53results about How to "Less activity" patented technology

The present invention provides 2′-fluorine-4′-substituted-nucleoside analogues or their pro-drugs or 5′-phosphate esters (including the pro-drugs of the 5′-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows:whereinB=R=CH3, CN, N3, C≡CH;R′=H, F;X=F, OH, NH2;Y=H, CH3, F, OH, NH2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

PCT No. PCT / JP96 / 03026 Sec. 371 Date Apr. 30, 1998 Sec. 102(e) Date Apr. 30, 1998 PCT Filed Oct. 18, 1996 PCT Pub. No. WO97 / 16249 PCT Pub. Date May 9, 1997A method for recovering the activity of a ruthenium catalyst which comprises a step of bringing a ruthenium catalyst decreased in activity by its use in hydrogenation of an unsaturated organic compound into contact with oxygen in a liquid phase, and a step of maintaining the catalyst at a hydrogen partial pressure lower than that at the hydrogenation and a temperature not lower than a temperature lower by 50 DEG C. than the hydrogenation temperature.

There is disclosed a therapeutic exercise in which the patient lies in a supine position on a flat surface, with a long, smooth cylindrical roller having a constant compressed diameter from about 2 to about 4 inches throughout its length beneath the patient's back. The roller should be of sufficient length to span laterally across the entire patient's back and shoulders. The patient's slowly rolls his body over the roller from the sacrum along the lumbar and thoracic vertebrae by the pushing against the support surface with his feet and hands, and while shifting or rocking his body, side-to-side. The roller fixture includes a pair of end brackets which rotationally support a pair of end shafts of the roller and includes a frictional brake to restrain the rotation of the roller.

A method and apparatus for directly connecting very large data streams from an archive command into a backup data system using an “intelligent process.” An output stream is piped into an intelligent pipe-reading process and distributed over a set of temporary data stores built from raw storage resources. A pipe interface process supervises backup of each filled data store, while the remaining output stream continues to be piped into another available data store. The backup system completes archiving of the datastream, keeping a catalog of the datastream storage locations. To retrieve the data, the intelligent process is run in reverse as a pipe-writing process, requesting data from the backup system. Retrieved data traverses the data stores from the backup system and are pumped into the pipe-writing process for delivery to the pipe output file identified by the retrieve or import command.

Paths in a transport network are identified by labels (n1-n4, b1-b4) and more than one restoration resources that can be used for setting up a particular backup path form a restoration group. Backup tables (R1, R7) are provided, which define restoration groups per path labels (b1-b4), only, rather than individual restoration resources. Upon initial receipt of a path label (b1-b4), a network element (1-13) selects according to pre-determined rules a particular restoration resource from the restoration group defined in the backup table (R1-R7) for this backup path label.

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; [0001]Z is CH2 or NH; W is O or S; [0002]T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and [0003]R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea / emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

An outlet tap assembly (1) for dispensing liquid packaged in flexible packaging bags is provided. The tap assembly comprises a tubular outlet member (2, 32) having a bore (8) therein, a tap (5, 6) at one end for controlling the flow of liquid through the bore, and a spike (3) at the opposite end for penetrating a plastic packaging bag. At least one aperture (4) communicates with the bore towards the inner end to allow liquid to enter from a bag into the bore. An endless clamping surface (11, 31) encircles the outlet member between the aperture and tap and a clamping element (12, 30, 35) having an endless clamping edge or surface (13) is movable axially on the outlet member so as to cooperate with the clamping surface on the outlet member to operatively clamp material of a flexible packaging bag therebetween. The outlet tap assembly has resilient means (16, 21, 26, 29, 33, 36) for urging the clamping element axially into engagement with the clamping surface on the outlet member automatically.

The invention discloses a method for separating active ingredients from an aquilaria sinensis lamina by utilizing a high-speed counter current chromatography. The method comprises the following steps of: extracting the dried and smashed aquilaria sinensis lamina by virtue of a percolation extract method at the room temperature to obtain an aquilaria sinensis lamina extracting solution extractum; extracting the extracting solution extractum for 3-4 times by sequentially utilizing petroleum ether,and ethyl acetate, respectively decompressing and concentrating a petroleum ether extract liquor and an ethyl acetate extract liquor to extractums; then respectively separating the petroleum ether part extractum and the ethyl acetate part extractum to obtain an active ingredient A of 7,4'-dimethoxy-5-hydroxy flavone by utilizing the high-speed counter current chromatography; and then separating the ethyl acetate part extractum through high-speed countercurrent chromatography to obtain an active ingredient B of 3,5,7,3',4'-pentahydroxy-flavone and an active ingredient C of 3,5,7,4'-tetrahydroxy-flavone after coarsely separating the ethyl acetate part extractum by virtue of a column chromatography on silica gel. The active ingredients separated by the method are low in loss, high in separation speed, high in purity, stable and easy to apply.

The invention relates to an anti-biological clogging device for a drip-irrigation system. The drip-irrigation system is started, an air intake brake valve is opened, an ozone generator is started, and compressed water which comes from the head part of the drip-irrigation system is sprayed at high speed from a jet orifice of a jet nozzle so as to form the negative pressure in a gas injection cavity; and under the action of the negative pressure, the ozone generator ensures that ozone generated through air ionization enters the gas injection cavity through the air intake brake valve, a check valve and an air inlet pipe along with the air filtered by an air filter, and enters an oscillating cavity for vortex oscillation, stirring and aerification along with the high-speed water flow sprayed by the jet nozzle so as to form 'ozone water' of which gas and liquid are distributed uniformly, and the 'ozone water' enters the drip-irrigation system to kill microorganisms in flow channels and cansynchronously inhibit crop root systems from growing toward the direction of a water outlet of a drip irrigation emitter in an underground drip-irrigation system, so that the aim of biological clogging resistance of the drip-irrigation system is fulfilled. Compared with a method of injecting a chemical agent into irrigation water, the invention has the advantages that: the residue of harmful substances which can pollute the environment is not produced, and the risk of using dangerous chemical agents is avoided.

The present invention provides 2′-fluorine-4′-substituted-nucleoside analogs or their pro-drugs or 5′-phosphate esters (including the pro-drugs of the 5′-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows:wherein:The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.

Determining the value of an item or event at a point in time or over a targeted period of time based on the values of the item over a past era. During the past era, data is obtained to represent the changes to the value during the era. This data is iteratively processed by: smoothing the curve, subtracting the smooth curve from the original curve to obtain a next level curve and repeating the process. After several iterations, a set of smoothed out curves are obtain and the projected time-wise to encompass the targeted time or period of time. Once projected, the curves are then combined together and the value at the targeted time or period of time can then be ascertained.

An orthotic device is developed and customized to control the (un)desired movements of the patient's defective lower limb. The device incorporates a footplate made of a rubber like elastomeric material, a proximal segment that encompasses the foot at the metatarsal phalengeal joints and the dorsal aspect of the foot, and a second proximal segment that encompasses the shin portion of the leg. Motion of the patient's talocrual is allowed and controlled by laminating mechanical joints to the medial and lateral aspects of the brace and providing cutouts in the lamination just anterior and posterior to the ankle joint axis of motion.

A mobile terminal includes a detector configured to detect presence of a first possible connection to a mobile network and a second possible connection to the mobile network, the first possible connection being a connection of a first technology and the second possible connection being a connection of a second technology. A selector identifies which of the first possible connection and the second possible connection causes less energy consumption in the mobile terminal in its low-power mode of operation, and a controller connects the mobile terminal to the mobile network through the identified possible connection. The disclosure is also directed to a corresponding operating method, a corresponding computer program, and a network entity for supporting a mobile terminal in performing a power consumption sensitive cell reselection.

Method and system for clearing a pipe system from its contents, the pipe having a proximal end and a distal end, the method including providing an air supply to the pipe system at the proximal end by applying an air pressure decreasing from an initial pressure as the bulk of the pipe contents get discharged gradually at the distal end for obtaining a contents flow in the pipe system. The method further includes determining a volume of air supplied to the pipe system by the air supply, determining an estimated contents travel speed from the volume of the air supplied to the pipe and regulating the air supply to the proximal end of the pipe for obtaining a predetermined pipe contents travel speed using the estimated contents travel speed.

A process is described for purifying insulin and insulin analogs that comprises use of two or more orthogonal chromatographic purification steps in tandem following enzymatic digestion of the propeptide-insulin precursor to remove specific product impurities, improve process consistency, and increase process redundancy in the purification of the insulin or insulin analog, e.g., insulin lispro.

The invention includes a computer readable medium with executable instructions to generate a report. The executable instructions include executable instructions to supply a prompt group corresponding to a cascading prompt. A list of values is accessed to identify values to be supplied to the prompt group. Prompt presentation values are selected in accordance with access restrictions for a specified user. Parameters are selected based upon the prompt presentation values. A report is then generated based upon the parameters. Thus, the specified user receives a personalized report in accordance with the access restrictions.

The smart wearable with embedded NFC (Near Field Communication) tags, vital health sensors and UV-C germicidal irradiation sources is provided for Prevention of spread of pathogens. The smart wearables is any of a hand glove, a footwear, a vest, a full body suit, a face mask, a footwear cover or a smart portables where all the smart wearables includes a plurality of re-programmable tags to facilitate touch less activities, and a plurality of body health monitoring sensors to monitor health of the wearer in real time for early warning health mechanisms, an Ultraviolet Germicidal Irradiation (UVGI) source to disinfect the surfaces coming in contact with the smart wearables with maximum efficacy and spread prevention. Further, the inner layer of the smart wearables which makes contact with the skin of the wearer is made of a Celliant synthetic polymer fabric material that traps the body's infrared energy and cycle it back to improve oxygenation and resolve minor aches and pains.

The present compositions and methods relate to a beta-glucosidase from Aspergillus terreus, polynucleotides encoding the beta-glucosidase, and methods of make and / or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates.

The present invention relates to a method for predicting the responsiveness of a patient to a treatment with mtor inhibitors. Using primary Eμ-Myc lymphoma cells, inventors observed that Eμ-Myc-GAPDHhigh clones presented less mTOR activity than Eμ-Myc-GAPDHlow clones, as determined by the increase in p70-S6K phosphorylation in the latter. Importantly, inhibition of mTOR with rapamycin in two independent Eμ-Myc-GAPDHlow clones induces a metabolic shift from OxPhos to glycolysis. These results suggest that GAPDH-dependent modulation of the mTOR pathway controls the metabolic status of malignant B lymphocytes. Accordingly, the invention relates to a method for determining whether a subject suffering from lymphoma will achieve a response to a treatment with mTOR inhibitor and to a method of treating with an mTOR inhibitor the subject identified as responder.

It is disclosed that a webserver (4) hosted by a second host (8) can be used for redirecting in an IP environment an initial request comprising an identifier. The identifier can be used for referring to a sub-domain that does not has its own IP-address. When via a browser an initial request is entered or selected, the initial request is sent to a DNS (7). The DNS (7) returns the IP address of the second host (8) to the browser. The browser receives this IP address after which the browser sends a request for the first domain name to the webserver (4). Upon receiving this request the webserver (4), accesses a database in order to return to the browser a domain name based on the identifier comprised by the request. When the browser has received the domain name, the browser sends another request comprising the domain name to the DNS (7), after which the appropriate webcontent in the sub-domain can be accessed.

An apparatus and method for creating a venturi effect in a food product molding machine. The venturi effect accelerates food product in order to cause the product to be stretched aligning the fibers of the product.

The invention discloses an in-vitro culture method of chondrocytes, which comprises the following steps: cutting off cartilage tissue pieces from the surface of a joint, and repeatedly cleaning in PBS(Phosphate Buffer Solution) added with double antibodies; putting the cleaned cartilage tissue into a culture medium, cutting the cartilage tissue into pieces, and fully washing the cut cartilage tissue with PBS containing double antibodies; collecting chopped cartilage tissues, centrifuging the tissues, adding a digestive solution, and digesting the tissues; centrifugally collecting cells, adding PBS to clean the cells, adding a culture solution into a cell cluster to prepare a cell suspension, counting the cells, and adjusting the cell density; inoculating the cell, adding a low-sugar DMEMculture medium of FBS, and culturing the cells in a saturated humidity incubator; and when the cells are fused and 80-90% of the bottom of the bottle is covered, carrying out subculture. According tothe invention, the defects and defects of low cell viability, small separation quantity and poor storability in the prior art are solved to the greatest extent, and the mammary epithelial cells cultured by the method have higher cell viability and more quantity and are easier to adhere to the wall compared with the cells obtained by the traditional laboratory method.

Compositions that are EGF polypeptides that possess improved biological activity as compared to the biological activity exhibited by wild-type EGF are provided. Also provided are methods for the preparation of these mutants, methods for the use of these mutants, methods for rationally designing new polypeptide mutants, and methods for screening mutants polypeptides to identify novel EGF mutants with desirable biological activities.

The present invention concerns a method for modifying the growth characteristics of plants by modulating expression in a plant of a nucleic acid sequence encoding a TAD protein and / or modulating activity in a plant of a TAD protein. The invention also relates to transgenic plants having modified growth characteristics, which plants have modulated expression of a nucleic acid encoding a TAD protein fragment.