874 results about "Micro electrode" patented technology

An electrophysiology medical probes, which may be incorporated into a system and used to perform an electrophysiology procedure, is provided. The medical probe comprises an elongated member (e.g., a flexible elongated member), and a metallic electrode mounted to the distal end of the elongated member. In one embodiment, the metallic electrode is cylindrically shaped and comprises a rigid body. The medical probe further comprises a plurality of microelectrodes (e.g., at least four microelectrodes) embedded within, and electrically insulated from, the metallic electrode, and at least one wire connected to the metallic electrode and the microelectrodes.

A microelectrophoresis chip comprises a substrate in which there are formed one or more channels, one channel for each sample to be evaluated. The channels extend for the length of the chip, a distance of generally around 1 cm, and are about 1 to 10 mum wide and 1 to 10 mum in depth. The channels are filled with a homogeneous separation matrix which acts as an obstacle to the electrophoretic migration of the charged molecules. Microelectrodes disposed in the channels are used to induce an electric filed within the homogeneous separation medium. When a voltage is applied across two or more of the microelectrodes, the charged molecules are induced to move and separate according to the electric field density, the type of solvent film, and the charge, shape and size of the charged molecule. The chip may further comprise detectors, such as light polarization detectors, fluorescence emission detectors, biosensors, electrochemical sensors or other microcomponents which may include sites for enzymatic or chemical manipulation of the moved or separated charged molecules.

A micro-circuit for performing analyses of multimolecular interactions and for performing molecular syntheses, comprising: (a) a support; (b) at least one micro-electrode attached to the support, the micro-electrode being selectively electronically activated and the micro-electrode having a protective layer which is removable; (c) a binding entity for attachment to the at least one micro-electrode, the binding entity being capable of attachment to at least one micro-electrode when the protective layer has been removed; and (d) a power source being operatively connected to at least one micro-electrode for electronically activating at least one micro-electrode. The micro-circuit of the present invention also includes embodiments featuring a micro-circuit reader for detecting the interaction of the binding entity to a complementary probe, as well as methods for making and using the micro-circuit of the present invention.

A self-contained, conveniently disposable percutaneous absorptive patch of the present invention utilizes, in a novel ways, the existing percutaneous absorptive principles to delivering topical medications quickly, painlessly, and effectively through the skin barrier. The absorptive principles include the epidermal microcuts / micro-needles, permeation enhancers, and micro-current iontophoresis. Most importantly, the transdermal absorptive patch of the present invention introduces a novel incorporation of self-producing micro-electrical currents and micro-electrodes into the existing conventional iontophoretic principle.

A cell potential measurement apparatus, which uses a planar electrode enabling a multi-point simultaneous measurement of potential change arising from cell activities, is provided which can conduct measurements accurately and efficiently as well as can improve convenience of arranging measurement results. According to the configuration of the cell potential measurement apparatus of this invention, it includes an integrated cell holding instrument 1, which includes a planar electrode provided with a plurality of microelectrodes arranged in a matrix form on the surface of a substrate, a cell holding part for placing cells thereon, drawer patterns from the microelectrodes, and electric contact points for outside connections; an optical observation means 20 for optical observations of cells; a stimulation signal supply means 30 to be connected to the cell holding instrument for providing electric stimulation to the cells; and a signal processing means 30 to be connected to the cell holding instrument for processing an output signal arising from electric physiological activities of the cells. It is preferable that a cell culturing means 40 is also provided for maintaining a culture atmosphere of the cells placed on the integrated cell holding instrument.

A rigid spine-reinforced microelectrode array probe and fabrication method. The probe includes a flexible elongated probe body with conductive lines enclosed within a polymeric material. The conductive lines connect microelectrodes found near an insertion end of the probe to respective leads at a connector end of the probe. The probe also includes a rigid spine, such as made from titanium, fixedly attached to the probe body to structurally reinforce the probe body and enable the typically flexible probe body to penetrate and be inserted into tissue, such as neural tissue. By attaching or otherwise fabricating the rigid spine to connect to only an insertion section of the probe body, an integrally connected cable section of the probe body may remain flexible.

The invention provides an implanted flexible neural microelectrode comb, and a preparation method and an implanting method thereof. The flexible neural microelectrode comb is mainly composed of a flexible substrate layer, a flexible insulation layer and a metal connection wire layer arranged between the flexible substrate layer and the flexible insulation layer; the flexible neural microelectrode comb comprises a comb-like structure, a grid structure, a solid structure and a welding pad connected in sequence; electrode sites are arranged on the comb-like structure; welding points are arranged on the welding pad; the metal connection wire layer is composed of metal connection wires connecting the electrode sites and the welding points; and the flexible insulation layer is arranged on the surfaces of the electrode sites and the welding points. The flexible neural microelectrode comb prepared according to the method provided by the invention has a wire-grid-plane gradual changing structure, and thus is improved in mechanical stability during a shape changing process. The mechanical property of the implanted flexible neural microelectrode comb is matched with a brain tissue, the implanting areas is small, an inflammatory response of the brain is avoided, and electroencephalogram signals can be stably tracked and measured in a multi-point manner for a long time.

An electrode device is disclosed. The electrode device comprises an electrically conductive core of micrometric size coated by at least one electrically isolating layer. The electrically conductive core comprises a substrate coated by at least one metallic layer having a nanometric pattern thereon and being at least partially exposed at a tip of the electrically conductive core.

The invention relates to a vision artificial element as medical tool, wherein it comprises that micro camera false eye and needle micro electrode array which can be planted into orbit; said micro camera false eye comprises solar energy battery board or charge device, micro optical lens group, photoelectric converter, signal processing converter, false eye base, and false eye sheet; the solar-energy battery board or charge device, micro optical lens group, photoelectric converter and signal processing converter are packed into false eye base; the signal processing converter is outside the false eye base; the micro camera false eye is planted into the orbit; the needle micro electrode array comprises base, micro electrode, inner wire, interface base, fixing hole, wire, and fixing plate; the fixing plate is fixed on the skull; the micro electrode via the drill hole of skull enters into vision layer; the vision electric signal via wire is transmitted into micro electrode array. The invention can improve the spatial accuracy of false eye.

The invention discloses a three-dimensional flexible neural microelectrode and a manufacturing method thereof. The microelectrode uses a flexible polymer as a base material, and performs progressive electroplating through a circular pattern design of a metal seed layer to form smooth three-dimensional convex features. The electrode site structure can not only ensure good contact between the electrode site and the nerve cells, but also avoid damage to the nerve tissue caused by the sharp edges and corners of the raised electrode sites in the existing three-dimensional neural microelectrode. In addition, through the composite electroplating process in the electroplating process, that is, nano-scale dispersants are added to the electroplating solution to form a submicron-scale microporous structure on the surface of the electrode, increasing the surface area of ​​the electrode site, thereby enhancing the current output capability of the electrode and ensuring the nerve. Effective stimulation of microelectrodes under the constraints of biosafety conditions. The three-dimensional flexible neural microelectrode provided by the invention can be widely used in the fields of neurological disease treatment, neurological rehabilitation, neurobiological basic research and the like.

This invention discloses a sort of method that it uses the light-sensitive lacquer hot-melt method to prepare the roundness heave biologic micro-electrode array. It uses the light-sensitive lacquer technique to prepare the heave cylindrical light-sensitive lacquer, and it adopts the hot-melt circumfluence light-sensitive lacquer to form the roundness salient point. A bed of polymer which is covered in the underlay is used for the protecting material of the bottom of the device, and the presented in figures forms the metal electrode point and the lead, and then that it covers the polymer to be the protecting material of the top of the device. The presented in figures reveals the electrode point and the weld point, and it gets the needed roundness heave smooth micro-electrode array. The cost of the invention is low, also the technical process is simple, and it has the upper irritant effect. It is used for the preparation of the biologic micro-electrode array which has the nerve-cell stimulation of the retina prosthesis and so on.

A method for detecting or assaying one constituting member in a specific binding pair, for example, the antigen in an antigen / antibody pair, by utilizing specific binding such as binding between an antigen and an antibody, together with redox reaction for detecting a label, wherein an oxygen micro-electrode with a sensing surface area of 1 mm2 or less is used; and an apparatus to which the method is applicable. According to the method and by using the apparatus, redox reaction for assaying the label can be completed in such a short time as several minutes. Therefore, an inexpensive disposable apparatus for household use can be realized.

An azimuthal resistivity logging tool includes one or more pads for making azimuthal resistivity measurements of earth formation. Current from the pads, guard electrodes and a measure electrode are measured while monitoring the voltage difference between pairs of monitor electrodes. The pads and an adjacent portion of the tool body form a guard electrode. In addition, microelectrodes are provided on the pads for obtaining high resolution resistivity measurements.

Disclosed herein is a micro-electrode array package including a micro-electrode array comprising: a substrate section including a liquid crystal polymer; an electrode section collecting and transferring bio-signals; and a cover section insulating and protecting the electrode section and including a liquid crystal polymer, wherein the electrode section is disposed in contact with one surface of the substrate section, the cover section is adhered in contact with the surface of the substrate section on which the electrode section is disposed, and a space independent from the external environment is formed between the substrate section and the cover section adhered thereto. Disclosed herein too is a method for manufacturing a micro-electrode array package, including: forming alignment holes in a substrate section including a liquid crystal polymer and a cover section including a liquid crystal polymer; forming site window holes for an electrode section-exposure in the cover section; forming an electrode section on one surface of the substrate section; aligning the substrate section and the cover section by the alignment holes, and adhering the substrate section and the cover section with each other; and cutting the substrate section and the cover section adhered thereto to provide an outer shape.

The invention discloses a flexible pressure resistance flow field sensor based on a single-wall carbon nanotube array and a manufacturing method thereof. The sensor comprises a flexible substrate, at least one group of micro-electrode pairs, and at least one group of single-wall carbon nanotube arrays, wherein each group of micro-electrode pairs comprises a first micro-electrode and a second micro-electrode which are arranged on the flexible substrate at intervals; two ends of each group of single-wall carbon nanotube arrays are respectively connected with the first micro-electrode and the second micro-electrode of one group of corresponding micro-electrode pairs, so that each group of single-wall carbon nanotube arrays can be in a stretch state, and each group of single-wall carbon nanotube arrays are spaced with the flexible substrate. The flexible pressure resistance flow field sensor based on the single-wall carbon nanotube array has the advantages of high sensitivity, small dimension, strong flexibility and low power consumption. The manufacturing method of the embodiment of the invention is simple in design and easy to implement and is suitable for mass production of the sensor.

Fabrication methods for a flexible device for retina prosthesis are described. Layered structures including an array of pixel units may be formed over a substrate. Each pixel unit may comprise a processing circuitry, a micro electrode and a photo sensor. A first set of biocompatible layers may be formed over the layered structures. The substrate may be thinned down to a controlled thickness of the substrate to allow bending of the substrate to the curvature of a retina. A second set of biocompatible layers may be formed over the thinned substrate. The second set of biocompatible layers may be in contact with the first set of biocompatible layers to form a biocompatible seal wrapping around the device to allow long-term contact of the device with retina tissues. Micro electrodes of the pixel units may be exposed through the openings of these biocompatible layers.