69 results about "Heroin" patented technology

The invention provides a method for rapidly identifying monoacetylmorphine and morphine in hair. The method sequentially comprises the following steps: 1, placing hair to be detected, an extract liquid, internal standard morphine-d3 and a billiard ball in a crusher, and carrying out micro-crushing treatment; 2, centrifuging a mixture obtained after the micro-crushing treatment; and 3, taking the supernatant of the centrifuged mixture, and carrying out liquid chromatography-tandem mass spectrometry analysis of the supernatant. The method for rapidly identifying monoacetylmorphine and morphine in hair can realize the simple and rapid separation and purification of monoacetylmorphine and morphine molecules in a complex biological matrix, has the advantages of strong specificity, strong selectivity and high sensitivity, can be used for detecting a practical drug addict hair sample, and can also be used for identifying and detecting heroin addict related cases in the forensic toxicological analysis field.

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.

It is a poison multiple and combination test agent box and its process method, which comprise plastic shell and test paper bar. The plastic shell comprises upper cover and down cover, wherein, the upper cover comprises specimen adding holes, test result display hole and fix mark hole; the down cover is set with flute. The test paper comprises test specimen area, test result display area and water absorption area, wherein, the test specimen area comprises glue gold and filter paper; the test result display area comprises pyroxylin film, C line control area with sheep and rabbit polyclonal antibody, test display area with heroin antigen and test display area with methyl amphetamine antigen. The water absorption area is set with absorption paper and fix mark.

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

A method is provided for treating a drug-dependent individual so as to effect withdrawal from a drug of abuse, e.g., an opiate such as heroin or oxycodone, a stimulant such as cocaine, or alcohol. The method involves substitution therapy wherein a substantially nonaddicting normorphine or norcodeine derivative is substituted for the drug of abuse. The active agent has the structure of formula (I) wherein: R is H, alkyl, or acyl; X is CH(OR′) or C═O, wherein R′ is H or acyl; α is an optional double bond, with the proviso that when α is present, then X is necessarily CH(OH), or an acid addition salt thereof, wherein preferred such agents are in a stereoisomerically pure form that corresponds to that of N-[(1R)-1-cyclopropylethyl]-normorphine (1) which melts at approximately 188° C.-189° C.

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

The invention is suitable for the technical field of traditional Chinese medicines, provides application of free sulfur in preparing drug treatment and rehabilitation medicaments and also provides a drug treatment and rehabilitation Chinese herbal composition of which crude drugs include a sulfur element and at least one Chinese herbal component, wherein the weight percentage of the sulfur element to the Chinese herbal component is (0.1-99):(99-0.1); the sulfur element is the free sulfur, sublimed sulfur, precipitated sulfur, sulphion or a sulfocompound. The free sulfur is applied to the preparation of the drug treatment and rehabilitation medicaments, can block the euphoria brought by drugs and can bring a long-efficient and secondary taking prevention effect. A Chinese herbal preparation prepared from the Chinese herbal composition provided by the invention has favorable curative effect for opioid drugs, excitotoxicity drugs and various controlled substances and has stronger inhibitory action for heroin dependent patients longing for the drugs, a certain inhibitory action in the euphoria generated by opioid substances, better curative effect for protracted withdrawal syndrome and action in promoting the restoring of physiological functions of organisms.

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

The invention relates to an application of a lead compound namely L-corydalmine (L-CDL) of isoquinoline compounds on treating diseases related with addiction. The diseases comprise drug addiction (heroin, opium, methyl amphetamine, morphine, marihuana, cocaine, and the like), nicotine addiction, and alcohol addiction, and also comprise novel drug addiction (stimulant type novel drugs) and brain damage caused by novel drugs.

The Chinese medicine preparation for stopping drug addiction is prepared with nine kinds of Chinese medicinal materials including fresh aloe leaf, kendir leaf, cordate houttuynia, balloonflower root, etc. as well as honey and medicinal acceptable additive. It is prepared into oral liquid capsule, chewing gum and other forms. It can reduce the harm of drug, such as heroin, cocain, marijuana, etc. effectively, raise immunity, regulate endorphin system and prevent re-taking in drug.

The invention discloses an antigen and a preparation method and application thereof. The antigen is a conjugate formed by connecting morphine-6-monoglutarate and a carrier protein through a covalent bond. The method for preparing the antigen comprises the following step of: conjugating the morphine-6-monoglutarate with the carrier protein so as to prepare the conjugate of the morphine-6-monoglutarate and the carrier protein, wherein the carrier protein is bovine serum albumin or hemocyanin. The antigen can stimulate an organism to generate a morphine antibody and specifically recognize the morphine and heroin. Mouse experiments prove that: a vaccine which takes the antibody as an active substance can prevent morphine relapse to a certain degree.

The present invention is asafetida extract and its pharmaceutical use, and aims at eliminating offensive odor of asafetida and providing one new use. The asafetida extract contains alpha-terpinene, 2-borneol, terpine tetraol, D-fenchol, pinocarveol, etc. and is extracted via conventional process. The asafetida extract is used in preparing drug addiction stopping medicine, and the medicine may be injection, capsule, tablet or granule.

The invention provides a discriminating method for heroin origins based on neutral or acidic impurities and partial least-squares discriminant analysis (PLS-DA), which is suitable for discriminating affiliation of heroin in two origins: southeast Asia and southwest Asia. The method comprises the following steps: firstly, putting forward a discriminating function of PLS-DA of the heroin origins; detecting peak area numerical values of independent variables of 25 neutral or acidic impurities in a heroin sample, and substituting the peak area numerical values into the PLS-DA discriminating function; calculating the numerical value t of the obtained discriminating function; when t is greater than 0 and less than 6, judging that the heroin origin is southeast Asia; and when t is greater than -6 and less than 0, judging that the heroin origin is southwest Asia.

The invention discloses a preparation process of standard products of morphine base and heroin base. The preparation process comprises the following steps: (1) carrying out methanol extraction and acid hydrolysis on a heroin sample obtained during drug control, so as to obtain a morphine crude product; (2) purifying by virtue of silica gel chromatography preparation column; (3) carrying out methanol recrystallization to obtain a morphine standard product; (4) carrying out acetylation on morphine, so as to obtain a heroin sample; and (5) recrystallizing concentrated liquid obtained in the step (4), so as to obtain a heroin base standard product, wherein the detection result of gas chromatography mass spectrometry shows that the purity of morphine base is more than or equal to 97.8% and the purity of heroin is more than or equal to 98.4%. According to a project design, all technique processes are carried out at normal temperature and normal pressure, the operation is simple, safe and environmentally friendly, and the preparation cost is low.

The invention is provided for detection of Heroin and Morphine in illicit drug samples, also for their differentiation. A liquid sample from a street sample is prepared and divided into two equal aliquots, one of them being reference sample, another being main sample. Both samples are treated with Hydrochloric acid and Sodium hydroxide, but those substances are added to the samples in the different sequence. After that the measurement of SFS of the reference sample is performed. Further the presence of specific spectral pattern of Morphine in the measured SFS of the reference, sample is detected and the value of SFS intensity at the specific spectral point is fixed (a reference value). After 15 minutes for acidification of the main sample, the analogous measurement and detection of the Morphine in the main sample are performed.

Dibenzo quinolizine compound entity has relatively low hygroscopicity and relatively high storage stability, and is applicable to preparation of analgesic, sedative, hypnotic and tranquillizing medicines, medicines for treating hypertension, arrhythmia and functional dyspepsia, stopping cough, resisting schizophrenia and heroin and other drug dependence, reversing tumor cell drug resistance and delaying or reducing myocardial ischemia reperfusion injury, calcium antagonists, and medicines for protecting the liver and preventing visceral implicated reaction and other effects, which are applied to humans or animals.

The invention relates to tetraodontoxin freeze-dried powder preparation, in particular to a freeze-dried powder preparation which takes tetraodontoxin which is exactly measured as main active ingredient, and contains reasonable excipient and stabilizing agent. The freeze-dried powder preparation of the invention can be used for avoiding dependent abstinence syndrome of opiates such as ices, heroin, and the like, as well as cannabis poison, and has the advantages of rapid onset effect and remarkable effects. In addition, the freeze-dried powder preparation of the invention is stable and safe as well as has little irritation for the human body.

The invention discloses an antigen and the application thereof. The antigen provided by the invention is shown as the formula I. The antigen takes morphine-6-glutaric acid monoester as hapten, the hapten and carrier protein are connected through a 6-carbon-atomic-link-shaped connecting arm of N-(Epsilon-trifluoro acetyl hexanoyl oxygen) succinimide ester (TFCS) derivant, and the distance between a morphine skeletal structure and the carrier protein is increased. The antigen can irritate a body to produce high-concentration morphine antibody, the duration of the antibody is long, and the antibody can be specifically bound with morphine and heroin and can prevent recrudescence of a heroin seeking behavior induced by ignition of heroin for a long time.

The invention discloses a preparation method and application of a multi-metal oxygen cluster functionalized cadmium sulfide nanowire sensor array. Due to multi-metal oxygen cluster modification, the specific recognition enrichment capability of a material upon a drug can be improved, the detection sensitivity of a single photoelectric sensor can be improved, and the response time can be shortened;due to construction of the sensor array, the cross sensitivity of the sensor array upon different types of drugs can be improved; due to adoption of the project, a nano photoelectric gas-sensitive sensor array is established according to expect, the response discrimination degree of a sensation element upon drugs of similar structures can be increased, non-contact recognition detection on commondrugs such as opium, heroin, amphetamin chloride, ketamine and cocaine can be achieved, and a base of sensitive material can be made for a portable drug detector. The sensor array can be applied to accurate and non-contact detection on hidden trace drugs.

The invention provides a capsule for drug addiction treatment and a preparation method thereof. The capsule comprises the following components in parts by weight: 3 to 10 parts of campsis grandiflora, 3 to 10 parts of berba aristolochiae mollissima, 3 to 10 parts of stasis blocking medicine, 20 to 30 parts of hedyotis diffusa, 8 to 10 parts of sculellaria barbata, 10 to 15 parts of phryma leptostachya, 3 to 6 parts of celastrus orbiculatus, 20 to 30 parts of herba pteridis multifidae, 10 to 30 parts of zuobanteng (traditional Chinese medicine), 10 to 20 parts of selfheal, 2 to 6 parts of baizhongzhi (traditional Chinese medicine), 10 to 12 parts of blackberry lily, 10 to 15 parts of oldenlandia chrysotricha chun, 8 to 15 parts of herba violae, 8 to 15 parts of dandelion, and 6 to 8 parts of wikstroemia indica, amounting to 16 medicines. The preparation method of the capsule for drug addiction treatment comprises the steps of processing, concentrating, extracting and refining. The capsule for drug addiction treatment is mainly used for detoxicating, cleaning, eliminating and de-addicting a person taking heroin, amphetamin chloride, marihuana, dancing outreach and various addiction drugs, and is safe and convenient.

The invention provides a method for rapidly identifying monoacetylmorphine and morphine in hair. The method sequentially comprises the following steps: 1, placing hair to be detected, an extract liquid, internal standard morphine-d3 and a billiard ball in a crusher, and carrying out micro-crushing treatment; 2, centrifuging a mixture obtained after the micro-crushing treatment; and 3, taking the supernatant of the centrifuged mixture, and carrying out liquid chromatography-tandem mass spectrometry analysis of the supernatant. The method for rapidly identifying monoacetylmorphine and morphine in hair can realize the simple and rapid separation and purification of monoacetylmorphine and morphine molecules in a complex biological matrix, has the advantages of strong specificity, strong selectivity and high sensitivity, can be used for detecting a practical drug addict hair sample, and can also be used for identifying and detecting heroin addict related cases in the forensic toxicological analysis field.

The invention relates to a method for detecting heroin hidden in a human body, in particular to a method for conducting fast and automatic nondestructive testing (NDT) to heroin hidden in a human body, which is characterized by comprising the following steps: 1) preparing testing equipment; 2) adopting a human body model with hidden heroin as a sample to detect scattering maps of a detector at different angles, and establishing a standard database of the human body model with hidden heroin; 3) adopting a human body model as a sample to detect scattering maps of the detector at different angles, and establishing the standard database of the human body model; and 4) adopting detected human body as the sample in the step 1), taking the scattering map of a detected target in the step 2) at the same scattering angle as a coherence function map, analyzing signal features of high frequency band to be determined whether the human body contains heroin if the coherence function analysis has a peak value at the high frequency band, otherwise, the heroin is not existed in the human body. The method can fast, accurately detect whether the heroin is hidden in the human body without destruction.

Disclosed are a prescription of intravenous medication for blocking a heroin or morphine intoxication path and its using. The prescription of intravenous infusion includes Cerebrolysin, Piracetam, Cimetidine, Scopolamine Butylbromide, Nefopam, B.C Complex, Vitamin B1, Ascorbic Acid, Ketorolac, Guronsan, Hyoscine Butylbromide and Sukerin. The prescription activates a patient's liver and circulatory system to block drug intoxication. The using for blocking drugs includes an acute withdrawal part, wherein the prescription of intravenous infusion is injected and the timing of drug administration and the safe dosage are controlled according to clinical symptoms, and an appropriate amount of a supplementary medicine such as Haloperidol is added, and the processes of detoxication, relieving symptoms, suppressing restlessness, and sobering are conducted to block acute withdrawal symptoms of an acute withdrawal addict quickly and successfully.

A method of identifying the presence of heroin in an impure heroin composition which contains heroin and at least one fluorescent contaminant which interferes with a Raman signal from the heroin. The method may include contacting the mixture with a solvent such as an alcohol, then contacting the resulting alcohol composition with a SERS surface. The surface may then be exposed to laser light from a hand-held Raman spectrometer to detect a Raman signal from the heroin. An apparatus for performing the method is also provided.

The invention discloses a hyperspectrum-based methamphetamine, heroin and hemp detection method and belongs to the field of drug detection. According to the method, a central processing module is adopted; the input end of the central processing module is connected with an image acquisition module; the output end of the central processing module is connected with an information display module; theconnecting end of the central processing module is connected with an image storage module and a model establishing module; and the output end of the central processing module is connected with an intelligent analysis module. According to the method of the invention, based on overall design, a series of operations such as impurity removal, correction and brightness adjustment are performed on an image through the central processing module, so that a comprehensive hyperspectrum image can be formed, and a model is built; the built model is optimized with an image optimization unit, so that the built model is more perfect. The method can be used for more accurately and effectively detecting objects such as methamphetamine, heroin and hemp on the whole, so that more comprehensive detection information is obtained.

The invention relates to an external-use Chinese medicament for fighting drugs, which comprises a main medicine and an adjuvant; the raw materials of the main medicine comprise the following crude medicines according to parts by weight: 1pbw to 15pbw of scorpion, 8pbw to 40pbw of radix aconiti agrestis, 20pbw to 50pbw of aconitum Chinese paxton, 25pbw to 40pbw of gecko, 15pbw to 30pbw of nux vomica, 40pbw to 80pbw of bloodsuckers, 35pbw to 90pbw of Chinese gall, 35pbw to 90pbw of radices euphorbiae kansui liou, 8pbw to 30pbw of brimstone, 3pbw to 25pbw of cantharis, 2pbw to 8pbw of borneol (borneolum syntheticum), 1pbw to 5pbw of camphor, 10pbw to 90pbw of dung beetles, 4pbw to 28pbw of musk and 250pbw to 500pbw of Sailong bone; the raw materials of the adjuvant comprise 15pbw to 20pbw of flos daturae, 8pbw to 12pbw of liquorice, 15pbw to 20pbw of safflower and 300pbw to 800pbw of Shanxi mature vinegar. The invention also relates to a preparation method of the external-use Chinese medicament. The external-use Chinese medicament is applied to the projection position of encephalic conarium inside in the occipital skin of a patient, utilizes the principles of using poison as an antidote to poison and removing toxin by normalizing meridian to help the patient withdraw addicting to narcotic drugs, such as heroin, methamphetamine, marijuana or dancing outreach, and the like.

The present invention is aimed at providing an opioid antagonist compound and preparation method thereof, and its medical use. The medical use for opioid antagonists such as the compound of formula (I) (shown below) include complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, such as heroin, fentanyl, oxycodone, hydrocodone, morphine, propoxyphene, methadone and certain narcotic-antagonist analgesics, such as nalbuphine, pentazocine and butorphanol. An opioid antagonist may also be useful as an adjunctive agent to increase blood pressure in the management of septic shock. Further, opioid antagonists also have been shown to reduce the craving for alcohol.