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6961 results about "Diagnostic methods" patented technology
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Diagnostic techniques and procedures encompass all investigations and tests intended to identify the cause of an illness or disorder. They include, for example, laboratory tests for infectious agents, and imaging techniques, such as radiology and ultrasound examination. Related Journals of Diagnostic Methods.
Methods for selectively stimulating proliferation of T cells
InactiveUS6905681B1Increase the number ofVirusesPeptide/protein ingredientsAccessory moleculeExogenous growth
Owner:GENETICS INST INC +2
Methods for selectively stimulating proliferation of T cells
InactiveUS6887466B2Expanding population of cellIncrease the number ofVirusesPeptide/protein ingredientsAccessory moleculeExogenous growth
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR) / CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
Owner:GENETICS INST INC +2
Methods for selectively stimulating proliferation of T cells
InactiveUS7175843B2Increase the number ofBiocideCell receptors/surface-antigens/surface-determinantsAccessory moleculeExogenous growth
Owner:GENETICS INST LLC +2
Methods of treating HIV infected subjects
InactiveUS6905680B2Expanding population of cellIncrease the number ofVirusesPeptide/protein ingredientsAccessory moleculeExogenous growth
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR) / CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
Owner:GENETICS INST INC +2
Methods for selectively stimulating proliferation of T cells
InactiveUS7144575B2Increase the number ofBiocidePeptide/protein ingredientsAccessory moleculeExogenous growth
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR) / CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY +2
System and method for vehicle diagnostics
InactiveUS7103460B1Low costPrecise positioningVehicle testingRegistering/indicating working of vehiclesReliability engineeringDiagnostic methods
Method and system for diagnosing whether vehicular components are operating abnormally based on data obtained from sensors arranged on a vehicle. In a training stage, output from the sensors during normal operation of the components is obtained, each component is adjusted to induce abnormal operation thereof and output from the sensors is obtained during the induced abnormal operation. A determination is made as to which sensors provide data about abnormal operation of each component based on analysis of the output from the sensors during normal operation and during induced abnormal operation of the components. During operation of the vehicle, the output from the sensors is obtained and analyzed, e.g., by inputting it into a pattern recognition algorithm or neural network generated during the training stage, in order to output an indication of abnormal operation of any components being diagnosed.
Owner:AMERICAN VEHICULAR SCI
Virtual remote monitor, alert, diagnostics and programming for implantable medical device systems
InactiveUS6878112B2Promote the patient's well beingSignificant compatibilityPhysical therapies and activitiesElectrotherapyClinical settingsData center
A plurality of co-operative and complementary software programs are implemented in a web-enabled high speed computer system to remotely monitor, manage and modify the operational and functional parameters of a plurality of implanted medical devices (IMDs). The system utilizes virtual electrophysiologist module (VEM), chronic monitoring module (CMM) and prescription program module (PPM) programs to effect specific therapeutic and diagnostic methods for managing the IMDs, remotely on a conditions and real-time basis. The modules enable remote and continuous monitoring, management and maintenance of the IMDs by identifying critical medical events, determining optimal clinical settings and upgrading performance parameters based on prescriptive data. The modules are implemented in a data center having high-speed computers operating in a web-enabled environment. The modules and the IMDs communicate through wireless communications system via a programmer or an interface medical unit (IMD).
Owner:MEDTRONIC INC
Methods for the Diagnosis of Fetal Abnormalities
ActiveUS20080138809A1Reliable and accurate clinical diagnosisAccurate and reliable diagnosisMicrobiological testing/measurementPreparing sample for investigationFetal abnormalityRare cell
The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.
Owner:VERINATA HEALTH INC +2
Protein scaffolds for antibody mimics and other binding proteins
InactiveUS7115396B2Easy to foldImprove stabilityPeptide/protein ingredientsAntibody mimetics/scaffoldsWAS PROTEINAntibody
Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
Owner:BRISTOL MYERS SQUIBB CO
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
InactiveUS7247301B2Less immunogenicReduce adverse side effectsInorganic active ingredientsImmunoglobulins against cytokines/lymphokines/interferonsV(D)J recombinationHuman epidermal growth factor receptor
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Owner:GENMAB INC
Intelligent model-based diagnostics for system monitoring, diagnosis and maintenance
InactiveUS20060064291A1Improve accuracyImprove consistencyAmplifier modifications to reduce noise influenceTesting/monitoring control systemsElectric power systemCompound (substance)
Systems and methods are provided for monitoring, diagnosis and condition-based maintenance of mechanical systems. The disclosed systems and methods employ intelligent model-based diagnostic methodologies to effectuate such monitoring, diagnosis and maintenance. According to exemplary embodiments of the present disclosure, the intelligent model-based diagnostic methodologies combine or integrate quantitative (analytical) models and graph-based dependency models to enhance diagnostic performance. The disclosed systems and methods may be employed a wide variety of applications, including automotive, aircraft, power systems, manufacturing systems, chemical processes and systems, transportation systems, and industrial machines / equipment.
Owner:TOYOTA TECHN CENT USA +1
Antibodies to neutrokine-alpha
InactiveUS6403770B1Peptide/protein ingredientsGenetic material ingredientsScreening methodTnf family
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and / or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and / or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and / or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
Owner:HUMAN GENOME SCI INC
Protein scaffolds for antibody mimics and other binding proteins
InactiveUS20050255548A1Easy to foldImprove stabilityAntibody mimetics/scaffoldsImmunoglobulins against cytokines/lymphokines/interferonsWAS PROTEINAntibody
Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
Owner:BRISTOL MYERS SQUIBB CO
Diagnostic method and apparatus for business growth strategy
Owner:CASE STRATEGY
Diagnostic method and apparatus using light
InactiveUS6990426B2Inflated body pressure measurementFluid pressure measurement by electric/magnetic elementsControl signalRespiration rate
A diagnosis method and apparatus for measuring blood hemoglobin concentration, oxygen saturation, pulse rate, respiration rate, or degree of aging of blood vessels using light includes an input / output unit for receiving a command for measurement from a user and for providing information on the result of a measurement to the user; a control unit for receiving the command for measurement from the input / output unit and for generating a control signal; a light generating unit for generating at least two light beams for measurement according to the control signal; a light receiving unit for receiving the light beams transmitted through an object that is subject to measurement and for converting the received light beams into electrical signals; and a data processing unit for processing the electrical signals received from the light receiving unit and for outputting information on the result of a predetermined measurement.
Owner:SAMSUNG ELECTRONICS CO LTD
Auto diagnostic method and device
InactiveUS6807469B2Reduce manufacturing costReduces component investmentVehicle testingRegistering/indicating working of vehiclesDiagnostic dataData acquisition
According to the present invention, a vehicle monitoring and maintenance device capable of being connected to a diagnostic port of a vehicle is provided. The monitoring and maintenance device comprises a hand holdable, data acquisition and transfer device. The data acquisition and transfer device includes a first data link connectable to a diagnostic port of a vehicle for retrieving diagnostic data from the vehicle; and a second data link connectable to a global computer network communicable device. The data acquisition and transfer device also includes a processor and memory unit capable of retrieving unprocessed diagnostic data containing error codes from the vehicle via the first data link, storing unprocessed diagnostic data for a limited time, and transferring the unprocessed data to the global computer network communicable device, to the second data link. The hand holdable data acquisition and transfer device lacks sufficient data processing capability to fully process the unprocessed diagnostic data into human useable diagnostic information.
Owner:INNOVA ELECTRONICS
Methods and compositions for detection of small interfering RNA and micro-RNA
InactiveUS20060019258A1Improve survivalDetermining for survivalSugar derivativesMicrobiological testing/measurementTreatment effectPhosphate
The invention provides a method of distinguishing small RNA from mRNA by contacting a biological isolate with a phosphate reactive reagent having a label moiety under conditions wherein the label moiety is preferentially added to the 5′ phosphate of small RNA over the 5′ cap structure of mRNA and distinguishing the small RNA from the mRNA according to the presence of the label. The invention further provides a method of identifying a plurality of different small RNAs by adding a unique extension sequences to different small RNA sequences and identifying the extended small RNA sequences. Furthermore, the invention provides diagnostic methods for determining presence of a disease or condition such as cancer. Also provided are prognostic methods for determining progression of a disease or condition or for monitoring effectiveness of a treatment for a disease or condition
Owner:ILLUMINA INC
Method for diagnosing non-small cell lung cancers
InactiveUS20060024692A1Reduce the overall heightTargeted optimizationMicrobiological testing/measurementNon-small cell lung cancer (NSCLC)Differentially expressed genes
Disclosed are methods for detecting, diagnosing, treating and preventing non-small cell lung cancer using differentially expressed genes. Furthermore, novel human genes, whose expression is elevated in non-small cell lung cancer compared to non-cancerous tissues, are provided. Also disclosed are agents for treating and preventing non-small cell lung cancer as well as methods for identifying further compounds for treating and preventing non-small cell lung cancer.
Owner:ONCOTHERAPY SCI INC
Marker for prenatal diagnosis and monitoring
The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
Owner:THE CHINESE UNIVERSITY OF HONG KONG
Methods for prenatal diagnosis of chromosomal abnormalities
ActiveUS20070059707A1Rapid productionAccurate detectionMicrobiological testing/measurementFermentationDiseaseNon invasive
Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus, for instance differences in their methylation states, as a means to enrich for fetal DNA in maternal plasma sample. The methods described herein can be used to detect chromosomal DNA deletions and duplications. In a preferred embodiment, the methods are used to diagnose chromosomal aneuploidy and related disorders, such as Down's and Turner's Syndrome.
Owner:TRUSTEES OF BOSTON UNIV
Diagnostic method for a torque control of an electrically variable transmission
ActiveUS20050252283A1Impaired speed controlImpaired torque controlVehicle testingRegistering/indicating working of vehiclesLoop controlLow speed
A condition of impaired speed and torque control of a parallel electrically variable transmission due to factors beyond nominal modeling and estimation errors is diagnosed under low speed operation. The transmission includes at least one electric machine and a motor torque controller for regulating the transmission input speed and output torque. The motor torque controller includes an open-loop control path based on predetermined torques and accelerations and a closed loop control path based on input speed error. The presence of a larger than expected closed-loop correction magnitude, combined with low output speed and one or more other conditions is used to diagnose a condition of potential torque error, in which case the transmission control is altered to prevent unwanted operation.
Owner:GM GLOBAL TECH OPERATIONS LLC
Human monoclonal antibodies against bacillus anthracis protective antigen
ActiveUS20050287149A1Neutralizing activityLess immunogenicAntibacterial agentsBacteriaV(D)J recombinationBispecific antibody
Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Owner:MEDAREX LLC
Method for diagnosing pancreatic cancer
InactiveUS20050260639A1Prevent relapseHigh activityMicrobiological testing/measurementNormal cellScreening method
Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
Owner:ONCOTHERAPY SCI INC
Enrichment of circulating fetal DNA
InactiveUS20070243549A1High accuracy of resultsMicrobiological testing/measurementImmunoglobulins against animals/humansNon invasiveMolecular diagnostics
A non-invasive screening or diagnostic method for determining the likelihood of a fetus with a genetic abnormality or a potential pregnancy complication, which utilizes a liquid blood sample from a pregnant woman. Antibodies specific to a section of histone 3.1 which is exposed to a far greater extent in chromatin of fetal origin than in chromatin of maternal origin are used to sequester and isolate such fetal nucleosomes including the associated fetal DNA. Following isolation / enrichment of such fetal DNA, genetic analysis is carried out using known molecular diagnostics.
Owner:BAYLOR COLLEGE OF MEDICINE
Regulation of gene expression
InactiveUS6022863APrevention of fetal rejectionSugar derivativesGenetic material ingredientsMHC class IDisease
The present invention relates to utrons, RNA molecules which contain promoter regulatory motif(s) and DNA analogs thereof and DNA molecules that can be transcribed to produce the foregoing. In particular, the invention provides gene promoter suppressing nucleic acids which suppress transcription from a promoter of interest. In a preferred embodiment, the invention provides the TSU gene, nucleotide sequences of the TSU gene and RNA, as well as fragments, homologs and derivatives thereof. Methods of isolating TSU genes are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are also provided. In particular, the invention relates to methods for cell replacement therapy, gene therapy or organ transplantation wherein TSU nucleic acids suppress MHC class I and II gene expression, thus preventing immuno-rejection of non-autologous cells or organs. The invention also provides methods for treatment of diseases or disorders by suppression of MHC class I, MHC class II, ICAM-1, B7-1, B7-2, and / or Fc gamma R expression by provision of TSU function.
Owner:YALE UNIV
Method and apparatus for diagnosis of a mood disorder or predisposition therefor
InactiveUS6629935B1Great absolute magnitude of changeEasy to changeIndividual molecule manipulationSensorsDiseaseBinocular rivalry
A method for diagnosis of a mood disorder or predisposition therefor in a test subject is disclosed. The method includes the steps of determining an interhemispheric switch rate of the test subject, and comparing the switch rate with a corresponding reference switch rate to diagnose presence or absence of the mood disorder or predisposition therefor. In a preferred embodiment, the interhemispheric switch rate is determined by measuring the rate of binocular rivalry in the test subject. Also disclosed is an apparatus for diagnosis of a mood disorder or predisposition therefor, use of the diagnostic method in genetic linkage studies for the identification of the molecular defect(s) underlying these disorders, and for the identification of compounds which may alleviate such disorders.
Owner:QUEENSLAND UNIV OF THE
Graphical user interface for display of anatomical information
A computer-aided diagnostic method and system provide image annotation information that can include an assessment of the probability, likelihood or predictive value of detected or identified suspected abnormalities as an additional aid to the radiologist. More specifically, probability values, in numerical form and / or analog form, are added to the locational markers of the detected and suspected abnormalities. The task of a physician using such a system as disclosed is believed to be made easier by displaying markers representing different regions of interest.
Owner:MEVIS MEDICAL SOLUTIONS
Specific binding proteins including antibodies which bind to the necrotic center of tumors, and uses thereof
Specific binding members, based on the third CDR of the antibody NHS76 (SEQ ID NO: 2) are provided, together with their use in methods of treatment and diagnosis.
Owner:PEREGRINE PHARMA INC +1
Peptidoglycan recognition proteins
InactiveUS7041802B2Regulate growth activityPrevent septic shockAntibacterial agentsOrganic active ingredientsFhit geneBiology
The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
Owner:HUMAN GENOME SCI INC
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