8577results about How to "The result is accurate" patented technology

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

An apparatus for detection and quantitation of an electrochemically-detect- able analyte, such as glucose, in blood or interstitial fluid includes a meter unit, a lancet and an electrochemical sensor. Of these components, the meter is preferably reusable, while the lancet and the electrochemical sensor are preferably incorporated in assemblies intended for single-use. The meter unit has a housing, within which a lancet is engaged with a mechanism for moving then lancet; a connector disposed within the housing for engaging an electrochemical sensor specific for the analyte and transmitting a signal indicative of the amount of analyte, and a display operatively-associated with a connector for displaying the amount of the analyte to user. The electrochemical sensor is adapted for detection of a particular analyte. In addition, the electrochemical sensor has an absorptive member for uptake of a sample of blood or interstitial fluid. In one version, the lancet moves from a initial position to a piercing position in which skin of the user is pierced and optionally back to a retracted position. The electrochemical sensor is disposed such that the absorptive member takes up a sample from the pierced skin of the user when it is pierced by the lancet without movement of the apparatus. In an alternative version, the lancet is a hollow cannula through which blood or interstitial fluid is transported from the puncture site to an absorbent portion of the electrochemical sensor. In either version, the apparatus provides single-step operation in which sample acquisition and analysis occur as a result of the single action of pressing the apparatus against the users skin.

The present invention relates to an apparatus and method for the non-invasive analysis of physiological attributes, such as heart rate, blood pressure, cardiac output, respiratory response, body composition, and blood chemistry analytes including glucose, lactate, hemoglobin, and oxygen saturation. Using a combination of multi-functioning disparate sensors, such as optical and electrical, improvements are made over existing physiological measurement devices and techniques. The special configuration of one or more multi-functional sensors is used to non-invasively measure multi-wavelength optical plus one or more of ECG, Bio-impedance, and RF-impedance spectroscopic data. This information is used to develop self-consistent, non-linear algorithm in order to derive the physiological attributes while compensating for various forms of interfering effects including motion artifacts, sensor attachment variability, device component variability, subject physical and physiology variability, and various interfering physiological attributes.

A method for generating a photolithography mask for optically transferring a pattern formed in the mask onto a substrate utilizing an imaging system. The method includes the steps of: (a) defining a set of calibration patterns, which are represented in a data format; (b) printing the calibration patterns on a substrate utilizing the given imaging system; (c) determining a first set of contour patterns corresponding to the calibration patterns imaged on the substrate; (d) generating a system pseudo-intensity function, which approximates the imaging performance of the imaging system; (e) determining a second set of contour patterns by utilizing the system pseudo-intensity function to define how the calibration patterns will be imaged in the substrate; (f) comparing the first set of contour patterns and the second set of contour patterns to determine the difference therebetween; (g) adjusting the system pseudo-intensity function until the difference between the first set of contour patterns and the second set of contour patterns is below a predefined criteria; and (h) utilizing the adjusted system pseudo-intensity function to modify the mask so as to provide for optical proximity correction.

An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.

This invention provides a novel means for creating a histogram for use in minimizing response time and resource consumption when optimizing a query in a database, and other like structures, the histogram being created by placing ordered elements into specific range until the next element to be considered for inclusion in the range is a predetermined distance from the (generalized) mean value associated with the elements within the range, whereupon that next element is placed in the following range. Similarly, the following ranges are closed when the next element to be considered for inclusion in the range is greater than a predetermined distance from the (generalized) mean value associated with the elements in that range, whereupon that next element is placed in the following range. For each range, the location and size of the range is recorded with, for example, the mean value, the slope or other attribute characterizing one or more elements in the range. The invention has also applications in pattern recognition, message routing, and in actuarial sciences.

Described is a technology by which raw GPS data is processed into segments of a trip, with a predicted mode of transportation (e.g., walking, car, bus, bicycling) determined for each segment. The determined transportation modes may be used to tag the GPS data with transportation mode information, and / or dynamically used. Segments are first characterized as walk segments or non-walk segments based on velocity and / or acceleration. Features corresponding to each of those walk segments or non-walk segments are extracted, and analyzed with an inference model to determine probabilities for the possible modes of transportation for each segment. Post-processing may be used to modify the probabilities based on transitioning considerations with respect to the transportation mode of an adjacent segment. The most probable transportation mode for each segment is selected.

This invention describes an electrochemical sensor which is adapted to reduce the effects of interfering compounds in bodily fluids when measuring an analyte in such fluids using an electrochemical strip. The sensor includes a substrate, a first and second working electrodes, and a reference electrode. A reagent layer is disposed on the electrodes such that, in one embodiment it completely covers all of the first working electrode, but only partially covers the second working electrode and, in a second embodiment, it only covers a portion of the first and the second working electrode. The portion of the working electrodes not covered by the reagent layer and is used to correct for the interference effect on the analyte measurement.

A document classification system and method reflects operator's intention in a result of classification of document so that an accurate result of classification can be achieved. The document to be classifies has contents contains a plurality of items. At least one of the items contained in the document is designated. The document data is converted into converted data so that the converted data contains only data corresponding to the designated item. Classification of the document is done by using the converted data.

A self-contained, integrated micro-cube-sized inertial measurement unit is provided wherein accuracy is achieved through the use of specifically oriented sensors, the orientation serving to substantially cancel noise and other first-order effects, and the use of a noise-reducing algorithm such as wavelet cascade denoising and an error correcting algorithm such as a Kalman filter embedded in a digital signal processor device. In a particular embodiment, a pair of three sets of angle rate sensors are orientable triaxially in opposite directions, wherein each set is mounted on a different sector of a base orientable normal to the other two and comprising N gyroscopes oriented at 360 / N-degree increments, where N≧2. At least one accelerometer is included to provide triaxial data. Signals are output from the angle rate sensors and accelerometer for calculating a change in attitude, position, angular rate, acceleration, and / or velocity of the unit.

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

An apparatus for detection and quantitation of an electrochemically-detectable analyte, such as glucose, in blood or interstitial fluid includes a meter unit, a lancet and an electrochemical sensor. Of these components, the meter is preferably reusable, while the lancet and the electrochemical sensor are preferably incorporated in assemblies intended for single-use. The meter unit has a housing, within which a lancet is engaged with a mechanism for moving then lancet; a connector disposed within the housing for engaging an electrochemical sensor specific for the analyte and transmitting a signal indicative of the amount of analyte, and a display operatively-associated with a connector for displaying the amount of the analyte to user. The electrochemical sensor is adapted for detection of a particular analyte. In addition, the electrochemical sensor has an absorptive member for uptake of a sample of blood or interstitial fluid. In one version, the lancet moves from a initial position to a piercing position in which skin of the user is pierced and optionally back to a retracted position. The electrochemical sensor is disposed such that the absorptive member takes up a sample from the pierced skin of the user when it is pierced by the lancet without movement of the apparatus. In an alternative version, the lancet is a hollow cannula through which blood or interstitial fluid is transported from the puncture site to an absorbent portion of the electrochemical sensor. In either version, the apparatus provides single-step operation in which sample acquisition and analysis occur as a result of the single action of pressing, the apparatus against the users skin.

The present invention provides a new application for an inductive coupler (12) used proximate a power transmission line (14). The magnetic field based power measurement method and system discussed herein in unique and differs from the prior technology by using near-real time intervals and periods that occur systemically in parallel with electrical systems rather than an accumulated period with little or no active capacity or proactive features. The inductive coupler (12) described herewith is used to collect, measure, and / or extract electromagnetic changes.

A system for detecting subtle differences in a signal in a set of linearly and / or non-linearly related signals that characterize a sensor-instrumented machine, process or living system. The system employs an improved similarity operator for signal differentiation. Signals or data representative of several linearly and / or non-linearly related parameters that describe a machine, process or living system are input to the inventive system, which compares the input to acceptable modeled states. If one or more of the input signals or data are different than expected, given the relationships between the parameters, the inventive system will indicate that difference. The system can provide expected parameter values, as well as the differences between expected and input signals; or the system can provide raw measures of similarity between the collection of input signals and the collection of acceptable modeled states. The system can be embodied in software or in a micro-controller.

In a system for stereo vision including two cameras shooting the same scene, a method is performed for determining scattered disparity fields when the epipolar geometry is known, which includes the steps of: capturing, through the two cameras, first and second images of the scene from two different positions; selecting at least one pixel in the first image, the pixel being associated with a point of the scene and the second image containing a point also associated with the above point of the scene; and computing the displacement from the pixel to the point in the second image minimising a cost function, such cost function including a term which depends on the difference between the first and the second image and a term which depends on the distance of the above point in the second image from a epipolar straight line, and a following check whether it belongs to an allowability area around a subset to the epipolar straight line in which the presence of the point is allowed, in order to take into account errors or uncertainties in calibrating the cameras.

A screening and survey selection system, method of screening and selecting for a survey and a computer system employing the system and method. In one embodiment, the screening and survey selection system includes a survey queue having a plurality of queue slots, each of the plurality of queue slots including a survey available for a respondent. The screening and survey selection system also includes a random number generator that generates a number pertaining to a selected one of the plurality of queue slots as a function of at least one characteristic associated with the respondent. The screening and survey selection system still further includes a screener block question generator that develops a plurality of screener block questions that determine if the respondent is qualified to participate in a survey corresponding to the selected one of the plurality of queue slots.

A computerized method for monitoring a water utility network, the water utility network comprising a network of pipes for delivering water to consumers and a plurality of meters positioned within the pipes across the water distribution network. The method includes receiving meter data representing parameters measured by the meters, such as flow, pressure, chlorine level, pH and turbidity of the water being distributed through the pipes. The method also includes receiving secondary data from sources external to the meters and representing conditions affecting consumption of water in a region serviced by the water utility network such as weather and holidays. The meter and secondary data is analyzed using statistical techniques to identify water network events including leakage events and other events regarding quantity and quality of water flowing through the pipes and operation of the water network. The events are reported to users via a user interface.

This invention pertains to processing continuous webs such as paper, film, composites, and the like, in dynamic continuous processing operations. More particularly, it relates to controlling tension in such continuous webs during the processing operation. Tension is controlled in a dancer control system by connecting a corresponding dancer roll to an actuator apparatus or the like, sensing variables such as position, tension, velocity, and acceleration parameters related to the web and the dancer roll, and providing active force commands, in response to the sensed variables, to cause translational movement, generally including a target acceleration, in the dancer roll to control tension disturbances in the web. In some applications of the invention, the dancer control system is used to attenuate tension disturbances. In other applications of the invention, the dancer control system is used to create tension disturbances.

A system, apparatus, method and computer program product to obtain comprehensive vehicle radio listener statistics based on parameters such as radio status (e.g., on / off status and CD / Tape / AM / FM setting), radio volume, station preset information, current frequency setting (i.e., station identification), and Global Positioning Satellite (GPS) system coordinates is disclosed. A vehicle-mounted field unit for collecting and transmitting such parameters to a base station is also disclosed. The system monitors and stores all events related to the occupants' interaction with the vehicle's radio, including automatic detection of the selected radio station through a speaker port. The stored data is then transmitted to a base station's central collection computer for immediate compilation and analysis. The system is capable of producing detailed reports containing error-free, unbiased, audience measurement statistics which can be made available to subscribers such as broadcasters, corporate advertisers, advertising agencies and the like.

The present invention relates to an apparatus and method for the non-invasive analysis of physiological attributes, such as heart rate, blood pressure, cardiac output, respiratory response, body composition, and blood chemistry analytes including glucose, lactate, hemoglobin, and oxygen saturation. Using a combination of multi-functioning disparate sensors, such as optical and electrical, improvements are made over existing physiological measurement devices and techniques. The special configuration of one or more multi-functional sensors is used to non-invasively measure multi-wavelength optical plus one or more of ECG, Bio-impedance, and RF-impedance spectroscopic data. This information is used to develop self-consistent, non-linear algorithm in order to derive the physiological attributes while compensating for various forms of interfering effects including motion artifacts, sensor attachment variability, device component variability, subject physical and physiology variability, and various interfering physiological attributes.

The present invention relates to laser ablation patterns to correct refractive errors of the eye (60) such as nearsightedness, farsightedness, astigmatism, and higher order aberrations of the eye (60). The laser ablation patterns used to control the laser (10) prevent induced aberrations by compensating for post-procedure epithelial smoothing. The position of laser pulses (12) is also controlled to optimize the achievement of the intended ablation pattern.

Apparatus comprising a housing; stimulation means mounted to the housing; a biosensor releasably mounted to the housing, the biosensor comprising a plurality of electrodes for detecting a sural nerve response evoked by the stimulation means; acquisition means mounted to the housing and electrically connected to the biosensor for acquiring the sural nerve response; processing means mounted to the housing and electrically connected to the acquisition means for digitizing, processing and storing the acquired sural nerve response; calculation means mounted to the housing and electrically connected to the processing means for calculating the conduction velocity and amplitude of the processed sural nerve response; and display means mounted to the housing for displaying the sural nerve conduction velocity and amplitude; wherein the stimulation means and the biosensor are designed to be placed on a patient's anatomy, in the vicinity of a sural nerve, by manipulating the housing.

A data analysis system that includes an information mining engine for extracting structured data from unstructured data, a data store for storing the extracted structured data, data received from third party data sources, and data received from sensors monitoring insured property is described. The system also includes a business logic processor that synergistically analyzes the structured data extracted by the text mining engine, the data received from the sensor, and the data received from the third party data source to make an insurance evaluation.

A CMOS imager includes an array of active pixel sensors, wherein each pixel is associated with a respective column in the array. The imager also includes multiple circuits for reading out values of pixels from the active sensor array. Each readout circuit can be associated with a respective pair of columns in the array and can include first and second sample-and-hold circuits. The first and second sample-and-hold circuits are associated, respectively, with first and second columns of pixels in the array. Each readout circuit also includes an operational amplifier-based charge sensing circuit that selectively provides an amplified differential output signal based on signals sampled either by the first sample-and-hold circuit or the second sample-and-hold circuit. The readout circuit also has an analog-to-digital converter for converting the differential output to a corresponding digital signal using a successive approximation technique. Use of the readout circuit can increase the parallel structure of the overall chip, thereby reducing the bandwidth which each readout circuit must be capable of handling.

The present specification discloses various embodiments of a digital device and a method for controlling the same. A method for controlling a digital device according to an embodiment of the present invention may comprise the steps of: connecting to a repeater; sensing an external device located within a preconfigured distance and connected to the repeater; receiving an audio reference data transmission request from the sensed external device; and transmitting the requested audio reference data to the external device.

Systems and methods are disclosed for segregating target individuals represented in a probe digital image from background pixels in the probe digital image. In particular, in one or more embodiments, the disclosed systems and methods train a neural network based on two or more of training position channels, training shape input channels, training color channels, or training object data. Moreover, in one or more embodiments, the disclosed systems and methods utilize the trained neural network to select a target individual in a probe digital image. Specifically, in one or more embodiments, the disclosed systems and methods generate position channels, training shape input channels, and color channels corresponding the probe digital image, and utilize the generated channels in conjunction with the trained neural network to select the target individual.

A method of determining reflective optical quality of a reflective product includes reflecting a first gray-scale pattern off the product; obtaining a first image of the first pattern with an image pickup device after the first pattern has reflected off of the product; and determining optical quality of the product based on data obtained from the first image. An apparatus for determining reflective optical quality of such a product is also disclosed.

The subject invention relates to facilitating text detection. The invention employs a boosted classifier and a transductive classifier to provide accurate and efficient text detection systems and / or methods. The boosted classifier is trained through features generated from a set of training connected components and labels. The boosted classifier utilizes the features to classify the training connected components, wherein inferred labels are conveyed to a transductive classifier, which generates additional properties. The initial set of features and the properties are utilized to train the transductive classifier. Upon training, the system and / or methods can be utilized to detect text in data under text detection, wherein unlabeled data is received, and connected components are extracted therefrom and utilized to generate corresponding feature vectors, which are employed to classify the connected components using the initial boosted classifier. Inferred labels are utilized to generate properties, which are utilized along with the initial feature vectors to classify each connected component using the transductive classifier.

A computerized method for monitoring a water utility network, the water utility network comprising a network of pipes for delivering water to consumers and a plurality of meters positioned within the pipes across the water distribution network. The method includes receiving meter data representing parameters measured by the meters, such as flow, pressure, chlorine level, pH and turbidity of the water being distributed through the pipes. The method also includes receiving secondary data from sources external to the meters and representing conditions affecting consumption of water in a region serviced by the water utility network such as weather and holidays. The meter and secondary data is analyzed using statistical techniques to identify water network events including leakage events and other events regarding quantity and quality of water flowing through the pipes and operation of the water network. The events are reported to users via a user interface.

Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes an illumination / laser beam delivery system that is adapted to both illuminate a sample and provide energy for laser capture microdissection of the sample. The systems and methods provide the advantages of increased speed and much lower rates of contamination.