The invention discloses a curcumin micelle eye drop. The eye drop comprises curcumin as a main drug, an antiseptic, an isotonic regulator, and also comprises a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol copolymer as a drug adjuvant, and dequalinium chloride as a mitochondrial targeting modifier and a stabilizer, a mass ratio of the curcumin main drug to the polyethylene caprolactam-polyvinyl acetate-polyethylene glycol block copolymer drug adjuvant is 1:12-1:20, and a mass ratio of dequalinium chloride to the polyethylene caprolactam-polyvinyl acetate-polyethylene glycol copolymer drug adjuvant is 1:20-1:40. The administration concentration of the curcumin micelle eye drop prepared in the invention can reach 5mg / ml, and the eye drop has the advantages of small micelle particle size, uniform distribution range, good drug stability, reduction of the administration irritation, improvement of the drug absorption of cornea, reduction of the administration concentration, prolongation of the action time of the drug, reduction of the administration frequency, improvement of the patient compliance, and very good economy.