168results about How to "Prevent bulk material" patented technology

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

The present invention aims to provide a supporting material for supporting the shape of a photofabrication model on photofabrication in ink-jet three dimensional printing method in which the photocured product is excellent in solubility in water and is easy to remove after photofabrication, and the like. A modeling material for forming a photofabrication model in ink-jet three dimensional printing method containing a curable resin component with a weighted average of SP value of 9.0 to 10.3; and a supporting material for supporting the shape of a photofabrication model on photofabrication in ink-jet three dimensional printing method containing a water-soluble monofunctional ethylenically unsaturated monomer (F), polyoxypropylene glycol with a number average molecular weight of 100 to 5,000 and / or water (G), and a photopolymerization initiator (D).

The invention relates to a method for producing an artificial tooth, comprising a base layer substantially determining strength and at least one cover layer substantially determining appearance of a finished artificial tooth, said method comprising: establishing the available outer shape and dimensions for the finished artificial tooth, e.g. with a CAD-CAM system; acquiring an image of a natural tooth to be replaced by the artificial tooth or a corresponding natural tooth over at least the in use visible outer surface thereof, including variations in appearance in said outer surface; determining in the appearance determining properties of the cover layer to correspond with the variations in the appearance of the natural tooth to be replaced or the corresponding natural tooth, and determining a thickness of the cover layer locally required for said correspondence; constructing the base layer to a shape and dimensions, which are based on the shape and dimensions available for the artificial tooth and prior to construction deducting, in the CAD-CAM system therefrom the locally required thickness of the cover layer; and applying the cover layer over the base layer to attain the available outer shape and dimensions for the finished artificial tooth.

The invention relates to a battery-driven screwdriver comprising a housing (12, 18) provided with a handle (14), an on / off switch (26) and, particularly, a permanently fixed rechargeable battery (40) and charge contact tongues (37) which are associated with the rechargeable battery (40). The battery-driven screwdriver is characterised in that it is safe and comfortable to use due to the on / off switch (26) being mounted in a pivotable manner and extending in a longitudinal manner over the innerside of the handle (14), said on / off switch being able to be successively interrupted and / or closed, independently from each other, during the actuation stroke of several electric circuits of the battery-driven screwdriver (10).

A drain cover having a main drainage surface with relatively larger apertures or openings therein, comprising generally 50 percent of the surface, so that larger debris is accepted into a related drain pipe when a depending skirt portion of the drain cover, having smaller perforations, becomes clogged. In this way a two-layer drainage system for a generally flat surface is provided that allows draining of water and small particulates alone when possible, but upon the clogging of the smaller openings the generally flat surface can be protected from flooding by allowing larger particulates to drain into the main drainage surface. The main drainage surface is held above the flat surface by the depending skirt, at a level of ⅜ to 1 inch above the flat surface. When the depending skirt openings are clogged the water and debris will rise until allowed to drain into the larger openings of the main drainage surface.

A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.

A compression drain for use with a preformed floor in which the height of the drain grate can be adjusted relative to said floor, and which positively locates the drain housing relative to the subfloor / waste water drain pipe. The arrangement provides a unitary, water tight, assembly that uses very little material to be manufactured, has very few moving parts, and is very easy to install.

A device for manipulating a tarpaulin so as to selectively cover and uncover a top aperture of a container. The top aperture defines an aperture peripheral edge, the aperture peripheral edge including two substantially opposed substantially longitudinal segments. The tarpaulin is configurable between an extended configuration and a retracted configuration. In the extended configuration, the tarpaulin substantially covers the top aperture. In the retracted configuration, the tarpaulin is substantially retracted from the top aperture. The device includes an elongated guiding component defining a guiding component longitudinal axis. The guiding component is securable to the container so as to extend at least partially along at least one of the longitudinal segments. A tarpaulin mounting component is usable for attaching the tarpaulin thereto. A link, mechanically coupled to the guiding component, is longitudinally movable therealong between a link proximal position and a link distal position. The tarpaulin mounting component is operatively coupled to the link in a manner such that when the link is in the link proximal position, and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the retracted configuration. When the link is in the link distal position and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the extended configuration.

A closed photo-bioreactor, which in at least one example comprises a plurality of flexible, repeating, substantially enclosed, parallel chambers flexibly connected along their lengths, where a liquid growth media is substantially still without the need for turbulent mixing of the bulk liquid. In many examples, each is connected into integrated, flexible pipelines that serve to supply gas to the chambers, to vent gas from the chambers, and to fill and drain the individual photo-bioreactor chambers of their liquid contents. In some installations, a bioreactor will be rolled up using, for example, a long rod as a spool, for storage and transportation. Some examples will be manually unfurled and positioned on an angled site including, for example, an earthen berm. In many embodiments, a photo-bioreactor will be manufactured from thin plastics using low cost manufacturing techniques. In at least one example, a photo bioreactor is described in which bubbles with a substantially non-convex shape are introduced to mix the liquid contents.

A device for manipulating a tarpaulin so as to selectively cover and uncover a top aperture of a container. The top aperture defines an aperture peripheral edge, the aperture peripheral edge including two substantially opposed substantially longitudinal segments. The tarpaulin is configurable between an extended configuration and a retracted configuration. In the extended configuration, the tarpaulin substantially covers the top aperture. In the retracted configuration, the tarpaulin is substantially retracted from the top aperture. The device includes an elongated guiding component defining a guiding component longitudinal axis. The guiding component is securable to the container so as to extend at least partially along at least one of the longitudinal segments. A tarpaulin mounting component is usable for attaching the tarpaulin thereto. A link, mechanically coupled to the guiding component, is longitudinally movable therealong between a link proximal position and a link distal position. The tarpaulin mounting component is operatively coupled to the link in a manner such that when the link is in the link proximal position, and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the retracted configuration. When the link is in the link distal position and the tarpaulin is attached to the tarpaulin mounting component, the tarpaulin is in the extended configuration.

A brushless peripheral-rotor electric motor comprises a stator assembly, having an axis, a stator plate holder, fixed on the axis, at least one stator plate assembly, mounted on the stator plate holder, and electric coils, would around the plates of the stator plate assembly; and a rotor assembly, having a casing, a rotor magnet retainer assembly, placed inside of the casing, and at least one permanent magnet, mounted on plates of the rotor magnet retainer assembly; wherein the stator plate assembly and / or the rotor magnet retainer assembly have plates which are stacked on top of each other and which are each divided into at least two sectors, saving production cost.

A piston capable of withstanding high temperatures and extreme conditions of a combustion chamber of an internal combustion engine and manufactured with reduced costs is provided. The method of manufacturing the piston includes casting or forging the bulk of the piston as a single-piece with an open cooling gallery from an economical first material, such as steel, cast iron, or aluminum. The method further includes forming a portion of a combustion bowl surface, which is a small area of the piston directly exposed to the combustion chamber, from a second material by additive machining. The second material has a higher thermal conductivity and higher resistance to oxidation, erosion, and oil coking, compared to the first material. The additive machining process is efficient and creates little waste, which further reduces production costs.

A self cleaning cutting assembly is provided, having an array of counter rotating cutters in which a plurality of cutters rotating in a first direction are mounted on a first shaft and a plurality of second cutters are mounted on a second shaft for rotating in an opposite direction. The array of cutters is provided with a plurality of clearing or cleaning rings located alternately with the cutters on each shaft. The cutting array is kept clear of debris or partially cut material by movement of the clearing or cutting rings against adjacent cutters. Movement of the clearing or cleaning rings is a combination of rotary motion and linear motion, in which the linear motion is imparted by the cutter located opposite the cleaning ring striking the cleaning rings so as to push the cleaning ring beyond the position of the widest part of the cutter to completely dislodge material from the cutter.

An apparatus for vertically supporting pipes in oil production rigs. The apparatus includes an outer frame and a centering device. In the area of an inner side of the outer frame, at least one wedge device is provided for clamping the pipe. The outer frame is connected to the centering device so as to be vertically aligned and facing upwardly. A wedge device may additionally include a positioning device and a carrier provided with at least one wedge.

The invention relates to a filter for the separation of leukocytes from whole blood, comprising a hydrophobic support material and a polymeric coating material, whereby the surface of the filter has a critical surface wetting tension in the range 50 to 80 dyn / cm and the polymeric coating material may be obtained by polymerisation reaction of mixtures comprising hydrophobic and hydrophilic monomers. The invention further relates to a method for production of said filter and devices for the separation of leukocytes from whole blood and the use of the filter.

The clamping system comprises a collar (10) having a band (12) that has two flanks (13A, 13B), between which an inside trough (14) is defined that receives projecting clamping surfaces (1A, 2A) of two tubes (1, 2) to be assembled together. The system further comprises a plurality of individual retaining clips (20) distributed angularly around the first flank (13A), each clip having an inside branch (30) and an outside branch (32) facing each other, and between which the first flank is pinched, and a retaining portion (34) that, in the pre-attached state, is suitable for co-operating with the clamping surface (1A) of the first tube (1), one of the branches carrying a first bearing zone (36) that co-operates with a first bearing surface (13′A) of the collar that faces towards the axis (A) of said collar.

A buckle includes a base, an individual jaw, a handle and an elastic element. The individual jaw is connected to the base. The handle includes a jaw formed thereon. The handle can be pivoted on the base between a first position where the jaw thereof is close to the individual jaw and a second position where the jaw thereof is distant from the individual jaw. The elastic element is used for keeping the handle in the first position.

The present invention provides a means of greatly reducing interferences from mercury vapor, UV-absorbing compounds and water vapor in the measurement of ozone by UV absorbance. A heated graphite scrubber destroys greater than 99% of ozone passing through it while reducing biases from typical atmospheric UV-absorbing interferents by large factors compared to conventional ozone scrubbers. Substitution of a heated graphite scrubber in place of traditional ozone scrubbers such as hopcalite, metal oxides and heated silver scrubbers, results in a more accurate measurement of ozone by reducing the responses to UV-absorbing interferences and water vapor. The heated graphite scrubber also may be used in combination with other ozone sensors, such as electrochemical and HMOS sensors, to provide a reference measurement with ozone selectively removed and thus greatly reduce contributions from interfering species in those measurement devices as well.

A plug-in wire connection terminal structure includes a main body having a receiving space. A lateral side of the receiving space is formed with an arched guide slot. A holding plate has a receiving section formed with a wire entrance and a conductive contact section formed with a socket. An annular wall of the socket is formed a slit. A small-diameter fitting section is disposed at an outer end of the conductive contact section. A collar member is tightly fitted on the fitting section. A connection section is disposed on the receiving section. A leaf spring has a bight section received in the arched guide slot. One end of the leaf spring is formed with a connected section latched with the connection section. The other end of the leaf spring is formed with an abutment end obliquely extending the receiving section.

It is a primary object of the present invention to provide a process for producing a pharmaceutical solid dispersion using a twin-screw compounding extruder, the pharmaceutical solid dispersion including hydroxypropyl methylcellulose as a carrier which is superior in elution property of pharmaceutical ingredients and in stability and the pharmaceutical solid dispersion being satisfactory for subsequent pharmaceutical preparations. The present invention is a process for producing a pharmaceutical solid dispersion including hydroxypropyl methylcellulose as a carrier with the use of a twin-screw compounding extruder, characterized in that a sugar alcohol is added as one of processing materials and kneading and extruding processes are performed for the processing materials with the use of the twin-screw compounding extruder.

The parabolic trough collector includes a single-axis parabolic mirror (1) and a receiver tube (2) arranged at the focal point (F) of the parabolic mirror (1). The receiver tube (2) includes an absorber tube (4) and an outer tubular glass jacket (3) around it. To compensate for focusing errors in the parabolic collector and thus to reduce associated geometric optical losses, the tubular jacket (3) is provided with structural elements (9a, 9b, 9c, 9d), which focus sunlight reflected from the mirror as well as sunlight that falls directly on the receiver tube from the sun on the absorber tube. The receiver tube is preferably arranged relative to the parabolic mirror, so that its center is displaced from the focal point (F) by a distance equal to half the spacing between the tubular jacket (3) and the absorber tube (4).

An electric motor design for hub motors comprises a stator assembly, having an axle, a stator plate sector holder, fixed on the axle, at least one stator sector assembly, mounted on the stator plate holder, and electric coils, would around the plates of the stator plate assembly; and a rotor assembly, having a casing, a rotor magnet retainer assembly, placed inside of the casing, and at least one permanent magnet, mounted on plates of the rotor magnet retainer assembly; wherein the stator sector assembly and / or the rotor magnet retainer assembly have plates which are stacked on top of each other and which are each divided into at least two sectors, saving production cost.

Polymer-containing solution can be purified and the solvent reused by subjecting the solution to microfiltration using tubular filters having an average pore diameter of less than 1 μm and a filtration pressure of at least 0.35 MPa. This method is particularly useful for reclaiming and reusing solvents that are used in the development or chemical washout of flexographic printing plates.

A plurality of templates include cutting and sewing lines for forming a plurality of various pieces of two coordinating fabrics for use in quilt making. The template is made of a relatively rigid sheet of transparent or semi-transparent material such as acrylic. The cutting and sewing lines are formed by a plurality of spaced openings extending through the sheet material.