100 results about "Tumor removal" patented technology

Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that express cytokines. Such compositions may be administered by, for example, direct intratumoral injection into tumors in mammals, resulting in tumor reduction or recission. Another aspect of the claimed invention concerns methods of promoting resistance to the reoccurence of tumors in mammals who have undergone such tumor recission. In a specific aspect of the claimed invention, the mammals are human subjects presenting with various forms of cancer.

An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Described herein is a device and method used to effectively remove volume inside a patient in various types of surgeries, such as spinal surgeries (e.g. laminotomy), neurosurgeries (various types of craniotomy), ENT surgeries (e.g. tumor removal), and orthopedic surgeries (bone removal). Robotic assistance linked with a navigation system and medical imaging it can shorten surgery time, make the surgery safer and free surgeon from doing repetitive and laborious tasks. In certain embodiments, the disclosed technology includes a surgical instrument holder for use with a robotic surgical system. In certain embodiments, the surgical instrument holder is attached to or is part of an end effector of a robotic arm, and provides a rigid structure that allows for precise removal of a target volume in a patient.

Breast cancer patients are treated intraoperatively with radiation shortly after excision of a tumor. Pathology of the tissue is determined with a nearly instantaneous method, further excision is performed if needed, and the patient, still anesthetized and preferably unmoved, is then treated with radiation therapy. In a preferred embodiment an applicator is inserted into the excision cavity, the cavity is three-dimensionally mapped using radiation sources and a sensor, a radiation treatment plan is developed using a radiation prescription and the determined shape and location of the cavity, and the treatment plan is executed, all while the patient remains under anesthesia.

An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

The disclosed invention is a unique, patient-friendly, laser-based tumor ablation system for the removal of malignant tumors of the prostate and, with modified delivery systems, may have application for other areas of the human body.The disclosed invention is an integrated, robotic treatment subsystem that takes advantage of the capabilities of the previously disclosed MedSci Detection, Mapping and Confirmation System, for the purpose of providing a patient friendly system and method for removing tumors detected by said diagnostic system. The invention is a laser-based endosurgical thermal treatment system that utilizes historical cancer mapping data together with real-time ultrasonic and other data to reliably target and control the eradication of cancer conditions. The system contains computer aided robotic control such that control of the boundary, size, position and orientation of the ablated volume of tissue has a tolerance of less than a millimeter. The disclosed system provides multimodal scanning methods for improved identification and localization of detected tumors, including multi-focal tumors. The disclosed system also provides multiple methods for monitoring the successful progress and conclusion of the treatment. The disclosed system provides the capability of closing the created cavity. The disclosed system resides in a subsystem module and when treatment is to be conducted, the treatment module is substituted in place of the previously disclosed ultrasonic diagnostic module of the MedSci system. The subject thermal treatment system meets the challenges confronting the advancement of thermal treatment systems in the search for a highly effective and patient-friendly cancer treatment.

Presented herein is a real-time target-locking confocal microscope that follows an object moving along an arbitrary path, even as it simultaneously changes its shape, size and orientation. This Target-locking Acquisition with Realtime Confocal (TARC) microscopy system integrates fast image processing and rapid image acquisition using, for example, a Nipkow spinning-disk confocal microscope. The system acquires a 3D stack of images, performs a full structural analysis to locate a feature of interest, moves the sample in response, and then collects the next 3D image stack. In this way, data collection is dynamically adjusted to keep a moving object centered in the field of view. The system's capabilities are demonstrated by target-locking freely-diffusing clusters of attractive colloidal particles, and actively-transported quantum dots (QDs) endocytosed into live cells free to move in three dimensions for several hours. During this time, both the colloidal clusters and live cells move distances several times the length of the imaging volume. Embodiments may be applied to other applications, such as manufacturing, open water observation of marine life, aerial observation of flying animals, or medical devices, such as tumor removal.

The present invention provides a minimally invasive, comprehensive same-day diagnosis and treatment method to remove tumor and ablate margins in breast cancer patients, comprising disease diagnosis by MRI and touch preparation cytology, followed by tumor removal and ablation of tumor margins.

The invention an article or composition of mammalian extracellular matrix (ECM) for placement in a lumpectomy space of a breast after tumor removal. The extracellular matrix article or composition can regenerate lost breast tissue, reduce the formation of scar tissue at the site of excision, and reduce a likelihood of local tumor recurrence at the lumpectomy site. The article can be sheet ECM, and the composition can be particulate ECM or emulsion or gel ECM.

The present invention relates to a fluorescence navigation system used in tumor surgery, which belongs to clinical medicine surgery. The present invention solves problems existing in the surgical excision operation process of tumors that tumor boundaries are difficult to identify, remnant tumor tissue is difficult to recognize, and tumor metastasis lymph glands are difficult to track. The fluorescence navigation system used in tumor surgery is characterized in that the system comprises a biofluorescence excitation light source, a light guide system, a specificity targeted marking fluorescent material, a video camera and an image display and processing device connected with the video camera. The present invention provides fluorescence navigation concept for tumor surgery based on the prior art. When physicians identify tumor boundaries, recognize remnant tumor tissue, and track tumor metastasis lymph glands with a fluorescence observing mirror or a camera display system, tumor tissue is thoroughly excited, operation therapeutic effect is effectively improved, and the death rate of tumor patients is reduced. The present invention makes a breakthrough in tumor surgery.

The invention belongs to the technical field of medical image three-dimensional reconstruction, in particular to a brain tumor medical image three-dimensional reconstruction display interaction methodand a system, comprising the following steps: acquiring a plurality of medical diacom images, preprocessing each medical diacom image to obtain a preprocessed image; According to the pre-processed images, the three-dimensional model of brain can be obtained by three-dimensional modeling. The brain tumor information was obtained by analyzing the three-dimensional brain model, and the brain tumor resection scheme was recommended according to the brain tumor information. According to the operation instruction, the tumor resection was simulated on the three-dimensional brain model, and the wholeoperation process was simulated by the doctor through the naked eye 3D display, and the operation was reminded according to the doctor's intraoperative operation. The invention constructs a three-dimensional model of the brain through the medical image of the brain tumor and simulates the operation, the human-computer interaction process is displayed through the naked eye 3D display, the sense ofvirtual reality is enhanced, and the analysis of the brain tumor is a scheme for the doctor to remove the tumor, thereby improving the diagnosis efficiency of the doctor.

The present invention relates to a biodegradable fibrin based composition for injection into osseous defects or voids, which can be the result of osteoporosis, surgery, bone cysts, tumor removal or traumatic bone injury.

An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

The invention provides a tumor removal medicine and a preparation process thereof. The traditional Chinese medicine is a drug prepared from 5 raw materials, namely luohao muxincao, huitouqing, red dates and raw ginger according to certain proportions. The preparation process comprises the following steps: adding water into the 5 traditional Chinese medicine raw materials for decoction twice, combining filtrates obtained twice, carrying out concentration and alcohol precipitation and cooling to obtain paste, and drying the paste to prepare electuaries, tablets or capsules. The medicine is relatively good in treatment effect on broad-spectrum tumors, particularly uterine fibroid, breast cancer and brain glioma, is nontoxic, safe and low in cost, and has no any side effects.

The invention belongs to the technical field of medicaments and particularly relates to a biological enzyme-carrying calcium phosphate bone cement with a controlled release effect and a preparation method thereof. The preparation disclosed by the invention comprises the following components in percentage by weight: 25 to 90 percent of calcium phosphate bone cement substrate, 0.001 to 50 percent of biological enzyme composite and 5 to 50 percent of curing liquid. When the biological enzyme-carrying calcium phosphate bone cement preparation is implanted, the biological enzyme with an antibacterial effect is released suddenly and then is stably released, so the biological enzyme-carrying calcium phosphate bone cement has the effect of filling and repairing bone defect as well as the effects of preventing and treating bacterial infection, and can be used for treating chronic osteomyelitis, preventing implanted part infection and preventing relapse after a bone tumor is removed.

A highly purified and heat stable cross-linked nonpolymeric tetrameric hemoglobin suitable for use in mammals without causing renal injury and vasoconstriction is provided. A high temperature and short time (HTST) heat processing step is performed to remove undesired dimeric form of hemoglobin, uncross-linked tetrameric hemoglobin, and plasma protein impurities effectively. Addition of N-acetyl cysteine after heat treatment and optionally before heat treatment maintains a low level of met-hemoglobin. The heat stable cross-linked tetrameric hemoglobin can improve and prolong oxygenation in normal and hypoxic tissue. In another aspect, the product is used in the treatment of various types of cancer such as leukemia, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngealcarcinoma and esophageal cancer.,The inventive tetrameric hemoglobin can also be used to prevent tumor metastasis and recurrence following surgical tumor excision. Further the inventive tetrameric hemoglobin can be administered to patients prior to chemotherapy and radiation treatment.

The invention belongs to the technical field of medical apparatuses and instruments, and provides a self-locking type half kidney loop ligature for a minimally invasive surgery. The self-locking type half kidney loop ligature for the minimally invasive surgery is formed by a kidney ligature (1), a hoop (2), a connecting rod handle (3), a hoop clamping sheet (4), a self-locking pull sheet (5), a self-locking sliding block (6), a sliding block clamping sheet (7) and a movable handle (8). According to the self-locking type half kidney loop ligature for the minimally invasive surgery, by means of controlling the kidney ligature (1), only the blood supply of the kidney of a tumor growth end can be cut off, the effect of tumor removal is guaranteed, blood loss volume in the surgery process is reduced, and most importantly, the ischemia time of reserved parts of the kidney is reduced to zero; the fact that blocking on the blood supply of the whole kidney is avoided, the functions of the reserved parts of the kidney are protected to the maximum extent, and the significance of nephron-sparing surgeries under a peritoneoscope is fully embodied.

The present invention refers to a pharmaceutical formulation for injection comprising fluorescent nanoparticles as in vivo diagnostics. The present invention relates to an injectable pharmaceutical formulation for human medicine and / or veterinary use, comprising 17% to 20% per weight of poloxamer 407 and 3%-15% per weight of poloxamer 188, 0.10 nM to 10.0 μM fluorescent nanoparticles and water or an aqueous buffer, wherein the pharmaceutical formulation is liquid at 4° C.-32° C. and forms a gel at about 37° C., their use as an in vivo marker and methods of their preparation. The inventive formulation is useful for local control and prevention of spreading / diffusion of nanoparticles, and thus allows full utilization of their quantum physics properties for example as a tool to enable surgical precision of tumor removal; even without tumor specific epitope binding antibodies.

A cutter (8) is telescopically received in a cannula (9) and both the cutter and cannula are telescopically mounted on a tubular carrier (7). A detection device (6) may be inserted through the open-ended carrier, cutter and cannula to properly place the surgical instrument in alignment with the tumor to be excised. Positioning tines (80) may penetrate the patient to firmly locate the carrier in its proper position on the patient. The cutter and cannula are moved about the carrier and are pressed into the tissue of the patient with the expectation that the circular core (60) of breast tissue formed by the cutter will have clear margins about the tumor. If the tumor extends too close to the circular incision, the cannula may be rotated so that its sidewall opening (26) faces the side of the remaining tissue to be excised and the surgeon can pull the remaining tissue through the sidewall and excise it, thereby avoiding a separate and delayed surgical procedure.

Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.

The invention provides a tumor treatment instrument, and relates to the field of medical apparatuses. The tumor treatment instrument mainly comprises a power source, a built-in positive electrode anda built-in negative electrode, wherein the positive pole of the power source is connected with the built-in positive electrode; the negative pole of the power source is connected with the built-in negative electrode; and the "built-in " of the built-in positive electrode and the built-in negative electrode represents that when the tumor treatment instrument is used, the two electrodes are locatedin a tumor cavity left after a patient is subjected to tumor resection. According to the tumor treatment instrument disclosed by the invention, the electrodes can be transplanted into an organism body, so that in the treatment process, the tumor treatment instrument has high coverage rate on tumor cells especially deep-seated tumor cells, and the restraint of the tumor can achieve a better effect;at present, the tumor is treated by an electric field, and generally, the electrode pieces are adhered to the skin surfaces of the organism body, and when an electric current is exerted on the surface of the organism body, the electric current is mainly conducted from the body surface, in the treating process, the cover failure rate of the deep-seated tumor cells is not high enough, and the treatment effect is not good enough.

The present invention relates to the detection of field cancerization by detection of aberrations in tumor target genes at the margins of resected tumors, and the use of such information to predict survival in cancer patients. Methods for treatment of cancer based thereon also are provided.

The invention discloses a filling material for a bone defect part caused after the giant bone cell tumor removal operation. The filling material comprises a magnesium alloy matrix and a calcium phosphate coating arranged on the surface of the magnesium alloy matrix, and diphosphonate is loaded on the calcium phosphate coating. The invention further discloses a preparation method of the filling material for the bone defect part caused after the giant bone cell tumor removal operation. The filling material for the bone defect part caused after the giant bone cell tumor removal operation takes amagnesium alloy material as a matrix, the calcium phosphate coating and a diphosphonate double-film layer are arranged on the matrix, the materials are taken as a filling material for a tumor cavity left after the giant bone cell tumor removal operation, the purpose of releasing the drug to the nidus is fulfilled, the effects that the diphosphonate drug inhibits the bone destruction of the tumor defect part and the bone absorption is prevented are achieved, meanwhile, the effect that the degradable magnesium alloy repairs the bone defect is achieved, the reconstruction of the bone defect caused after the giant bone cell tumor removal operation is realized, and the relapse rate of the tumor is reduced.

Structural arrangement for post-surgery garment for domestic animals and the like, more specifically a garment (1) for domestic animals (N) such as dogs and cats, inter alia, in particular used by animals on which abdominal interventions were performed, during their recovery, such as castration, caesarean section, tumor removal, etc. The garment (1) is formed by four parts, (Q1) and (Q1′), and (Q2) and (Q2′), joined at the edges thereof by longitudinal seams, (A) and (A1′), (C) and (D), (C) and (D′), both identical parts (Q1) and (Q1′) having on the sides (A) and (A′) two transverse seams (CO1), (CO2), (CO1′), (CO2′) which form a base (AB) and (AB′) that can be optionally opened. The ends are joined by sewing together parts (E) and (F), (G) and (H), (E′) and (F′), and (G′) and (H′). Thus, at the vertices of parts (Q1) and (Q2), (Q1′) and (Q2′), cutouts (PSQ1) and (PSQ2), (PIQ1) and (PIQ2), (P1C) and (P1), (P2), (PSQ1′) and (PSQ2′), (PIQ1′) and (PIQ2′), (P1B) and (P1A), and (P2A) are provided, with cuffs sewn around the periphery of each cutout; parts (Q1) and (Q2), as well as (Q1′) and (Q2′), are provided with longitudinal seams along the sides (C) and (D) and (C) and (D′) thereof, as already mentioned, the end of the longitudinal seams being located after the central portion (LC1) and (LC2), as well as (LC1′) and (LC2′); the free longitudinal edges (B) and (B′) of parts (Q2) and (Q2′) are provided with closure means formed by long zipper fasteners (Z) and (Z′).

The invention discloses a bimetallic doped graphene nano material and application thereof. The preparation method of the bimetallic doped graphene nano material comprises the following steps: taking ametal organic framework as a synthesis precursor, loading transition metal elements and dicyandiamide on the metal organic framework by adopting a double-solvent method, and harvesting precipitates from a mixed solution; drying the precipitate, and carrying out high-temperature calcination in an inert atmosphere to obtain a carbonized product; and sequentially carrying out acid etching, washing and drying on the obtained carbide to obtain the bimetallic doped graphene nano material. The bimetallic doped graphene nano material is characterized in that hydrogen peroxide can be efficiently catalyzed in a weak acid or even neutral environment to generate free radicals with a strong oxidizing property, and the bimetallic doped graphene nano material has high catalytic efficiency and a high hydrogen peroxide utilization rate. The bimetallic doped graphene nano material can be applied to inhibition of bacterial growth, degradation of formaldehyde in the environment and assistance of tumor surgery excision, and the tumor excision rate is increased. Therefore, the material has a good social value and clinical application prospect.

The invention relates to an assembled tumor type artificial tibiotalar joint prosthesis. The assembled tumor type artificial tibiotalar joint prosthesis comprises a tibia assembly, a talus assembly and a tibiotalar hinge type connecting assembly, wherein the tibia assembly is connected with the human tibia; the talus assembly is mainly composed of a talus base, a talus connecting column and a locking screw; the talus base is of a shell type structure matched with the surface shape of the talus; the talus connecting column is integrally formed on the lower portion of the talus base and extendsdownwards along the vertical axis; the locking screw penetrates through the talus base, the talus connecting column and the human talus along the coronal axis; and the tibiotalar hinge type connectingassembly is rotationally connected between the tibia assembly and the talus assembly, so that the tibia assembly and the talus assembly can relatively rotate in a sagittal plane, and the plantar flexion and dorsal extension functions of the tibiotalar joint are recovered. The prosthesis can be widely applied to bone defect reconstruction of limb continuity interruption after tumor resection underthe condition that the far end of the tibia or the far end of the fibula seriously affects the tibia, the purpose of limb structure recovery can be achieved, meanwhile, perfect combination of immediate stability and long-term stability of the tibiotalar joint is achieved, and therefore the long-term tibiotalar joint function of a patient is remarkably improved.

A cutter (8) is telescopically received in a cannula (9) and both the cutter and cannula are telescopically mounted on a tubular carrier (7). A detection device (6) may be inserted through the open-ended carrier, cutter and cannula to properly place the surgical instrument in alignment with the tumor to be excised. Positioning tines (80) may penetrate the patient to firmly locate the carrier in its proper position on the patient. The cutter and cannula are moved about the carrier and are pressed into the tissue of the patient with the expectation that the circular core (60) of breast tissue formed by the cutter will have clear margins about the tumor. If the tumor extends too close to the circular incision, the cannula may be rotated so that its sidewall opening (26) faces the side of the remaining tissue to be excised and the surgeon can pull the remaining tissue through the sidewall and excise it, thereby avoiding a separate and delayed surgical procedure.

The invention discloses an operation navigation system based on near infrared imaging. The operation navigation system comprises an near infrared image probe, an endoscopy probe, an imaging work station and a virtual reality display device, wherein the near infrared image probe is used for targeting pathological change tissues to be cut through operation, and can generate near infrared fluorescence signals under the irradiation of exciting light; the endoscopy probe comprises an exciting light source and a near infrared fluorescence collector; the exciting light source is used for generating the exciting light; the near infrared fluorescence collector is used for collecting the near infrared fluorescence signals; the image work station is at least used for converting the near infrared fluorescence signals into digital images and building a three-dimensional scene corresponding to an operative site; the virtual reality display device is at least used for showing the three-dimensional scene to an operator. The operation navigation system provided by the invention has the characteristics that the sensitivity is high; the moving is flexible; the design, the development and the operation are simple and easy; information is reliable; the safety is high, and the like. The tumor removal operation can be guided in real time; the wide application prospects are realized in the fields of medicine tracing, curative effect evaluation, drug metabolism distribution, tumor early stage detection, stem cell differentiation and restoration and the like.