397 results about "Nanogel" patented technology

Provided are compositions comprising a block copolymer of the following formula: [A]-B-[Q], wherein [A] is a polymer that has an affinity for a substrate; B is a linking group comprising an optionally-substituted, polyvalent linking group having a molecular weight of no more than 1000 g / mole; and [Q] comprises a semi-crosslinked, ungelled polymer derived from copolymerization of an ethylenically unsaturated monomer with a poly-functional ethylenically unsaturated monomer. Such block copolymers are cross-linked via the [Q] segment, but not macroscopically gelled. The [Q] segment is hydrophilic and has a degree of polymerization in the range of about 10 to about 10,000. The [A] segment is located on at least one terminal end of said block copolymer, comprises between about 1 and about 200 repeating units. The block copolymer is associated, via the linear substrate associative segment with a surface comprising at least one hydrophobic site, such as a silicone hydrogel. The polymers may be incorporated into a formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post-formation.

The invention discloses a compound reverse osmosis membrane with interpenetrating network desalting layer and a preparation method of the membrane. The desalting layer consists of a stereoscopic network which is formed by interpenetrating macromolecule nanogel and polyamide. The preparation method comprises the following steps of: pre-adding hydrophilic and / or oleophylic macromolecule nanogel with good dispersion into a solvent of solution A and / or B, preparing a water phase A solution containing m-phenylenediamine and / or p-phenylenediamine, preparing an organic phase B solution containing trimesoyl chloride, enabling the solution A and the solution B to fully contact on a porous support carrier for interface reaction, rinsing by using deionized water, carrying out moisturizing treatment by using glycerol, and drying. The compound reverse osmosis membrane disclosed by the invention has a sodium chloride removal rate of not less than 99% and a flux of not less than 25GFD (Geophysical Fluid Dynamics) under a pressure of 225psi; the microstructure and the charge property of the desalting layer can be regulated and controlled through the macromolecule nanogel so that the reverse osmosis membrane with high anti-pollution capability is prepared; and the compound reverse osmosis membrane can further be used for developing novel low-pollution reverse osmosis membranes.

The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. Reversible nanogels can also be formed from a dilute solution of the copolymers. The hydrogel is formed with nanoparticles embedded therein to form a nanocomposite whose refractive index and modulus can be controlled by varying the amounts of nanoparticles and the polymer concentration of the hydrogel, respectively

The present invention includes a method for preparing polymer hydrogel spherical particles on a nanometer scale (nanogels). The method includes encapsulating hydrogel-forming components into liposomes, diluting the large unilamellar liposomes suspension to prevent polymerization outside the liposomes, and polymerizing the encapsulated hydrogel-forming components. The lipid bilayer may be solubilized with detergent. The phospholipid and detergent molecules and their micelles may then be removed by dialysis. The resulting nanogels may then be dried by evaporation in a temperature gradient. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) hydrogel particles with a diameter from 30 to 300 nm were detected and characterized by dynamic light scattering technique. The solvent, temperature, pH, and ionic sensitivities of the nanogels were studied.

The invention discloses a novel method for preparation of a chitosan nano carrier and functionalization thereof, which relates to the chitosan nano carrier. The invention provides a novel method for preparation of the chitosan nano carrier and functionalization thereof. The chitosan is dissolved in acetic acid solution, meanwhile, pH is adjusted to 4.5-5.5 with NaOH solution, STPP (sodium tripolyphosphate) solution is added to the chitosan solution to obtain nanogels, then, crosslinking glutaraldehyde is provided for the chitosan, centrifugation is conducted after ending of reaction, reduction reaction is conducted with excess sodium borohydride, then centrifugation is conducted again, then, the obtained compound is dispersed in hydrochloric acid solution to remove the unreacted sodium borohydride, then dialysis is conducted, in order to wash STPP to obtain nanoparticles; the folic acid is weighed to be dissolved in the phosphate buffer solution, then the solution is added to chitosan nanoparticles water solution, after adding EDCI to the solution, folic acid modified nanoparticles are obtained through reaction; PEG succinimidyl propionate is weighed to be dissolved in the phosphate buffer solution, then is added to the chitosan nanoparticles water solution, after reaction, PEG modified nanoparticles are obtained.

The present invention is generally directed to novel polymeric mateirals for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating such novel polymers, and related methods of their use.

The invention relates to a preparation method of ferric oxide nanoparticle supported sodium alginate nanogel. The preparation method comprises steps as follows: (1), PEI (polyethylenimine) coated Fe3O4 nano-particles (Fe3O4-PEI) are synthesized with a hydrothermal method; (2), an aqueous solution of sodium alginate is firstly activated by EDC (carbodiimide) and has a double emulsion reaction to form a W / O / W polymer emulsion; (3), Fe3O4-PEI in the step (1) is taken as a crosslinking agent and added into the polymer emulsion in the step (2) to have a crosslinking reaction, and the ferric oxide nanoparticle supported sodium alginate nanogel is obtained after an organic solvent and a surface active agent are removed. The method is very simple, and operation and separation are easy; meanwhile, sources of raw materials are extensive; the prepared sodium alginate nanogel has a smaller grain diameter, is uniformly distributed, high in relaxation rate and low in cost, has a remarkable radiography effect, simultaneously has excellent water solubility, gel stability, biocompatibility and blood compatibility, doesn't have a harmful effect on a living body, and has potential application value in the magnetic resonance imaging diagnosis field.

The invention discloses a chitosan nanogel immobilized capsule preparation technology used for oral drug delivery and discloses a method for preparing composite chitosan nanogel immobilized multi-layer capsules. The method comprises the step of fixing chitosan-carboxymethyl chitosan composite nanogel which is uniformly dispersed in an aqueous solution to multi-layer sodium alga acid capsules through an ionotropic gelation process. The multi-layer capsules have high pH responsiveness and are stable in structure in a gastric acid environment, and complete nanogel can be rapidly released in a neutral and faintly alkaline intestinal environment. The composite chitosan nanogel can be effectively prevented from being disintegrated in advance in the acid environment, and the oral drug delivery efficiency is improved. The method can be used for medical biological materials and drug carriers and has high research and development and utilization prospect.

The invention relates to an immobilized ionic liquid catalyst and application thereof. The immobilized ionic liquid catalyst has a general structural formula as defined in the specification. In the general structural formula, P is a nanogel resin matrix; n is an integer in a range of 2 to 12; and M<-> is a negative ion selected from a group consisting of a trifluoromethanesulfonate group, a p-toluenesulfonate group, a benzenesulfonate group, a methanesulfonate group, a tetrafluoroborate group and a hexafluorophosphate group. The immobilized ionic liquid catalyst can be applied to industrial olefine acid addition for preparation of corresponding esters.

The invention discloses a preparation method of pH responsive cation nanogel. The preparation method comprises the following steps: lauryl sodium sulfate and polyethylene glycol dimethyl acrylic ester are sufficiently dissolved in water to prepare a water-phase solution, ethylene glycol dimethacrylate and cationic monomer methylacrylic acid-(N, N-diethyl amine) ethyl ester or 2-(diisopropyl amino) ethyl methacrylate are uniformly mixed to obtain a mixture, and then the mixture is added into the water-phase solution to prepare microemulsion, and a water solution with an initiator is added in the microemulsion to react for 20-24 h to obtain the pH responsive cation nanogel dispersion liquid. The nanogel prepared has good pH responsiveness and dispersion stability, can be placed stably for more than 3 months, and the number-average grain size of the nanogel is smaller than 100 nm.

The invention belongs to the field of crop fertilizer and particularly relates to compound fertilizer synergist modified by oxidized graphene and a preparation method of the compound fertilizer synergist. The compound fertilizer synergist is prepared from, by weight, 70-80 parts of forestry and agricultural residues, 10-20 parts of a modifying agent, 0.5-1 part of a catalyst, 1-5 parts of stabilizer, 5-10 parts of cyclodextrin and 0.3-0.5 part of the oxidized graphene. The preparation method includes the steps that plasma illumination is utilized to conduct bombardment on the surfaces of forestry and agricultural residues, hydroxide radicals, carbanyl groups, carboxyl and other functional groups containing oxygen are introduced into the surfaces of the forestry and agricultural residues, then polymerization with water-soluble polymer modifier occurs under the action of high-field-intensity ultrasound waves, stable nanometer gel particles of three-dimensional network structures are formed, after modification with the oxidized graphene and cyclodextrin is completed, high adsorption, complexing power and a water-retaining property are achieved, nutrient elements in soil can be subjected to complexing, losing of fertilizer nutrients is reduced, the water retention and fertilizer retention performance of soil is improved, and the utilization rate of compound fertilizer can be remarkably raised. The compound fertilizer synergist has the advantages of being environmentally friendly, free of pollution, capable of raising the utilization rate of fertilizer and improving soil environment and the like.

A film-forming composition comprises a solvent and unimolecular nanoparticles of a self-crosslinkable nanogel star polymer. The nanogel star polymer comprises i) a crosslinked polymer core (nanogel core) and ii) 6 or more independent polymer arms covalently linked to the core by respective first end groups. A plurality of the arms comprise reactive groups for effecting crosslinking of the nanoparticles. An essentially solvent-free film layer comprising the nanoparticles self-crosslinks, optionally assisted by subjecting the film layer to a thermal treatment and / or a photochemical treatment. A surface treated article comprising the crosslinked film layer can effectively inhibit growth of and / or kill Gram-negative microbes, Gram-positive microbes, fungi, and / or yeasts.

The invention belongs to the field of a pharmaceutical preparation and discloses a method and a device for rapidly preparing a vesica (including liposome) with inner and outer water phase gradient difference in a large scale, and an application thereof. According to the device and the method disclosed by the invention, a membrane separation mechanism, and an ion exchanging and adsorption mechanism are ingeniously combined; and when the property, the ion gradient type and the preparation scale of the vesica with the needed gradient are different, a membrane separation device and an ion exchanging device, which have the different performances, are combined. With the adoption of a membrane separation method, cations, anions, zwitter ions and / or charge macromolecular substances in a vesica mixed suspension hydrated medium are distributed into a dialysis medium; and an ion exchanging method is used for selectively exchanging or cleaning the cations, the anions, the zwitter ions and / or the charge macromolecular substances in the dialysis medium, so that the vesica can establish the greater inner and outer water phase gradient difference in shorter time. The method and the device can be applied to preparing liposome gel, magnetic liposome, and nano grain / nano gel.

The invention belongs to the field of pharmaceutical preparations and discloses vesicles with inner and outer aqueous-phase gradient difference. The vesicles are prepared by treating blank vesicles by adopting an ion exchange method or combining the ion exchange method and a dialysis method or an ultrafiltration method. The invention also provides a preparation method and application of the vesicles; and the preparation method comprises the following steps of: preparing the blank vesicles; treating the prepared blank vesicles by using an ion exchanger; and performing elution treatment so as to prepare the vesicles with inner and outer aqueous-phase gradient difference. The prepared vesicles can be mixed with medicinal solution to realize active medicament carrying so as to prepare the pharmaceutical preparations. The prepared preparations also can be subjected to ion exchange treatment or freeze-drying treatment. The provided vesicles have higher inner and outer aqueous-phase gradient difference, can realize ion gradient medicament carrying of the vesicles and achieve higher encapsulation rate; meanwhile, the preparation method is simple and is low in cost, and the vesicles can be better applied to preparing liposome gel, magnetic liposome and nanoparticles / nanogel.

Provided herein are methods of inhibiting proliferation of one or more tumor cells comprising contacting the one or more tumor cells with a composition comprising one or more epigenetic drugs that inhibit one or more epigenetic mechanisms of the tumor cells, wherein the one or more epigenetic drugs are encapsulated in a nanogel. The invention is also directed to methods of treating a tumor, metastasis of a tumor or a combination thereof in an individual in need thereof. The invention is also directed to a method of sequentially delivering one or more epigenetic drugs that alter one or more epigenetic mechanisms of a tumor cell and one or more chemotherapeutic drugs to an individual that has a tumor. Compositions which comprise one or more epigenetic drugs that alter one or more epigenetic mechanisms of a tumor cell, wherein the one or more epigenetic drugs are encapsulated in a nanogel.