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53 results about "Antiangiogenic therapy" patented technology
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Antiangiogenic therapy is a treatment option for metastatic kidney cancer. These are a group of drugs which slow down tumour growth or possibly even shrink the tumour. They prevent the formation of new blood vessels which feed the cancer and allow it to grow.
Detecting mutations for cancer screening and fetal analysis
ActiveUS20170073774A1Accurate detectionMicrobiological testing/measurementProteomicsCell freeEmbolization Therapy
Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free DNA) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management, and prognostication of cancer patients. For example, a mutational load can be determined from the identified somatic mutations, and the mutational load can be used to screen for any or various types of cancers, where no prior knowledge about a tumor or possible cancer of the subject may be required. Embodiments can be useful for guiding the use of therapies (e.g. targeted therapy, immunotherapy, genome editing, surgery, chemotherapy, embolization therapy, anti-angiogenesis therapy) for cancers. Embodiments are also directed to identifying de novo mutations in a fetus by analyzing a maternal sample having cell-free DNA from the fetus.
Owner:THE CHINESE UNIVERSITY OF HONG KONG
Bispecific binding molecules for Anti-angiogenesis therapy
InactiveUS20110172398A1Reduce manufacturing costImproving desired propertySenses disorderSugar derivativesAngiogenesis EffectAntiangiogenic therapy
Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
Owner:BOEHRINGER INGELHEIM INT GMBH
Molecular Diagnostic Test for Cancer
InactiveUS20140342924A1Microbiological testing/measurementLibrary screeningCancer typeAntiangiogenic therapy
Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.
Owner:ALMAC DIAGNOSTICS SERVICES LIMITED
Antiangiogenesis therapy of autoimmune disease in patients who have failed prior therapy
InactiveUS20060134111A1Reduce riskAntipyreticAnalgesicsAngiogenesis AntagonistsAntiangiogenesis Therapy
The present application describes therapy with angiogenesis antagonists such as anti-VEGF antibodies. In particular, the application describes the use of such antagonists to treat autoimmune disease in a patient who has failed prior treatment such as treatment with DMARDs or TNFα-inhibitors.
Owner:GENENTECH INC
Endothelial cell expression patterns
To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed 79 differentially expressed genes, including 46 that were specifically elevated in tumor-associated endothelium. Experiments with representative genes from this group demonstrated that most were similarly expressed in the endothelium of primary lung, breast, brain, and pancreatic cancers as well as in metastatic lesions of the liver. These results demonstrate that neoplastic and normal endothelium in humans are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Detection of activation of endothelial cells as surrogate marker for angiogenesis
InactiveUS20060199231A1Sensitively and conveniently measurePeptide preparation methodsDepsipeptidesCellular componentProtein-protein complex
Methods, compositions and kits are provided for assessing angiogenesis through sensitive, direct detection of activation of endothelial cells at molecular levels. In general, activation of endothelial cells is detected by measuring the levels of cellular components and their protein complexes participating in a specific angiogenesis signaling pathway in endothelial cells. The methods can be used for assessing status of diseases associated with undesirable angiogenesis, such as the likelihood of developing the disease, presence or absence of the disease, prognosis of the disease and the likelihood of response or resistance to a particular anti-angiogenic therapy. The methods can also be used to guide the design of effective therapeutic regimens targeting a specific angiogenic signaling pathway, as well as in conjunction with therapeutic intervention of diseases or conditions associated with undesirable angiogenesis.
Owner:MONOGRAM BIOSCIENCES
Method and Apparatus for Diagnosing Pre-eclampsia
InactiveUS20080071151A1Microbiological testing/measurementEvaluation of blood vesselsAnti-angiogenic drugsObesity Factor
A method is provided that allows a subject to be diagnosed as having one of a variety of hypertensive states, including pre-eclampsia, based on the measurement of a plurality of factors including the level of soluble fms-like tyrosine kinase 1 (sFlt-1), an obesity factor and optionally one or more additional factors, which may be physiological parameters or biomarkers. The method can be used to determine hypertensive states associated with pregnancy, or associated with anti-angiogenic drug therapy. The method is thus useful for diagnosing the hypertensive status of pregnant women, as well as patients undergoing anti-angiogenic treatment (e.g., chemotherapy).
Owner:ABBOTT LAB INC +1
Detection of activation of endothelial cells as surrogate marker for angiogenesis
InactiveUS7939267B2Sensitively and conveniently measurePeptide preparation methodsDepsipeptidesCellular componentMolecular level
Methods, compositions and kits are provided for assessing angiogenesis through sensitive, direct detection of activation of endothelial cells at molecular levels. In general, activation of endothelial cells is detected by measuring the levels of cellular components and their protein complexes participating in a specific angiogenesis signaling pathway in endothelial cells. The methods can be used for assessing status of diseases associated with undesirable angiogenesis, such as the likelihood of developing the disease, presence or absence of the disease, prognosis of the disease and the likelihood of response or resistance to a particular anti-angiogenic therapy. The methods can also be used to guide the design of effective therapeutic regimens targeting a specific angiogenic signaling pathway, as well as in conjunction with therapeutic intervention of diseases or conditions associated with undesirable angiogenesis.
Owner:MONOGRAM BIOSCIENCES
Endothelial cell expression patterns
To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed 79 differentially expressed genes, including 46 that were specifically elevated in tumor-associated endothelium. Experiments with representative genes from this group demonstrated that most were similarly expressed in the endothelium of primary lung, breast, brain, and pancreatic cancers as well as in metastatic lesions of the liver. These results demonstrate that neoplastic and normal endothelium in humans are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
In-vivo monitoring of circulating apoptotic cells
InactiveUS20060134005A1Interference minimizationMinimize interferenceUltrasonic/sonic/infrasonic diagnosticsBioreactor/fermenter combinationsAbnormal tissue growthFluorescence
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest. In some embodiments, the circulating cells comprise apoptotic cells whose detection can allow, e.g., non-invasive monitoring of the efficacy of a cancer treatment, such as an anti-tumor or an anti-angiogenic therapy.
Owner:THE GENERAL HOSPITAL CORP
Using cardiac troponin for monitoring Anti-angiogenesis therapy
The present invention relates to a method for monitoring subjects being on anti-angiogenesis therapy based on determining the amount of a cardiac troponin in a first and second sample of a subject and comparing the amount in the first sample with the second sample. Thereby, it can be assessed whether a subject is susceptible to a continuation of the therapy or not. Moreover, the present invention relates to a method for predicting the risk of a cardiovascular event as a consequence of anti-angiogenesis therapy. Also encompassed by the present invention are kits and devices adapted to carry out the method of the present invention.
Owner:ROCHE DIAGNOSTICS OPERATIONS INC
6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula Iin which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z are as defined in the specification. The compounds are useful in treating malignant tumours, for example, ovarian, stomach, colon, breast, adeno-, head and neck carcinomas, acute lymphocytic and myelocytic leukemia. In addition, these compounds are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases such as psoriasis and arthritis. Methods of use and preparation of the compounds are also described.
Owner:BAYER INTPROP GMBH
Detecting mutations for cancer screening
Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free DNA) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management, and prognostication of cancer patients. For example, a mutational load can be determined from the identified somatic mutations, and the mutational load can be used to screen for any or various types of cancers, where no prior knowledge about a tumor or possible cancer of the subject may be required. Embodiments can be useful for guiding the use of therapies (e.g. targeted therapy, immunotherapy, genome editing, surgery, chemotherapy, embolization therapy, anti-angiogenesis therapy) for cancers. Embodiments are also directed to identifying de novo mutations in a fetus by analyzing a maternal sample having cell-free DNA from the fetus.
Owner:THE CHINESE UNIVERSITY OF HONG KONG
Brain Endothelial Cell Expression Patterns
To gain a better understanding of brain tumor angiogenesis, new techniques for isolating brain endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from brain ECS derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed genes that were specifically elevated in tumor-associated brain endothelium. These results confirm that neoplastic and normal endothelium in human brains are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.
Owner:GENZYME CORP
Predictive and prognostic biomarkers related to Anti-angiogenic therapy of metastatic colorectal cancer
ActiveUS20170281725A1Effective treatmentPeptide/protein ingredientsDisease diagnosisFAVORABLE RESPONSEPrognosis biomarker
The present invention provides methods for treating metastatic cancer comprising identifying subjects who will respond favorably to anti-VEGF therapy. According to certain aspects of the invention, subjects are identified based on their expression level of one or more predictive biomarkers. Favorable response to anti-VEGF therapy is indicated by high expression levels of certain biomarkers or by low expression levels of certain biomarkers. An exemplary predictive biomarker is VEGF-A. Also disclosed herein are prognostic biomarkers useful for identifying cancer-bearing subjects who are expected to have better relative survival outcomes.
Owner:REGENERON PHARM INC
Methods and Systems for Detecting Antiangiogenesis
InactiveUS20080318241A1Inhibiting or decreasing angiogenic tumors in the patientMicrobiological testing/measurementDisease diagnosisAntiangiogenic therapyTumor vessel
The present invention provides methods and systems for the detection of tumor vessel response to antiangiogenic therapies. The present invention also provides compositions and methods for therapeutic and research applications. In particular, the present invention provides systems and methods that employ CD26, HIF-1, and HIF-1 pathway components as biomarkers for monitoring antiangiogenic therapies and as therapeutic targets.
Owner:NEVADA CANCER INST +1
Endothelial specific targeting
InactiveUS6974791B2Easy to optimizeFacilitate anti-angiogenic therapiesIn-vivo radioactive preparationsPeptide/protein ingredientsTumor responseLymphatic Spread
Peptide motifs which define specificity of tumor-derived endothelial cells. These peptides possess a charge motif of positive-positive-hydrophobic which is important in determining the specificity of binding to tumor-derived endothelium. The specific molecular peptide motifs will facilitate diverse therapeutic and diagnostic applications including: anti-angiogenic therapies to be used in alone or in conjunction with standard therapies; imaging tools for both detection of very small metastasis that are undetectable by current techniques; for monitoring tumor response; for targeting and directing chemotherapy drugs to the tumor; for treatment of chronic inflammatory diseases such as rheumatoid arthritis and psoriasis, for treating some forms of blindness; as well as other diagnostic and therapeutic applications.
Owner:PITTSBURGH UNIV OF
Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
The invention provides methods of using expression levels of one or more stroma signature genes as selection criteria for determining a patient with cancer that is chemotherapy-resistant who may benefit from a particular anti-cancer therapy, such as stroma-targeted therapy, anti-angiogenic therapy, and / or immunotherapy. The present invention also provides methods of using expression levels of one or more stroma signature genes as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a stroma-targeted agent.
Owner:F HOFFMANN LA ROCHE & CO AG
Methods for controlling pathological angiogenesis by inhibition of a6b4 integrin
InactiveUS20070104716A1Reduce the amount requiredGuaranteed functionIntegrin superfamilyGenetic material ingredientsAnti angiogenicΑ6β4 integrin
It has now been determined that α6β4 integrin is a pro-angiogenic receptor, and thus that it provides a novel and heretofore unrecognized target for anti-angiogenic therapy. Thus, angiogenesis, particularly pathological angiogenesis, can be inhibited, and conditions with which pathological angiogenesis is associated treated using inhibitors of α6β4 integrin. A tissue in which angiogenesis is to be inhibited is exposed to a therapeutic agent effective to reduce the amount of active α6β4 integrin in the tissue. The tissue may be within a patient, and in particular a human patient to be treated for a disease condition with which pathological angiogenesis is associated. The therapeutic agent may be an antibody or a small molecule, for example a laminin-5 analog, which binds to α6β4 integrin and inhibits its normal function. The therapeutic agent may also be a chemical species that interferes with the production of α6β4 integrin, including for example an antisense or RNAi species.
Owner:SLOAN KETTERING INST FOR CANCER RES
Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
InactiveUS10260097B2Microbiological testing/measurementDisease diagnosisCancer typeAntiangiogenic therapy
Owner:ALMAC DIAGNOSTICS SERVICES LIMITED
Peptide homing to brain tumors
The present invention relates to a peptide, which specifically homes to the intracranial, early stage astrocytoma model that grows as islets and harbors co-opted tumor vessels in the brain. The peptide finds its use in targeted delivery of therapeutic substances to invasive brain cancer or metastatic brain lesions as such and in combination with conventional therapies, such as surgery and radiation, and anti-angiogenic therapies, and as a tool in diagnosis of, e.g., invasive brain cancer or metastatic brain lesions.
Owner:BURNHAM INST FOR MEDICAL RES +1
6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2b, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and / or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.
Owner:BAYER INTELLECTUAL PROPERTY GMBH
6-Alkenyl -, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and / or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.
Owner:BAYER INTELLECTUAL PROPERTY GMBH
Bispecific binding molecules for Anti-angiogenesis therapy
InactiveUS20140120095A1Improving desired propertyExtended half-lifeSenses disorderSugar derivativesAngiogenesis EffectAntiangiogenic therapy
Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a DII4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and DII4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
Owner:BOEHRINGER INGELHEIM INT GMBH
Anti-angiogenic therapeutics efficacy enhanced by nanoformulation
ActiveUS8524685B1Improve efficacyReduced viabilityBiocideCarbohydrate active ingredientsNanoparticleAntiangiogenic therapy
Preparation of nano-conjugated Tunicamycin enhances the efficacy of the drug Tunicamycin. The invention provides several nanoformulations such as Tunicamycin encapsulated in peptide nanotubes, nanotubes bound to gold nanoparticles conjugated with Tunicamycin, Tunicamycin conjugated with nanotubes, gold nanoparticles bound to tubes and conjugated with Tunicamycin, and gold nanoparticles conjugated with Tunicamycin.
Owner:UNIVERSITY OF PUERTO RICO
Anti-galectin antibody biomarkers predictive of Anti-immune checkpoint and Anti-angiogenesis responses
ActiveUS20170343552A1Good curative effectReduced survivalSerum immunoglobulinsImmunoglobulins against growth factorsMedicineAntiangiogenic therapy
The present invention is based on the identification of novel biomarkers predictive of responsiveness to a combination of anti-immune checkpoint and anti-angiogenesis therapies.
Owner:DANA FARBER CANCER INST INC
Vaccine based on simulating human blood vessel endothelial cell growth factor VEGF epitope and preparation method thereof
InactiveCN101429234APrevent proliferationInhibit migrationLibrary screeningPeptidesAntiangiogenesis TherapyVascular endothelium
The invention provides a vaccine based on an epitope simulating human vascular endothelial growth factor VEGF, as well as a preparation method thereof. A VEGF mimic epitope which is specifically affinitive with human-mouse chimeric monoclonal antibody Avastin is screened out by use of a phage random presentation technique, and the amino acid sequence of the mimic epitope is Asp-His-Thr-Leu-Tyr-Thr-Pro-Tyr-His-Thr-His-Pro; the mimic epitope has no homology with the protein sequence of VEGF. A vaccine which can induce a polypeptide epitope aiming at VEGF molecular autoantibody in vivo is constructed on the basis of the mimic epitope. The invention provides a strategy for developing and designing the tumor therapeutic vaccine, which is targeted at the VEGF. The VEGF is one of molecules which has the strongest effect of promoting vascular growth, and is an ideal target for resisting angiogenesis and treating tumors. Therefore, the vaccine replaces or replenishes monoclonal antibody passive immunotherapy with an active immunity mode, so as to lay foundations for overcoming the defects of monoclonal antibody therapy.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
Disclosed are copper-binding compounds with improved properties and methods of using such compounds in the prevention and treatment of angiogenic diseases, such as cancer. Advantages of the invention include the enhanced stability of the compounds, which is achieved without reduction in efficacy. Pharmaceutical compositions, therapeutic kits and combination treatment methods and uses are also provided.
Owner:RGT UNIV OF MICHIGAN
Method and composition for enhancing anti-angiogenic therapy
The present invention relates to the surprising discovery that agents that increase intracellular accumulation of NADH + H<+> enhance the anti-cancer effects of angiogenesis inhibitors. Furthermore, treatment of a mammal with a combination of at least one angiogenesis inhibitor and at least one agent that enhances intracellular accumulation of NADH + H<+> allows for the enhanced treatment and / or prevention of ,angiogenic diseases and disorders.
Owner:TILTAN PHARMA LTD
Use of Rhizoma-paridis alcohol extract for inhibiting blood-vessel generation
InactiveCN101024031AInhibit migrationPromote apoptosisAntineoplastic agentsPlant ingredientsAntiangiogenic therapyChemistry
The present invention relates to a paris polyphylla alcohol extract and its application for inhibiting vascularization. It is characterized by that the preparation method of paris polyphylla alcohol extract includes the following steps: drying root and stem of paris polyphylla, pulverizing, soaking the pulverized root and stem of paris polyphylla in ethyl alcohol whose concentration is 80%, heating and boiling, filtering so as to obtain the paris polyphylla alcohol extract. Said invention also provides the application method for inhibiting vascularization by using said paris polyphylla alcohol extract.
Owner:THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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