150 results about "Tumor ablation" patented technology

A medical probe assembly, system, and methods for the use thereof to treat tissue are described. The system optionally comprises an energy source, two internally-cooled probe assemblies, and one or more cooling devices to provide cooling to at least one of the probe assemblies. The probe assemblies may be configured in a bipolar mode, whereby current flows preferentially between the probe assemblies. The probe assemblies and system described herein are particularly useful to deliver radio frequency energy to a patient's body. RF energy delivery may be used for various applications, including the treatment of pain, tumor ablation and cardiac ablation.

A novel medical probe assembly, system, and methods for the use thereof to treat tissue are described. The system optionally comprises an energy source, two probe assemblies, and one or more cooling devices to provide cooling to at least one of the probe assemblies. The probe assemblies may be configured in a bipolar mode, whereby current flows preferentially between the probe assemblies. The probe assemblies and system described herein are particularly useful to deliver radio frequency energy to a patient's body. RF energy delivery may be used for various applications, including the treatment of pain, tumor ablation and cardiac ablation.

The present invention relates to an apparatus and method for utilizing energy, such as radio frequency (RF) energy, to treat defined areas of tissue and more particularly to ablate tumors with RF energy through the use of a needle having a spreading array of individually traversing conductive tines which are independently positioned and activated.

A medical probe assembly, system, and methods for the use thereof to treat tissue are described. The system optionally comprises an energy source, two internally-cooled probe assemblies, and one or more cooling devices to provide cooling to at least one of the probe assemblies. The probe assemblies may be configured in a bipolar mode, whereby current flows preferentially between the probe assemblies. The probe assemblies and system described herein are particularly useful to deliver radio frequency energy to a patient's body. RF energy delivery may be used for various applications, including the treatment of pain, tumor ablation and cardiac ablation.

A method of performing radiation therapy includes delivering a therapeutic dose such as X-ray only to a target (e.g., tumor) with continuous broad beam (or in-effect continuous) using arrays of parallel planes of radiation (microbeams / microplanar beams). Microbeams spare normal tissues, and when interlaced at a tumor, form a broad-beam for tumor ablation. Bidirectional interlaced microbeam radiation therapy (BIMRT) uses two orthogonal arrays with inter-beam spacing equal to beam thickness. Multidirectional interlaced MRT (MIMRT) includes irradiations of arrays from several angles, which interleave at the target. Contrast agents, such as tungsten and gold, are administered to preferentially increase the target dose relative to the dose in normal tissue. Lighter elements, such as iodine and gadolinium, are used as scattering agents in conjunction with non-interleaving geometries of array(s) (e.g., unidirectional or cross-fired (intersecting) to generate a broad beam effect only within the target by preferentially increasing the valley dose within the tumor.

The present invention relates to an apparatus and method for utilizing energy, such as radio frequency (RF) energy, to treat defined areas of tissue and more particularly to ablate tumors with RF energy through the use of a needle having a spreading array of individually traversing conductive tines which are independently positioned and activated.

The disclosed invention is a unique, patient-friendly, laser-based tumor ablation system for the removal of malignant tumors of the prostate and, with modified delivery systems, may have application for other areas of the human body.The disclosed invention is an integrated, robotic treatment subsystem that takes advantage of the capabilities of the previously disclosed MedSci Detection, Mapping and Confirmation System, for the purpose of providing a patient friendly system and method for removing tumors detected by said diagnostic system. The invention is a laser-based endosurgical thermal treatment system that utilizes historical cancer mapping data together with real-time ultrasonic and other data to reliably target and control the eradication of cancer conditions. The system contains computer aided robotic control such that control of the boundary, size, position and orientation of the ablated volume of tissue has a tolerance of less than a millimeter. The disclosed system provides multimodal scanning methods for improved identification and localization of detected tumors, including multi-focal tumors. The disclosed system also provides multiple methods for monitoring the successful progress and conclusion of the treatment. The disclosed system provides the capability of closing the created cavity. The disclosed system resides in a subsystem module and when treatment is to be conducted, the treatment module is substituted in place of the previously disclosed ultrasonic diagnostic module of the MedSci system. The subject thermal treatment system meets the challenges confronting the advancement of thermal treatment systems in the search for a highly effective and patient-friendly cancer treatment.

An antenna for microwave tumor ablation provides coaxial antenna conductors surrounded by an insulated sleeve of length and size promoting destructive interference of axial microwave energy passing inside and outside of the sleeve to limit the tail of SAR power toward the skin.

Therapeutic methods, compositions, and apparatus are provided for the treatment and ablation of body masses, such as tumors. RF treatment is combined with pharmaceutical compositions so that tumor masses are ablated and therapeutically effective compositions and doses that include or produce p53 tumor suppressor or peptides and variants thereof are administered to manage recurrence and metastasis.

The invention relates to ultrasound imaging method and apparatus suitable for minimally invasive ultrasound diagnostic devices in cardiac ablation monitoring and in tumor ablation monitoring. The present invention proposes to manufacture a transducers assembly and system on a patterned flexible foil by embedding transducers patches in apertures on the foil surface. This provides great control of the acoustic properties of the transducer.

The present invention provides improved methods, systems, and kits for protecting body tissues which are adjacent to tissues undergoing thermal treatment. Thermal treatment is often prescribed for tumors and other disease conditions within body organs and other tissue masses. The methods, systems, and kits are particularly useful for treating tumors which lie at or near the surface of an organ, such as the kidney, pancreas, stomach, spleen, and particularly the liver. One risk of treating such tumors is the possibility of mistargeting the tumor and penetrating a delivery cannula or portions of a treatment device beyond the surface into the adjacent tissues or organs. In the case of radiofrequency or electrosurgical treatment, healthy surrounding tissue may be directly ablated. An additional risk, present even when the tumor is correctly targeted, is the possibility of thermal damage to the surrounding, non-targeted tissue. In radiofrequency or electrosurgical treatment, heat may dissipate into surrounding tissues which are more fragile and heat sensitive than the tissue in the organ being treated, thus causing unwanted tissue damage. These risks and others may be lessened or avoided with the use of an interface shield between the target region and adjacent body tissues to shield surrounding organs and tissue from treatment effects.

A method and system are provided for determining a condition of a selected region of tissue to facilitate the location of surgical resection margins. Electropotential and impedance are measured at one or more locations in an area of the body where tissue is to be removed. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics of that tissue. The condition of the tissue is measured by electropotential and impedance profile. Differences in the profile are used to determine the borders between normal and abnormal tissue so as to facilitate what tissue to resect. Methods and apparatus are also disclosed to determine the efficacy of various therapies.

A hypodermic needle outer surface deflects ultrasound signals hitting the surface. The reflected signals depend on the surface which the ultrasound signal hits. According to the invention the outer surface of the needle, beginning at the tip or cutting edge of the needle featuring any one or more of: a) dimples having one or more distinct patterns; b) pits, randomly scattered; and, c) double helix, i.e., two grooves starting at an angle apart, preferably 180 degrees, and spiraling backwards in a helical fashion from the tip. By periodically repeating different pattern(s) for a predetermined length of the needle the position of the needle can be accurately identified using ultrasound imaging. The needle, in different lengths and gauges, can be used to facilitate stenting of the carotid artery as well as other ultrasound guided procedures such as biopsies, drainages / aspirations, solid organ tumor ablations and vascular access in general.

A system for use in tumor ablation. The tumor ablation system includes a pair of probes connectable to a radiofrequency generator. Each of the probes includes two electrodes located between three temperature sensors, wherein the radiofrequency generator may apply radiofrequency energy between any two electrodes.

A device, method, and system are provided for immobilizing and stabilizing a breast in preparation for tumor ablation or biopsy while the patient is lying supine. The breast is lifted away from the chest wall of the patient, so that the tissue abnormality to be treated is also lifted away from the chest wall. This reduces the possibility of damage to the neighboring costochondral wall and the surrounding healthy tissue. The device includes a medical device holder that can be used to accurately aim a medical probe, and hold it in place during treating.

Certain embodiments of the present invention provide methods and systems for improved tumor ablation. Certain embodiments include determining a distance between a tumor and at least one of a plurality of landmarks bounding the tumor in at least one acquired image of an area of interest for a patient, obtaining positional data for an ablation instrument, and displaying a position of the ablation instrument with respect to the tumor. Additionally, a position of the ablation instrument may be dynamically displayed on the fluoroscopic image and / or the at least one acquired image during tumor ablation. Furthermore, a location cursor on the fluoroscopic image may be linked with a location cursor on the one or more acquired images. In certain embodiments, a location of a tip of the ablation instrument may be dynamically displayed with respect to a starting location and an ending location of the tumor.

The invention discloses an injection type aciculiform microwave antenna for tumor ablation treatment and belongs to medical instruments of tumor ablation treatment. The injection type aciculiform microwave antenna comprises a radiator, an aciculiform radiator case is mounted on the radiator, the radiator is mounted at the front end of a needle rod, a radio-frequency coaxial connector is mounted at the rear end of the needle rod, and a coaxial cable is arranged in the needle rod. A water inlet channel and a water outlet channel are arranged in the needle rod, the water outlet channel is communicated with a water outlet structure of the tail end of the needle rod and further provided with capillary tubes for injection, and micropores communicated with the capillary tubes are arranged on the needle rod and near the radiator. During microwave ablation, the capillary tubes are used for injecting saltwater, carbonizing probability at the high temperature due to overhigh power at the front end of the needle rod is decreased, ablation range is enlarged, and ablation curative effect is effectively improved. Meanwhile, the injection type aciculiform microwave antenna for tumor ablation treatment is simple in structure, applicable to industrialized production and easy to popularize.

The invention discloses a medical mechanical arm tail end device which comprises a loading and unloading guide mechanism, an assembly and a connecting plate, wherein the loading and unloading guide mechanism is used for loading and unloading a needle-shaped medical appliance; the assembly is used for installing the loading and unloading guide mechanism; the connecting plate is used for fixing the assembly on a connecting rod at the tail end of a mechanical arm; the loading and unloading guide mechanism comprises four fixture bodies with the same structure and a loading and unloading transmission mechanism for driving the four same fixture bodies to rotate; and each fixture body comprises a rotating shaft, an upper clamping plate, a lower clamping plate and a plurality of guide sleeves. Under the action of the transmission mechanism, a closed hole is formed by the corresponding guide sleeves of the two adjacent fixture bodies so as to guide an actuator; and after the guidance is completed, the transmission mechanism is reversely driven to separate the fixture bodies. The medical mechanical arm tail end device is mainly used for automatically loading, unloading and guiding an ablation needle in a tumor ablation operation, ensures that a doctor has a sufficiently large operating space after the ablation needle is positioned / subjected to posture positioning, and has high automation degree, high accuracy, simpleness for operation and strong coordinability between people and a machine.

The invention provides synthesis of a platinum-based bodipy compound and a new application thereof in pharmacy, and particularly relates to the synthesis of platinum-based bodipy molecules and derivatives thereof, preparation of a nano-scale medicament, and an application to anti-tumor photosensitive medicament in photodynamics and photothermal therapy. Self-assembling nano-particles with photodynamic and photothermal dual activities are constructed by taking bodipy dye molecules as parent nuclei, introducing divalent platinum ions in a covalent coordination mode, and performing modifying through a polymer hydrophilic chain. Under light conditions, a self-assembling nano-scale medicament shows good photodynamic and photothermal therapeutic effects. The platinum-based bodipy compound confirms dual effects of the photodynamics and photothermal therapy at cell and animal levels, and the light induction of tumor ablation is realized.

A radio frequency (RF) treatment flexible endoscope, for the in depth destruction of tumors by endo luminal access, like in a lung, esophagus, colon, rectum, etc . . . The electrodes (2′,2″) working in bipolar mode, deploy laterally and in parallel from the endoscope main body (1), reaching a tumor deeply located in the organ parenchyma. The use of different disposable distal end portions (15) of the endoscope allows the deployment of the electrodes (2′,2″) at different distances one from each other, in order to fit the destruction are to the tumor's size and shape. The deployment of the parallel electrodes (2′,2″) from the endoscope's main body (1) is controlled by motor drives (4) or a mechanical handled system (3), in order to reach the tumor with near a millimeter precision. In order to fix the endoscope's distal end to the tissue, so to allow a perfect parallel deployment of the electrodes, an inflating cuff (5) is placed at the opposite side of the distal end, as well as a suction system, with its holes (21) placed near the electrodes' deployment location. An external RF generator and a imaging system are associated to the use of the device.

The invention relates to a high frequency bipolar unrecoverable electroporation system. The high frequency bipolar unrecoverable electroporation system comprises an upper layer information managementmodule, a lower computer control module and a bipolar high voltage pulse discharging circuit, wherein the upper layer information management module is used for receiving set working parameters, and transmitting the received working parameters to the lower computer control module, and then a control signal is generated and transmitted to the bipolar high voltage pulse discharging circuit to producebipolar high voltage pulse. Compared with a conventional unipolar irreversible electroporation pulse sequence, the high frequency bipolar unrecoverable electroporation system can better and more uniformly increase the induced transmembrane potential of cells which are tightly arrayed to a simulation electroporation threshold, so that an ablation region is more uniform; and through the adoption ofthe high frequency bipolar unrecoverable electroporation system disclosed by the invention, favorable tumor ablation effects and the purpose of restraining the growth of tumor can be achieved, and the high frequency bipolar unrecoverable electroporation system has favorable safety and favorable validity.

The invention provides a tumor ablation therapy mechanical device having a force / position control protection function. The tumor ablation therapy mechanical device comprises a lifting degree-of-freedom module, a force / position control module and a treatment module, wherein the lifting degree-of-freedom module has a vertical lifting degree of freedom, and the lifting degree-of-freedom module is in charge of offering a lifting motion to the treatment module; by virtue of the force / position control module, the force / position control protection function is achieved, and the treatment module can rotate and swing left and right; and the treatment module, which can perpendicularly rotate around an axle and can rotate and swing front and back, has one degree of freedom of rotating and swinging left and right, one degree of freedom of rotating and swinging front and back, one degree of freedom of perpendicularly rotating around the axle and one degree of freedom of lifting. The mechanical device provided by the invention, when applied to ultrasonic ablation therapy, can automatically regulate contract force between a water bag and the abdomen of a patient in accordance with patient's feeling; and corresponding motions are stopped when the contact force reaches preset force, so that safety protection on patient contact is achieved.

The invention provides a microwave ablation simulation system. The types of ablation needles are received by virtue of a simulation computing module, and after configuring corresponding parameters to the types of the ablation needles in accordance with parameters of the different types of the ablation needles, an optimum scheme is computed out in accordance with a received 3D model of tumor and surrounding environment thereof as well as the corresponding parameters of the types of the ablation needles, so that the problem that normal tissues of a patient can get injured easily in the case that an ablation range is too large or tumor residue can be caused when the ablation range is too small; and then, the optimum ablation scheme, as tumor ablation simulation scheme information is outputted, so that an optimum multi-needle arranging microwave ablation scheme is offered to relatively large tumors.

The invention provides a microwave tumor ablation instrument which comprises a microwave generation device, a power supply driving the microwave generation device to work, an ablation needle guiding microwave energy to an ablation structure, and a temperature measuring device used for detecting the temperature near the ablation structure. The instrument further comprises an anode current measuring device used for measuring the anode current value of the microwave generation device, and a fuzzy PID control device used for generating control signals according to the anode current value of the microwave generation device and controlling the phase angle of a phase control rectification device in the power supply so that the anode current of the microwave generation device can be equal to or close to a set value. The instrument effectively solves the technical problems that consistency of average power output by an existing microwave tumor ablation instrument is poor and / or instantaneous power consistency under the same average power is poor.