72 results about "Prior treatment" patented technology

Improved devices, systems, and methods for diagnosing, planning treatments of, and / or treating the refractive structures of an eye of a patient incorporate results of prior refractive corrections into a planned refractive treatment of a particular patient by driving an effective treatment vector function based on data from the prior eye treatments. The exemplary effective treatment vector employs an influence matrix which may allow improved refractive corrections to be generated so as to increase the overall accuracy of laser eye surgery (including LASIK, PRK, and the like), customized intraocular lenses (IOLs), refractive femtosecond treatments, and the like.

The present invention provides a method of treating a breast cancer disease in a patient who has failed prior treatment with an anti-VEGF antibody, comprising administering to the patient a therapeutically effective amount of an anti-HER2 antibody while continuing said anti-VEGF antibody therapy. The invention also provides corresponding pharmaceutical kits and pharmaceutical compositions.

A process for the recovery of natural gas liquids (NGL) (ethane, ethylene, propane, propylene and heavier hydrocarbons) from liquefied natural gas (LNG) is disclosed. The LNG feed stream is split with at least one portion used as an external reflux, without prior treatment, to improve the separation and recovery of the natural gas liquids (NGL).

A process for the recovery of natural gas liquids (NGL) (ethane, ethylene, propane, propylene and heavier hydrocarbons) from liquefied natural gas (LNG) is disclosed. The LNG feed stream is split with at least one portion used as an external reflux, without prior treatment, to improve the separation and recovery of the natural gas liquids (NGL).

Electrical stimulation is applied to the inferior colliculus or colliculi (IC), in order to diminish tinnitus by revising auditory pathway neuronal activity. This intervention diminishes tinnitus and treats other neurological and otological disorders. The locations and methods of electrode placement and anchoring and the structure of the electrodes are an advance over prior treatments. Other treatment locations in the nearby region of the IC, including the superior colliculi (SC) and Peri-aqueductal gray (PAG), provide treatments for other disorders and symptoms such as partial hearing loss and pain. The IC is a unique choice for the treatment of tinnitus and other disorders because an electrode placed in that region enables minimal invasiveness. The anchoring location also uniquely minimizes invasiveness by providing the option of residing in the meninges instead of the brain tissue. The shape of the electrode and its anchoring process uniquely match the brain's anatomy in order to provide greater specificity in diagnosis and treatment. Stimulation of areas near the IC, particularly the superior colliculus and peri-aqueductal gray, can be used to treat various neurological disorders. Customized feedback from the implantable system enables the creation of customized treatment programs.

The present application describes therapy with angiogenesis antagonists such as anti-VEGF antibodies. In particular, the application describes the use of such antagonists to treat autoimmune disease in a patient who has failed prior treatment such as treatment with DMARDs or TNFα-inhibitors.

The present invention provides a method of treating a breast cancer disease in a patient who has failed prior treatment with an anti-VEGF antibody, comprising administering to the patient a therapeutically effective amount of an anti-HER2 antibody while continuing said anti-VEGF antibody therapy. The invention also provides corresponding pharmaceutical kits and pharmaceutical compositions.

An automated system for managing inventories of medical supplies at medical offices is disclosed wherein a database and intelligent computer system is used to anticipate the need for supplies based on appointments with patients, for example, so that inventories are maintained at optimum levels without the need for individuals to guess at which supplies to order at which particular times and a computer method for inventory management and replenishment comprising storing records of items of supplies and durable medical equipment at each medical office, clinic, and hospital subscribing to a management system, storing patient records comprising prior treatments, health diagnoses, and health status, storing tables of treatment and diagnostic codes corresponding to supplies and / or durable medical equipment required for each of said codes, wherein upon entry by a medical office, clinic, or hospital of a treatment or diagnostic event for a patient using a treatment or diagnostic code, looking up the corresponding patient record to determine whether a redundancy event has occurred and if no redundancy event is determined, issuing an order for the corresponding supplies and / or equipment.

Methods of treating patients having metastatic or unresectable locally advanced HER2 positive cancer, e.g., breast cancer, with the antibody-drug conjugate trastuzumab-MCC-DM1 are provided, wherein the patients have received extensive prior treatment, e.g., with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab.

A process for the recovery of natural gas liquids (NGL) (ethane, ethylene, propane, propylene and heavier hydrocarbons) from liquefied natural gas (LNG) is disclosed. The LNG feed stream is split with at least one portion used as an external reflux, without prior treatment, to improve the separation and recovery of the natural gas liquids (NGL).

The method of aseptically treating containers in accordance with the invention comprises the step of subjecting the containers while held upside-down in a heat treatment station to steam at 140° C. for 2 s to 20 s and then in subjecting the containers in a station to a disinfectant mixture comprising peracetic acid, hydrogen peroxide, acetic acid, and water raised to a maximum temperature of 60° C.

The invention relates to a medicine for treating tumor and hemorrhoid and a manufacturing method thereof. The medicine aims at the disadvantages that: the prior treatment method for removing the hemorrhoid and the tumor can only kill or remove partial tumor cells, has large pain and high recurrence rate during the treatment period, has the phenomena of lassitude, hypodynamia, nausea, vomiting and hemogram reduction during the radiotherapy period, causes low immunity, damages self-immunologic function of a human body, inhibits functions of bone marrow stem cells, is easy to produce drug dependence, and is easy for recurrence. The invention prepares tannic acid, atropine, gallic acid, quinin hydrochloride, ferrous sulfate, caffeine, pure sulfuric acid, urethane, carbolic acid, sterile water and the like, into medicines for local parts of pathological changes, does not hurt normal tissues, has no pain, does not need to treat for a long time, and has the advantages of taking effect by injecting at one time, no recurrence, wide raw materials, low cost, wide clinical application, and small side effect.

In certain embodiments, the invention provides methods for treating cancer, comprising: (a) obtaining a specimen of cancer tissue and normal tissue from a patient; (b) extracting total protein and RNA from the cancer tissue and normal tissue; (c) obtaining a protein expression profile of the cancer tissue and normal tissue; (d) identifying over-expressed proteins in the cancer tissue; (e) comparing the protein expression profile to a gene expression profile; (f) identifying at least one prioritized protein target by assessing connectivity of each said over-expressed protein to other cancer-related or stimulatory proteins; (g) designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding the prioritized target protein; (h): designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding a protein of higher priority in the signaling pathway in which the first protein is a component; (i) incorporating the first cassette into a first delivery vehicle; (j) providing a patient with an effective amount of the first delivery vehicle; (k) extracting total protein and RNA from the treated cancer tissue; (l) identifying over-expressed proteins in the treated cancer tissue; (m) designing a second RNA interference expression cassette to modulate the expression of a second prioritized protein in the treated tissue; (n) incorporating the second cassette into a second delivery vehicle; (o) providing the previously treated patient with an effective amount of the second delivery vehicle; (p) identifying a novel protein signal following prior treatment with protein specific knockdown; (q) identifying a gene mutation provided by gene sequencing / microarray on assessment of other protein signals; and (r) identifying of a novel protein signal as a result of determination of the gene mutation and assessment of other protein signals to, directly or indirectly, modify the expression (i.e., production) of such proteins.

The invention relates to a laser and magnetoelectricity comprehensive therapy and a multi-functional therapeutic instrument. The laser and magnetoelectricity comprehensive therapy is a comprehensive physical energy therapy without injecting and taking medicines, that is, the comprehensive energy of laser, a magnetic field, and an electric field acts on a human body to generate photochemical effect, magnetic water effect and electric effect, activate cells for promoting microcirculation, activate blood vessels for improving the activity of erythrocytes, reducing the aggregation of blood platelets and promoting blood circulation with oxygen, purify blood for promoting the metabolism of the human body, and stimulate channels and acupuncture points to ensure that an autonomic nerve is balanced further to resist and remove the damage of free radicals on the human body. The laser and magnetoelectricity comprehensive therapy and the multi-functional therapeutic instrument are used for the treatment of common diseases and frequently encountered diseases, the prevention of subhealthy state, health care, cosmetology, weight losing and so on. The comprehensive therapy is integrated with laser and magnetoelectricity, and the light, the magnetism and the electricity are compatible with one another in principle, so the prior treatment range of the laser, the magnetic field, the electric field and so on, is covered; and the laser and the magnetoelectricity comprehensively act on the human body, and the treatment effects of the laser and the magnetoelectricity are the superposition of various single physical energy therapies due to the all-round three-dimensional treatment.

The invention provides a method for balancing moisture in wood by microwave, which belongs to the field of wood processing. Currently, in order to solve the problem of uneven water ratio, the prior mode is to put wood which is generally dried in a health preserving room, control temperature and humidity in space, and process the product after at least 10 days of temperature and humility control to ensure the evenness of the water ratio inside the wood. Thicker wood requires more time, even requires about a month. With the prior treatment mode, the materials not only occupy mass fields and storage capacity, but also use great capital, and have low efficiency. The method comprises the following steps: a sawed timber or a wood part which is subjected to the prior drying or air drying with water ratio of between 8 and 15 percent is treated by microwave for 3 to 30 seconds with power density of microwave radiation of between 0.5 and 5 watt / centimeter<3>, the gradient and the stress of water ratio of treated wood are obviously reduced. The method has the advantages of simple process, good treatment effect, capability of continuous treatment and the like.

The present invention relates to therapeutic ADCs comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment, more particularly sacituzumab govitecan. The ADC is administered to a subject with a Trop-2 positive cancer that is resistant to or relapsed from prior treatment with a checkpoint inhibitor. The therapy is effective to treat cancers that are resistant to checkpoint inhibitors.

The invention relates to a treatment device for orthopedic spinal injury, which effectively solves the problems that the prior treatment device is single in function, inconvenient in use and high in cost and a patient is painful during treatment. The technical solution includes a seat base body and a storage box at the lower end. The seat base body is provided with a transfer pulley at the front end thereof. A bearing wheel seat of the transfer pulley has a telescopic rod cooperatively rotated thereon. A hand turntable is arranged rotatably and cooperatively on the upper end of the telescopicrod. Rotating handles are mounted on both sides of the hand turntable. The hand turntable cooperates with the transfer pulley in a transmission manner through a main belt. The transfer pulley is in transmission connection with a driving wheel arranged rotatably and cooperatively inside the storage box through an auxiliary belt. The driving wheel is coaxially matched with two unidirectional wheelswith opposite directions of rotation. The unidirectional wheels are rotatably matched with the storage box. The two unidirectional wheels control a lumbar vertebra tapping device and a back spine massaging device respectively. A cervical vertebra turning device controlled and driven by the same unidirectional wheel is arranged on the upper end of the back spine massaging device. The treatment device of the invention has the advantages of ingenious structure, strong practicability and good treatment effect of the patient.

The invention relates to a high-temperature hydrolysis type oil-containing sediment harmless comprehensive treatment process. The invention mainly solves the problems that the prior treatment processof oil-containing sediment in oil fields is simple, and the treatment of oil-containing sediment which contains many impurities is not thorough. The treatment process is characterized by comprising the following steps: (1) sludge fluidization and pretreatment: discharging solid particles with a diameter larger than 5mm by a sorting box and a rotary drum separating device; (2) sludge tempering: sequentially introducing the conveyed mixture into three tempering tanks connected in series, conveying the oil-containing sediment separated by the tempering tanks to a two-phase centrifuge, and conveying the floating oil to an oil water separator; and (3) mechanical separation: carrying out solid liquid separation by the two-phase centrifuge, and carrying out oil water separation by the oil-water separator. The high-temperature hydrolysis type oil-containing sediment harmless comprehensive treatment process can be used to treat oil-containing sediment with different oil field types and complexcomponents, the reduction and harmless treatment of the oil-containing sludge can be effectively realized, the operation is simple, and the running cost is low.

The invention belongs to the field of Chinese medicines, and provides a Chinese medicine preparation for treating various rheumatisms, namely senile dementia, ischium and lumbar, swollen furuncle and wind-cold invasion, wherein certain weight portions of fresh whole toads as well as bone and meat of weasel are adopted and prepared into pills through the refining. The preparation has efficacies of relieving swelling and releasing toxin, promoting blood circulation by removing blood stasis, clearing heat and diminishing inflammation, and dispelling wind and promoting urination, and can treat various rheumatisms such as senile dementia, sciatica, lumbar intervertebral disc protrusion, edema, hematoma, furuncle, wind-cold invasion, common cold and expectoration and the like; and compared with the prior treatment method, the preparation has the remarkable advantages of short treatment course, good therapeutic effect, no side effect, low cost and the like.

The invention discloses a river course pollution remediation treatment technology, relates to the field of river course treatment, and solves the problem that river course pollution cannot be fundamentally eliminated in a prior treatment method. The technology comprises the steps that one, a sewage discharging pipe is arranged in a river course; two, cut-off dikes are arranged at the two ends of the river course, and river water within the cut-off dikes is pumped to the downstream of the river course; three, microorganisms in sludge at the bottom of the river course are analyzed to obtain beneficial bacteria, and the beneficial bacteria are directionally proliferated to clear the sludge at the bottom of the river course; four, cleaned and clear river water is introduced into the river course, and the beneficial bacteria, aquatic creatures and a water quality regulating agent are put into the river course; five, the cut-off dikes are removed, and river water flows again. The technologyhas the advantages that the sewage discharging pipe is arranged in the river course, and the two ends of the sewage discharging pipe are directly communicated with a sewage discharging port and a sewage treatment plant to eliminate a sewage source of the river course and greatly reduce the source of the pollution; a manner in which the river course is treated by completely draining water is adopted, and the downstream of the river course can be effectively prevented from being affected by pollutants.

The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides the use of an antibody composition with two distinct non-overlapping binding specificities to human EGFR. The antibody composition is effecting in treating cancer following treatment with other anti-EGFR antibodies, whether the cancer shows progression during or following the prior treatment or not. The antibody composition can also be used for repeated treatment of recurrent tumors following first-line therapy with the antibody composition of the invention, as the composition does not lead to selection of resistant tumors. A further therapeutic use is the use of an antibody composition of the invention for treatment of cancer that is resistant to known anti-EGFR antibodies.

In certain embodiments, the invention provides methods for treating cancer, comprising: (a) obtaining a specimen of cancer tissue and normal tissue from a patient; (b) extracting total protein and RNA from the cancer tissue and normal tissue; (c) obtaining a protein expression profile of the cancer tissue and normal tissue; (d) identifying over-expressed proteins in the cancer tissue; (e) comparing the protein expression profile to a gene expression profile; (f) identifying at least one prioritized protein target by assessing connectivity of each said over-expressed protein to other cancer-related or stimulatory proteins; (g) designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding the prioritized target protein; (h): designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding a protein of higher priority in the signaling pathway in which the first protein is a component; (i) incorporating the first cassette into a first delivery vehicle; (j) providing a patient with an effective amount of the first delivery vehicle; (k) extracting total protein and RNA from the treated cancer tissue; (l) identifying over-expressed proteins in the treated cancer tissue; (m) designing a second RNA interference expression cassette to modulate the expression of a second prioritized protein in the treated tissue; (n) incorporating the second cassette into a second delivery vehicle; (o) providing the previously treated patient with an effective amount of the second delivery vehicle; (p) identifying a novel protein signal following prior treatment with protein specific knockdown; (q) identifying a gene mutation provided by gene sequencing / microarray on assessment of other protein signals; and (r) identifying of a novel protein signal as a result of determination of the gene mutation and assessment of other protein signals to, directly or indirectly, modify the expression (i.e., production) of such proteins.

Essential tremor can effectively be treated with high doses of Riboflavin (vitamin B2), either on its own or coupled with one or more other B vitamins and / or coenzyme Q10 (CoQ10). The treatment constitutes a significant improvement over prior treatment methods in that it not only alleviates essential tremor, but results in better performance of the affected body portion and may delay the progression of the disease. The preferred addition of other B vitamins and / or CoQ10 also provides balance to the nutrient energy requirements of a patient's body.

A medical treatment queuing method and system based on mobile location information. Pre-build a queuing platform for medical treatment, which includes a server, mobile client, process management terminal, communication network and mobile location positioning system; the patient submits an appointment registration request; The expected visit time of each patient in the sequence queue; the server judges the expected late patient; the server moves the expected late patient one or more places to update the dynamic sequence queue to obtain the dynamic visit time; when the patient completes the visit, the process management end The server sends a confirmation signal that the patient's visit is completed, and the server updates the dynamic sequence queue and the dynamic visit time of each patient in the dynamic sequence queue; the server publishes the latest information in the dynamic sequence queue.

The invention discloses an intelligent treatment system for a cornea photo-crosslinking operation. The intelligent treatment system comprises a corneal topography image collecting system, a photo-crosslinking operation guiding system and a prior-treatment corneal topography and photo-crosslinking operation parameter corresponding database; the corneal topography image collecting system is configured to collect corneal topography images of a user; the photo-crosslinking operation guiding system is configured to compare a corneal topography before corneal laser crosslinking with an expected postoperative corneal topography to output parameters of the photo-crosslinking operation; the prior-treatment corneal topography and photo-crosslinking operation parameter corresponding database is usedfor pre-training and correcting the photo-crosslinking operation guiding system. The corneal topography image collecting system obtains images and a corneal topography of a patient, then the corneal topography is input to the photo-crosslinking operation guiding system which is pre-trained by the prior-treatment corneal topography and photo-crosslinking operation parameter corresponding database,and then the parameters of the photo-crosslinking operation are obtained. The invention further discloses an establishment method of the intelligent treatment system. By means of the intelligent treatment system, an efficient, precise and stable treatment guidance can be provided for the cornea photo-crosslinking operation.

The invention discloses an endoscopic minimally invasive hoe scaler, comprising a catheter, hemostatic forceps, an operating grip and an operation control device. The endoscopic minimally invasive hoe scaler is characterized in that a head of the catheter is connected with the hemostatic forceps while a tail of the catheter is matched connection with the operating grip; the hemostatic forceps are composed of a subwarhead-shaped hollow binding clip of which two halves are closed and opened correspondingly; the hoe scaler is a plasma hoe scaler formed by a steel wire structure, and extends into a linked tube of the hemostatic forceps; the operating grip is provided with a hemostatic forceps push ring and a hoe scaler control grip capable of moving back and forth; and the operation control device comprises a hemostatic forceps operation control device and a hoe scaler operation control device. The endoscopic minimally invasive hoe scaler solves the defects in the prior treatment on digestive tumor, and comprises both the hoe scaler and the hemostatic forceps, so that cockamamie operations of repeatedly changing a plurality of prior instruments in the world at present are avoided; and after being powered on, the endoscopic minimally invasive hoe scaler has the functions of the biopsy forceps and the hemostatic forceps, and the function of incision, so that the detection, the incision and the haemostasis in time can be convenient, and the complications of bleeding can be reduced.

The present invention is a versatile cosmetic composition in form of a liquid concentrate which is useful as additive or ingredient for conventional keratin fiber treatment compositions. It can be used as ready to use additive to conventional yet damaging treatments to which it is added at the time of the treatment. Such treatments are typically hair bleaches, hair colorants or permanent wave compositions. The concentrate comprises a combination of ingredients intended to reduce damage during treatments and / or to prevent undesired deposits on fibers. Such a composition comprises at least a thiol and a polymer or copolymer comprising cystine units. Such a composition is further useful as additive or ingredient for a keratin fiber caring or repairing composition to reduce damage caused by prior treatments and / or reduce undesired deposits on fibers by using the concentrate directly after treatments causing such deposits.

The invention relates to a method and a system for a high-pressure soil-extruding mortar pile. The method comprises the following steps: a drilling rod is driven to reach the designed elevation of the depth of a soil layer by utilizing a drilling machine or a vibrating pile driving machine; grouting materials are compressed into a soil body gradually from the bottom to up; and the drilling rod is lifted at slow speed, so as to form a coherent mortar pile body. The grouting materials quickly bleed after being compressed out by high pressure, so that the fluidity is reduced; the pile body forms spherical stemlike grouting by pushing the prior soil body to displace and then vacate the space; and the added stress in the soil is manually increased to extrude soil bodies between piles, and the pressure of water in gaps of the soil is improved and is discharged, so that the soil between the piles is extruded to be compact. The system for realizing the method is as follows: a compression system of a compression device is a system which has double cylinders, and absorbs and discharges materials continuously. The method has the advantages of the prior treatment (consolidation treatment and compound treatment) technologies; and various information such as the reclaiming pressure and the flow rate (curve) is digitally displayed in time through a PLC, and extrusion and extension of the diameter of the pile are simulated, so that the method is more favorable for constructors to know about the construction state in time to perform accurate control.

The invention provides a treatment method for industrial wastewater. The treatment method solves the technical problems that the prior treatment technology steps are too complex, the treatment is tedious, and the like. The treatment method of industrial wastewater comprises the following steps: a, putting a precipitating agent in the industrial wastewater, and carrying out standing for 2-5 hours;b, filtering the industrial wastewater in the step a through a treatment device; and c, carrying out filtration and adsorption on the industrial wastewater in the step b through activated carbon to obtain treated industrial wastewater. The treatment method provided by the invention has the advantages of convenient treatment.