31results about How to "Inexpensive and disposable" patented technology

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Instruments for thermally-mediated treatment of a patient's lower esophageal sphincter (LES) to induce an injury healing response to thereby populate the extracellular compartment of walls of the LES with collagen matrices to altere the biomechanics of the LES to provide an increased intra-esophageal pressure for preventing acid reflux. A preferred embodiment is a bougie-type device for trans-esophageal introduction that carries conductive electrodes for delivering Rf energy to walls of the LES (i) to induce the injury healing response or (ii) to "model" collagenous tissues of the LES by shrinking collagen fibers therein. Typically, an Rf source is connected to at least one conductive electrode that may be operated in a mono-polar or bi-polar fashion. A sensor array of individual sensors is provided in the working end. A computer controller is provided, which together with feedback circuitry, is capable of full process monitoring and control of: (i) power delivery; (ii) parameters of a selected therapeutic cycle, (iii) mono-polar or bi-polar energy delivery, and (iv) multiplexing of current flow between various paired electrodes. The controller can determine when the treatment is completed based on time, temperature, tissue impedance or any combination thereof.

A catheter with a small optical fiber or bundle of fibers includes a scanning mechanism constructed with the use of any vibration capable component. Magnetic, piezoelectric or other mechanisms are used to vibrate the end of the fiber and thus create a scanning effect which extends the field of view. One or more lenses may be utilized, including a lens attached to the distal tip of the image fiber, or a lens attached to the distal tip of the catheter for creating an image plane which can be scanned by the fiber. In one embodiment, multiple light sources may be connected to the fiber for enabling the use of field sequential color techniques for real-time imaging, as well as real-time fluorescent imaging for disease detection. A photodetector assembly connected to the proximal end may contain both filtered and unfiltered detectors for use with both standard imaging and fluorescent imaging. The resulting vision catheter is relatively inexpensive and disposable.

A catheter with a small optical fiber or bundle of fibers includes a scanning mechanism constructed with the use of any vibration capable component. Magnetic, piezoelectric or other mechanisms are used to vibrate the end of the fiber and thus create a scanning effect which extends the field of view. This configuration can be used in a catheter with a relatively small diameter. A glass lens or lenses placed in front of the fiber focuses and magnifies the image. A CCD, CMOS, or photodiode camera at the proximal end of the fiber captures the image and transfers it to a computer or processor. A light splitter coupled to a light source provides light through an illumination fiber. The resulting vision catheter is relatively inexpensive and disposable.

A disposable imaging catheter that produces high resolution, color images comparable to those obtained from an endoscope. The device may also be made to function as a guidewire. The device may also include a sheath which slides over the catheter body for stiffening and which may include a working channel for accepting interventional devices, as well as LEDs to illuminate the field of view. The vision catheter system includes a detector assembly, scanning mechanism, and distal objective lens. In one embodiment, a photodetector is mated to a lens / pinhole assembly that allows the detector to read light from a small discrete point. This assembly is then scanned in raster or spiral patterns via electric wire coils that actuate a magnetic scan plate to read the area of interest. By adding a fixed objective lens, such as an aspheric lens that is attached to the distal tip of the catheter body, the field of view or acceptance angle of the system is magnified, yielding a wide angle image similar to that commonly obtained from an endoscope.

Instruments for thermally-mediated treatment of a patient's lower esophageal sphincter (LES) to induce an injury healing response to thereby populate the extracellular compartment of walls of the LES with collagen matrices to altere the biomechanics of the LES to provide an increased intra-esophageal pressure for preventing acid reflux. A preferred embodiment is a bougie-type device for trans-esophageal introduction that carries conductive electrodes for delivering Rf energy to walls of the LES (i) to induce the injury healing response or (ii) to "model" collagenous tissues of the LES by shrinking collagen fibers therein. Typically, an Rf source is connected to at least one conductive electrode that may be operated in a mono-polar or bi-polar fashion. A sensor array of individual sensors is provided in the working end. A computer controller is provided, which together with feedback circuitry, is capable of full process monitoring and control of: (i) power delivery; (ii) parameters of a selected therapeutic cycle, (iii) mono-polar or bi-polar energy delivery, and (iv) multiplexing of current flow between various paired electrodes. The controller can determine when the treatment is completed based on time, temperature, tissue impedance or any combination thereof.

An apparatus and method for treatment of end stage renal decline and failure through peritoneal dialysis enabling ambulatory transfer of dialysate to and from the peritoneum of a renal patient, this in synthesis and coordination with normal physiological rhythms of the patient. The system remains unobtrusive and less restrictive of patient ambulation and orientation. The present invention includes expendables disposability of which facilitates safe reuse of more expensive portions and is sufficiently simple for use in a home care environment. It may be designed to incorporate real-time, interactive or remote monitoring and regulation and visual or audible indication of system pressures, chemical balances and other important variables.

An inexpensive and disposable cooling device for relieving pain associated with hypodermic injection that can be used with any hypodermic syringe includes a body and a sterile cooling medium within the body. A removable cover closes the body and maintains the sterility of the cooling medium before use. The device can be used to simultaneously cool a number of injection sites, eliminating the additional time required to serially cool the multiple injection sites.

Systems and methods for the rapid and reliable detection of analytes in liquid solutions such as water, drinking fluids, extracts of solids such as foods, soils, industrial fluids such as oils, cooling water, fuels, solutions of drugs or chemicals, etc. The systems preferably include an inexpensive and disposable capillary containing a dry chemical system of detection that reacts chromogenically or in other manner to indicate the presence of the analyte.

A disposable imaging catheter that produces high resolution, color images comparable to those obtained from an endoscope. The device may also be made to function as a guidewire. The device may also include a sheath which slides over the catheter body for stiffening and which may include a working channel for accepting interventional devices, as well as LEDs to illuminate the field of view. The vision catheter system includes a detector assembly, scanning mechanism, and distal objective lens. In one embodiment, a photodetector is mated to a lens / pinhole assembly that allows the detector to read light from a small discrete point. This assembly is then scanned in raster or spiral patterns via electric wire coils that actuate a magnetic scan plate to read the area of interest. By adding a fixed objective lens, such as an aspheric lens that is attached to the distal tip of the catheter body, the field of view or acceptance angle of the system is magnified, yielding a wide angle image similar to that commonly obtained from an endoscope.

The present invention relates to systems and methods for the rapid and reliable detection of acutely dangerous levels of poisons in liquid food and / or water samples. The systems preferably include an inexpensive and disposable laminated card including a dry chemical system of detection.

An water pipe mold for making a water pipe includes an outer concentric sheath, an inner concentric sheath, a bottom, an outside sleeve and an inside rib. The water pipe mold is flexible and is configured to make an ice water pipe by being filled with water and then freezing the water. The ice water pipe includes a body comprising ice, the body and an opening at a side of the body, a base coupled to a bottom of the body, a mouth piece coupled to a top of the body, and a grommet coupled to an opening at the side of the body. The grommet is made of a flexible material and includes a concaved oval portion configured to stay coupled to the opening as the ice of the body of the water pipe melts or deforms.

A Foley catheter drainage collection system which is capable of permitting the removal and reconnection of drainage bags without compromising the sterility of the drainage system lumen. The collection system has a tubing element which includes a drainage valve associated with an end thereof remote from the insertion end of a Foley catheter. The drainage valve associated with the tubing element is movable from an open catheter drainage position to a closed position. The collection system also includes a drainage bag having a first connector element associated therewith and a second connector element is associated with the drainage valve. The second connector element is adapted for mating engagement with the first connector element. The collection system further includes a retaining element for maintaining the connector elements in mating engagement when the drainage valve is disposed in the open catheter drainage position.

An absorbent disc designed to be releasably secured proximate the bottom portion of a conventional vehicle beverage holder. The disc further includes a body having a first and second layer. Intermediate the first and second layer is a third layer that is manufactured from absorbent materials. The disc further includes a tab integrally mounted to the circumferential edge that extends upward when the absorbent disc is engaged with the bottom portion of the vehicle cup holder to facilitate the easy removal of the absorbent disc from the beverage holder.

Disclosed is a temporary door lock assembly. The assembly is formed from five major components: a rosette; a bolt; a barrel; a locking arm; and an inside plate. These components are lockingly interconnected without any fasteners or the use of any tools to form a door lock. The lock can be temporarily secured within the lock opening and barrel of a door frame during residential or commercial construction to thereby delay the need to install more complicated and expensive permanent locks.

A combination dispenser and applicator has a dispenser body for mounting the dispenser body over a valve of a container of nail polish. The dispenser body has a brush receiver that receives the nail polish from the valve of the container. A disposable applicator brush, not including a valve, but with bristles adjacent a distal end, is shaped to removably engage the brush receiver. The disposable applicator brushes are inexpensive and disposable, and may be readily changed during use of the combination, so that one of the brushes is not used on multiple persons, thereby enabling a more hygienic method of applying nail polish.

A disposable dispensing device for storing and dispensing fluids, such as liquids and gels is disclosed. The dispensing device is a scalable packaging solution including an outer protective housing or shell, optionally a fluid reservoir, and an orifice from which the materials are expelled. The dispensing device can also include a dispensing button that activates an internal pumping system via an actuator mechanism that translates a force in a first direction into a force in a second direction. The dispensing device is particularly useful for liquids such as fragrances or colognes, gels, purified water, dry powders, creams, and pharmaceutical products such as eye ear drops or sprays. The device by design has many uses, is highly portable, and can include an outer reusable and decorative case.

Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.

A disposable dispensing device for storing and dispensing fluids, such as liquids and gels is disclosed. The dispensing device is a scalable packaging solution including an outer protective housing or shell, optionally a fluid reservoir, and an orifice from which the materials are expelled. The dispensing device can also include a dispensing button that activates an internal pumping system via an actuator mechanism that translates a force in a first direction into a force in a second direction. The dispensing device is particularly useful for liquids such as fragrances or colognes, gels, purified water, dry powders, creams, and pharmaceutical products such as eye ear drops or sprays. The device by design has many uses, is highly portable, and can include an outer reusable and decorative case.

Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.

A glove that is operable to protect a user's hand from harsh materials wherein the glove is configured to promote the easy removal thereof. The glove includes a body having an integrally formed palm portion and plurality of digit members wherein the palm portion and plurality of digit members are operable to receive a palm and fingers therein. A cuff section is formed with the palm portion opposite the plurality of digit members. Integrally formed with the cuff section is a release member. The release member is v-shaped and is manufactured from a material that has a greater elasticity than the body of the glove. A gripping member is further mounted to the cuff section opposite the release member.

Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.

An articulated instrument and method of its manufacture includes a plurality of segments connected to one another end-to-end, each having a hollow tubular shape defined by a wall, the wall comprising three or more rectangular panels connected along their respective edges at acute angles. A plurality of tendons extends at least partially through the plurality of segments and is configured to apply tension that selectively causes two adjacent segments from the plurality of tendons to bend relative to one another along a pivot joint disposed between the two adjacent segments. The plurality of segments is formed by staggered rectangular portions of a single sheet of stock material, each rectangular portion being folded to form the hollow tubular shape and connected to an adjacent rectangular portion by a tab, each tab defining a respective pivot joint.