The invention relates to a trepang capsule and a preparation process thereof. The trepang capsule is composed of 500-1000 parts of trepang, 50-100 parts of rhodiola root, 50-80 parts of mulberry leaf, 50-80 parts of Chinese wolfberry; 50-80 parts of hawthorn, 50-80 parts of Chinese date, 10-20 parts of fructus momordicae, 50-80 parts of calcium gluconate, and 50-80 parts of vitamin C. The preparation process comprises the following eleven steps: raw material purification, vacuum freeze drying, coarse cracking, superfine grinding, microwave auxiliary enzymolysis, enzyme deactivation, filtration, desalting, auxiliary seasoning processing, material proportioning and pelletization, as well as sterilization and packing. The obtained trepang capsule is reasonable in formulation composition, and stable in property, has blood sugar decreasing and blood pressure reducing efficacy, and is especially prominent in blood fat reducing efficacy.