The present invention discloses a preparation for gout, soft tissue injury and rheumatalgia, and a preparation method thereof, wherein the preparation comprises the following raw materials by weight: 20-40 parts of clematis chinensis osbeck, 20-60 parts of zanthoxylum nitidum, 10-30 parts of cremastra appendiculata, 20-40 parts of panax notoginseng, 20-60 parts of angelica sinensis, 60-100 parts of curcuma longa l, 20-40 parts of cape jasmine, 10-30 parts of safflower, and 10-30 parts of rhizoma paridis. According to the present invention, the preparation has effects of heat clearing, blood cooling, wind evil expelling, dampness removing, blood circulation activation, blood stasis removing, tendon relaxing and activating, swelling subsiding and pain stopping, can provide good treatment effects for gout, soft tissue injury and rheumatalgia, and further has characteristics of convenient use, safety, no toxicity, and no side effect; and the preparation method has characteristics of simple process, low production cost and low energy consumption, and is suitable for industrial production.