The invention discloses a bionic exosome as well as preparation and application thereof. An artificial lipid material is subjected to tumor cell membraneprotein chimerism to prepare a nano-liposome with a particle size similar to that of an exosome structure, and NE is combined on the surface of the nano-liposome through electrostatic adsorption so as to be used as the bionic exosome. The bionicexosome has a stable lipid membrane structure, tumor targeting and a tumor matrix degradation function. After the bionic exosome degrades a tumor matrix in a targeting manner, the permeation of an anti-cancerdrug into a tumor and the immersion of immune cells into the tumor can be enhanced, the anti-tumor curative effect is greatly improved, and the bionic exosome has huge conversion value and application prospect in the aspect of combined chemotherapy / immune anti-tumor.
The invention belongs to a dosage form and preparation technology field, and relates to a anticancer medicament-carried targeting long circulatingliposomedrugdelivery system for injection, which is characterized in that the long circulatingliposome is modified by hydrophobic peptides. Wherein, the hydrophobic peptides has strong endophilicity with a cell membrane, and can be inserted into the cell membrane by hydrophobic effect, and the hydrophobic peptide-modified long-circulation liposome provided by the invention can increase capability of the liposome in a tumor tissue to permeate a tumor cell membrane, so as that a carried medicament can reach a target in a cell, thereby raising curative effect of an anticancer medicament. The hydrophobic peptide-modified long-circulation liposome drugdelivery system for injection is characterized in that: by a membrane inserting function, the hydrophobic peptides are modified on the surface of the long circulating liposome, in order to increase transhipment of the anticancer medicament in the tumor cells.