34 results about "Diphenoxylate" patented technology

A biochemical deratization, its composition consists of cultivator of killing active dung streptococcus, barium sulfate, diphenoxylate, grain and attractant. Weight percentage of the composition is as follows: nutrient medium of killing active dung streptoccus 3-5 %, barium sulfate 20-80%, diphenoxylate 0.01-0.05%, grain and attractant 15-75 %.

The invention belongs to the field of medicine healthcare, and particularly discloses a composition and a manufacturing method and application thereof. The composition is manufactured from xylooligosaccharide, psyllium seed husks, citrus dietary fiber, barley grass and water-soluble dietary fiber, and achieves the good effects of relaxing bowels and adjusting the intestinal health due to the synergistic effect. The manufacturing method of the composition comprises the steps of smashing and mixing the xylooligosaccharide, psyllium seed husks, citrus dietary fiber, barley grass and water-soluble dietary fiber to obtain the composition, the effective ingredients of the raw materials are reserved to the maximum extent, and the obtained composition has the remarkable effect of relaxing bowels, and is easy to operate and suitable for industrial production. The composition has the remarkable improving effect on the intestine inhibiting effect caused by diphenoxylate, can remarkably shorten the defecation time, promote alvine motion and increase the number of defecations and the weight of defecations and has the much better effect than a raw material single experiment set. It is shown that the composite can remarkably improve constipation.

A medicine for treating postoperative gastrointestinal diseases, which is composed of 6-12% of rhubarb, 14-26% of astragalus, 10-15% of hemp seed, 5-10% of Citrus aurantium, 5-10% of Magnolia officinalis, and 6% of Atractylodes Rhizoma ~12%, Muxiang 6~12%, Angelica 6~12%, Peach Kernel 5~10%, Paeonia suffruticosa 5~10%, the oral medicine prepared according to the conventional preparation method. The medicine of the present invention has been tested on the efficacy of the medicine, and the experimental results show that the medicine of the present invention can promote the defecation process of normal mice; Promoting effect; the medicine of the present invention also has obvious improvement effect on delayed gastric emptying and delayed intestinal propulsion in rats caused by abdominal surgery; the medicine of the present invention can resist the weakening of small intestine activity caused by compound diphenoxylate. The above results provide a reliable experimental basis for the drug of the present invention to be used for complications such as abdominal distension and constipation after abdominal surgery.

The invention discloses a method for measuring electrophysiological activity of colon muscles of mice and application thereof. The method comprises the following steps of: performing gavage on the mice by using compound diphenoxylate suspension to establish a constipation model, selecting medical suture needles, manufacturing copper wires into copper wire electrodes, and measuring the change of electrophysiological activity of colon. Compared with the result of the control group, the result shows that the slow wave colon frequency, the frequency variation coefficient, the amplitude and the amplitude variation coefficient of the mice in a constipation group have an extremely obvious difference P which is less than 0.01. The method for measuring the electrophysiological activity of colon muscles of mice has the advantages that 1, the measuring method is easily available in raw materials, simple, practicable, high in repeatability and high in success rate; 2, the method is slight in damage to a subject and suitable for mice and other animals; 3, according to the measuring method, the change of the electrophysiological activity of colon muscles of the mice can be objectively reflected; and 4, a powerful tool is provided for researching the movement mechanism of the colon and controlling constipation in the system.

The invention discloses a composition of an antidiarrheal agent, which consists of the following weight portions of ingredients: 1.5-3 portions of compound diphenoxylate, 2.5-6 portions of prednisone and 5-15 portions of hydrochlorothiazide. The composition of the antidiarrheal agent has clear curative effect, good efficacy, rapid disappearance of diarrhea; diuresis effect of the hydrochlorothiazide is utilized to absorb water and reduce intestinal water, and the anti-inflammatory and anti-infection functions of prednisone are applied to mitigate clinic sympton, the cooperation of these three medicines accelerates the antidiarrheal speed and relieves the pain of the sufferers. The composition of the antidiarrheal agent has low cost, which is lower than Xieliting by 5-6 times.

The invention discloses a bactericidal composition containing dikestrobin and acetostrobin. The film component is 0.5%-15%, and the rest are additives and water, and the percentage concentration is weight percentage. The fungicidal composition has a technically feasible composition ratio, and shows a good synergistic effect on the prevention and treatment of grape downy mildew, and can effectively reduce the risk of resistance of grape downy mildew to dikestribin , is an ideal grape fungicide composition.

The invention discloses a composition of an antidiarrheal agent, which consists of the following weight portions of ingredients: 1.5-3 portions of compound diphenoxylate, 2.5-6 portions of prednisone and 5-15 portions of hydrochlorothiazide. The composition of the antidiarrheal agent has clear curative effect, good efficacy, rapid disappearance of diarrhea; diuresis effect of the hydrochlorothiazide is utilized to absorb water and reduce intestinal water, and the anti-inflammatory and anti-infection functions of prednisone are applied to mitigate clinic sympton, the cooperation of these threemedicines accelerates the antidiarrheal speed and relieves the pain of the sufferers. The composition of the antidiarrheal agent has low cost, which is lower than Xieliting by 5-6 times.

The present invention provides a powder pharmaceutical formulations for treating infantile diarrhea which overcomes weak pocket of other medicament for treating the disease. The powder pharmaceutical formulation is prepared by raw materials as follows: biofermin 0.1-1 g, compound diphenoxylate 0.25-2.5 mg, acetylsalicylic acid 0.3-0.15 g, chlorphenamine 0.04-0.2 mg and hydrochlorothiazidum tablet1-5 mg, the above medicine are grinded to dead small, then are measured and packed for obtaining the powder pharmaceutical formulation. The powder pharmaceutical formulation for treating infantile diarrhea is used about twenty years and is consulted by patients 10000 times, wherein, males 5500 times, females 4500 times, curative rate 98% and efficiency rate 100%.

The invention relates to an application of fulvic acid sodium in preparing drugs for treating diarrhea. Research discovers that the fulvic acid sodium in the invention has low toxicity, can restrain the gastrointestinal motility of a normal mice, can cooperate with reinforced compound diphenoxylate to restrain the gastrointestinal motility of the mice, can obviously improve the physical sign of amice suffering splenasthenic diarrhea caused by rheum officinale, and restrain the gastrointestinal motility of the mice suffering diarrhea, thus treating the diarrhea; and the research shows that the fulvic acid sodium has obvious effect of treating the diarrhea.

The invention discloses application of ethanolamine in preparation of a composition for preventing, relieving or treating constipation. The composition comprises food, a health care product and a medicine. Ethanolamine promotes intestinal tract movement and prevents, relieves or treats constipation by increasing the content of serotonin in colon. Animal experiments prove that ethanolamine can significantly improve the small intestine propulsion rate and the defecation grain number of compound diphenoxylate modeling mice, and has the function of relieving constipation; Meanwhile, the ethanolamine promotes intestinal tract movement and prevents, relieves or treats constipation by increasing the content of serotonin in colon.

The invention discloses a dendrobium officinale mixture. The dendrobium officinale mixture is prepared from the following traditional Chinese medicinal materials serving as raw materials in parts by weight: 10 to 12 parts of dendrobium officinale, 15 to 25 parts of raw atractylodis macrocephalae rhizome, 10 to 20 parts of radix scrophulariae, 10 to 20 parts of radix ophiopogonis, and 10 to 20 parts of raw radix rehmanniae. The dendrobium officinale mixture has the effects of increasing fluid, moistening dryness, nourishing yin, clearing heat, strengthening spleen and tonifying qi, and is used for constipation and the diseases that the defecating frequency is reduced, the excrement amount is little and hard in texture, a pleasant feeling disappears after defecating, and the defecating time or the defecating interval time is prolonged. In order to prove a good effect of the dendrobium officinale mixture to the constipation better, the effect of the mixture to a mouse with the constipation induced by compound diphenoxylate is investigated through an animal experiment; the effect shows that the mixture can promote the pushing of small intestines of the mouse with the constipation, promote defecation, protect intestinal mucosa and improve serum SOD.

The invention discloses application of chrysophanic acid in preparation of medicines for treating constipation. The key point of the technical scheme adopted by the invention is as follows: application of the chrysophanic acid in preparation of medicines for treating constipation caused by gastrointestinal motility dysfunction resulting from compound diphenoxylate medicines. The application disclosed by the invention is beneficial to finding of a new and effective medicine for preventing and treating constipation caused by gastrointestinal motility dysfunction resulting from compound diphenoxylate drugs, meanwhile, the application is used for further verifying the extensive pharmacological action of the chrysophanic acid, having important significance of promoting clinical application of traditional Chinese medicine chrysophanic acid to become a new clinical drug, and providing experimental evidence for illustration of the action mechanism of the chrysophanic acid and market promotion of the chrysophanic acid.

The invention relates to a method for detecting diphenoxylate in a biological sample by liquid chromatography-tandem mass spectrometry for criminal investigation. The method comprises the following steps: (I) extracting diphenoxylate from the biological sample; and (II) detecting diphenoxylate extracted in the step (I) by a liquid chromatography-tandem mass spectrometry instrument. The method provided by the invention improves the sensitivity of the detection of diphenoxylate in the biological sample to be detected, and reduces the degree of detection difficulty of diphenoxylate in the biological sample to be detected.

A composite medicine for treating colitis is prepared from 7 Chinese-medicinal materials including black plum, dahurian angelica root, yam, liquorice, etc and 3 Western medicines including thiaminogen, diphenoxylate and fossyol.