77 results about "Paramagnetic nanoparticles" patented technology

The invention relates to a method for detecting gentamicin through clinical magnetic resonance imaging, and belongs to the technical field of immunodetection. The method is to add standard gentamicin supernatant or gentamicin supernatant to be measured, gentamicin antibodies and goat-anti and rabbit-anti antibodies into gentamicin modified magnetic nano particles, and use the antibodies and the gentamicin modified magnetic nano particles to form immune polymers so as to generate magnetic resonance signals and perform magnetic resonance detection. The magnetic resonance signal detection method utilizes the antibodies and the gentamicin modified magnetic nano particles to form the immune polymers, and effectively shortens the transverse relaxation time T2 value of protons in water so as to generate signals. In general, when the concentration of the gentamicin in a sample is larger, the quantity of the gentamicin caught by the antibodies is more, the quantity of the antibodies which are combined with the gentamicin on the surface of the magnetic nano particles is fewer, and the measured T2 value is larger. The method does not need complex sample pretreatment, is simple and convenient to operate, only needs to add the sample to be measured for incubation and directly measure the T2 value, and can complete the process by one step. Moreover, the particle diameter of superparamagnetic nano particles for marking is approximately 10 nanometers, so that the water solubility is high and the dispersity and the stability are good.

The invention provides a polymer-brush-modified magnetic composite microsphere as well as a preparation method and application thereof. The polymer-brush-modified magnetic composite microsphere comprises a polymer core, a super-paramagnetic nanoparticle shell and a polymer brush in sequence from inside to outside, wherein the polymer brush is directly grafted onto the super-paramagnetic nanoparticle shell through atom transfer radical polymerization by using a carboxyl-containing water-soluble unsaturated monomer. By grafting the polymer brush onto a magnetic nanoparticle surface, the specific surface area and the protein binding site of the microsphere can be increased greatly, and the probability of the contact of a protein with a material is increased. Moreover, a specific functional group can be further grafted onto the polymer brush conveniently, so that the specific binding ability of the microsphere with a separation object is improved, and the aim of finer separation is fulfilled. The preparation method is simple, and is convenient to promote and apply; and the stability, operability and environmental friendliness of a reaction system are improved.

A double-emulsion core-shell nano-structure and preparation methods thereof is provided. The double-emulsion core-shell nano-structure is a structure of an oil shell enclosing a water core. The double-emulsion core-shell nano-structure can be prepared by simply mixing and stirring to emulsify an aqueous solution of a water soluble polymer and an organic solution of hydrophobic paramagnetic nanoparticles.

The invention relates to a flexible photon nanometer chain with an adjustable photonic band gap and a preparation method and application thereof. The flexible photon nanometer chain can serve as a sensor to sense the outside physical and chemical stimulation and has a single-chain one-dimensional nanometer structure formed by arranging monodisperse super-paramagnetic nanoparticles at equal particle distance in a responsive polymer matrix. The method for preparing the flexible photon nanometer chain with the adjustable photonic band gap comprises the following steps: fully dispersing the monodisperse super-paramagnetic nanoparticles in a solution containing a responsive polymer monomer, carrying out an ultraviolet or thermal induced polymerization under the action of an external magnetic field, thereby obtaining the product. Compared with the prior art, the flexible photon nanometer chain disclosed by the invention has the following main advantages that 1, the flexible photon chain is fixed in the responsive polymer; 2, the prepared flexible photon nanometer chain has the adjustable photonic band gap, the outside physical and chemical stimulation can be responsed by virtue of movement of a reflection peak, and the flexible photon nanometer chain can serve as a sensor; and 3, the diffusion distance of a detected object in a gel layer is greatly shortened and the response speed is improved.

Nanoparticle-based compositions and emulsions that are specifically targeted to leukotriene B4 (LTB4) receptors, and employing LTB4 receptor antagonist targeting agents, are set forth. In addition, there is provided the use of non-antibody based compositions for such targeting. The compositions of the invention are useful as imaging agents in diagnostic and therapeutic applications.

Described herein is a method of making modified paramagnetic nanoparticles with improved therapeutic loading efficiency and enhanced circulation properties. The method comprises coating a paramagnetic nanoparticle (PMNP) with a hydrophobic coating comprising lipophilic drug and a polymer. Also described herein is a PMNP, and a composition comprising PMNP. In certain embodiment, the PMNP have improved permeability through the blood brain barrier. Also described herein is a method of using the PMNP for the treatment of diseases. In certain embodiments, the method of treatment is a combination therapy. Described herein are imaging of therapeutic delivery of PMNP and diagnostic methods using the PMNP. Also described herein is a diagnostic kit that comprises the PMNP. The invention provides compositions comprising a paramagnetic nanoparticle having an external coating comprising a small organic molecule, a polymer, a blood protein, oleic acid, a lipophilic pharmaceutical or an allosteric effector of hemoglobin, as well as methods of making thereof, and use thereof in treatment and imaging.