284 results about "Long circulating" patented technology

The invention relates to an injection anticancer long circulating targeting liposome which is characterized in that anti-angiogenic drug is combined with anticancer drug, the liposome modified by polypeptide with tumor targeting function and hydrophilic polyethyleneglycol is adopted for loading and transporting the two drugs to tumor positions, and the tumor curative effect is enhanced through the different releasing rates and action mechanism of the two drugs.

The invention relates to an ion sieve for selectively extracting lithium and the application thereof. The ion sieve adopts one or the compound of more than one of the following components: Li4Ti5O12, LixMeyTi5O12, and Li4MemTinO12, wherein Me is one or the compound of more than one of the following components: V, Fe, Co, Mn, Al, Ba, Ag, Zr, and Nb, x is greater than 3 and smaller than 4, y is greater than 0 and smaller than 1, m is greater than 0 and smaller than 1, and n is greater than 4 and smaller than 5. The ion sieve is particularly applicable to magnesium and lithium separation in brine with a high magnesium / lithium ratio, and has favorable intercalation and deintercalation performances to Li ions. The material for the titanic acid lithium ion sieve provided by the invention is easy to get and low in cost, the ion sieve has high selectivity and higher adsorptive capacity to the Li ions, as well as long circulating life. The process adopting the titanic acid lithium ion sieve to perform magnesium and lithium separation has the advantages of short procedure, simplicity in operation, low manufacturing cost, and easiness in industrial application.

The invention relates to a mapping method of specific downgoing pilot frequency with long-circulating front frame structure and physical resource block. The method comprises: the first specific downgoing pilot frequency at each path is mapped to the specific location of the physical resource block, the frequency domain position thereof is set as the same sub-carrier of the common pilot frequency at the first column of the physical resource block; other specific downgoing pilot frequencyes of the path are mapped according to the time domain interval, the frequency domain interval and the predetermined rule; the time domain interval is two or three orthogonal frequency division multiplex symbols, and the frequency domain interval is two sub-carrier with the same time domain. The method clarifies the position of the pilot frequency symbol in the physical resource block, and solves the problem which is unable to obtain the entire signal channel information by the common pilot frequency in the existing LTE standard version when the base-station terminal is formed by the wave beam of more than four antennas, and enables the signal channel information obtained by the specific pilot frequency to contain the true signal channel information and the processing weight formed by the wave beam, enables the terminal to form the transmission weight without obtaining the specific wave beam, thereby avoiding the feedback spending of the wave beam to form weight.

The present invention provides a long circulating non-pegylated liposomal doxorubicin hydrochloride composition for parenteral administration and a process for its preparation. The circulation time in Swiss albino mice is at least 25 times longer than conventional non-liposomal formulations. The non-pegylated liposomes are stable, exhibit low toxicity and have been found to be efficacious in different tumor models.

The invention discloses long-circulating solid lipid docetaxel nanoparticles and a preparation method thereof. The long-circulating solid lipid docetaxel nanoparticles comprise the following materialsin therapeutic effective dose: docetaxel, lipid materials, long-circulating auxiliary materials and an emulsifier. The long-circulating solid lipid docetaxel nanoparticles have small particle size, high encapsulation rate and good stability, and not only improve the solubility and the stability of the docetaxel, reduce the toxicity of the docetaxel, but also prolong the circulating time of a medicament in blood, and improve the therapeutic index of the medicament, so that the preparation has the characteristics of low toxicity, low allergy, high efficiency and targeting in clinical application.

The invention belongs to the field of medicine preparation and particularly relates to a docetaxel solid lipid nanoparticle and a preparation method thereof. The docetaxel solid lipid nanoparticle consists of an effective curative dose of docetaxel, solid lipid materials, liquid lipid materials, an emulsifying agent, additives, long-circulating auxiliary materials and water for injection. The docetaxel solid lipid nanoparticle provided by the invention has the characteristics of stable docetaxel structure, phagocytosis prevention of an in-vivo reticuloendothelial system and active tumor targeting, and can be stably stored.

The invention provides a long-circulating and targeting synergistic multifunctional anti-tumor targeting nano-drug carrier. The carrier is composed of a composite micelle which has a grain size of 30-200nm and is even in distribution, wherein the composite micelle is composed of two amphiphilic block copolymers, including a pH-responsive amphiphilic block copolymer of which the hydrophyllic terminal is modified by a targeting group and an amphiphilic block copolymer of which the hydrophyllic terminal is PEG; the composite micelle is of a core-shell structure at pH 7.4, the core layer is composed of the hydrophobic terminals of the amphiphilic block copolymers, while the shell layer is composed of PEG and the targeting group-modified pH-responsive hydrophobic terminal. The long-circulating and targeting synergistic multifunctional anti-tumor targeting nano-drug carrier has the advantages that the surface structure of the drug carrier can be flexibly controlled by changing the proportions of the different block copolymers, the targeting group has specific targeting effect on tumor cells, and the drug carrier has responsible release capacity, excellent biocompatibility and biodegradability; the preparation process of the drug carrier is simple and easy to operate.

The invention discloses preparation and application of an insoluble drug-entrapped poloxamer / amphiphilic polysaccharide mixed micelle. The insoluble drug-entrapped poloxamer / amphiphilic polysaccharide mixed micelle is prepared through a dialysis method or a solvent evaporation method. The mixed micelle is low in critical micelle concentration, is high in drug-loading rate, is capable of obviously prolonging the stabilization time and has the long-circulation function of a nanomicelle and has dual functions of restraining the metabolism of P-glycoprotein and cytochrome P450 enzyme and is capable of increasing the bioavailability of oral administration. The mixed micelle is simple in preparation method, is mature in process and is high in yield and can be prepared into preparations for the oral administration, such as tablets, capsules, pills and syrups.

The invention belongs to the new technical field of a drug preparation and in particular relates to a precursor liposome containing a glycyrrhetinic acid and a method for preparing the same. The precursor liposome containing the glycyrrhetinic acid consists of glycyrrhetinic acid, phospholipids, cholesterol, a surfactant and a water-soluble material; a suspension solution of the glycyrrhetinic acid liposome is prepared by an ethanol injection method or a thin-film dispersion method; and solid liposome powder is prepared by a freeze drying method or a spray drying method. The precursor liposome has simple process and good repeatability, is suitable for industrialized production; through drug administration by intravenous injection, the precursor liposome has long-circulating function, can remarkably reduce the toxicity of drug and achieve the function of prolonging the drug effect; and through oral administration, a solid preparation of the liposome can increase absorption and improve bioavailability by three to five times.

The invention belongs to the field of pharmaceutic preparations, and relates to a targeted ligand-PEG (polyethylene glycol)-cholesterol / tocopherol derivative, and a preparation method and an application of the derivative, in particular to an application of the derivative in a composite mechanism mediate tumor targeted drug delivery system. According to the derivative, the preparation method and the application, a drug delivery system consisting of the targeted ligand-PEG-cholesterol / tocopherol derivative with a targeting function, a long circulating function and a pH (power of hydrogen) sensitive function as a functional material, a cation liposome and a drug can simultaneously carry anticancer polypeptide and gene / chemotherapy drugs. According to the system, different drugs are jointly entrapped into the lipid nano drug delivery system and delivered into a targeted cell by utilizing a physicochemical property difference between components or by in-vivo specific targeted recognition, signal conduction blocking and pH triggering PEG chain breaking charge reversion methods, so that a targeted tumor therapeutic effect is improved. According to the derivative, the preparation method and the application, the advantages of the system in directional delivery, co-delivery and the like are proved by in-vivo and in-vitro activity evaluation, the anticancer activity is improved significantly, and definite synergic therapeutic and immunity effects are provided.

The invention discloses a graphite material at the negative pole of a lithium ion battery, which comprises interphase graphite and artificial graphite in mass ratio of 90:10 to 20:80. The graphite material has the advantages of highly compacted density, small specific surface area, high discharge capacity, long circulating life, high charge-discharge efficiency and high product performance-price ratio. The invention also provides a method for preparing the graphite material, which has the advantages of simple, convenient and feasible technology, wide raw material sources and lower cost.

A method of preparing low water-soluble medicine into solid nanometer pharmaceutical formulation is disclosed. According to the characters of molecular aggregates such as supramolecular chemical micelles and vesicles, the formulation, which based on the hydroxypropyl-beta-cyclodextrin and phospholipid, is prepared under the condition of hyperthermia sterilization and decompression. Such nanometer formulation is sterile particle or powder with loose porosity. For directly intravenous use, the formulation has targeting activity, sustained release and long circulating characters. While as a solid oral product, it is fast-release, fast-effective, and improved bioavailability characters, and is readily melted in mouth. The formulation utilizes secure accessories, traditional equipments and methods, thus, it is suited to be used and manufactured widely. Also disclosed is intravenous formulation of anticancer paclitaxel, which characterized that there has no polyoxyethylenated castor oil in it. Such intravenous formulation is nonallergic so that it has higher security and efficiency compared to present commercially available paclitaxel formulations.

The invention relates to a long-circulating liposome capable of avoiding an accelerated blood clearance (ABC) phenomenon, a medicine preparation containing the long-circulating liposome, and a preparation method and an application of the long-circulating liposome. The long-circulating liposome provided by the invention comprises phospholipid, auxiliary lipid and poly carboxyl betaine lipid, wherein the long-circulating liposome and the preparation thereof can be applied to medicines for treating related diseases. According to the long-circulating liposome for avoiding the ABC phenomenon provided by the invention, the defect that a common liposome is easily recognized by a reticular endothelium system is overcome; a long-circulating effect of blood is reached; meanwhile, the ABC phenomenon caused by multiple intravenous injections of the PEG-modified long-circulating liposome is avoided; the medicine effect of a therapeutic medicine is effectively improved; and the long-circulating liposome has a high application prospect in the field of medicines.

The invention belongs to the fields of polymer chemistry and medicinal preparations, and particularly relates to a method for synthesizing an active targeted hyaluronic acid-polylactic acid carrier, a method for preparing an anti-tumor medicinal micelle of the active targeted hyaluronic acid-polylactic acid carrier and an application thereof. By adopting a novel self-assembly technology, amphipathic PEG (polyethylene glycol) block polyester copolymer and tumor targeted ligand hyaluronic acid-polylactic acid copolymer are self-assembled by means of the electrostatic interaction to form a multifunctional composite micelle; the solubility of insoluble tumor medicaments and the drug loading capacity and encapsulation efficiency of water-soluble anti-tumor medicines can be remarkably improved by virtue of the anti-cancer drug-loaded micelle and composite micelle composition, the medicines can be biodegraded in a body, phagocytosis of a reticuloendothelial system (RES) and excretion of a kidney can be avoided. The active targeted hyaluronic acid-polylactic acid carrier has a long-circulating effect, the multifunctional composition has a prominent advantage of tumor active targeting effect, and parameters of pharmacodynamics in vitro and in vivo of the micelle are remarkably superior to those of common anti-tumor injections. Clinically acceptable administration means of the micelle includes injection administration or mucosal administration, and preparations of the micelle can be injection, transfusion, injection lyophilized powder injections or dry powder inhalation.

The invention relates to a novel long-circulating liposome composition and an application method thereof. The long-circulating liposome composition is mainly prepared from phospholipid, cholesterol, an electronegative material and a long-circulating material serving as main raw materials, wherein tocopheryl acetate succinate or cholesterol succinate is used as the electronegative material particularly, and tocopheryl acetate polyethylene glycol succinate (TPGS) is used as the long-circulating material particularly, so that the stability of combining the long-circulating liposome composition and medicaments is improved; the long-circulating liposome composition can be used as a carrier of anti-tumor medicaments such as paclitaxel, docetaxel and 10-hydroxycamptothecine, and simultaneously, the tolerance is improved; and when the long-circulating liposome composition is used as the medicinal carrier, the circulating time of the carried medicaments in vivo is longer than that of various carriers sold on the market obviously, and the long-circulating liposome composition has the advantages of low cost and suitability for wide popularization and application.

The invention provides a long-circulating preparation which is an invisible nano particle, a stealth lipidosome, or an invisible micelle containing docetaxle, carrier materials and additive. The long-circulating preparation is prepared by wrapping the docetaxle with the carrier materials that are modified by polyethylene glycol, a hydrotropic substance. The long-circulating preparation of the docetaxel can avoid being captured or swallowed by the hepatolienal reticular endothelial system in the body, thus prolonging circulation time in blood. Compared with the common injection of the docetaxel or the non-stealth lipidosome of the docetaxel, the long-circulating preparation of the docetaxel provided by the invention has stronger inhibit function on a tumor.

The invention discloses a cobaltosic oxide and cobalt molybdate core-shell heterostructure nanowire array, a preparation method and application thereof. The preparation method includes two steps: taking cobaltosic oxide nanowires as a framework; coating a cobalt molybdate nano thin film material outside the framework. The array perpendicularly grows, is orderly in arrangement, has regular three-dimensional heterostructure and can directly serve as an electrode material of a supercapacitor. Compared with the prior art, the preparation method has the advantages that a product is high in purity, good in dispersibility, good in crystalline form and controllable, and the preparation method is low in production cost and high in reproducibility. Serving as the electrode material of the supercapacitor, long circulating stability, high specific capacitance, high energy density and power density are realized.

The invention which belongs to the medicine processing field concretely relates to a preparation method of a long-circulating nanoparticle. The preparation method of the long-circulating nanoparticle provided in the invention has the advantages of simple operation, and good targeting and good in vitro release of products. The method comprises the following steps: 1, dissolving 5-Fu (5-fluorouracil), PEG-PHDCA (polyethylene glycol-poly(hexadecyl cyanoacrylate)) and a phosphatide in a mixed organic solvent of tetrahydrofuran and ethanol to form an organic phase; 2, slowly adding the organic phase to a water phase of a surfactant in a dropwise manner under magnetic stirring, and fully diffusing the organic phase by continuously stirring for 1h after finishing the dropwise addition; 3, carrying out reduced pressure evaporation to remove the organic solvent to obtain a nanoparticle colloidal suspension with a blue opalescence; 4, carrying out ultracentrifugation separation deposition on the nanoparticle, and washing; and 5, carrying out ultrasonic dispersion with a 4% mannitol solution, and freeze-drying.

The invention discloses a manufacturing method of a lithium iron phosphate-cobalt acid lithium composite anode plate of a lithium ion battery, which comprises the following steps: A, ball-milling and uniformly mixing a nanometer cobalt acid lithium anode active material with a nanometer Super-C conductive agent in proportion to obtain a cobalt acid lithium active material mixture; uniformly mixing the mixture with polyvinylidene fluoride; mixing the mixture with sodium carboxymethylcellulose to obtain anode active material slurry; B, preparing the anode active material slurry: ball-milling and uniformly mixing nanometer lithium iron phosphate with the nanometer Super-C conductive agent in proportion to obtain a lithium iron phosphate active material mixture; mixing the mixture with the sodium carboxymethylcellulose in proportion; adding distilled water into the mixture, ball-milling and mixing uniformly to obtain anode active material slurry B; and C, coating the slurry A on a single surface of an anode current collector, and coating the slurry B on double surfaces of an initial pole piece according to coating process, thus obtaining an anode pole piece. A nickel-metal hydride battery prepared by the invention has high volume, high multiplying power, a good discharging effect, and long circulating service life.

The invention belongs to the technical field of graphite preparation, and more specifically relates to a preparation method of a low-expansion long-circulating natural graphite. The preparation method comprises following steps: 1, smashing shaping is carried out; 2, mixing is carried out; 3, low temperature heat treatment is carried out; 4, graphitization high temperature treatment is carried out; and 5, material mixing sieving is carried out. An adhesive convenient for graphitization is an ingredient or a mixture of ingredients selected from petroleum asphalt, coal pitch, phenolic resin, epoxy resin, furane resin, or furfural resin; and the using amount of the adhesive accounts for 10 to 30% of the weight amount of a microcrystalline graphite raw material. Compared with the prior art, the preparation method possesses following advantages: the preparation method is simple and feasible, and is suitable for industrialized production; prepared graphite is low in expansion performance, large in discharge capacity, and long in cycle life; and the comprehensive properties of button cells prepared from the low-expansion long-circulating natural graphite are excellent.

The invention belongs to the technical field of lithium ion batteries, and in particular relates to a silicon / aligned carbon nanotube composite negative electrode material for a lithium ion battery and a preparation method thereof. The composite material consists of an aligned carbon nanotube film, nano-silicon uniformly distributed on the aligned carbon nanotube film and a vertically aligned nanotube array on the surface of nanosilicon. The bottom aligned carbon nanotube film provides a matrix with high strength and good flexibility to ensure the integrity of the electrode material in the battery circulating process. Silicon expansion is limited in a certain ranged due to the top aligned carbon nanotube array to prevent the silicon material from falling in the circulating process. Meanwhile, the material is porous, so that electrolyte can enter into the material so as to accelerate transmission of lithium ions. Therefore, the composite negative electrode material provided by the invention has the advantages of high capacity, good rate capability, long circulating service life and the like.

The invention provides a novel Irinotecan carrier which is circulating nano liposome and a novel preparation method thereof which is an ethanol injection-ammonium sulfate active medicament-loading method. The preparation process comprises: a, dissolving a lipid material for forming the liposome in ethanol to prepare solution; b, dissolving a polyethylene glycol compound in solution of ammonium sulfate to prepare a hydration medium; c, injecting solution obtained by the step a into the hydration medium obtained by the step b with stirring in a water bath, stirring at a constant temperature for a certain period under a condition of introducing N2 to form circulating blank liposome; d, dialyzing the blank liposome obtained by the step c in physiological saline; and e, adding solution of Irinotecan into the blank liposome, regulating the pH value of an external phase, and performing incubation and medicament loading at a certain temperature to obtain the Irinotecan circulating nano liposome. The process is simple, the particle size is 80 to 150 nanometers, the coating rate is over 95 percent, the sterile preparation can be obtained easily, and an industrialization requirement is met.

The invention provides a photosensitive liposome carrying oxygen to enhance photodynamics, which is composed of phospholipids, cholesterol, long-circulation materials, hemoglobin, and chemotherapeutic drugs and / or photosensitizers, each component is dissolved in an organic solvent, and the Steam to form a thin film, then add oxyhemoglobin solution, or a mixed solution of photosensitizers and / or chemotherapeutic drugs and oxyhemoglobin, and hydrate to obtain a multilayer liposome solution, which is obtained by ultrasonication and purification. The liposome of the present invention can simultaneously carry oxygen, chemotherapeutic drugs and / or photosensitizers to the tumor site, alleviate the hypoxic state of tumor cells, improve the sensitivity of tumor cells to chemotherapeutic drugs, inhibit tumor growth and metastasis, and can also Under the irradiation of near-infrared light, the photosensitizer in the liposome generates more singlet oxygen, resulting in an enhanced photodynamic therapy effect. The loaded drug molecules are released to realize remote control of drug release.

The invention discloses a double-phase rotating stream separation system. Operation and maintenance of the double-phase rotating stream separation system are convenient, and the separation efficiency is higher. The double-phase rotating stream separation system is composed of a motor, a booster pump, a long circulating pipeline, a short circulating pipeline, a rotating stream body and a one-way valve which are connected successively; the rotating stream body is composed of a rotating stream chamber cylinder, a separation cone segment cone body, an external bottom flow segment cylinder, and a bottom flow pipe with reduced diameter steps which are connected successively; the rotating steam body comprises tow overflow ports and two bottom flow ports. Compared with conventional rotating flow separation devices, the double-phase rotating stream separation system can be used for eliminating short-circuit flow, reducing circulation flow, and reducing bottom flow port light phase content greatly; flow field stability of the double-phase rotating stream separation system is increased; high efficiency separation treatment of mixed phases is promoted; the double-phase rotating stream separation system can be used for circulating treatment of the mixed phase containing light phase in short-circuit flow and the bottom flow ports, is small in occupied space, and is simple in operation and management.

The invention is an electric vehicle colloidal storage battery, comprising battery tank, battery cover, anode plate, cathode plate, glass fiber baffle, colloidal electrolyte, safety explosion-proof valve, terminals and bus, where the anode and cathode plates are composed of positive and negative grids and positive and negative active matters, respectively, the grids are of a special designed structure, the anode active matter is added with tin dioxide and gas phase silicon dioxide, and the colloidal electrolyte uses vitriol as the principal and uses the mixture of gas phase silicon dioxide and functional high molecular polymer as gel. And it has characters of high specific energy, heavy discharge current, excellent overcharge and overdischarge resistances, long circulating service life, completely applied to electric vehicles, such as electric buses, mixed electric buses, electric cars, electric forklifts, purely electric tourist cars, and electric motor cars.

The invention relates to the technical field of preparation of new energy source materials and provides a preparation method and application of sweet potato leaf based active carbon. The preparation method comprises the following steps: 1, washing sweet potato leaves with de-ionized water and then drying and crushing; carrying out pre-carbonization treatment under the protection of inert gas to obtain a pre-carbonized product; 2, mixing the obtained pre-carbonized product with potassium hydroxide; after drying, carrying out high-temperature activation treatment under the protection of the inert gas to obtain an activated product; and 3, carrying out acid washing and water washing on the obtained activated product, and then freezing and drying to obtain the sweet potato leaf based active carbon. The preparation method provided by the invention is simple in process and low in equipment cost; the raw materials are easy to obtain; and the sweet potato leaf based active carbon prepared by the method is of a sheet-shaped structure and has a series of advantages of high specific capacitance, good rate performance, long circulating long service life and the like when being used as an electrode material of a super-capacitor.

Provided are lipidic particles comprising phopatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and / or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and / or proteins.

The invention relates to an anti-tumor multi-medicine resistant targeted liposome and a preparation method thereof, in particular to an anti-tumor multi-medicine resistant long circulating targeted liposome. The invention is characterized in that: quercitin and an anti-tumor medicine are jointly coated in the liposome, and simultaneously target tumor tissues to reverse the multi-medicine resistance of tumors, cytotoxicity of anti-tumor medicines on medicine resistant tumors is enhanced, the change of pharmacokinetic properties of the anti-tumor medicines in vivo and the enhancement of toxic and side effects of the anti-tumor medicines in vivo, which are caused by the difference and interaction of the pharmacokinetic properties of different medicines in vivo, are avoided, and the treatmenteffect on medicine resistant tumors is improved.