Surface enhanced
Raman Scattering (SERS) and related modalities offer greatly
enhanced sensitivity and selectivity for detection of molecular species through the excitation of
plasmon modes and their
coupling to molecular vibrational
modes. One of the chief obstacles to widespread application is the availability of suitable
nanostructured materials that exhibit strong enhancement of
Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use
semiconductor and
metal surfaces fabricated using
femtosecond laser processing. A
noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the
laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including
label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for
cell culture and microlabs incorporating
microfluidics and electrochemical
processing can be fabricated as well.
Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an
electric potential enables separation of materials by
electrophoresis or electro-
osmosis.