles with an average particle diameter of 0.01 to 10 mu m and a specific surface area of 50 to 500 m2 / g and represented by the following chemical formula, and a film made thereof. A polyester film excellent in such basic properties as slipperiness and abrasion resistance, and also in electric properties, perforability, processability as a laminate with a metallic sheet, flavor properties, etc. can be obtained.Ca(PO4)l(OH)m(CO3)nYx(where Y stands for any optional anions other than phosphate group, hydroxyl group and carbonate group, l=0.4 DIFFERENCE 0.6, m=0.1 DIFFERENCE 0.4, n=0 DIFFERENCE 0.2, x=0 DIFFERENCE 0.2, 3xl+m+2xn+zxx=2 (z is the valence of anion(s) Y))

Oral care compositions suitable for whitening and remineralizing teeth are described. The oral care compositions comprise a phosphate source and regeneration-source calcium salt having a particle size of five (5) microns or less so that in-situ hydroxyapatite may be generated upon use.

The invention relates to a preparation method of a silk fibroin two-layer periosteum-imitation material. The preparation method comprises the steps of preparation of an outer-layer spinning solution, preparation of an inner-layer spinning solution and preparation of the two-layer periosteum-imitation material, wherein the obtained two-layer fibrous membrane is soaked in 70-100% methanol / water solution for aftertreatment to obtain the two-layer periosteum-imitation material which is insoluble in water. The prepared two-layer periosteum-imitation material can be used for repairing bone and wrapping a bone defect portion. The silk fibroin two-layer periosteum-imitation material has the advantages that the inner-layer base material and the outer-layer base material are the same, the layer compatibility is good, the inner layer and the outer layer are designed by stimulating the periosteum structure, the two-layer structure is provided, fibroin load growth factors are on the outer layer, fibroin composite hydroxyapatite is on the inner layer, and the fibroin load growth factors and the fibroin composite hydroxyapatite play the role of promoting angiogenesis and promoting bone growth ability, the two-layer periosteum is prepared through the electrospinning technology, and therefore the micro-nano fiber network structure of the periosteum can be better stimulated.

The process of preparing spherical nanometer hydroxyapatite crystal in water solution features that spherical nanometer hydroxyapatite crystal is synthesized with water soluble polymer PVP as template and through a biomineralization process. The process includes: spreading Ca(NO3)2íñ4H2O powder in the bottom of container A, preading (NH4)3PO4íñ3H2O powder in the weight ratio to Ca(NO3)2íñ4H2O of 1 to 1.67 in the bottom of container B, setting the container B inside the container B, slowly adding PVP aqua of pH 10.5 and concentration 0.02-2 wt% along in inner walls of the two containers to Ca(NO3)2íñ4H2O concentration of 0.01-0.20 mol / L and (NH4)3PO4íñ3H2O concentration of 0.006-0.12 mol / L and the solution overflow through the edge of the container B, stilling at 25 deg.c for 7 days to obtain precipitate, washing the precipitate, sucking filtering and drying to obtain the spherical nanometer hydroxyapatite crystal product. Altering the PVP concentration can regulate the crystal size in 15-150 nm.

A process for preparing a nano-class decorative organic silane layer on the surface of hydroxyphosphorite features use of non-protonic system as solvent and includes reflux in solvent, reaction, centrifugal separation, washing and drying. Its advantages are high decorative effect and controllable thickness (1.5-2.7 nm).

A thermoplastic polyester film including a virtually particle free polyethyleneterephthalate core layer and a skin layer comprising inorganic and organic fillers disposed on the core layer. The inorganic fillers may include aluminum oxide particles, silicon dioxide, zirconium oxide, titanium dioxide, tin oxide, calcium carbonate, barium sulfate, calcium phosphate, zeolite, hydroxy apatite, aluminum silicate and mixtures thereof. The inorganic fillers may have a particle size of from 0.01 μm to 0.60 μm. The organic filler particles may have an average particle size of less than or equal to 1 μm and may be present in an amount of less than 0.1% by weight, based on the weight of the polyethyleneterephthalate. The skin layer may have a thickness of less than 7 μm.

The invention relates to biologic medical composite materials, in particular to a magnetic nano porous composite bone tissue engineering support material and a preparation method thereof. The support material is formed by compounding nano hydroxy-apatite (HA), polylactic acid (PLLA) and magnetic nano particles. By utilizing a low-temperature quick shaping technique, the Nano-HA, the PLLA and the magnetic nano particle Fe2O3 are compounded to prepare a three-dimensional porous Nano-HA / PLLA / Fe2O3 artificial bone, and the three-dimensional porous magnetic nano artificial bone support material integrates the advantages of the Nano-HA, the PLLA and the Fe2O3, is improved in flexibility and biodegradability on the basis of good bone conductibility and biocompatibility, is improved in biomechanical performance, further facilitates the adhesion growth and vascularization of osteocytes, certainly improves the healing speed and effect of a transplanted artificial bone for a bone defect position, and is an ideal novel nano composite artificial bone material.

The invention relates to a biomimetic bone material containing graphene / hydroxyapatite / fibroin and a preparation method of the biomimetic bone material. The biomimetic bone material is prepared by assembling hydroxyapatite which is obtained through coprecipitation on the surface of carboxylation modified graphene through electrostatic adsorption, then blending the graphene assembled with the hydroxyapatite with fibroin solutions different in mass concentration, and freeze-drying layer by layer sequentially from higher mass concentration to lower mass concentration so as to obtain the biomimetic bone material. The graphene / hydroxyapatite / fibroin biomimetic bone material prepared by the invention simulates natural bone in ingredient and structure; the biomimetic bone material is excellent in biocompatibility and biodegradability, and is outstanding in mechanical property and porosity of graded distribution; and the biomimetic bone material, which can be used as a repair or substitute material of bone tissues, is broad in application prospect.

The present invention includes the following steps: hypotonic process to prepare extraction of algae, mixing hydroxyl apatite and the extraction of algae and eliminating the other components of extraction of algae in the supernatant; washing hydroxyl apatite with combined biliprotein with low concentration phosphate buffering liquid to eliminate other components; eluting phycocyanin or phycoerythrin from hydroxyl apatite with medium concentration phosphate buffering liquid and collecting phycocyanin or phycoerythrin; and eluting hydroxyl apatite with higher concentration phosphate buffering liquid to obtain allophycocyanin component. The present invention has high yield and purify of biliprotein and is favorable to production in industrial scale.

The invention discloses a zirconia, hydroxyapatite and magnesium phosphate laminar composite and belongs to the field of medical laminar composites. A method for preparing the laminar composite is characterized in that a zirconia and hydroxyapatite two-component slurry layer and a zirconia, hydroxyapatite and magnesium phosphate three-component slurry layer are coated outside a zirconia ceramic surface layer with stable yttria through a physical coating method in sequence. The flexure strength and the breaking tenacity of the laminar composite are enhanced through adjusting the addition of zirconia of an inner layer, and the bone-growth inducibility of the laminar composite is improved through regulating the addition of hydroxyapatite and magnesium phosphate of an outer layer. The prepared multilayer ceramic composite is superior to a traditional bone repair material in flexure strength and breaking tenacity. Moreover, the multilayer ceramic composite is higher in biocompatibility and inducing osteogenesis capability and can be used for repairing bone defects of parts, such as shanks, thigh joints and the like.

A tissue-engineered scaffold material for medical purpose is composed of nano-class hydroxy apatite and the medical high-molecular material, and has the pores communicated with each other. It features that the dispersed microporous microballs are proportionally contained by it. Its preparing process includes such steps as proportionally mixing said microballs, nano-class hydroxy apatite, medical high-molecular slurry and the salt able to thermally generate gas, heating, and freeze-drying at -20 deg.C for at least 24 hr.

A hydroxy apatite marked by the nanoparticles of near-infrared fluorescent quantum point for researching the growth of bone and diagnosing and treating the diseases, such as coronary sclerosis, bone cancer, etc is prepared by linking the nanoparticles of near-infrared fluorescent quantum point with the hydroxy opatite via adsorption, ion exchange, or covalent bonding.

A process for preparing the composite hydrogel of nano-hydroxy apatite and polyvinyl alcohol includes such steps as preparing nano-class hydroxyapatite crystal slurry, preparing purified polyvinyl alcohol solution, mixing them together, and freeze-thaw shaping.

An artificial skull with high surficial bioactivity is prepared from methyl polymethacrylate, biological carbon (or glass) fibres and hydroxy apatite (or beta-tricalcium phosphate) micropowder through laminating or hot pressing, and immersing in simulative body fluid.

The invention discloses a preparation method of a hydroxy apatite / polylactic acid / chitosan composite microballoon. The hydroxy apatite / polylactic acid / chitosan composite microballoon is prepared by using hydroxy apatite HA, polylactic acid PLA and chitosan CS as raw materials and employing manufacturing principles of a solution blending method and an emulsion method. The method comprises steps of: dropping a prepared apatite / polylactic acid / chitosan acetate acid gracial solution into a stirred liquid paraffin / petroleum ether mixed liquor ; carrying out stewing; removing the liquid paraffin / petroleum ether mixed liquor; washing; carrying out stewing; and refrigerating drying to obtain the composite microballoon product. The hydroxy apatite / polylactic acid / chitosan composite microballoon of the invention compounds three materials with different performances to solve problems of strength, toughness and biocompatibility of the material; and the hydroxy apatite / polylactic acid / chitosan composite microballoon is mainly used in bone tissue restoration material, cell engineering and transmission of medicament and bioactive molecule.

The preparation process of artificial bone with spherical inner hole in gradient changing structure includes the following steps: mixing PVC balls and table salt crystal in certain ratio, setting the mixture inside mold, injecting adhesive, washing out salt with deionized water after the adhesive is cured to obtain PVC polymer template, injecting hydroxy apatite slurry, heating to dry and sintering. The hydroxy apatite rack with 3D communicated spherical structure has high strength, good pore communication, gradiently changing porosity and pore size, structure similar to natural bone, raised mechanical performance and biocompatibility, and important significance on the clinical research in bone tissue engineering.

The invention discloses a two-phase calcium phosphate material, a preparation method thereof, and a two-phase calcium phosphate artificial bone ceramic, and belongs to the field of biological ceramic materials. The two-phase calcium phosphate artificial bone ceramic is prepared through preparing a beta phase tricalcium phosphate (beta-TCP) and hydroxy apatite (HA) mixture (the two-phase calcium phosphate material) from egg shells and carrying out a sintering process. The beta-TCP and the HA are prepared from the egg shells with abundant sources through a one-step chemical synthesis process, the mass proportions of the beta-TCP and the HA in the two-phase calcium phosphate are controlled through changing the particle dimensions of the egg shells in the hydrothermal synthesis process, and the preparation cost of the two-phase calcium phosphate material is low. The two-phase calcium phosphate ceramic is prepared through a template process under pressureless sintering conditions, and the two-phase calcium phosphate ceramic with different degradation speeds can be prepared through controlling the mass proportions of the beta-TCP and the HA, so different demands of bone defect patients on the degradation period of artificial bone scaffold materials due to individual difference are met.

The invention discloses a method for preparing titanium base hydroxy apatite or titanium oxide nano tube composite coating, comprising the following steps: the pure titanium is taken as an anode while a platinum plate is taken as a cathode; in the dimethyl sulfoxide solution containing HF with the weight percent of 1 to 4 percent, under the voltage of 20 to 70 V, the pure titanium and the platinum plate are oxidized for 2 to 10 hours in the water bath with the temperature of 10 to 30 DEG C; then, a titanium oxide nano tube array film is arranged in aqueous solution which contains 0.1 to 0.5mol per liter of CaC12, 0.1 to 0.5 mol per liter of NaH2PO4 and 0.2 mol per liter of EDTA. The PH value of the solution is adjusted by NaOH to be 4 to 6. Under the condition of the temperature of 100 to 200 DEG C and hydrothermal reaction of 2 to 10 hours, the hydroxyapatite is induced to be crystallized and deposited on the surface of the array film of the nano tube and a novel hydroxyapatite coating layer which takes the array film of the titanium oxide nano tube as a buffer layer is formed. The method is characterized by taking the array film of the titanium oxide nano tube as the buffer layer, which reduces the residual stress caused by mismatch of coefficient of heat expansion of the hydroxyapatite and the titanium base and enhances the binding strength of the coating layer and the base interface.