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Method for preparing CuS photothermal therapy nano material with good biocompatibility

A technology of biocompatibility and nanomaterials, applied in the field of preparation of CuS photothermal nanomaterials, can solve the problems of photothermal nanomaterials restricting biological applications, etc., and achieve easy large-scale popularization and application, simple reaction conditions, safe and convenient operation Effect

Inactive Publication Date: 2015-07-22
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the toxicity of photothermal nanomaterials seriously restricts their further biological applications

Method used

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  • Method for preparing CuS photothermal therapy nano material with good biocompatibility
  • Method for preparing CuS photothermal therapy nano material with good biocompatibility

Examples

Experimental program
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Effect test

Embodiment 1

[0017] The preparation method of CuS nanomaterials for photothermal therapy with good biocompatibility is prepared by a one-pot method, and the steps are as follows:

[0018] 1) In a 50mL round bottom flask, dissolve 250mg bovine serum albumin in 7.5mL water, add 1mL 0.2M Cu(NO 3)2 solution, after mixing, add 0.5mL 1M NaOH solution, then add 2mL 0.2M NaOH 2 S solution, react the obtained solution in a 90°C water bath for 30min.

[0019] 2) Dialyzing and purifying the obtained nanomaterials, the dialysis time is 12-24 hours, and the water is changed every 3-4 hours.

[0020] 3) The obtained dialysate is freeze-dried to obtain CuS nanomaterial solid particles.

[0021] The ultraviolet-visible-near-infrared absorption spectrum of the CuS photothermal nanomaterial prepared in this embodiment is as follows: figure 1 As shown in the figure, it shows that CuS photothermal nanomaterials have strong absorption in the near-infrared region, and the absorption intensity increases as th...

Embodiment 2

[0023] The preparation method of CuS nanomaterials for photothermal therapy with good biocompatibility is prepared by a one-pot method, and the steps are as follows:

[0024] 1) In a 50mL round bottom flask, dissolve 200mg human serum albumin in 7mL water, add 0.1mL 0.2M Cu(NO 3)2 solution, after mixing, add 0.5mL 1M NaOH solution, then add 0.2mL 0.2M NaOH 2 S solution, react the obtained solution in a water bath at 60-90°C for 30-60min.

[0025] 2) Dialyzing and purifying the obtained nanomaterials. The dialysis time is 24 hours, and the water is changed every 4 hours.

[0026] 3) The obtained dialysate is freeze-dried to obtain CuS nanomaterial solid particles.

[0027] The CuS photothermal nanomaterial prepared in this example was taken for spectral analysis and photothermal effect examination, and the test results were similar to Example 1.

Embodiment 3

[0029] The preparation method of CuS nanomaterials for photothermal therapy with good biocompatibility is prepared by a one-pot method, and the steps are as follows:

[0030] 1) In a 50mL round bottom flask, dissolve 260mg transferrin in 8mL water, add 0.5mL 0.2M Cu(NO 3)2 solution, after mixing, add 0.5mL 1M NaOH solution, then add 1mL 0.2M NaOH 2 S solution, react the obtained solution in a 90°C water bath for 30min.

[0031] 2) Dialyzing and purifying the obtained nanomaterials. The dialysis time is 24 hours, and the water is changed every 4 hours.

[0032] 3) The obtained dialysate is freeze-dried to obtain CuS nanomaterial solid particles.

[0033] The CuS photothermal nanomaterial prepared in this example was taken for spectral analysis and photothermal effect examination, and the test results were similar to Example 1.

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Abstract

The invention discloses a method for preparing a CuS photothermal therapy nano material with good biocompatibility. A one-pot method is adopted and the preparation method comprises the following steps: weighing a biomacromolecule in a container, adding water, stirring and dissolving, adding a Cu(NO3)2 solution, fully stirring and mixing uniformly, adding a NaOH solution, and finally adding a Na2S solution (the mol ratio of Cu to S is 1:2), fully stirring and uniformly mixing, putting into a water bath pot at the temperature of 90 DEG C, and stirring for 30 min to obtain a dark green solution; dialyzing and purifying the obtained CuS nano material, wherein the dialyzing time is 24h, and water is changed every 4h; and freezing and drying the obtained dialyzate to obtain the product. The reagent used in the invention is green and environmentally friendly, the preparation method is simple by performing heating reaction at the temperature of 90 DEG C, the operation is safe and simple, toxin is small, the cost is low and the large-scale popularization can be easily realized. The prepared nano material is small in size, good in water solubility, stable in near-infrared thermal performance and good in biocompatibility without immunogenicity.

Description

technical field [0001] The invention relates to the field of preparation of photothermal therapy nanomaterials, in particular to a preparation method of CuS photothermal nanomaterials with good biocompatibility. Background technique [0002] Photothermal therapy is the conversion of absorbed light energy into heat by photothermal nanomaterials, which increases the temperature of tumor tissue and leads to apoptosis of cancer cells. Compared with traditional tumor treatment methods, photothermal therapy, as a non-invasive treatment method, can effectively kill cancer cells while avoiding damage to normal tissues, and has less toxic and side effects on the body as a whole, thus becoming a research hotspot in tumor treatment. However, the toxicity of photothermal nanomaterials seriously restricts their further biological applications. [0003] At present, the photothermal materials that have been studied mainly include gold nanorods, gold nanocages, gold nanotubes, carbon nanot...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/36A61K47/42A61P35/00
Inventor 孙少凯张彩张雪君于春水
Owner TIANJIN MEDICAL UNIV
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