634 results about "Intestinal mucosa" patented technology

A composition for oral delivery of a poorly absorbed drug is disclosed. The composition includes the drug, an enhancer for increasing absorption of the drug through the intestinal mucosa, a promoter, which alone does not increase absorption of the drug through the intestinal mucosa, but which further increases the absorption of the drug in the presence of the enhancer, and optionally a protector for protecting the drug from physical or chemical decomposition or inactivation in the gastrointestinal tract. Illustrative enhancers include sucrose fatty acid esters, and illustrative promoters include aminosugars and amino acid derivatives, such as poly(amino acids). Illustrative protectors include methylcellulose, poly(vinyl alcohol), and poly(vinyl pyrrolidone).

The invention relates to compositions and methods for the administration of therapeutic and/or diagnostic agents such as polypeptides to a mammal, and in particular, compositions suitable for oral administration. The invention provides polymeric particles, and in particular, nano/microparticles such as, but not limited to, microspheres and nanospheres, as well as methods of synthesizing them. The invention also provides methods of increasing the serum concentration of a therapeutic agent such as a polypeptide by orally administering polymeric particles comprising the therapeutic agent. The compositions of the invention allow the absorption of polypeptides through intestinal mucosa and intestinal cells and into the bloodstream of a mammal. The invention further provides a method of treating type II diabetes through the oral administration of compositions comprising insulin and also provides a related glucose-responsive insulin delivery system.

The invention relates to infant formula milk powder and a production method thereof. The infant formula milk powder contains nutrition constituents such as protein, fat, carbohydrate, vitamins, mineral elements and the like with content regulated by the national standards on infant foods. Moreover, whey peptides, collagen peptides and casein phosphopeptides are added in the milk powder. Since the three kinds of binding peptides are added, the invention has the advantages that the immunity of cesarean infants is improved and the disease resistance of the infants is enhanced; the digestive function of the infants is improved, the intestinal mucosa proliferation is promoted and the digestive function is improved; and the development of the nervous system is promoted, the nutrition supply to the nervous system is guaranteed and the memory and the learning ability of the infants are improved.

The invention discloses small molecule polypeptide Ca-chelate of fishbone, which belongs to the field of functional food or additive. The method for preparing the small molecule polypeptide Ca-chelate of the fishbone comprises the following steps: boiling the fishbone at high temperature and high pressure; pulping to obtain the fishbone paste; utilizing the compound protease to execute enzymolysis; centrifuging to obtain the liquid supernatant and the sediment; filtering the liquid supernatant to obtain the small molecule polypeptide liquid of the fishbone; executing the composite acid acidification through citric acid and lactic acid for the sediment so as to obtain the fishbone calcium liquid; mixing the small molecule polypeptide liquid of the fishbone with the fishbone calcium liquid; executing the chelation at 40-50 degrees centigrade while the pH value is 7.5-8.5; and drying to obtain the small molecule polypeptide Ca-chelate of the fishbone. The invention has high Ca-chelate rate which reaches over 90%, and has high biological absorption rate of the calcium which reaches over 70%. The invention has no side effects, has good flavor, can be directly absorbed from intestinal mucosa after being eaten, solves the problems that the solubility of the traditional calcium source is bad, the absorption rate is low and the side effect is large, and solves the problem of producing calculi. In addition, the invention has a simple preparation method and low cost.

The invention specifically relates to a bifidobacterium microcapsule and a preparing method thereof. The bifidobacterium is obligatorily anaerobic and very sensitive to oxygen, PH, temperature, humidity, and other adverse external environment, thereby being very hard to remain activity during production, storage and transport; besides, if taken orally in a form of dry bifidobacterium powder, the bifidobacterium cannot tolerate low-pH value gastric acid, bile salt, and other environments, so a purpose that massive survived bifidobacteria arrive at an intestinal tract and colonise on the intestinal mucosa is hard to be guaranteed. The preparing method disclosed by the invention comprises the following steps of: adding freeze-dried bifidobacterium powder into a sodium alginate solution and then mixing in soybean oil, emulsifying the mixed solution and standing; centrifugally collecting micro-capsules; and drying the micro-capsules by using a vacuum freeze-drying technology. The bifidobacterium microcapsule disclosed by the invention has the advantages of gastric acid resistance, bile salt resistance and entericsolubility, high survival rate of bifidobacterium, simple preparation method, strong practicality, convenience for industrial production, and excellent storage stability and solves the problem of short storage period of probiotics preparations.

A method for treating obesity in a human patient is provided whereby an ablation source is introduced into the small intestine of the patient via a working channel of an endoscope, and the intestinal mucosa of the patient is ablated over a length of the small intestine in a range of approximately 40 cm to 100 cm.

The invention discloses a biological healthcare-type compound feed for soft-shelled turtles, wherein the material ingredients of the biological healthcare-type compound feed are as follows in percentage by mass: 30 to 40% of white fish meal, 10 to 20% of red fish meal, 4 to 10% of bulked bean pulp, 6 to 12% of yeast powder, 19 to 22% of starch a, 5 to 8% of fermented bean pulp, 2 to 5% of gluten powder, 2 to 5% of monocalcium phosphate, 0.05 to 0.3% of enzymic preparation, 0.1 to 0.3% of microbial preparation, 0.1 to 0.5% of compound vitamins, 1 to 3% of composite polymineral, 0.2 to 0.8% of 50% choline chloride, 0.1 to 0.5% of additive for protecting liver and gallbladder and 0.3 to 0.6% of additive for repairing intestinal mucosa. The feed has an increased feed utilization rate, and canbe used for improving the water body environment, reducing the disease occurrence and protecting the normal growth of the soft-shelled turtles, and thus, a high-quality and safe feed is provided for healthy cultivation.

The invention discloses a preparation method for separating biochemical medicaments from mucous membranes of porcine small intestines, in particular a preparation method for producing heparin sodium by using porcine small intestines. The preparation method for producing the heparin sodium by using the porcine small intestines is characterized by comprising the following steps of: preparing intestinal mucosa, and performing enzymolysis, adsorption, elution, precipitation, desalination, dehydration and drying to obtain the heparin sodium. The method has the advantages that: the heparin sodium has high yield, low activity loss and stable quality; the waste liquor is pollution-free in discharge and can be recycled; the problem of stench in a heparin sodium workshop is solved by adopting a workshop waste gas purification treatment device; and 2,000 to 2,400 pieces of porcine small intestines are needed for producing 0.1 billion units of heparin sodium by using the conventional process, only 1,400 to 1,600 pieces of porcine small intestines are needed for producing 0.1 billion units of heparin sodium by using the preparation method, and the effect and the activity of the heparin sodium are greatly improved, so that the production cost is greatly reduced, and the profit can be improved by over 40 percent.

The invention relates to a method for extracting sodium heparin, which comprises the following steps: (1) enzymic hydrolyzing intestinal mucosa in a conventional method, and adopting enzyme preparation for the hydrolysis: mixture which is formed by mixing prolease, papain and lipase at a mass ratio of 1 to 4: 1 to 3: 0.1 to 0.3, and selecting the prolease from one of 2709 enzyme, AS1.398 enzyme and pancreatin; (2) resin adsorbing in a conventional method; (3) resin eluenting in a conventional method; (4) settling out the sodium heparin in a conventional method; (5) purifying the sodium heparin in a conventional method; (6) drying the sodium heparin in a conventional method to obtain the pure sodium heparin. An improved solution is characterized in that precipitator is added before filtering and hydrolyzing the mixture in the step 1. The method has simple process, short production period, simple and convenient operation and less investment, and is applicable to the industrialized mass production. The purity of the heparin can reach 100 to 120IU/mg, the extraction efficiency can reach 100 million IU/1700 to 1800 chatterlings, the extraction efficiency can be improved by 20 to 30 percent, consumed salt can be reduced by 30 to 50 percent, water can be reduced by 50 to 70 percent, energy can be reduced by 30 to 40 percent, and the recycling rate of the crude protein can reach 60 percent.

A method of providing a pet with a benefit relating to effective assimilation of a lipid is described wherein the pet is administered, as a part of, or in addition to its regular diet, an edible composition that contains intestinal mucosa function-promoters in an effective amount to maintain, improve or enhance the capacity of the pet to digest lipid efficiently. The invention extends to compositions for use in promoting lipid assimilation in pets, particularly senior or elderly pets. The compositions preferably include pancreatic, liver and intestinal mucosa function-promoters.

The invention discloses a traditional Chinese medicinal feed additive for treating dysentery and diarrhea of livestock and poultry, which is prepared from the following raw material medicines: indigowoad root, pomegranate rind, rabdosia rubescens, amur corktree bark, baical skullcap root, golden thread, lightyellow sophora root, honeysuckle and dandelion. A preparation method for the traditional Chinese medicinal feed additive comprises the following steps of: respectively crushing the selected medicinal materials and mixing; or mixing and crushing. The selected raw material medicines are combined to achieve the effects of clearing heat and eliminating toxin, killing parasite and relieving itching, and astringing intestine and relieving diarrhea, can strengthen intestine to stop diarrhea, repair intestinal mucosa and improve the body resistance, and can quickly cure the dysentery, the diarrhea, inflammatorydiarrhea and stubborn diarrhea of livestock and poultry. Through application, the traditional Chinese medicinal feed additive has the advantages of good prevention and control effect, no toxic or side effect, readily available materials and low price.

The invention relates to a method for extracting a crude product of heparin sodium, which comprises the following steps of: firstly, taking the gut skin and the intestinal mucosa of a primitive gut as raw materials for extracting the heparin sodium, putting sodium chloride, sodium hydroxide and proteinase into an enzymolysis tank simultaneously according to a certain proportion and heating to carry out enzymolysis on the raw materials to form a liquid state; filtering, putting filtrate into an adsorption tank, eluting resin by brine after adsorbing the filtrate by adopting the higher resin, enabling the heparin sodium to enter eluent, putting the eluent into a depositing tank and depositing by alcohol; and drying and pulverizing. The invention has high efficiency, high stability, resource saving and high product yield and purity, is easy for large-scale production, can meet the requirements of markets at home and abroad to a crude product of heparin and has extensive application prospect.

The invention provides a PED (Porcine Epedemic Diarrhea) inactivated vaccine and a preparation method thereof and relates to the field of biopharmacy. The PED inactivated vaccine comprises inactivated PEDV (Porcine Epedemic Diarrhea Virus), and is characterized in that the PED inactivated vaccine comprises 0.05-10 mg/mL Beta-glucosylceramide, 0.1-21 mg/mL monophosphoryl lipid A, 1.5-125 mg/mL muramyl dipeptide and 0.7-4.5 mg/mL Beta-glucan. According to the ingredients of the PED inactivated vaccine, Beta-glucosylceramide, monophosphoryl phosphoryl lipid A, muramyl dipeptide and Beta-glucan have the synergistic effect, the immune response of animals to antigens in the vaccine is significantly improved, the immune window phase is shortened, the antibody production duration of the animal body is obviously prolonged, the serum antibody level is improved, and the level of total intestinal mucosa secretory antibodies (the total SIgA) is improved.

The invention relates to a special clinical nutrient composition for an inflammatory bowel disease. The special clinical nutrient composition comprises protein, amino acid, peptides, fat, carbohydrate, dietary fibers, macro-elements, micro-elements, vitamins, dietary essence, medicinal and edible components, natural plant compounds and new resource food, wherein the dietary essence comprises millet powder, oat powder and apple powder, and the medicinal and edible components comprise lanceleaf lily bulbs, wild mint herbs, ural licorice roots, Indian bread, palmleaf raspberry fruits, barbary wolfberry fruits, king solomonseal rhizome and Chinese dates. A preparation method of the special clinical nutrient composition includes the steps: preparing the components into powder in advance and uniformly mixing the powder to prepare corresponding forms; performing water extracting concentration and freeze drying on the medicinal and edible components to prepare powder, microencapsulating the vitamins and the fat into powder and freeze-drying the dietary essence into powder. Compared with the prior art, the nutrient composition can provide needed energy, key nutrients and necessary micro-elements for a patient suffering from the inflammatory bowel disease, and improve blood sedimentation, C reactive protein and intestinal mucosa permeability symptoms of the patient.

The invention discloses a compound feed for preventing soft-shelled turtle from the white abdominal shell disease. The compound feed comprises the following raw materials of both components and air dry matters by weight percent: 35-40 percent of imported white fish meal, 10-18 percent of steam brown fishmeal, 5-8 percent of soybean protein concentrate, 4-8 percent of fermented soybean meal, 3-6 percent of extruded soybean, 1-2 percent of wheat gluten, 4-8 percent of beer yeast, 18-23 percent of pre-gelatinized starch, 1-2 percent of calcium biphosphate, 0.3-0.6 percent of acid alkaline buffering agent, 0.03-0.08 percent of yeast culture, 0.1-0.4 percent of active strains preparation, 0.05-0.15 percent of sodium butyrate, 0.1-0.3 percent of compound Vitamin, 0.5-1.5 percent of complex ore and 0.2-0.5 percent of choline chloride. The feed provided by the invention can effectively keep the pH value in the intestinal canal of soft-shelled turtle to be stable and conditions the balance of intestinal flora, so that beneficial bacterium is in the ascendance in intestinal canal, the integrity and barrier action of intestinal mucosa are protected, and accordingly, the soft-shelled turtle is effectively prevented from the white abdominal shell disease.