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Two-phase calcium phosphate material, preparation method thereof, and two-phase calcium phosphate artificial bone ceramic

A calcium phosphate, artificial bone technology, applied in ceramic products, chemical instruments and methods, phosphorus compounds, etc., can solve the problems of fast degradation and refractory degradation of β-TCP

Active Publication Date: 2015-11-25
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that β-TCP degrades too fast and HA is difficult to degrade in common calcium phosphate artificial bone materials, and provides a two-phase calcium phosphate material and its preparation method and two-phase calcium phosphate artificial bone ceramics. Inexpensive eggshells are used as raw materials to prepare the required two-phase calcium phosphate material composed of β-TCP and HA, and further prepare the two-phase calcium phosphate artificial bone ceramic material with controllable degradation rate, which has important clinical application value

Method used

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  • Two-phase calcium phosphate material, preparation method thereof, and two-phase calcium phosphate artificial bone ceramic
  • Two-phase calcium phosphate material, preparation method thereof, and two-phase calcium phosphate artificial bone ceramic
  • Two-phase calcium phosphate material, preparation method thereof, and two-phase calcium phosphate artificial bone ceramic

Examples

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Embodiment 1

[0029] Raw materials and requirements: egg shells and diammonium hydrogen phosphate (analytical pure).

[0030] Removal of organic matter: After peeling and removing the egg membrane on the eggshell, immerse in boiling water and boil for 30 minutes, and ultrasonically vibrate in 10wt.% NaClO solution for 40 minutes to remove organic matter in the eggshell and impurities on the surface. After taking it out, wash it three times with deionized water and dry it in a vacuum oven at 100°C.

[0031] Grinding and sieving: Grind the eggshells after removing organic matter in a mortar and pass through 20 and 40 mesh sieves, and take 20-40 mesh eggshell particles (355-850 μm in size) for the next step of hydrothermal reaction.

[0032] Hydrothermal reaction: mix 20-40 mesh eggshell particles with (NH 4 ) 2 HPO 4 The solution was mixed according to a weight ratio of 1:15 and placed in a hydrothermal reaction kettle, and the hydrothermal reaction was carried out at 200° C. for 24 hours ...

Embodiment 2

[0037] This example will select 40 and 100 mesh sieves to sieve to obtain eggshell particles (size 150-355 μm) as raw materials, and the mass percentage of β-TCP in the two-phase calcium phosphate material obtained by hydrothermal reaction is about 70% ( figure 2 ). All the other are with embodiment 1.

Embodiment 3

[0039] This example will select 100 and 300 mesh sieves to sieve to obtain eggshell particles (size 45-150 μm) as raw materials, and the mass percentage of β-TCP in the two-phase calcium phosphate material obtained by hydrothermal reaction is about 45% ( figure 2 ). All the other are with embodiment 1.

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Abstract

The invention discloses a two-phase calcium phosphate material, a preparation method thereof, and a two-phase calcium phosphate artificial bone ceramic, and belongs to the field of biological ceramic materials. The two-phase calcium phosphate artificial bone ceramic is prepared through preparing a beta phase tricalcium phosphate (beta-TCP) and hydroxy apatite (HA) mixture (the two-phase calcium phosphate material) from egg shells and carrying out a sintering process. The beta-TCP and the HA are prepared from the egg shells with abundant sources through a one-step chemical synthesis process, the mass proportions of the beta-TCP and the HA in the two-phase calcium phosphate are controlled through changing the particle dimensions of the egg shells in the hydrothermal synthesis process, and the preparation cost of the two-phase calcium phosphate material is low. The two-phase calcium phosphate ceramic is prepared through a template process under pressureless sintering conditions, and the two-phase calcium phosphate ceramic with different degradation speeds can be prepared through controlling the mass proportions of the beta-TCP and the HA, so different demands of bone defect patients on the degradation period of artificial bone scaffold materials due to individual difference are met.

Description

technical field [0001] The invention relates to a two-phase calcium phosphate material, a preparation method thereof and a two-phase calcium phosphate artificial bone ceramic, belonging to the field of biological ceramic materials. Background technique [0002] Bone defect repair is one of the common clinical symptoms of orthopedics. In my country alone, there are about 3 million patients with bone defects or bone injuries caused by various accidents and diseases every year. Small bone defects can be healed by the body's own regeneration function; large bone defects cannot be repaired by themselves, and may cause "bone nonunion" if not treated, so implant materials are needed to help bone tissue repair and heal . Artificial bone materials (including calcium phosphate ceramics, bone cement and polymers) are more and more widely used in clinical bone defect repair; among them, calcium phosphate ceramics include hydroxyapatite (HA), β-phase tricalcium phosphate (β -TCP) and t...

Claims

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Application Information

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IPC IPC(8): C01B25/32C04B35/447C04B38/06C04B35/622C04B35/626
Inventor 张兴崔嵬杨锐杨丽娜
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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