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124 results about "Atropine" patented technology

This medication is used before eye examinations (e.g., refraction) and to treat certain eye conditions (e.g., uveitis).

Buccal, polar and non-polar spray containing atropine

Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide atropine for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, atropine, and optional taste mask and / or flavoring agent; formulation II: aqueous polar solvent, atropine, optionally flavoring agent, and propellant; formulation III: non-polar solvent, atropine, and optional flavoring agent; and formulation IV: non-polar solvent, atropine, optional flavoring agent, and propellant; formulation V: a mixture of a polar and a non-polar solvent, atropine, and optional flavoring agent; formulation VI: a mixture of a polar and a non-polar solvent, atropine, optional flavoring agent, and propellant.
Owner:NOVADEL PHARMA

Low-concentration atropine medicine-containing eye drop and preparation method thereof

A low-concentration atropine medicine-containing eye drop comprises the following components: (A) 0.001-1% (w / v) of an atropine medicine, (B) 0-10% (w / v) of a solute with the effects of lubricating, solubilizing and moisturizing, (C) an acidity and alkalinity regulating agent of which the amount is proper to ensure that the pH is regulated to 6.0-8.0, (D) an osmotic pressure buffering agent of which the amount is proper to ensure that the osmotic pressure is regulated to 280-380 mOsm / L, (E) a thickener of which the amount is proper to ensure that the viscosity is regulated to 6-10 mps, (F) 0.001-1% (w / v) of a solute with an atropine medicine stabilizing effect, (G) 0-0.1% (w / v) of a bacteriostatic agent, 0-0.1% (w / v) of one or more of mint, natural borneol, vitamin B6, dipotassium glycyrrhizinate or other substances with auxiliary effects which can be also optionally added under the premise that the safety is ensured and the efficacy of the main medicine is not affected, and the balance of water. The eye drop is good in stability of the main medicine and safe, is unlikely to be contaminated by microorganisms, and can effectively prevent and relieve juvenile myopia.
Owner:杭州赫尔斯科技有限公司

Compound low-concentration atropine eye drops and preparation method thereof

ActiveCN109091675ASafe and effective prevention and treatment of myopiaPrevention and treatment of myopiaSenses disorderHydroxy compound active ingredientsDiseaseSide effect
The invention discloses compound low-concentration atropine eye drops and a preparation method thereof. The eye drops are mainly prepared from low-concentration atropine, lutein or a lutein derivative, fructus lycii, taurine, liquid pearl and multiple vitamins (A, B1, B6, B12 and E) by processing in a certain ratio. Drugs used in the compound eye drops conform to Chinese pharmacopoeia and United States Pharmacopeia, by means of functional collaborative treatment synergy of various natural drug active factors and atropine for vision, dose of atropine is reduced effectively, side effects on human eyes are reduced, ciliary muscle spasm can be eliminated, eyeball nutrition can be improved, asthenopia can be relieved, the eye drops have effects of improving eyesight and clearing away heat and toxic materials and have the capacity of enhancing human eye immunity and resisting eye diseases, the effect of preventing and treating myopia of adolescents and children is enhanced effectively, and the eye drops are high in safety, long in shelf life and good in biocompatibility with eye environment and has positive promotion and application values.
Owner:上海阿尔福斯医药科技有限公司

Method of early detection of Duchenne muscular dystrophy and other neuromuscular disease

The mdx mouse is a model of Duchenne muscular dystrophy. The present invention describes that mdx mice exhibited clinically relevant cardiac phenotypes. A non-invasive method of recording electrocardiograms (ECGs) was used to a study mdx mice (n=15) and control mice (n=15). The mdx mice had significant tachycardia, consistent with observations in patients with muscular dystrophy. Heart-rate was nearly 15% faster in mdx mice than control mice (P<0.01). ECGs revealed significant shortening of the rate-corrected QT interval duration (QTc) in mdx mice compared to control mice (P<0.05). PR interval duration were shorter at baseline in mdx compared to control mice (P<0.05). The muscarinic antagonist atropine significantly increased heart-rate and decreased PR interval duration in C57 mice. Paradoxically, atropine significantly decreased heart-rate and increased PR interval duration in all mdx mice. Pharmacological autonomic blockade and baroreflex sensitivity testing demonstrated an imbalance in autonomic nervous system modulation of heart-rate, with decreased parasympathetic activity and increased sympathetic activity in mdx mice. These electrocardiographic findings in dystrophin-deficient mice provide new bases for diagnosing, understanding, and treating patients with Duchenne muscular dystrophy.
Owner:MOUSE SPECIFICS

Atropine Pharmaceutical Compositions

The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.
Owner:VYLUMA INC

Frostbite and chilblain treating ointment

InactiveCN1706381AIt has the function of windproof, waterproof and antifreezeRelieve spasmsHeterocyclic compound active ingredientsSide effectWhite petrolatum
The ointment for treating frostbite and chilblain is prepared with anticholine drug powder and vaseline and through homogeneous mixing. Pharmacological test proves the effects of resisting peripheral M choline receptor, relieving acetylcholine caused smooth muscle spasm, improving circulation, etc of anticholine drug. Vaseline has the effects of preventing wind, preventing water and preventing frostbite. Therefore, the ointment with combined anticholine drug and vaseline has obvious frostbite and chilblain treating effect and no side effect when it is applied to the affected parts.
Owner:李爱华

Method of treating organophosphate intoxication

ActiveUS20170246188A1Effective post-exposure treatmentPrevents subsequent neuronal injuryOrganic active ingredientsNervous disorderBenzodiazepineAntidote
The present invention provides new compositions and methods for treating and / or reversing organophosphate intoxication, manifested by both cholinergic and non-cholinergic crisis, in a mammal resulting from exposure to organophosphate compounds. The neurosteroidal compounds of this invention are those having the general structural formula of pregnane, androstane, 19-norandrostanes, and norpregnane with further moieties as defined herein. These compounds include, but are not limited to, ganaxolone, pregnanolone, and androstanediol and their analogs, salts and prodrugs. The present invention further relates to combining a therapeutically effective amount of a neurosteroidal compound with a standard organophosphate antidote (e.g. atropine, pralidoxime). The data suggests that neurosteroids are effective or more effective than benzodiazepines, whether given earlier or later than 40-min (up to several hours) after organophosphate compound exposure. Neurosteroids are effective to attenuate long-term neuropsychiatric deficits caused by organophosphate exposure.
Owner:TEXAS A&M UNIVERSITY

Sodium hyaluronate eye drops containing 0.01% of atropine and preparation method of sodium hyaluronate eye drops

The invention discloses sodium hyaluronate eye drops containing 0.01% of atropine. The eye drops comprise sodium hyaluronate, atropine, sodium hydroxide, hydrogen chloride, sodium chloride and water for injection. The mass concentration of sodium hyaluronate is 0.1-10 g / L, the mass concentration of atropine is 0.1 g / L, sodium hydroxide and hydrogen chloride are pH regulators, and sodium chloride is an osmotic pressure regulator. The eye drops contain no traditional Chinese medicinal components, bacteriostatic agent, preservative, cosolvent, thicken agent, complexing agent or the like, the components are simple and are normal substances of human bodies except for atropine, so that corneal damage caused by damage of the microenvironment on the surfaces of eyeballs is avoid, harm to the humanbodies and growth and development due to long-term excessive use of components such as traditional Chinese medicine is also avoided, and the incidence of allergic reaction is effectively reduced. Inaddition, the eye drops have pH and osmotic pressure adjusted, use comfort is improved, small-dose independent packages are also produced based on aseptic filling and a hot pressing sterilization process, and biological safety of the product is ensured.
Owner:SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV
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