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Composite nanometer hydroxy apatitel medical polymer material tissue engineering stent material and preparation method

A nano-hydroxyapatite, tissue engineering scaffold technology, applied in medical science, prosthesis and other directions, can solve problems such as unfavorable tissue growth needs, drug burst release, etc., and achieve the effect of maintaining the release effect.

Inactive Publication Date: 2007-02-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After these materials are implanted in the body, because a large amount of active ingredients such as drugs contact with body fluids at the same time, it will cause a sudden release of drugs, which is not conducive to the growth of tissues.

Method used

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  • Composite nanometer hydroxy apatitel medical polymer material tissue engineering stent material and preparation method
  • Composite nanometer hydroxy apatitel medical polymer material tissue engineering stent material and preparation method
  • Composite nanometer hydroxy apatitel medical polymer material tissue engineering stent material and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of nano-hydroxyapatite / chitosan tissue engineering scaffold loaded with sodium alginate / chitosan microspheres

[0031] 1′: Preparation of sodium alginate / chitosan microspheres

[0032] The chitosan raw material is added into an aqueous solution containing 1% (w / v) acetic acid, stirred to dissolve, and prepared into a 3% (w / v) aqueous solution of chitosan acetic acid for future use. In addition, the sodium alginate raw material was dissolved in deionized water heated and kept at 70° C. and stirred to dissolve, and a 2% (w / v) sodium alginate solution was prepared for use.

[0033] Pour 150ml of liquid paraffin, 50ml of turpentine and 4ml of Tween 80 into a beaker, stir evenly, and obtain a mixed phase liquid containing 2% (v / v) Tween 80 oil. Although the amount of oil phase materials such as liquid paraffin and turpentine used does not need to be too limited, it is not conducive to the microspheres being sufficiently dispersed in the oil phase without agglome...

Embodiment 2

[0041] Preparation of nano-hydroxyapatite / chitosan tissue engineering scaffold loaded with chitosan microspheres

[0042] 1′: Preparation of chitosan microspheres

[0043] The chitosan raw material is added into an aqueous solution containing 2% (w / v) acetic acid, stirred to dissolve, and prepared into a 3% (w / v) aqueous solution of chitosan acetic acid for future use.

[0044] Pour liquid paraffin 100ml and turpentine 60ml and 2.5ml Tween 80 and 2.5ml span (span) in the beaker, stir, obtain containing 3.12% (v / v) Tween 80 / span oil mixed phase liquid.

[0045] Get 2ml of 50% glutaraldehyde solution, mix with distilled water to prepare 10ml of solution containing glutaraldehyde 10%. Then mix it with 10ml of liquid paraffin for later use.

[0046] Take 60ml of spare 3% chitosan solution, and add it dropwise to the above mixed oil phase liquid at a speed of 1-2 drops / min under the stirring condition of 3300-3500 rev / min. After half an hour, use The separatory funnel drips the ...

Embodiment 3

[0052] Preparation of nano-hydroxyapatite / chitosan tissue engineering scaffold loaded with sodium alginate microspheres

[0053] 1′: Preparation of sodium alginate microspheres

[0054] The sodium alginate is prepared into a 2% solution for later use.

[0055] Pour 100ml of liquid paraffin and 2.5ml Tween 80 into the beaker, stir well to obtain a mixed oil phase liquid containing 2.5% (v / v) Tween 80.

[0056] Take CaCl 2 10g and ZnCl 2 5g was added into 10ml of distilled water to prepare a solution for later use.

[0057] Take 60ml of spare 2% sodium alginate solution, and add it dropwise to the above-mentioned mixed oil phase liquid at a speed of 1-2 drops / min under the stirring condition of rotating speed of 3000-3400 rpm. After half an hour, use The separatory funnel drips CaCl into the sodium alginate solution emulsion at a rate of 1-2 drops / second 2 and ZnCl 2 mixed oil phase liquid. After stirring for 3 hours, after the sodium alginate fully forms a gel, it is tak...

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Abstract

A tissue-engineered scaffold material for medical purpose is composed of nano-class hydroxy apatite and the medical high-molecular material, and has the pores communicated with each other. It features that the dispersed microporous microballs are proportionally contained by it. Its preparing process includes such steps as proportionally mixing said microballs, nano-class hydroxy apatite, medical high-molecular slurry and the salt able to thermally generate gas, heating, and freeze-drying at -20 deg.C for at least 24 hr.

Description

technical field [0001] The invention relates to a composite nano-hydroxyapatite / medical polymer material tissue engineering support material and a preparation method thereof. Background technique [0002] Tissue engineering is a science that applies the principles of cell biology and engineering to research, develop, repair and maintain or improve the function and shape of human tissues and some organs for the purpose of biological substitutes. It is used to repair and treat tissues or An important measure and means of organ dysfunction or loss. [0003] There have been many reports on tissue engineering repair materials based on nano-hydroxyapatite / polymer composites prepared from nano-hydroxyapatite and various medical polymer materials and / or their preparation methods. For example, the patent document with the publication number CN1460526A discloses a porous bone prosthesis composed of 1 / 1-1 / 0.3 hydroxyapatite / medical polyamide components. The Chinese patent documents w...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/50
Inventor 李玉宝石浦江张利
Owner SICHUAN UNIV
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