69results about How to "Improve general condition" patented technology

The present invention provides a kit for bone surgery comprising a chirurgical drill and a base frame for positioning of said drill on an anatomical part of a patient. The base frame comprises at least one guiding tube with a cylindrical inner surface of predetermined diameter and also comprises a longitudinal cutout for direct view of the drilling site. The kit further comprises a burr-ring with a cylindrical outer surface of predetermined diameter arranged to be placed around the chirurgical drill. The diameter of the cylindrical outer surface of the burr-ring is slightly less than the diameter of the cylindrical inner surface of the guiding tube such that the burr-ring and the guiding tube are at most in a two-degree of freedom relationship along the longitudinal axis of the guiding tube when the burr-ring is engaged in the guiding tube. The invention also provides a bone surgery method using the kit.

The present invention relates to one kind of broad-spectrum cancer treating Chinese medicine capsule and its preparation process. It is prepared with trichosanthes root, edible tulip bulb, zedoary, pinellia tuber, grisaema tuber and other Chinese medicinal materials. It has the functions of nourishing Yin, promoting blood circulation, warming Yang, promoting urination, dredging meridian and dissipating mass. The animal experiment and the clinical application show that the Chinese medicine has obvious curative effect, no negative reaction and no toxic side effect.

A Chinese medicine as an immune regulator used for preparing the antineoplastic Chinese medicine is prepared from astragalus root and acanthopanax bark through decocting, concentrating, depositing inalcohol, and extracting from its deposit by alcohol. Its advnatage is high effect on improving immunity and playing its synergistic role in chemicotherapy and radiotherapy.

The Chinese medicine preparation for stopping drug addiction is prepared with nine kinds of Chinese medicinal materials including fresh aloe leaf, kendir leaf, cordate houttuynia, balloonflower root, etc. as well as honey and medicinal acceptable additive. It is prepared into oral liquid capsule, chewing gum and other forms. It can reduce the harm of drug, such as heroin, cocain, marijuana, etc. effectively, raise immunity, regulate endorphin system and prevent re-taking in drug.

The invention discloses application of ampelopsin in preparing medicines for treating obesity, and relates to preparation and application of flavonoids compounds. The ampelopsin is used for preparing medicines or health products for treating the obesity, including oral tablets, capsules, granules, oral solution, sustained-release agents, pills and injection solution for treating the obesity, and pharmaceutically acceptable conventional formulations. The ampelopsin has obvious weight-losing effect on obese mice and overweight mice induced by high-fat diet; after the ampelopsin is poured into stomachs of the obese mice in a dose of 25.0mg / kg for 2 weeks, the abdominal fat is obviously reduced, shoulder fat cells are obviously shrunk, the weight is reduced to be normal, and the mice are generally good in conditions, freely acts and have smooth hairs. The maximum tolerance does of the mice through stomach perfusion can reach 18g / kg.

The invention provides a method for constructing a lung tumor experimental animal model. The method comprises the following steps of: 1, feeding a dog with cyclosporin according to the weight ratio of the dog to cyclosporin of 10mg to 1kg 4 days before inoculation; 2, preparing canine transmissible venereal tumor (CTVT) tissue blocks; and 3, puncturing to a predetermined target part by using a 16G guide puncture needle, placing 2 to 3 CTVT tissue blocks into the puncture needle, arranging a sterile gelatin sponge strip behind the CTVT tissue blocks, pushing the tissue blocks into lung tissues by a needle core and pulling the needle out. In the method, CTVT cells are used as tumor strains, the tumor tissue blocks are prepared through subcutaneous tumor cell passage by using the characteristics of transplantability and genetic stability; in-lung planting is performed by a minimally invasive intervention method to establish a dog transplantable lung cancer model; and the model can be applied to related experimental researches such as growth, invasion, transfer and the like of large-sized animal lung tumors.

The invention discloses traditional Chinese medicine composition having sleep improvement and immunity boost effects as well as a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition having the sleep improvement and immunity boost effects is prepared from Siberian ginseng, American ginseng, semen ziziphi spinosae, polygonatum, psoralea corylifolia and wolfiporia extensa. Animal function test results prove that the provided traditional Chinese medicine composition has the sleep improvement and immunity boost effects; animal safety test results prove that the traditional Chinese medicine composition is safe and has no toxic and side effects and no teratogenic and mutagenic actions. Human feeding trials prove that the traditional Chinese medicine composition can effectively improve symptoms such as insomnia, low immunity and the like, has significant effect, can be used for preparing drugs or health care products and has broad market prospects.

The invention discloses a preparation method and application of a quercetin lipidosome. The preparation method comprises the steps of using a nano-liposome to encapsulate water-fast quercetin, and preparing into a quercetin lipidosome. The influence of the quercetin lipidosome (LQ) on the expressions of diabetic rat kidney advanced glycation end products (AGES), a receptor thereof (RAGE) and TGF-teta 1 , and the influence of the LQ on DM rat kidney are researched through experiments, the LQ is compared with aminoguanidine (AG), and the intervention of the LQ on DM kidney is discussed. Experiments show that the LQ can be used for reducing the morphologic pathology change of diabetic nephropathy to a certain degree and improving the general condition of STZ DM rats, and has a function of decreasing blood sugar. The preparation method and the application of the quercetin lipidosome lay a foundation for the next clinic application research of the quercetin lipidosome, and meanwhile, provide a new idea and a theoretical basis for exploring clinic traditional Chinese medicine treatment of DM.

The invention pertains to the field of traditional Chinese medicine preparations, in particular to a medicine preparation for treating endometriosis and a preparation method thereof. The medicine preparation takes the traditional Chinese medicine stagnated heat theory as the basis, selects sargentodoxa cuneata, cattail pollen, yanhusuo and the like as raw materials, the alcohol extraction and the water extraction are carried out for extraction, and pharmaceutical excipients are added for preparing infusion, granules, tablets, capsules or oral liquor. The observation results of animal experiments and clinical trails prove that the medicine preparation can significantly inhibit the size of a heterotopic cyst, obviously improve the general situation and have convenient administration, good safety, affirmative efficacy and cheap price, thereby being applicable to patients with endometriosis for long-term administration.

The invention discloses a wild ginseng planting method. The method includes the first step of field selection, the second step of area clearing, the third step of seed selection, the fourth step of germination acceleration, the fifth step of seeding, the sixth step of field management, the seventh step of pest control and the eighth step of storage. By adopting the method, vegetation can be well protected, the efficacy of wild ginseng can be more obvious, and the wild ginseng can achieve more significant tonifying effects like regulating human immunity functions, balancing the central nervous system, enhancing gonad functions, preventing cancer and diseases and improving blood pressure and blood sugar.

The invention relates to a traditional Chinese medicine composite as well as a product and an application of the traditional Chinese medicine composite. The composite comprises the following traditional Chinese medicine raw materials in parts by weight: 20-40 parts of Astragalus mongholicus and 10-20 parts of mulberry and also comprises one or several of the following traditional Chinese medicine raw materials in parts by weight: 5-15 parts of salviae miltiorrhizae, 5-15 parts of angelica sinensis, 10-20 parts of processed fleece-flower root, 5-15 parts of rhizoma chuanxiong and 1-5 parts of pseudo-ginseng. The traditional Chinese medicine composite has better actions on lowering sugar, lowering fat, improving a blood rheology index, reducing urine protein or improving the creatinine clearance rate and especially has the actions on protecting the vascular endothelial cell, alleviating the damage degree of the endarterium and the like, and therefore the traditional Chinese medicine composite can be prepared into oral administration or external application products used for treating or controlling renal damage, neuropathy around limbs, high blood fat, impotence, prostatic hyperplasia, diabetes mellitus and complications, such as diabetic foot, diabetic nephropathy and diabetic retinal inflammation, and has good protecting action on the liver, the kidney, the pancreas and the intestinal mucosa.

The present invention is a kind of Chinese medicine suppository for treating colitis and its preparation process, and belongs to the field of medicine technology. The Chinese medicine suppository is prepared with astragalus root, notoginseng, frankincense, gallnut, Japanese ampelopsis and bletilla tuber in certain weight proportion, and through grinding gallnut, frankincense, bletilla tuber and notoginseng into fine powder; twice decocting astragalus root and Japanese ampelopsis, filtering the decoction, drying and crushing; mixing with supplementary material and the fine powder; and forming suppository. The Chinese medicine suppository has high curative effect on colitis, no toxicity and taking convenience.

The invention discloses a salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by a general formula I, a preparation method, a solubility characteristic and a pharmaceutical composition thereof, and application of the salicylic acid berberine type alkaloid quaternary ammonium salt compound in preparation of medicinal products. According to the invention, the salicylic acid berberine type alkaloid quaternary ammonium salt compound represented by the general formula I can be prepared by an organic synthesis method, shows obvious alcohol-water mixed solvent solubility, can be conveniently prepared on a large scale, has remarkable ulcerative colitis resisting activity, has the characteristics of no toxicity or low toxicity, and can be used for preventing, relieving and / or treating ulcerative colitis.

The invention provides a traditional Chinese medicine composition for treating trigeminal neuralgia, which comprises Codonopsis pilosula, bighead atractylodes rhizome, poria, rehmanniae radix, Chinese angelica, Ligusticum wallichii, cassia twig, Asarum Herb, dahurian angelica root, white peony root, red sage root, jujube kernel, pinellia ternate, root of large-flowered skullcap, dried orange peel, Seed of Jobs Tears, scorpion, earthworm and muscardine silkworm. The traditional Chinese medicine composition has the advantages of fast take effect, definite therapeutic effect and wide adaptation performance, and the disadvantages of non-uniform curative effect standard and syndrome differentiation and poor repeatability in the current trigeminal neuralgia treatment by traditional Chinese medicine can be overcome. The traditional Chinese medicine composition has the effect of relieving pain, and has advantages of improving whole body condition of patients, such as insomnia, inappetence and the like, and has good clinical application prospect.

The invention relates to a Chinese medicine anticancer medication for anti liver and lung cancer and preparation thereof. Said medication is prepared comprising ginseng , toad skin, whole scorpion and pore fungi as medicinal materials, whereof part by weight is , ginseng 10.8-16.2%,toad skin 16.2-27.0%,whole scorpion 16.2-27.0%,pore fungi 32.4-54.0%. Process for said inventive medication is as follows:toad skin and whole scorpion having been through over 95% alcohol extraction, extracting solution thereof being collected and ready for use, dregs thereof being combined with other components and through water extraction , combining water extraction solution with alcohol one, distilling, spraying and drying, making into pellet, packing into capsule and to obtain said medication.

The invention relates to a diabetic foot ointment. The ointment is prepared by processing the following raw materials at a certain weight ratio: pseudo-ginseng, coptis chinensis, paris polyphylla, rhizoma bletillae, Japanese ampelopsis root, cynanchum atratum, rheum officinale, centella, bullbrier, uniflower swisscentaury root, cortex phellodendri, astragalus membranaceus, scutellaria baicalensis, corydalis tuber, cape jasmine, common cissampelos herb, fructus forsythiae, rabdosia rubescens, glechoma, polygonum cuspidatum, fructus arctii, salviae miltiorrhizae, borneol, liquorice, radix berberidis, Chinese holly, senecio scandens, Chinese lobelia, scutellariae barbatae, rhizoma et radix baphicacanthis cusiae, christina loosestrife herb, herba houttuyniae, common andrographis herb, gingko leaf, dandelion, Chinese angelica, picria fel-terrae lour, beewax and non-genetically modified salad oil. More than twenty years of clinical practice prove that the ointment can be used for relieving and inhibiting pains of patients with diabetic feet, inhibiting bacteria growth content to enable bacteria to be extinct naturally, and a moistened environment is formed in the wound to facilitate rehabilitation of wound tissues, so that pains of surgical eschar and tangential excisions, amputation and toe amputation and accompanying serious injury can be avoided, and growth of epithelial tissues, granulation tissues and wound capillary vessels can be promoted.

The invention discloses an oral-administration Chinese medicinal preparation for treating nasopharyngeal carcinoma, which is prepared from astragalus root 20g, selfheal 20g, seaweed 20g, sea apron 20g, red peony root 15g, hornet nest 12g, atractylodes rhizome 12g, peach kernel 6g, dahurian angelica root 10g, arisaema with bile 6g, root of Chinese trichosannthes 10g, polygala root 6g, earthworm 6g, centipede 6g, buthus martensi kirsch 6g and licorice root 6g.

The invention relates to a traditional Chinese medicine compound preparation capable of improving hematopoietic function. The raw materials include: 30-60 parts of astragalus, 9-18 parts of angelica, 15-24 parts of Ligustrum lucidum, 15-24 parts of medlar, and 15-24 parts of curculigo 15-24 parts of Epimedium, 9-18 parts of Polygonatum, 15-24 parts of Jiao Shenqu, 15-24 parts of Jiao Hawthorn, 15-24 parts of Jiao Malt, 15-24 parts of Fried Atractylodes Rhizome, 9-18 parts of Chenpi, Poria cocos 9‑18 parts, jujube 3‑9 parts. Granules can be prepared by conventional methods. During preparation, decoct the 14 raw materials with water twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate into a clear paste with a relative density of 1.25-1.30 (60°C); dry under reduced pressure at 70°C, and pulverize into a fine powder; then add dextrin to mix, granulate; dry at 60°C to obtain. The invention replenishes qi and invigorates the spleen, nourishes blood and promotes body fluid, promotes the hematopoietic function of the body, can improve the hematopoietic function of the body, increase white blood cells, and reduce the toxic and side effects of chemotherapy drugs.

A traditional Chinese medicine composite of daphne giraldii nitsche and liquorice is characterized in that the weight ratio of bulk drugs, namely, the weight ratio of the daphne giraldii nitsche to the liquorice ranges from 3:1 to 3:2.5, the optimized weight ratio of the daphne giraldii nitsche to the liquorice ranges from 3:1 to 3:2 or 3:1.8, and the optimal ratio of the daphne giraldii nitsche to the liquorice is 3:1.5; the concentrated water of the bulk drugs is adopted to perform decoction so as to realize the further optimization, to be specific, daphne giraldii nitsche medical material coarse powder and liquorice decoction pieces are taken, and decoction are performed for two times through adding water respectively, water with the volume 10 times as large as the volume of the daphne giraldii nitsche medical material corase powder and the liquorice decoction pieces is added for decoction for 2 hours for the first time, and water with the volume 5 times as large as the volume of the daphne giraldii nitsche medical material corase powder and the liquorice decoction pieces is added for decoction for 1 hour for the second time, and the decoction water is mixed and concentrated, so as to obtain the final product. The traditional Chinese medicine composite of the daphne giraldii nitsche and the liquorice is helpful in preventing inflammation, alleviates an AA symptom, and improves the immunologic function and a tissue structure of an AA rat; the compatibility function of the daphne giraldii nitsche and liquorice is superior to the function of the single adopted daphne giraldii nitsche, and the pesticide effect of the compatibility group with the ratio being 3:2 of the daphne giraldii nitsche to the liquorice is superior to the compatibility group with the ratio being 3:1 of the daphne giraldii nitsche to the liquorice; the capability of the traditional Chinese medicine composite for reducing the content of serum inflammation cell factors as TNF-Alpha and IL-1 Beta is likely to be one of the mechanisms for treating rheumatoid arthritis.

The invention discloses an oral administration Chinese medicinal broth for treating nasopharyngeal carcinoma, which is prepared from astragalus root 30g, selfheal 30g, seaweed 30g, phlogopite each 30g, sea apron 24g, hooked uncaria 24g, red peony root 15g, hornet nest 12g, silver flower 15g, atractylodes rhizome 12g, peach kernel 6g, dahurian angelica root 6g, arisaema tuber 6g, root of Chinese trichosannthes 10g, polygala root 6g, grassleaved sweetflag rhizome 6g, earthworm 6g, centipede 6g, buthus martensi kirsch 6g and licorice root 6g.

The invention belongs to the field of biotechnology and medicines, discloses an application of MANF protein in preparation of a medicine for treating sicca syndrome. The application of the MANF protein in preparation of the medicine for treating the sicca syndrome is creatively provided, so that autoimmune diseases including primary sicca syndrome or secondary sicca syndrome can be treated; and the MANF protein has good clinical application prospects and can achieve obvious social benefits.

The invention discloses a reagent for individual detection and treatment of diabetes, a medical composition and a preparation method of the medical composition. The detection reagent is used for detecting two SNP site subtypes of metformin medication, namely an rs77474263 site of an SLC47A1 gene and an rs77630697 site of the SLC47A1 gene; the detection reagent comprises 10*TaqMan Master Mix, a 100[mu]M forward primer, a 100 [mu]M backward primer and a 100[mu]M probe; and the medical composition comprises traditional Chinese medicines and Western medicines, wherein the Western medicines are metformin hydrochloride tablets, and the traditional Chinese medicines are prepared by mixing a Chinese yam alcohol extract with a rhizoma polygonati methanol extract, a dried rehamnnia root alcohol extract, a ginseng alcohol extract, a discolorous clinquefoil root alcohol extract, a radix trichosanthis alcohol extract, a radix puerariae alcohol extract and a corn stigma water extract. The composition has cooperativity, and the glucose metabolism and the insulin sensibility of patients are notably adjusted.

The invention relates to an anti-tuberculous traditional Chinese medicine fritillary and burdock fruit tuberculosis-eliminating extractive and application and belongs to the field of traditional Chinese medicine treatment preparations. Alcohol water, water and / or alcohol are adopted to extract three extractives, adopted raw medicinal materials include, by weight, 3-5 parts of burdock fruits, 5-10 parts of common bletilla pseudobulb, 3-5 parts of fritillary fruits, 3-5 parts of platycodon grandiflorum, 3-10 parts of sticky rice and 3-5 parts of houttuynia cordata and are weighed in proportion, ethyl alcohol and / or water are / is added into the raw medicinal materials, heating is performed for reflux extraction after soaking, filtration is performed to obtain an extracting solution, pressure reduction is performed to recover a solvent, the solvent is concentrated to form thick paste, pressure-reduction drying is performed to form dry paste, and the dry paste is smashed and screened to obtain the extractive. The fritillary and burdock fruit tuberculosis-eliminating extractive serves as a traditional Chinese medicine treatment preparation and enables the weight of a mouse to be inordinately increased than the weight before the mouse is treated, and the weight is more than the weight increased by means of existing medicine powder combinations. Bacterial quantity of the spleen tissues can be remarkably decreased, the lung lesions are inordinately relieved, and a normal lung structure can be seen. The fritillary and burdock fruit tuberculosis-eliminating extractive is better than existing medicine powder in overall treatment effect and can be used for preparation of medicines for treating tuberculosis of patients.

The invention discloses a traditional Chinese medicine for reducing the side effects of chemotherapy and a preparation method. The traditional Chinese medicine is prepared from the following major active pharmaceutical ingredients in parts by weight: 20-30 parts of radix astragali, 10-20 parts of fructus lycii, 9-15 parts of fructus leonuri, 10-16 parts of radix puerariae, 10-16 parts of concha arcae, 8-12 parts of fructus aurantii, 6-15 parts of trichosanthes kirilowii, 8-16 parts of drumfish bladder, 9-12 parts of herba salviae chinensis, 9-15 parts of hedyotis diffusa, 10-15 parts of radix glycyrrhizae, 6-10 parts of japonese pearlwort herb and 5-9 parts of hericium erinaceus. Through the traditional Chinese medicine disclosed by the invention, the pain of a patient can be relieved, the survival time of the patient is effectively prolonged, and the quality of life is improved; the immune function of the body can be enhanced, and general conditions of the patient can be obviously improved; and in cooperation with chemotherapy, the toxic and side reactions of chemotherapy can be obviously relieved so as to improve the tolerance of the patient to the chemotherapy and promote successful implementation of chemotherapy.

The invention discloses a Chinese medicinal preparation for treating cervical cancer, which adopts a method of addressing both the symptoms and root causes to strengthen body resistance and eliminate evil, relieve the pain and fulfill the aims of treating the cervical cancer by inhibiting the proliferation of cancer cells and killing the cancer cells. Based on a hereditary secret formula and Chinese medicinal and pharmacologic theory, through years of clinical practice, the medicament is prepared by blending components according to the composition principle of monarch, minister, assistant andguide of Chinese medicinal prescriptions, wherein danshen root, airpotato yam rhizome, nidus vespae, turtle shell and myrrh are taken as monarch medicaments; cattail pollen, trogopterus dung, common monkshood mother root, folium artemisiae leaf and Indian mockstrawberry herb are taken as ministerial medicaments; and Japanese thistle herb or root, vietnamese sophora root, placenta hominis, common selfheal fruit-spike and scorpion are taken as adjuvant medicaments; and centipede, toad skin, stiff silkworm, gecko, sanguisuga and musk are taken as guiding medicaments, so that the Chinese medicinal preparation is prepared by scientific compatibility and preparation process.

The invention belongs to the technical field of medicines, and relates to a new medical application of 2,3-indolequinone, and in particular relates to an application of 2,3-indolequinone in preparation of a medicine for treating or preventing atherosclerotic cardiovascular and cerebrovascular diseases. Pharmacological experiment results show that the 2,3-indolequinone can significantly improve atherosclerosis injury of apoE- / -mice. The 2,3-indolequinone can reduce the content of macrophages in atherosclerotic plaques, the content of smooth muscle cells is increased, the lipid content is reduced, and the plaque stability is obviously improved.

The invention discloses an immunoadjuvant based on diffuse large B-cell lymphoma of a chemotactic factor CCL20 and an application of the immunoadjuvant. Target ODN of a total-phosphorothioate chemotactic factor CCL20mRNA 3'UTR is used as the immunoadjuvant to be applied to the diffuse large B-cell lymphoma. The immunoadjuvant exerts favorable antitumor effects on DLBCL in vivo and in vitro research, and through co-hatching of the immunoadjuvant and DLBCL cells, the cell proliferation rate of the DLBCL can be obviously reduced; after the immunoadjuvant and inactivated tumor cells are mixed forlocal injection, the general information of mice is favorable, and the mice do not have abnormal conditions of convulsions, disturbance, pilo-erection, twitch and the like. The immunoadjuvant does nothave abnormal phenomena of red and swollen, inflammation, ulceration, scleroma and the like in local injection parts. The mice without bearing cancer do not have the death phenomenon, the immunoadjuvant is promoted to be a DLBCL immunoadjuvant, can be used for clinical treatment, and has wide prospects.

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating pancreatic fibrosis and application thereof. The traditional Chinese medicine composition is mainly prepared from the following components in parts by weight: 10-60 parts of processed rhizoma pinelliae, 10-60 parts of processed rhizoma arisaematis, 5-60 parts of pericarpium citri reticulatae, 5-60 parts of poria cocos, 5-60 parts of endothelium corneum gigeriae galli, 1-30 parts of curcuma zedoary and the like. Cell experiments prove that the traditional Chinese medicine composition can be used for inhibiting PSC cell activation of rats and lowering to cause fibrosis factor expression; animal experiments prove that the composition can be used for improving the general condition of pancreatic fibrosis rats, increasing body weight, inhibiting expression of fibrosis promoting factors, improving anti-fibrosis factor expression and remarkably alleviating the pancreatic fibrosis degree of the rats; and clinical experiments prove that abdominal pain, diarrhea, dyspepsia and other symptoms caused by pancreatic fibrosis of patients can be quickly improved, and chronic pancreatitis and pancreatic fibrosis can be effectively treated. The traditional Chinese medicine compound preparation has the characteristics of no toxicity and long-term taking availability, and has a wide market prospect.

An oral medicine for treating sores and ulcers, which is prepared by conventional preparation method from traditional Chinese medicine raw materials in proportions of 30-60 parts by weight of astragalus, 10-30 parts of angelica, 10-20 parts of honeysuckle and 10-20 parts by weight of saponins. Pharmacodynamic tests show that the medicament of the present invention can significantly shorten the wound healing time of animal models of wound infection after burns and trauma, reduce local inflammatory reactions, promote tissue regeneration, and have a strong muscle-inducing function; Qi and blood function and heat-clearing and detoxifying effect; it has obvious inhibitory effect on rat paw swelling caused by carrageenan and mouse auricle swelling caused by xylene, and can reduce the damage of rat granulation tissue caused by cotton balls. Formation; can significantly reduce the number of mouse writhing reactions caused by acetic acid, and can obviously increase the tolerance time of mice to pain caused by thermal injury, indicating that the medicine of the present invention has better anti-inflammatory and analgesic effects.