205 results about "Nausea sickness" patented technology

An electro-acupuncture device for controlling nausea. The device includes a base unit which is includes a wrist-watch like housing, circuitry for generating electro-acupuncture stimulus disposed within the housing, and a strap for securing the housing to the wrist. The base unit has a standardized construction. The device also includes a releasably attachable electrode assembly. The electrode assembly attaches to the base unit of the device. The electrode assembly includes a pair of electrodes and connectors for connecting the electrodes to the circuitry of the base unit. The output of the device is dependent upon the circuitry of the electrode assembly. Thus various electrode assemblies can be made. The circuitry of the base unit modifies the output of the device depending upon which electrode assembly is attached to the base unit.

The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugate of the invention.

Tranexamic acid formulated in an oral dosage form with at least one agent that decreases tranexamic acid release in the stomach. Such formulations minimize nausea, vomiting, and other adverse gastric effects that may accompany tranexamic acid therapy, for example, to treat heavy menstrual bleeding. One embodiment is an extended release formulation with waxes, polymers, etc. that prevent a bolus release of tranexamic acid in the stomach. An alternative embodiment is a delayed release formulation with polymers that prevent release of tranexamic acid in the acid environment of the stomach and delay its release until the formulation reaches the less acid environment of the intestines. Such formulations enhance patient compliance with therapy because adverse effects of tranexamic acid therapy are reduced.

The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

An electro-acupuncture device for controlling nausea. The device includes a base unit which is includes a wrist-watch like housing, circuitry for generating electro-acupuncture stimulus disposed within the housing, and a strap for securing the housing to the wrist. The base unit has a standardized construction. The device also includes a releasably attachable electrode assembly. The electrode assembly attaches to the base unit of the device. The electrode assembly includes a pair of electrodes and connectors for connecting the electrodes to the circuitry of the base unit. The output of the device is dependent upon the circuitry of the electrode assembly. Thus various electrode assemblies can be made. The circuitry of the base unit modifies the output of the device depending upon which electrode assembly is attached to the base unit.

A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and / or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.

The present invention aims at providing a tongue cleaner which can be used with one hand without damaging an inside surface of a roof of the mouth. A tongue cleaner of the present invention comprises a head 1, and a rod-shaped handle 3 connected to one end of the head 1. The tongue cleaner includes, on either its front or its back face, a flat and thin head with a concavely curved face having a valley portion extending parallel to a longitudinal direction of the rod-shaped handle, and a woven textile 4 having a roughened surface, serving as a sheet having a porous or multi-gap structure, attached to the concavely curved face 1a. When cleaning both sides of a tongue, the concavely curved face 1a of the head 1 is used. The head 1 can be moved back and forth while pressing it against a tongue, without causing any concerns for possible lateral displacement of the head on the surface of the tongue and without causing nausea during the cleaning.

An anti-intoxication composition and method of making and using are provided for treating and preventing drinker's remorse and other toxic effects of excessive alcohol consumption by humans. The anti-intoxication composition is an acidic mixture containing sweeteners, flavoring agents, food additives and a processed mixture of metallic salts, sulfuric acid, ammonium sulfate and water. When the anti-intoxication composition is ingested, it promotes the beneficial metabolism of alcohol, primarily ethanol, in the body. The beneficial metabolism results in the conversion of alcohol to amino acids and eliminates the toxic reactions of a hangover, including, but not limited to, a pounding headache, nausea, dry mouth, shaking hands, hypersensitivity to bright lights and sounds.

The invention relates to soybean dietary fiber bread which is produced by using soybean dregs as a main raw material and a preparation method thereof. The preparation method comprises the following steps of: treating the soybean dregs in high-pressure steam, mixing 450 to 500-mesh ground soybean dietary fibers and flour, milk, eggs, cream, sugar, table salt and the like, and fermenting and baking to prepare the soybean dietary fiber bread, wherein the soybean dietary fibers account for 30 to 60 percent, and the soybean dietary fiber bread also contains protein, bifidus factors, isoflavone, phospholipid, unsaturated fatty acid, saponin, and multiple trace elements and vitamin such as calcium, zinc, phosphorus, selenium, ferrum, magnesium, potassium, vitamin B (VB) and the like, so four side effects of goiter, discomfort in intestines and stomach and nausea, flatulence, beany flavor, bitter and puckery favor, easiness for gout and the like which are intrinsic in the soybean dietary fibers are eliminated completely, and the problems of high dietary fiber content and difficult fermentation are solved.

Tranexamic acid formulated in an oral dosage form with at least one agent that decreases tranexamic acid release in the stomach. Such formulations minimize nausea, vomiting, and other adverse gastric effects that may accompany tranexamic acid therapy, for example, to treat heavy menstrual bleeding. One embodiment is an extended release formulation with waxes, polymers, etc. that prevent a bolus release of tranexamic acid in the stomach. An alternative embodiment is a delayed release formulation with polymers that prevent release of tranexamic acid in the acid environment of the stomach and delay its release until the formulation reaches the less acid environment of the intestines. Such formulations enhance patient compliance with therapy because adverse effects of tranexamic acid therapy are reduced.

The invention discloses a Chinese medicinal composition for treating malignant tumor, belonging to the field of Chinese medicines. The Chinese medicinal composition is a medicament preparation formed from herba oldenlandiae, astragalus root, tuckahoe, prepared pinellia tuber, herba scutellariae barbatae, teloon, scorpion, scolopendra and the like by adopting advanced processes including extraction with water, extraction with ethanol, enzymolysis of trypsinase and the like according to a certain compatible requirement, and the medicament preparation is preferably prepared into capsules and tablets. The Chinese medicinal composition has a certain function for relieving symptoms for lung cancer, liver cancer, gastric cancer, intestinal cancer, breast cancer, encephaloma, lymph cancer and other malignant tumors, reducing tumor bodies, inhibiting the growth of the tumors and the like; and according to the Chinese medicinal composition, the human immune capability can be improved, the lives of patients suffered from tumors can be prolonged and the adverse reactions of leukocytopenia, dizzy, weakness and fatigue, skinniness, poor appetite, nausea and vomiting and the like due to radiotherapy chemotherapy for cancers can be effectively relieved.

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

8′-Hydroxy-Dihydroergotamine (8′-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of diseases, conditions or disorders selected from amyotrophic lateral sclerosis (ALS), Parkinson's disease, stress / anxiety, nausea, emesis, aggression, pain, neuropathic pain, sleeplessness, insomnia, restless leg syndrome and depression using the compounds, compositions, dosage forms and administration techniques disclosed herein.

The invention discloses a control method for an electronic cigarette. The method comprises the following steps that: S1, when a smoking signal is detected, a battery assembly supplies electric power to an atomization assembly and makes a thermal fuse of the atomization assembly atomize tobacco tar to generate smoke; and S2, during the time when the thermal fuse keeps working, when the accumulated energy consumption of the thermal fuse reaches preset energy, the battery assembly stops supplying electric power to the atomization assembly. The method has the following beneficial effects: when the accumulated energy consumption of the thermal fuse reaches preset energy, the battery assembly stops supplying electric power to the atomization assembly, so that it is ensured that the smoke amount sucked by a user each time during smoking is approximately same and stable, so that nicotine sucked by the user is fundamentally same. The precision for controlling the smoke amount (TPM) each time is improved, and the phenomena that the taste is reduced due to too little smoke and emesis and nausea resulting from excessive smoke are prevented. The method further can prevent hazardous substances, such as formaldehyde generated from cotton burning.

The invention discloses a new Chinese medicine composite for treatment of acute gastroenteritis and a preparation method thereof. The Chinese medicine composite of the invention mainly comprises the following materials of tuckahoe, magnolia officinalis, rhizoma atractylodis macrocephalae, plantain seed, dried ginger, rhizoma pinelliae, styrax, medicated leaven, fructus hordei germinatus, semen arecae prepareta, endothelium corneum gigeriae galli, rhizoma corydalis, medicinal evodia fruit, cassia, fructus quisqualis, pericarpium citri reticulatae, rhizoma coptidis, oriental water plantain rhizome, cortex periplocae radicis, taraxacum, bunge corydalis herb , pollen typhae carbonisatus, honeysuckle flower, jobstears seed, and the like. The Chinese medicine composite of the invention can be prepared into any common oral preparation according to the conventional Chinese medicine preparation method. The composite can obviously improve nausea, emesis, abdominal pain, diarrhea, fever, and the like. The serious patient may have symptoms of dehydration, electrolyte disturbance, shock bowel, septicemia and the like. The composite has reliable and apparent clinical effect and fast desired effect. Due to the combination of the medicines both as food and medicine according to state-promulgated pharmacopoeia, the Chinese medicine composite of the invention has the advantages of low cost and no toxic and side effect basically.

The present invention relates to non-psychoactive derivatives of tetrahydrocannabinol, (3R,4R)-Δ8-THC-11-oic acids, for treating or preventing nausea and relieving symptoms thereof.

The present invention relates to a method comprising administering to a patient diagnosed as being in need of treatment for nausea, emesis, or symptoms associated therewith comprising administering to a patient in need thereof a compound of formula (I) wherein: R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl; Y is pyrrolidinyl, 4-methyl-piperidinyl or NR2R2; R2 are each independently C1-C6 alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6 alkoxy or phenyl; and R4 is H or CH3; or a pharmaceutically acceptable salt or solvate thereof, in an amount that is effective in treating nausea, emesis, or symptoms associated therewith in said patient.

Compositions are provided for the intranasal administration of granisetron or a pharmaceutically acceptable salt thereof. Preferred compositions are in the form of an aqueous solution. Optionally, the compositions comprise chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention of nausea and / or vomiting.

Methods are provided to teat post-operative nausea and vomiting, as well as emeses generally, with 5-HT3 receptor antagonists. In particular, the invention discloses methods for reducing post-operative nausea and vomiting and other emetic events with palonosetron.

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; [0001]Z is CH2 or NH; W is O or S; [0002]T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and [0003]R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea / emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

The present invention relates to non-psychoactive cannabinol analogs of tetrahydrocannabinol, (3R,4R)-Δ8—THC-11-oic acids, for treating and preventing nausea and relieving symptoms thereof.

The invention discloses a traditional Chinese medicine combination and a preparation method for intestinal depression disease treatment; the traditional Chinese medicine combination includes the following raw materials: rhizoma acori graminei, semen raphani, dried tangerine, immature bitter orange, medicated leaven, fried malt, costustoot, cyperus rotundus, storax, agilawood, dalbergia wood, bunge cherry seed, angelica, white paeony root, rehmannia glutinosa, dendrobe, radix polygonati officinalis, ligusticum wallichii, radix asparagi, liriope, medlar, radices trichosanthis, gypsum, the root of kudzu vine, rhizome of Chinese goldthread and scutellaria baicalensis. The traditional Chinese medicine combination can be prepared into any type of common oral preparation according to the conventional traditional Chinese medicine preparation method. The invention can significantly improve the symptoms of abdominal distension, abdominal pain, nausea, vomit, belching, body energy loss and loss of appetite, and also has definite clinical curative effect, significant curative and quick effect. As the traditional Chinese medicine combination basically combines medicinal and edible medicine sources specified in the National Formulary, the traditional Chinese medicine combination has low cost and basically has no toxic and side effect.

The invention discloses an engine anhydrous cooling liquid and a preparation method thereof, wherein the engine anhydrous cooling liquid comprises the following raw materials by the weight percentage:60-70% of propylene glycol, 25-30% of ethylene glycol, 3-4% of 1,2-aminoazophenylene, 1-2% of sodium nitrate, 2-3% of glycerol, 1-2% of triethanolamine, 0.5-1.5% of sodium hydroxide, and 0.1-1% of apigment. The anhydrous cooling liquid has the freezing point lower than -52 DEG C and the boiling point more than 190 DEG C and has a large thermal safe space, so with the use of the product, the anhydrous cooling liquid can maintain a good state for operation, adequate power is maintained, noise is reduced, a water tank does not produce 'boiling', and cylinder score is not generated. With use ofthe anhydrous cooling liquid, zero corrosion can be achieved, no water rust is generated, cleaning and repair are not needed forever, and boiling, cylinder score, water tank blocking, water rust, water scale, corrosion and cavitation corrosion, engine fatigue, nausea, explosive vibration, precombustion, large noise, unstable idle speed, cylinder pressure reduction, insufficient power, oil consumption increase and large exhaust gas emission smoke and other phenomena are thoroughly eliminated.

The invention discloses a Chinese medicine composition for treating ablepsia and a preparation method thereof. The Chinese medicine composition is mainly formed by the following raw medicine materials: cassia seed, rhizoma atractylodis, Cassia occidentalis, abalone shell, chrysanthemum, kudzu-vine root, Radix achyranthis Bidentatae, flesh rehmannia, Scutellaria baicalensis, coptis, notopterygium root, Ligusticum wallichii, cassia twig, Salvia miltiorrhiza Bunge, motherwort herb, Gastrodia elata Blume, Rhizoma acori Graminei, Chinese angelica, radix trichosanthis, red paeony root, white paeony root, angelica root, pseudo-ginseng and the like. The Chinese medicine composition of the invention can be prepared into any kind of common oral preparation according to the conventional Chinese medicine preparation method. The Chinese medicine composition can obviously improve serious hypopsia even blindness and ablepsia with symptoms such as dry eyes, dizziness and tinnitus, eyeball swollen pain, dizziness and chest stuffiness, nausea and vomiting and the like, and has the advantages of exact clinical curative effect, obvious curative effect, rapid effect, low cost, basically no toxic side effect and the like.

The invention relates to a traditional Chinese medicine combination for curing gastric diseases and a preparation method thereof, which solve the problem that the original traditional Chinese combinations for curing gastric diseases do not have prominent effects and have high recurrence rate. The medicine combination is prepared by corydalis tuber, Chinaberry fruit, turmeric root tuber, evodia rutaecarpa, coptis chinensis, villous amomum fruit, costus root, radix linderae, rhizoma cyperi, frankincense, myrrh and cuttlebone. The traditional Chinese medicine combination has the functions of soothing the liver and regulating vital energy, removing heat from the liver, promoting blood circulation to arrest pain, promoting wound healing and granulation, and can be used for curing gastric and duodenal ulcer, gastritis, stomachache, salivation and sour regurgitation, nausea, retching, epigastric distension and depression; besides, the traditional Chinese combination has special curative effects on gastric ulcer and duodenal ulcer and has inhibiting effect on helicobacter pylori.

Methods and apparatus are provided to prevent, treat, and cure chemotherapy induced nausea in human beings. The inhalation of an effective amount of vaporized essential oil from Mentha piperita (peppermint oil) has been shown in practice to prevent, treat, and cure chemotherapy induced nausea. A simple hand-held apparatus provides the vapors to be inhaled through the nostril to prevent, treat, and cure chemotherapy induced nausea.

The invention discloses a new traditional Chinese medicine compound for treating intestinal abscess and a preparation method thereof, wherein the traditional Chinese medicine compound of the invention mainly comprises the following raw material medicines: rhizoma coptidis, fresh rehmannia root, figwort, kudzu vine root, red paeonia, root of herbaceous peony, china root, honeysuckle, dandelion, Chinese violet, Chinese lobelia, satrwort root, rhizoma cyperi, fruit of immature citron, tambac, dalbergia wood, Szchuan lovage rhizome, fried fumitory, fried frankincense, fried myrrh, salvia miltiorrhiza, woodlouse, dragon's blood and the like. The traditional Chinese medicine compound of the invention can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can markedly improve the symptoms of QI stagnation and blood stasis, stomachache or periumbilical pain, fever with chilliness, nausea and vomiting, excessive noxious heat, tense abdomen, tenderness, local lump, spontaneous perspiration due to high fever and the like, and has exact clinical curative effect, remarkable curative effect and rapid effect taking. Because the traditional Chinese medicine compound of the invention is combined by basically adopting medicine-food homologous medicaments specified in National Formulary, the traditional Chinese medicine compound has the advantages of low cost, basically no toxic or side effect and the like.

The invention pertains to the field of traditional Chinese medicine, in particular to a medicine preparation for treating amyotrophic lateral sclerosis and a preparation method thereof. The medicine preparation adopts the treatment principles of benefiting qi, nourishing yin and reinforcing yang, the traditional Chinese medicine compound preparation is prepared by taking pharmaceutical raw materials of membranous milkvetch root, dried rehmannia root, epimedium herb, medicinal Indianmulberry root and common macrocarpium fruit; the clinical studies show that the medicine preparation can significantly reduce the clinical integral of the traditional Chinese medicine symptoms of flaccidity diseases and improve the clinical symptoms of the patients with the flaccidity diseases / ALS; compared with the prior art, the treatment effects are significantly improved, furthermore, the medicine preparation is safe, reliable and has no nausea, vomit, decreased appetite, abdominal distension or other evident common side effects of riluzole.