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Method for extracting crude product of heparin sodium

An extraction method, the technology of heparin sodium, which is applied in the field of extraction of pharmaceutical products, can solve the problems of low intensification, raw material waste cost, and low heparin yield, and achieve the effects of saving human resources, reducing production costs, and high collection rate

Inactive Publication Date: 2010-10-06
喻延安
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AI Technical Summary

Problems solved by technology

However, due to the low degree of intensive pig breeding and slaughtering in my country, the quality of crude heparin products varies widely, and the heparin extraction process in Europe and the United States is not suitable for the quality characteristics of crude heparin products in my country, resulting in low yield of heparin, waste of raw materials and rising costs

Method used

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  • Method for extracting crude product of heparin sodium
  • Method for extracting crude product of heparin sodium

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Experimental program
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Effect test

Embodiment 1

[0032] 1. Salt solution, alkalization and enzymatic hydrolysis

[0033] 1. Scrape the original intestine of the pig to remove the mixture of intestinal skin and mucous membrane, including the water contained therein.

[0034] 2Put the intestinal skin and mucous membrane mixture into the enzymatic hydrolysis tank, mix well and stir, and adjust the salinity to 3.0-5.0 with solid salt or brine. Use NaoH solution to adjust the pH value to 8.5-9.5, and confirm it with precision test paper.

[0035] 3 Slowly raise the temperature to 40-45°C, add 1.5-4.0g of alkaline protease per 6Kg of intestinal skin and mucous membrane mixture. Enzyme powder is dissolved in cold water and stirred into a paste in advance.

[0036] 4. Stir the reactants and heat up to 50-55°C. Insulate for 2-3 hours, and adjust its pH value to about 8.2-8.5.

[0037] 5 After the heat preservation is over, quickly raise the temperature of the tank to 80-90°C. Keep warm for ten minutes.

[0038] 2. Filtration an...

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Abstract

The invention relates to a method for extracting a crude product of heparin sodium, which comprises the following steps of: firstly, taking the gut skin and the intestinal mucosa of a primitive gut as raw materials for extracting the heparin sodium, putting sodium chloride, sodium hydroxide and proteinase into an enzymolysis tank simultaneously according to a certain proportion and heating to carry out enzymolysis on the raw materials to form a liquid state; filtering, putting filtrate into an adsorption tank, eluting resin by brine after adsorbing the filtrate by adopting the higher resin, enabling the heparin sodium to enter eluent, putting the eluent into a depositing tank and depositing by alcohol; and drying and pulverizing. The invention has high efficiency, high stability, resource saving and high product yield and purity, is easy for large-scale production, can meet the requirements of markets at home and abroad to a crude product of heparin and has extensive application prospect.

Description

technical field [0001] The invention belongs to the field of extraction of pharmaceutical products, in particular to a method for extracting crude heparin sodium. Background technique [0002] Heparin and its derivatives are classic anticoagulant and antithrombotic drugs, which have been clinically used for more than 70 years. With the prolongation of human life expectancy, changes in living habits and dietary structure, the incidence and mortality of cardiovascular and cerebrovascular diseases such as thrombosis are increasing year by year, which has become the primary factor affecting human health. Therefore, antithrombotic drugs are used worldwide It has huge development space and market prospects. In recent years, its market capacity has grown rapidly. In 2008, the global sales were 19.706 billion US dollars. It is estimated that the sales in 2012 will reach 29.198 billion US dollars, with an average annual compound growth rate of 10.33%. At the same time, the scope of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10C12S3/02
Inventor 喻延安
Owner 喻延安
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