31results about How to "Inexpensive and disposable" patented technology

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Instruments for thermally-mediated treatment of a patient's lower esophageal sphincter (LES) to induce an injury healing response to thereby populate the extracellular compartment of walls of the LES with collagen matrices to altere the biomechanics of the LES to provide an increased intra-esophageal pressure for preventing acid reflux. A preferred embodiment is a bougie-type device for trans-esophageal introduction that carries conductive electrodes for delivering Rf energy to walls of the LES (i) to induce the injury healing response or (ii) to "model" collagenous tissues of the LES by shrinking collagen fibers therein. Typically, an Rf source is connected to at least one conductive electrode that may be operated in a mono-polar or bi-polar fashion. A sensor array of individual sensors is provided in the working end. A computer controller is provided, which together with feedback circuitry, is capable of full process monitoring and control of: (i) power delivery; (ii) parameters of a selected therapeutic cycle, (iii) mono-polar or bi-polar energy delivery, and (iv) multiplexing of current flow between various paired electrodes. The controller can determine when the treatment is completed based on time, temperature, tissue impedance or any combination thereof.

A disposable imaging catheter that produces high resolution, color images comparable to those obtained from an endoscope. The device may also be made to function as a guidewire. The device may also include a sheath which slides over the catheter body for stiffening and which may include a working channel for accepting interventional devices, as well as LEDs to illuminate the field of view. The vision catheter system includes a detector assembly, scanning mechanism, and distal objective lens. In one embodiment, a photodetector is mated to a lens / pinhole assembly that allows the detector to read light from a small discrete point. This assembly is then scanned in raster or spiral patterns via electric wire coils that actuate a magnetic scan plate to read the area of interest. By adding a fixed objective lens, such as an aspheric lens that is attached to the distal tip of the catheter body, the field of view or acceptance angle of the system is magnified, yielding a wide angle image similar to that commonly obtained from an endoscope.

A fillable, sealable, disposable container for storing, transporting and consuming a liquid, such as an individual beverage serving, has opposed front and back walls joined along their opposed sides. Each wall has an upper portion, defining an opening for filling the container, and a lower portion, connecting the lower portions of the front and back walls, for stabilizing the container for filling. A sealable fluid-tight liquid retaining seal is provided at the opening, for sealing the container when filled. Means are provided for creating a hole in the front wall of the container to extract the liquid.

A disposable imaging catheter that produces high resolution, color images comparable to those obtained from an endoscope. The device may also be made to function as a guidewire. The device may also include a sheath which slides over the catheter body for stiffening and which may include a working channel for accepting interventional devices, as well as LEDs to illuminate the field of view. The vision catheter system includes a detector assembly, scanning mechanism, and distal objective lens. In one embodiment, a photodetector is mated to a lens / pinhole assembly that allows the detector to read light from a small discrete point. This assembly is then scanned in raster or spiral patterns via electric wire coils that actuate a magnetic scan plate to read the area of interest. By adding a fixed objective lens, such as an aspheric lens that is attached to the distal tip of the catheter body, the field of view or acceptance angle of the system is magnified, yielding a wide angle image similar to that commonly obtained from an endoscope.

Disclosed is a temporary door lock assembly. The assembly is formed from five major components: a rosette; a bolt; a barrel; a locking arm; and an inside plate. These components are lockingly interconnected without any fasteners or the use of any tools to form a door lock. The lock can be temporarily secured within the lock opening and barrel of a door frame during residential or commercial construction to thereby delay the need to install more complicated and expensive permanent locks.

An applicator has reservoir for fluid and a supply passage. A valve in the passage has a seat and a member movable between closed and open positions. A spring biases the member toward its closed position. An elongated nib is mounted in the supply passage and has an end extending from the passage, the nib engaging the member so that the member moves to its open position. An adapter has a portion for holding a pad that has at least one dimension elongated transversely to the nib. The adapter includes an engagement portion with a cavity for detachably receiving an end of the reservoir, the cavity having a depth so that it engages the nib when the end of the reservoir is detachably received in the cavity to apply pressure on the nib to move the member to its open position.

A disposable dispensing device for storing and dispensing fluids, such as liquids and gels is disclosed. The dispensing device is a scalable packaging solution including an outer protective housing or shell, optionally a fluid reservoir, and an orifice from which the materials are expelled. The dispensing device can also include a dispensing button that activates an internal pumping system via an actuator mechanism that translates a force in a first direction into a force in a second direction. The dispensing device is particularly useful for liquids such as fragrances or colognes, gels, purified water, dry powders, creams, and pharmaceutical products such as eye ear drops or sprays. The device by design has many uses, is highly portable, and can include an outer reusable and decorative case.

Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.

A glove that is operable to protect a user's hand from harsh materials wherein the glove is configured to promote the easy removal thereof. The glove includes a body having an integrally formed palm portion and plurality of digit members wherein the palm portion and plurality of digit members are operable to receive a palm and fingers therein. A cuff section is formed with the palm portion opposite the plurality of digit members. Integrally formed with the cuff section is a release member. The release member is v-shaped and is manufactured from a material that has a greater elasticity than the body of the glove. A gripping member is further mounted to the cuff section opposite the release member.

Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.