The invention belongs to the technical field of
biology, and in particular relates to a polydopamine coated
gold nanorod material as well as a preparation method and application of the polydopamine coated
gold nanorod material. The preparation method disclosed by the invention comprises the following steps: by taking CTAB (cetyl trimethyl
ammonium bromide) as a template agent, synthesizing a polydopamine coated
gold nanorod material; modifying an
antibody onto the surface of the material, thereby obtaining a multifunctional polydopamine coated gold
nanorod material. Thus, a tumor
cell Raman imaging detection and real-time
photothermal therapy platform is constructed. The experiments prove that the gold
nanorod material is capable of realizing specific effective
tumor target cell marking and performing rapid surface-enhanced Raman
spectral imaging scanning on the
tumor cells under excitation of near-
infrared light; and the
tumor target cells are accurately identified by the imaging results, and after the target cells are identified, the
infrared light can be focused onto the
tumor target cells, the
irradiation time is prolonged, and the material is heated by utilizing the photo-thermal conversion effect of the gold
nanorod material so as to kill the
tumor cells in real time. The polydopamine coated gold nanorod material disclosed by the invention is novel, convenient, practical and efficient and has huge clinical application potential.