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Zirconia, hydroxyapatite and magnesium phosphate laminar composite

A layered composite material, the technology of hydroxyapatite, applied in medical science, prosthesis, etc., can solve the problems of accelerating the decomposition of hydroxyapatite and reducing biocompatibility, so as to increase the bending strength and fracture toughness, Good biocompatibility and remarkable effect

Inactive Publication Date: 2012-12-19
CHINA UNIV OF GEOSCIENCES (BEIJING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results show that the addition of particles and fibers can increase the hardness and strength of the material, but the introduction of the second phase often leads to a decrease in the biocompatibility of the material and even accelerates the decomposition of hydroxyapatite

Method used

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  • Zirconia, hydroxyapatite and magnesium phosphate laminar composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Use analytical pure H 3 PO 4 , 4MgCO 3 ·Mg(OH) 2 ·XH 2 O as the experimental material, press Mg 3 (PO 4 ) 2 The stoichiometric ratio is designed for the ingredients, the two are added with water until they are completely mixed and dried. After the synthesis is kept at 1100°C for 45 minutes, the synthesized powder is crushed and ground to obtain magnesium phosphate powder.

[0018] The prepared Mg 3 (PO 4 ) 2 Powder, 3mol% Y 2 O 3 Stable ZrO 2 Powder, Ca10(PO 4 ) 6 (OH) 2 Powder and polyethylene are used as raw materials, and a layered composite material of zirconium oxide, hydroxyapatite and magnesium phosphate is prepared according to the following method.

[0019] 3mol% Y 2 O 3 Stable ZrO 2 The powder is ball milled for 12 hours and dried to obtain the powder. The green body is obtained by dry pressing or grouting, and then subjected to 100MPa cold isostatic pressing to obtain the green body. The green body is sintered at 1550°C for 3 hours and cooled to room temperature nat...

Embodiment 2

[0024] Use analytical pure H 3 PO 4 , 4MgCO 3 ·Mg(OH) 2 ·XH 2 O as the experimental material, press Mg 3 (PO 4 ) 2 The stoichiometric ratio is designed for ingredients, the two are added with water until they are completely mixed and then dried. After the synthesis is kept at 1200°C for 90 minutes, the synthesized powder is crushed and ground to obtain magnesium phosphate powder.

[0025] The prepared Mg 3 (PO 4 ) 2 Powder, 3mol% Y 2 O 3 Stable ZrO 2 Powder, Ca10(PO 4 ) 6 (OH) 2 Powder and polypropylene are used as raw materials, and a layered composite material of zirconia, hydroxyapatite and magnesium phosphate is prepared according to the following method.

[0026] 3mol% Y 2 O 3 Stable ZrO 2 The powder is ball milled for 24 hours and dried to obtain the powder. The green body is obtained by dry pressing or grouting, and then subjected to 200MPa cold isostatic pressing to obtain the green body. The green body is sintered at 1550°C for 3 hours and cooled to room temperature naturall...

Embodiment 3

[0031] Use analytical pure H 3 PO 4 , 4MgCO 3 ·Mg(OH) 2 ·XH 2 O as the experimental material, press Mg 3 (PO 4 ) 2 The stoichiometric ratio is designed for the ingredients, the two are added with water until they are completely mixed and then dried. After the synthesis is kept at 1300°C for 60 minutes, the synthesized powder is crushed and ground to obtain magnesium phosphate powder.

[0032] The prepared Mg 3 (PO 4 ) 2 Powder, 3mol% Y 2 O 3 Stable ZrO 2 Powder, Ca 10 (PO 4 ) 6 (OH) 2 Powder and polystyrene are used as raw materials, and a layered composite material of zirconia, hydroxyapatite and magnesium phosphate is prepared according to the following method.

[0033] 3mol% Y 2 O 3 Stable ZrO 2 The powder is ball milled for 48 hours and dried to obtain the powder. The green body is obtained by dry pressing or grouting molding method, and then subjected to 300MPa cold isostatic pressing to obtain the green body. The green body is sintered at 1600°C for 3 hours and cooled to room t...

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Abstract

The invention discloses a zirconia, hydroxyapatite and magnesium phosphate laminar composite and belongs to the field of medical laminar composites. A method for preparing the laminar composite is characterized in that a zirconia and hydroxyapatite two-component slurry layer and a zirconia, hydroxyapatite and magnesium phosphate three-component slurry layer are coated outside a zirconia ceramic surface layer with stable yttria through a physical coating method in sequence. The flexure strength and the breaking tenacity of the laminar composite are enhanced through adjusting the addition of zirconia of an inner layer, and the bone-growth inducibility of the laminar composite is improved through regulating the addition of hydroxyapatite and magnesium phosphate of an outer layer. The prepared multilayer ceramic composite is superior to a traditional bone repair material in flexure strength and breaking tenacity. Moreover, the multilayer ceramic composite is higher in biocompatibility and inducing osteogenesis capability and can be used for repairing bone defects of parts, such as shanks, thigh joints and the like.

Description

Technical field [0001] A layered composite material of zirconium oxide, hydroxyapatite and magnesium phosphate belongs to the field of medical layered composite materials. Background technique [0002] Bone tissue injury is a common and frequently-occurring disease in clinic. Bone defects caused by various diseases such as trauma, inflammation, and bone tumor removal are common clinical problems. Some of these diseases cause large-scale bone defects that exceed the bone itself. The limit of repair ability, or the loss of bone tissue function due to disease. At this time, surgery is required to repair or replace the defect or diseased tissue with the help of biological materials. [0003] Bone transplantation methods mainly include autologous bone transplantation and allogeneic bone transplantation. Autologous bone transplantation has no immune rejection. The cells and biologically active molecules in the transplanted bone can continue to survive at the recipient site and perform ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42C04B35/48C04B35/447C04B35/622
Inventor 刘书跃房明浩闵鑫黄朝晖刘艳改唐浩文瑞龙唐潮
Owner CHINA UNIV OF GEOSCIENCES (BEIJING)
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