81 results about "Acute injury" patented technology

Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition are treated with the substantially homogenous cells populations which co-express CD49c, CD90 and telomerase. In another embodiment, committed progenitor cells are made are made by selecting from a cultured source of a cell population which co-express CD49c and CD90 and modifying the cell population. The committed progenitor cells can be employed to treat a human suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition and formulate pharmaceutical compositions.

We disclose a new and useful biomarker for acute kidney injury (i.e., AKI), renal ischemia reperfusion injury (i.e., IRI), ischemic acute kidney injury, and / or ischemic acute tubular necrosis (i.e., ATN). The biomarker is GRO-alpha (i.e., CXCL1, chemokine C-X-C ligand 1, GRO1, GROa, MGSA, MGSA alpha, MGSA-a, NAP-3, SCYB1). We detected the biomarker using a QUANTIKINE® human GRO-alpha immunoassay (Cat. No. DGR00, R & D Systems, Minneapolis, Minn.). In addition, we disclose a method of treating lung damage.

KATP channel closers (KCCs) are useful for the prophylactic and / or therapeutic treatment of a CNS acute damage in a mammal, including a human, because their administration, particularly in the case of glibenclamide, potientates the neuroprotector microglial effect. Therefore, they may be useful in treating the acute phase of CNS diseases such as stroke, seizure, axonal injury, traumatic damage, neurodegeneration, spinal cord injury, infectious and autoimmune CNS diseases. KCCs, isotopically modified, are also useful for the preparation of diagnostic agents for detection and follow-up of CNS acute damage.

The invention relates to a bacterial cellulose (BC) based antibacterial dry film applied to acute injury, comprising the following components: a BC dry film and an antibacterial agent, wherein the drug loading rate of the BC based antibacterial dry film is 0.0114-0.2027mg / cm2. A preparation method of the BC based antibacterial dry film comprises the steps of: after implanting production strains of the BC into a seed culture medium for propagation culture, transplanting the strain to a fermentation medium for static culture, obtaining a BC wet film for soaking and water-bath, cutting the wet film into sheets for drying, dipping the sheets in a prepared antibacterial agent solution for the secondary drying to obtain the BC based antibacterial dry film. In the invention, the BC based antibacterial dry film has the advantages of light and soft texture, good biocompatibility, high hygroscopicity, good air permeability, durable antibiotic property and the like; in addition, the preparation method is simple, convenient and easy in operation and has low cost; in the practical application process, the BC based antibacterial dry film can be sheared into any shapes, is not adhered, does not irritate to skin, can be rapidly degraded in the environment after being abandoned, and can be taken as a green and environment-friendly functional antibacterial dressing.

The invention relates to the usage of pirfenidone for treating hepatic injury and necrosis and acute lung injury, more specifically the invention relates to the application of pirfenidone in abatement of symptoms for patients with hepatic injury, necrosis and acute lung injury, and in lowering mortality rate. The invention also provides the medicinal composition for treating hepatic injury, necrosis and acute lung injury.

Methods and compositions comprising antagonists of αvβ6 are provided for the treatment of acute lung injury fibrosis.

The present invention discloses a flexible neural electrode and an implantation method of a flexible neural electrode. The flexible neural electrode comprises a flexible substrate, a flexible insulation layer and a conductive layer and a magnetic material layer which are located between the flexible substrate and the flexible insulation layer. The conductive layer comprises at least one conductivewire, each conductive wire comprises one interconnection wire and one record site and one welding spot which are respectively located at two ends of each interconnection wire; the magnetic material layer comprises a plurality of magnetic material portion which are in one-to-one correspondence with the interconnection wires of a first portion; at least one through hole is formed on the flexible insulation layer, the through holes are in one-to-one correspondence with the record sites, and the through holes penetrate the flexible insulation layer to expose the corresponding record sites. The flexible neural electrode has magnetism and can be implanted to the cerebral cortex under the traction effect of the magnetic field force so as to allow the implantation of the flexible neural electrodenot to influence the large acute injury of the brain tissue.

Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition are treated with the substantially homogenous cells populations which co-express CD49c, CD90 and telomerase. In another embodiment, committed progenitor cells are made are made by selecting from a cultured source of a cell population which co-express CD49c and CD90 and modifying the cell population. The committed progenitor cells can be employed to treat a human suffering from a degenerative, traumatic, acute injury cardiac or neurological condition and formulate pharmaceutical compositions.

The injection preparation for treating acute lung injury and acute respiratory distress syndrome is bacteria-free freeze dried powder for injection with Sivelestat as active component, stuffing frame agent, co-solvent and pH regulator. It has improved water solubility of Sivelestat and improved medicine stability.

A method to speed recovery from acute injury and / or reduce and prevent chronic inflammation in an animal or human is disclosed. The method includes providing a grounded plane, conductively coupling said animal or human to the grounded plane to conduct the earth's mobile negative surface charge of free electrons from the earth to said animal or human in order to provide the body with an abundant supply of free electrons to reduce residual immune system produced reactive oxygen specie free radicals and prevent the same from oxidizing healthy tissue and exhibiting chronic inflammation in said animal or man. Applying earth's free electrons to the human body for prevention of chronic inflammation and therapeutic reduction of inflammation is described. Further described are methods to apply and maintain earth's mobile free electron charge on an animal or human while residing in modern home or work environments or in a treatment facility.

The invention relates to lignans lizardtail ketone enantiomorph which is expressed by the following formula (1), a method for preparing the compound and the application in the aspect of protecting liver. The method is characterized in that Saururus Chinensis (Lour.) bail1 is refluxed and extracted by methanol or ethanol; after the methanol or the ethanol is recycled, the extract is placed at the room temperature; after being separated and dried, the separated precipitation is dissolved by the mixed solvent of chloroform and methanol, and then silicagel column chromatography is carried out; sherwood oil-ethyl acetate is taken as eluant, and gradient elution is carried out from 20:1-3:1; flow separation with the rf value of 0.5 is carried out on collecting thin-laver chromatography by using the sherwood oil-ethyl acetate with the volume ratio of 10:1, the separated granularcrystaline is placed, and the product is obtained by recrystal. The experiment proves that the compound of the invention has better protective function for liver which is suffered from acute injury. Formula (1).

The invention relates to the technical field of medicines, and particularly relates to cryptotanshinone for preventing and treating pulmonary fibrosis and an application thereof. The cryptotanshinone (I) is quinone diterpene extracted from the root part of salviae miltiorrhizae; the modern pharmacological research shows that the cryptotanshinone has a bacteriostatic effect, an anti-inflammatory effect and a hormone-like pharmacologic effect, and is clinically used for treating myocardial fibrosis, lung acute injury and arthritis, can be used for preventing and / or treating a pulmonary fibrosis disease, can also be used for preparing medicines for reducing body weight of a pulmonary fibrosis rat, a lung coefficient and the content of hydroxyproline in tissue and can be used for preparing the medicines for reducing the content of IL-1beta, IL-6 and TNF-alpha in a bronchoalveolar lavage liquid and the medicines of effecting the pathogeny structure of pulmonary fibrosis tissue of the rat. The formula (I) is as shown in the specification.

The invention relates to a bacterial cellulose (BC) based antibacterial dry film applied to acute injury, comprising the following components of a BC dry film and an antibacterial agent, wherein the drug loading rate of the BC based antibacterial dry film is 0.0114-0.2027mg / cm<2>. A preparation method of the BC based antibacterial dry film comprises the steps of: after implanting production strains of the BC into a seed culture medium for spreading cultivation, transplanting the strains to a fermentation medium for static culture, obtaining a BC wet film for soaking and water-bath treatment, cutting the wet film into sheets for drying, dipping the sheets in a pre-prepared antibacterial agent solution for secondary drying to obtain the BC based antibacterial dry film. In the invention, the BC based antibacterial dry film has the advantages of light and soft texture, good biocompatibility, high hygroscopicity, good air permeability, long-lasting antibiotic property and the like; in addition, the preparation method is simple, convenient and easy in operation and has low cost; in the practical application process, the BC based antibacterial dry film can be sheared into any shape, is not adhesive, has no irritation on skin, can be rapidly degraded in the environment after being abandoned, and can be taken as a green and environment-friendly functional antibacterial dressing.

The invention discloses a composition for treating acute injury of soft tissue. The composition is prepared from Chinese angelica, divaricate saposhnikovia root, hovenia dulcis, thunberg fritillary bulb, anemarrhena, rhizoma arisaematis (processed), snakegourd fruit, angelia and safflower. The composition disclosed by the invention has the effects of regulating qi, activating blood and resolving stasis and subsiding swelling and reliving pain, is used for treating acute injury of the soft tissues such as chest, waist and back, limbs and the like, and can be made into capsules which are convenient to carry and use by the patients. The composition disclosed by the invention is proved to be safe and effective by pharmacodynamics and toxicological experiments as well as clinical trials.

The invention relates to a plasma substitute and a preparation method thereof. The plasma substitute comprises vesicles, hydroxyethyl starch and an isoosmotic adjusting agent. Blood volume is replenished while the blood oxygen supply is maintained, so that the plasma substitute can be used for treating anaemia, fainting, shock and acute injury.

The present invention provides compositions, formulations and methods for treating liver diseases related to tissue inflammation and progressive fibrosis, e.g., progressive liver fibrosis following either chronic or acute injury. The compositions of the invention provide the use of therapeutic agents as an adjunct therapy to transplantation of cell populations capable of effecting liver repair.

The invention discloses a pedestrian protection safety system for vehicles and a control method, and relates to the field of vehicle safety. The pedestrian protection safety system comprises an image acquiring device, an image processing device, a safety net and a controller. The image acquiring device is used for acquiring the images in front of the vehicles. The image processing device is used for judging whether pedestrians exist or not in front of the vehicles. The safety net is surrounds a front compartment of the vehicles and the side face of a passenger compartment after being unfolded. The controller is arranged to control the safety net to be unfolded when it is judged that pedestrians exist in front of the vehicles. The invention further provides the corresponding control method. The safety net is arranged, at the moment that the vehicles and the pedestrians collide and then drivers are thrown out of the vehicles, and the safety net is quickly unfolded between a vehicle wheel fender and an pillar A, so that protection is achieved between the ground and the heads of the pedestrians. The heads of the pedestrians are in contact with the safety net first, and then the pedestrians fall into the ground after a large amount of collision energy is buffered. Accordingly, the acute injury degree due to the hitting to the heads of the pedestrians is effectively lowered.

Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of Δ6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain inflammatory disorders and chronic degenerative diseases characterized by neuronal loss and chronic pain including neuropathic pain.

The invention relates to a low-damage implanted nerve electrode. The low-damage implanted nerve electrode comprises a base portion, a connecting portion and a handle portion; flexible hinges are connected between the base portion and the connecting portion; and one end of the handle portion is connected with the connecting portion. According to the low-damage implanted nerve electrode of the invention, the base is designed based on a flexible mechanism design ideal, and therefore, coupling degree between the electrode and an brain tissue interface can be enhanced, and fretting damage caused by long-term contact between the electrode and a nerve tissue can be decreased in a multi-degree-of-freedom manner; the front end of the handle is designed to a semicircle corner, so that fretting damage can be further reduced; and the exterior of the electrode is provided with an outwards-protruding streamline degradable coating, so that electrode implantation damage can be reduced. The implantation shape of the electrode and the fretting working state shape of the electrode do not interfere each other; acute injuries are smaller when the electrode is implanted; when the electrode works for a long time, fretting damage can be decreased in a plurality of directions; damage to nerve cells can be decreased through the integration of many aspects; the reliability of the micro electrode can be improved; and the nerve electrode can be left in vivo for a long term stably.

The present invention relates to a Chinese medicine for curing acute injury of the muscle and tendon, and it is made up by using 12 Chinese medicinal materials of notoginseng, dragon's blood, myrrh, frankincense, corydalis tuber, pyrite and others through the processes of pulverizing, decoction, filtering, concentration, drying, granulating and capsulizing to obtain the invented product. Said invented capsule possesses the functions of promoting blood circulation, removing stasis and stopping pain, and its total effective rate is up to 95%.

The invention relates to a medical cold compress bandage and a production method thereof. The medical cold compress bandage consists of a cold compress agent and a fabric for carrying the cold compress agent, wherein the cold compress agent consists of borneol, camphor, menthol and derivatives of menthol, N,2,3-trimethyl-2-isopropyl butyrylamide, plant essential oil, glycerol, ethanol, a thickening agent, a solubilizing agent and a preservative. The medical cold compress bandage provided by the invention is preserved at normal temperature, is convenient to carry and convenient and safe to use, and can last for more than 2 hours at once cold compress; the medical cold compress bandage provided by the invention has the functions of pressurizing, binding and fixation, has a good effect on detumescence, pain relieving and hemostasis in cold compress 48 hours before surgery of noninvasive acute injury and closed fracture, and the pain relieving effect is superior to that of an ice bag.

We disclose a new and useful biomarker for acute kidney injury (i.e., AKI), renal ischemia reperfusion injury (i.e., IRI), ischemic acute kidney injury, and / or ischemic acute tubular necrosis (i.e., ATN). The biomarker is GRO-alpha (i.e., CXCL1, chemokine C-X-C ligand 1, GRO1, GROa, MGSA, MGSA alpha, MGSA-a, NAP-3, SCYB1). We detected the biomarker using a QUANTIKINE® human GRO-alpha immunoassay (Cat. No. DGR00, R & D Systems, Minneapolis, Minn.). In addition, we disclose a method of treating lung damage.

Erythropoietin (Epo), a member of the cytokine superfamily, is a pluripotent molecule that is involved in a number of signal transduction pathways that include the stimulation of the production of red blood cells and the protection of the central nervous system from acute injury and ischemia. The invention is the discovery of Epo and the Epo receptor in the peripheral nervous system where it can act as a neuroprotective agent. The invention is also a method of use for the treatment of neuropathic pain and to increase the rate of healing from nerve injury comprising administration of Epo.

The present invention provides isolated or synthetic peptides derived from the d subunit of mammalian F1Fo ATP synthase (dF1Fo) protein for the purposes of tissue protection and improved energy production following acute injury from ischemia / reperfusion or other toxic insults, or in chronic diseases such as diabetes and cancer. The major focus of the patent protection will be 2 peptides comprising an amino acid sequence having at least 75% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 2 and pharmaceutical compositions thereof. However, additional peptide sequences within the dF1Fo protein may also have efficacies in these disease states and therefore all peptides shown in the Figures of this application (combined with the HIV-Tat protein transduction, COIV mitochondrial targeting and Flag domains) are included for their efficacies in these conditions.

The invention relates to a substrate improver for the fishery industry. The substrate improver is prepared from 50% of sodium percarbonate, 40% of zeolite powder, 5% of ferrous chloride and 5% of carboxymethyl cellulose. A preparation method of the improver comprises steps as follows: 1000 kg of raw materials are weighed in percentage by weight; ferrous chloride or ferrous sulfate with weight thesame as that of ferrous chloride is added to 150 L of water and dissolved, and a ferrous chloride solution is obtained; the obtained ferrous chloride solution is mixed with the zeolite powder, and a mixture is sufficiently stirred and dried; the dried ferrous chloride and zeolite powder mixture is sufficiently mixed with sodium percarbonate and carboxymethyl cellulose in sequence and uniformly stirred, and preforming treatment is performed. The substrate improver and the preparation method have the beneficial effects as follows: the cost is lower, the oxidizing ability is strong, the application effect is remarkable, the action time is short, the probability of causing acute injuries on cultured species is low and the like.

Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of Δ6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain inflammatory disorders and chronic degenerative diseases characterized by neuronal loss and chronic pain including neuropathic pain.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating scalds. The traditional Chinese medicine consists of the following raw material components: 300-800 parts of vegetable oil, 100-150 parts of yellow wax, 50-100 parts of borneol and 10-50 parts of carbonized hair. The scald-treating medicine is specially used for treating various acute injuries of department of surgery such as burns, scalds and the like; the medicine that various medicinal materials are properly matched is significant in curative effect and good in prognosis effect, and the medicine is capable of treating the scalds timely without leaving a scar; renascent skin has pores, pain in patients is low and repeated injury to the patients is avoided. The invention also provides a preparation method of the traditional Chinese medicine for treating the scalds, and the method is simple in preparation process and easy to master. The invention also provides application of the traditional Chinese medicine for treating the scalds in treating hemorrhoids.

The present invention relates to a preparation method of H2 receptor antagonist compound salt and its application. The optimized H2 receptor antagonist is famotidine, and the optimized metal ions forming compound salt are bismuth and ammonium. Said compound salt is applicable for curing gastrointestinal disorder, specially for curing gastroduodenal diseases. It also has the stronger protecting action for rat acute injury of gastric mucosa due to ethyl alcohol, and has the action of raising gastric juice acidity and reducing gastric acid secretion for gastric secretion due to pyloric ligation.

The invention relates to a medical cold compress bandage and a production method thereof. The medical cold compress bandage consists of a cold compress agent and a fabric for carrying the cold compress agent, wherein the cold compress agent consists of borneol, camphor, menthol and derivatives of menthol, N,2,3-trimethyl-2-isopropyl butyrylamide, plant essential oil, glycerol, ethanol, a thickening agent, a solubilizing agent and a preservative. The medical cold compress bandage provided by the invention is preserved at normal temperature, is convenient to carry and convenient and safe to use, and can last for more than 2 hours at once cold compress; the medical cold compress bandage provided by the invention has the functions of pressurizing, binding and fixation, has a good effect on detumescence, pain relieving and hemostasis in cold compress 48 hours before surgery of noninvasive acute injury and closed fracture, and the pain relieving effect is superior to that of an ice bag.

The invention discloses a Chinese giant salamander beverage. Active peptides of Chinese giant salamander as a raw material react with oyster polysaccharides and black chokeberry lyophilized powder togenerate two reaction substances, and the two reaction substances are reasonably blended with blackcurrant lyophilized powder, black chokeberry lyophilized powder, blueberry lyophilized powder, lemonlyophilized powder and pectin to obtain the Chinese giant salamander beverage having good color, character and taste; the Chinese giant salamander beverage also has the effects, such as quick sobering, evident relief to hepatic tissue acute injury due to ethanol, fatigue resistance, and oxidation resistance.