This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt,
amide or ester thereof, wherein R1 represents a
hydrogen atom or a
halogen atom; R2 represents a
hydrogen atom, etc.; R3 represents an
alkyl group having from 1 to 10 carbon atoms; said
alkyl group of R3 is substituted by at least one
substituent selected from the group consisting of substituents α; said substituents α is
aryl, hydroxy, oxo, etc.; said
aryl having 6 to 10 carbon atoms; said
aryl is unsubstituted or substituted by at least one
alkyl group having from 1 to 6 carbon atoms; said heterocyclic and the heterocyclic
moiety of said heterocycliccarbonyl, both of substituents α, are 5- to 10-membered cyclic groups containing from 1 to 4 heteroatoms selected from the group consisting of
nitrogen atoms,
oxygen atoms and
sulfur atomsThese compounds have 5-HT4
receptor binding activity, and thus are useful for the treatment of gastroesophageal
reflux disease, non-ulcer dyspepsia, functional dyspepsia,
irritable bowel syndrome or the like in mammalian, especially humans. This invention also provides a pharmaceutical composition comprising the above compound.