Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medical application of berberine derivative

A berberine and drug technology, which is applied in the field of berberine derivatives, can solve the problems of unseen glioma migration and invasion, and unsatisfactory drug efficacy.

Active Publication Date: 2014-12-17
SUN YAT SEN UNIV
View PDF1 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that berberine can inhibit the migration and invasion of liver cancer, human tongue squamous cell carcinoma, melanoma, breast cancer, bladder cancer, etc., but there is no report on the effect on the migration and invasion of glioma
On the other hand, although berberine has inhibitory activity against certain tumors, its efficacy is not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical application of berberine derivative
  • Medical application of berberine derivative
  • Medical application of berberine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] Synthesis and Identification of Berberine Derivatives

[0031]Berberine hydrochloride was purchased from Xi’an Xiaocao Plant Technology Co., Ltd., with a purity of 97%; bromododecane, bromohexadecane, bromooctadecane, and benzyl bromide were all analytically pure, purchased from Aladdin Reagent Co., Ltd. Company; N, N-dimethylformamide (DMF) is analytically pure, dried with molecular sieves, and purchased from Tianjin Fuyu Fine Chemical Co., Ltd.; neutral alumina for chromatography is a product of Sinopharm Group; DMEM medium (R10 -013-cv), fetal bovine serum (FBS), trypsin, penicillin and streptomycin were all purchased from Cellgro, USA; tetramethylazozolium salt (MTT) and dimethyl sulfoxide (DMSO) were purchased from Sigma Company of the United States; 4% paraformaldehyde was purchased from Guangzhou Jingxin Technology Co., Ltd.; the experimental water was ultrapure water. Rat glioma C6 cells and human glioma U87 cells were from the ATCC cell bank in the United St...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides application of a compound shown in the formula (I) or a salt thereof in the aspects of preparing of medicines for treating malignant glioma or a mitochondrial targeting drug delivery system, and in the formula (I), R is C10-C18 alkyl, or R is benzyl. The experiments find that compared with a control, a berberine derivative not only can more effectively inhibit glioma cell proliferation, and can also effectively inhibit the migration and invasion ability of cells. In addition, the compounds can be well positioned to mitochondria, so that the compounds can be used as the mitochondrial targeting drug delivery system.

Description

technical field [0001] The present invention relates to the new application of berberine derivatives, especially the new application of C9-O substituted long-chain alkyl or benzyl derivatives in treating malignant glioma. Background technique [0002] Malignant glioma (Malignant Glioma) is the most common primary malignant tumor in the central nervous system, accounting for 46% of intracranial tumors. Surgery is the preferred treatment method, but because of its invasive growth and no obvious boundary with normal brain tissue, surgery is difficult to remove, and the postoperative recurrence rate is as high as 96%. Even with supplementary radiotherapy and chemotherapy, the average postoperative survival period is no more than 14 months, and the prognosis is extremely poor. The incurability of malignant glioma is closely related to its strong ability of migration and invasion. Therefore, inhibiting the migration and invasion of glioma cells is extremely critical for the trea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4375A61P35/00
Inventor 胡海燕付胜楠庹珏谢彦奇张国光王亚龙朱文博颜光美
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com