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Field-programmable lab-on-a-chip based on microelectrode array architecture

A micro-electrode array, lab-on-a-chip technology, applied in the field of lab-on-a-chip microfluidic systems, can solve problems such as high one-time engineering costs and achieve low-cost effects

Inactive Publication Date: 2012-09-19
王崇智 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, this implies high one-time engineering costs relative to the LOC design and limited ability to update functionality or partially reconfigure parts of the LOC after shipment

Method used

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  • Field-programmable lab-on-a-chip based on microelectrode array architecture
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  • Field-programmable lab-on-a-chip based on microelectrode array architecture

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Embodiment Construction

[0092] exist Figure 1A A conventional electrowetting microactuator structure is shown in (shown on a smaller scale for illustrative purposes only). The EWOD-based digital microfluidic device includes two glass plates 120 and 121 parallel to each other. The bottom plate 121 contains a patterned array of individually controllable electrodes 130 and the top plate 120 is coated with a continuous ground electrode 140 . The electrodes are preferably formed from a material such as indium tin oxide (ITO), which has the combined characteristics of electrical conductivity and light transmission in a thin layer. A dielectric insulator 170 (e.g. Parylene C) coated with a hydrophobic film 160 such as Teflon AF is added to the plate to reduce the wettability of the surface and increase the distance between the droplet and the control electrode. capacitance between. Droplets 150 containing biochemical samples and a fill medium such as silicone oil or air are sandwiched between plates to f...

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Abstract

The invention discloses a field-programmable lab-on-a-chip based on microelectrode array architecture, concretely a system related to filed-programmable lab-on-chip (FPLOC) microfluidic operations, fabrications, and programming based on microelectrode array architecture. The FPLOC device by employing a microelectrode array interface may include the following: (a) a bottom plate comprising an array of multiple microelectrodes disposed on a top surface of a substrate covered by a dielectric layer; wherein each of the microelectrode is coupled to at least one grounding elements of a grounding mechanism, wherein a hydrophobic layer is disposed on the top of the dielectric layer and the grounding elements to make hydrophobic surfaces with the droplets; (b) a field programmability mechanism for programming a group of configured-electrodes to generate microfluidic components and layouts with selected shapes and sizes; and, (c) a FPLOC functional block, comprising: I / O ports; a sample preparation unit; a droplet manipulation unit; a detection unit; and a system control unit.

Description

[0001] Cross References to Related Applications [0002] This application is incorporated by reference into co-pending U.S. Patent Application No. "Droplet Manipulations on EWOD Microelectrode Array Architecture," filed February 17, 2011. 13,029,137 , a joint pending US Patent Application No. entitled "Field-Programmable Lab-on-a-Chip and Droplet Manipulations Based on EWOD Micro-Electrode Array Architecture" filed on February 17, 2011 13,029,138 and co-pending U.S. Patent Application No. "Microelectrode Array Architecture," filed February 17, 2011. 13,029,140 the entire content of . technical field [0003] The present invention relates to lab-on-a-chip (LOC) microfluidic systems and methods. More specifically, the present invention relates to field programmable lab-on-a-chip (FPLOC) systems employing microelectrode array structures. [0004] FPLOC can be field-programmed for microfluidic applications including (but not limited to) droplet-based microfluidic manipulation, ...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/502761B01L3/502792B01L2200/0668B01L2200/0673B01L2300/0645B01L2300/0816B01L2400/0424B01L2400/0427
Inventor 王崇智何庆延黄大卫王文生
Owner 王崇智
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