1707results about How to "Inhibit production" patented technology

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

A computer, terminal and a method for blocking the use and creating of vulgar and pornographic material in a responsive and interactive matter that comprehensively monitors computer operations for creation or transmission of vulgar and pornographic material. Data created by the keyboard, data passing through the clipboard, data selected by the mouse pointer, and data passing through the Internet interface are monitored for content and further operation of the computer terminal is blocked. The computer terminal may only be unblocked by a supervisory intervention, such as by entering of a password, or by restarting or resetting the terminal. Key word searches, such as those in Internet search engines, are also monitored, but the terminal adapts to monitor not only for words of a profane and vulgar nature, but also for words that are behaviorally tested to produce lists containing vulgar and profane items, e.g., Internet sites. The computer terminal and method can be modified to block other forms of communication or computer operation, such as blocking transmission of secret business data, blocking execution or opening of certain programs or files, and the like.

A process for selective formation of ethanol from acetic acid includes contacting a feed stream containing acetic acid and hydrogen at an elevated temperature with catalyst comprising platinum and tin on a high surface area silica promoted with calcium metasilicate. Selectivities to ethanol of over 85% are achieved at 280° C. with catalyst life in the hundreds of hours.

This invention relates to improved methods for completing wells in unconsolidated subterranean zones. More specifically, the present invention relates to cement compositions useful in subterranean applications, and more particularly, to permeable cement compositions and methods for forming consolidated permeable cement masses in well bores to prevent sand influx into the well bores with produced fluids. In one embodiment, the permeable cement compositions of the present invention comprise a hydraulic cement, water, and a degradable material capable of undergoing an irreversible degradation downhole.

Packages and methods for storage and dispensing of materials, e.g., high purity liquid reagents and chemical mechanical polishing compositions used in the manufacture of microelectronic device products, including containment structures and methods adapted for pressure-dispensing of high-purity liquids. Liner packaging of liquid or liquid-containing media is described, in which zero or near-zero head space conformations are employed to minimize adverse effects of particle generation, formation of bubbles and degradation of contained material.

Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. Th1, Th17 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation.

The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.

A system for determining whether arcing is present in an electrical circuit includes a sensor for monitoring a current waveform in the electrical circuit, and an arc fault detection circuit which determines whether an arc fault is present in response to the sensor. The arc fault detection circuit includes a controller which produces a trip signal in response to a determination that an arcing fault is present in the electrical circuit, and an inhibit/blocking function for preventing the production of the trip signal under one or more predetermined conditions.

A pumping system comprises a pump barrel that is adapted to be placed into a well casing. A plunger is reciprocatably positioned within the pump barrel and has an open top end, a bottom end, and a traveling valve at the bottom end. A connector is coupled to the plunger below the top end. A rod is coupled to the connector and is translatable to reciprocate the plunger within the pump barrel using an upstroke and a downstroke. Further, the top end of the plunger is adapted to direct particulate into the plunger and away from the pump barrel upon each upstroke.

This invention provides a class of androgen receptor targeting agents (ARTA). The compounds are selective androgen receptor modulators (SARM) useful for, inter-alia, suppressing spermatogenesis, treating a subject having a hormone related condition, treating a subject suffering from prostate cancer, delaying the progression of prostate cancer, preventing the recurrence of prostate cancer, and treating the recurrence of prostate cancer.

Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.

The invention relates to compounds of structural formula (I):

or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein A, Y, L, R₁, W₁ and W₂ are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.