The invention discloses Fe@Fe3O4 nanoparticles having a photothermal function, and a preparation method and an application thereof, and belongs to the field of
medical science materials. The preparation method is significantly characterized by comprising: firstly, utilizing
octadecene as a
solvent, utilizing Fe(CO)5 as an
iron source, utilizing oleyl amine as a surfactant and a stabilizer, and preparing an Fe nanomaterial having good
dispersity by high temperature
pyrolysis; sequentially, adding (CH3)3NO at the high temperature for oxidization to form one layer of Fe3O4 shell on the
surface layer of each Fe
nanoparticle, and then improving water
solubility by a ligand exchange method to obtain the Fe@Fe3O4
composite material as a photothermal
reagent and having high
magnetization strength. The
composite material has the advantages of uniform particle size,
high saturation magnetization strength, and controllable morphology, and has excellent dispersion and excellent stability in
aqueous solution. The reaction time is short, the raw materials are easy to get, and operation processes are convenient. On the basis of the raw materials, the Fe@Fe3O4 nanoparticles are developed to connect PEG to the surface of the material, so that the Fe@Fe3O4 nanoparticles can be applied to biological bodies. The invention provides the application of the Fe@Fe3O4 nanoparticles in the field of tumor
photothermal therapy.