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Pharmaceutical formulation for treating muscular atrophy lateral sclerosis and preparing method

A technology of lateral sclerosis and pharmaceutical preparations, applied in the field of traditional Chinese medicine, can solve the problems of lack of immune damage, redundancy, etc., and achieve the effect of improving curative effect, improving curative effect, and no nausea

Inactive Publication Date: 2008-10-29
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above treatments have achieved certain results, there are still deficiencies. For example, nearly 70% of the patients have symptoms of kidney yang deficiency such as chills, cold limbs, and weakness of the waist and knees. Theoretical analysis shows that rhubarb and licorice are redundant, and there is no modern medical evidence to support that rhubarb and licorice have neuroprotective effects on ALS; thirdly, according to the pathogenesis of ALS and the pharmacological research results of modern Chinese medicine, the above herbs mainly target Glutamate excitotoxicity and neuronal oxidative damage play a role in delaying the course of ALS, deficiency can reduce immune damage, and protect skeletal muscle to treat ALS

Method used

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  • Pharmaceutical formulation for treating muscular atrophy lateral sclerosis and preparing method
  • Pharmaceutical formulation for treating muscular atrophy lateral sclerosis and preparing method
  • Pharmaceutical formulation for treating muscular atrophy lateral sclerosis and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 pharmaceutical preparation of the present invention

[0023] Weigh the raw materials according to the following ratio:

[0024] 3 parts of astragalus, 2 parts of raw land, 2 parts of fairy spleen, 1 part of Morinda officinalis, and 1 part of dogwood.

[0025] Take half of the above drug, add 5 times the amount of water, soak for half an hour, decoct for 45 minutes, add 5 times the amount of water, decoct for 30 minutes, filter, combine the decoction liquid, concentrate under reduced pressure, dry under reduced pressure to obtain a dry extract, and crush it into Fine powder (over 80 mesh). The other half of the crude drug was crushed to 80 mesh, and the 60 Sterilize (irradiation dose gk), mix with extract powder, add mannitol, lactose, sucrose powder, aspartame and menthol, mix well and use 60-70% ethanol as a binder to make granules.

Embodiment 2

[0027] Weigh the raw materials according to the following ratio:

[0028] 1 part of astragalus, 2 parts of raw land, 2 parts of fairy spleen, 1 part of Morinda officinalis, and 1 part of dogwood.

[0029] Take half of the above drug, add 5 times the amount of water, soak for half an hour, decoct for 45 minutes, add 5 times the amount of water, decoct for 30 minutes, filter, combine the decoction liquid, concentrate under reduced pressure, dry under reduced pressure to obtain a dry extract, and crush it into Fine powder (over 80 mesh). The other half of the crude drug was crushed to 80 mesh, and the 60 Sterilize (irradiation dose 8k), mix with extract powder, add mannitol, lactose, sucrose powder, aspartame, menthol, mix well and use 60-70% ethanol as binder to make granules.

Embodiment 3

[0031] Weigh the raw materials according to the following ratio:

[0032] 3 parts of astragalus, 1 part of raw land, 1 part of fairy spleen, 1 part of Morinda officinalis, and 1 part of dogwood.

[0033] Take half of the above drug, add 5 times the amount of water, soak for half an hour, decoct for 45 minutes, add 5 times the amount of water, decoct for 30 minutes, filter, combine the decoction liquid, concentrate under reduced pressure, dry under reduced pressure to obtain a dry extract, and crush it into Fine powder (over 80 mesh). The other half of the crude drug was crushed to 80 mesh, and the 60 Sterilize (irradiation dose 8k), mix with extract powder, add mannitol, lactose, sucrose powder, aspartame, menthol, after mixing evenly, use 60~70% ethanol as binding agent to make granule, 60 ℃ dried for 4 hours, added magnesium stearate, compressed into tablets.

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PUM

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Abstract

The invention pertains to the field of traditional Chinese medicine, in particular to a medicine preparation for treating amyotrophic lateral sclerosis and a preparation method thereof. The medicine preparation adopts the treatment principles of benefiting qi, nourishing yin and reinforcing yang, the traditional Chinese medicine compound preparation is prepared by taking pharmaceutical raw materials of membranous milkvetch root, dried rehmannia root, epimedium herb, medicinal Indianmulberry root and common macrocarpium fruit; the clinical studies show that the medicine preparation can significantly reduce the clinical integral of the traditional Chinese medicine symptoms of flaccidity diseases and improve the clinical symptoms of the patients with the flaccidity diseases / ALS; compared with the prior art, the treatment effects are significantly improved, furthermore, the medicine preparation is safe, reliable and has no nausea, vomit, decreased appetite, abdominal distension or other evident common side effects of riluzole.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a pharmaceutical preparation for treating amyotrophic lateral sclerosis and a preparation method thereof. Background technique [0002] The so-called flaccidity in the field of traditional Chinese medicine refers to a kind of disease that causes muscle atrophy or paralysis due to relaxation of limbs and tendons, weakness, and prolonged use. Diseases with muscle weakness and muscle atrophy as the main symptoms, such as post-stroke muscle weakness, all belong to the category of "atrophy disease" in traditional Chinese medicine. ALS is the third largest neurodegenerative disease alongside Alzheimer's disease and Parkinson's disease. Its pathogenesis is closely related to glutamate excitotoxicity, oxidative stress, and immune damage. The pathological features are spinal cord anterior horn cells and Selective loss of motor neurons in the pyramidal tract gradually causes m...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P21/00
Inventor 支惠萍蒋健高月求高俊鹏詹红生邹菁李超生
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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