The invention relates to a curcumin nano micelle preparation and a preparation method thereof. The preparation consists of curcumin and amphiphilic block copolymer. The preparation method comprises the following steps of: jointly dissolving the curcumin and the amphiphilic block copolymer in an organic solvent, performing rotary evaporation to remove the organic solvent, performing vacuum drying on the obtained a medicine-containing film, sanding overnight, removing residual organic solvent, adding an aqueous phase, combining ultrasonic dispersion and 35-38 DEG C thermostatic oscillation to obtain a micelle solution, centrifuging at a high speed, and taking supernate, namely the curcumin nano micelle preparation. The curcumin nano micelle preparation is prepared by an improved film dispersion method, the solubility of the curcumin in water is improved, the loading rate of the preparation can reach 8 percent, the micelle particle size is less than 100nm, and the curcumin nano micelle preparation has the advantages of stable structure, small particle size, low toxicity, high safety, long in-vivo circulation time, simple storage and the like.