47results about How to "Achieve long cycle" patented technology

Disclosed is a near infrared laser-driven mitochondrial targeting fluorescent polymer and a preparation method and application thereof. A nano-scale photosensitizer, which is prepared from a polymer of poly-(2Z, 2'Z)-3,3'-(2, 5-bis(diphenylamino)-1, 4-phenyl) bis(2-(3, 5-bis(trifluoromethyl) phenyl) acrylonitrile-copolymer (N-(2-hydroxypropyl) methacrylamide)-copolymer (2-dimethylamino ethyl methacrylate) and an inorganic upconversion nano-scale particle of ytterbium and thulium codoped sodium yttrium fluoride in aqueous solution; when irradiated by laser of a wavelength of 980 nm, the nano-scale photosensitizer can produce reactive oxygen to effectively kill cells. The invention provides a novel and effective nano-scale photosensitive material for research and application of photodynamic therapy of tumor cells in the future.

The invention relates to a tetramethylpyrazine phosphate liposome drug and a preparation method; wherein, the drug is characterized in that: the effective efficacy components and weight accounts of the liposome drug are as following: a mixture 200 to330 with a weight ratio 4 to 1 of egg yolk lecithin and sheep cerebral lecithin, a mixture 170 to 280 with a weight ratio 3 to 1of stigmasterol and campestrol, reduction glutathione 2.5 to 10, tetramethylpyrazine phosphate 15 to 25, a mixture 720 to 1200 with a weight ratio 1 : 0.01 to 0.05 : 0.02 to 0.07 of tert-butyl alcohol, ethanol, acetone, a mixture 140 to 160 with a weight ratio 4:05 to 1 of polyethylene glycol-2000 and tween 801, and hydroxyl propyl methyl cellulose 100 to 120. The invention also provides the preparation method for the liposome drugs. The invention has the advantages of adopting the provided drugs, enabling to decrease the drug dosage by two third and once a day, and improving the efficacy above fifteen percent.

The invention belongs to the technical field of polymer materials, in particular to an amphiphilic chitosan derivative, a preparation method thereof and an application in pharmacy. The acid-chlorinated long-chain fatty acid is connected to the hydroxyl group of chitosan through esterification reaction, and then the end-activated polybenzyl malate is connected to O-long-chain alkyl chitosan through amide bond, and finally the hydrogenation dehydrogenation is carried out. Remove the protecting group to prepare amphiphilic O-long chain alkyl-N-polymalic acid chitosan graft copolymer. It can form nanoparticles of 100-300nm in aqueous solution. Compared with the prior art, the polymer is completely biodegradable, has good biocompatibility, and has easily modified functional groups.

The invention relates to a bifunctional polyethylene glycol and adriamycin conjugate and a preparation method thereof. The bifunctional polyethylene glycol and adriamycin conjugate is prepared in the following steps: modifying methoxy polyethylene glycol which serves as a raw material through hydroformylation, carrying out a reductive amination reaction on the modified methoxy polyethylene glycol and disulfide-bond containing dihydrazide to generate terminal-hydrazide polyethylene glycol, and carrying out a reaction on the terminal hydrazide of the terminal-hydrazide polyethylene glycol and the ketone carbonyl of the adriamycin to generate a hydrazone bond to obtain the bifunctional polyethylene glycol and adriamycin conjugate. The bifunctional polyethylene glycol and adriamycin conjugate provided by the invention can adapt to the reductive acidic environment in a cancer cell to release drugs rapidly to improve the cancer treatment effect and reduce the drug resisting possibility of the cancer cell, and in addition, the bifunctional polyethylene glycol and adriamycin conjugate can be self-assembled into a nano particle in a water phase to be able to circulate for a long time in blood to improve the pharmacokinetics of the doxorubicin. The method for preparing the bifunctional polyethylene glycol and adriamycin conjugate has the advantages of simple process, mild reaction conditions, high drug carrying rate and low cost, and the raw materials are easy to obtain. The bifunctional polyethylene glycol and adriamycin conjugate has potential application values in the aspects of targeted delivery of drugs, controlled release of drugs and improvement of clinical cancer resisting and treating effects.

The present disclosure relates to a Silicate-1 microsphere molecular sieve catalyst containing trace metal ions, a preparation method thereof, and a method for preparing caprolactam from cyclohexanone oxime. ~95% by weight of Silicate-1 molecular sieve containing trace metal ions, and 5-30% by weight of binder; the particle size of the catalyst is 20-100 μm, and the wear index K is less than 10; BET specific surface area of ​​400‑500 m 2 / g, the weight ratio of silicon oxide to metal ions is (5000‑200000):1. The catalyst has a low attrition index and can effectively improve the selectivity of caprolactam when used in the gas-phase Beckmann rearrangement reaction of cyclohexanone oxime in a fluidized bed process.

The invention relates to the field of all-silicon molecular sieves, and discloses a preparation method of a spherical MFI topological structure all-silicon molecular sieve catalyst containing trace rare earth ions and a caprolactam preparation method. The preparation method of the spherical MFI topological structure all-silicon molecular sieve catalyst comprises: a. Silicon source, rare earth ion source, organic template and water are mixed to obtain a colloidal mixture; b. The colloidal mixture is subjected to two-stage variable temperature hydrothermal crystallization to obtain a crystallization product; c. Washing and separation of the crystallization product to obtain a rare earth-containing ionic all-silicon molecular sieve; d, the all-silicon molecular sieve containing rare earth ions is shaped, roasted, and post-treated with an alkaline buffer solution of nitrogen-containing compounds, and then washed, separated, and dried to obtain a spherical all-silicon molecular sieve containing a very small amount of rare earth ions Silicon molecular sieve catalyst. The method can effectively change the performance of the all-silicon molecular sieve catalyst, and the application of the catalyst in the production of caprolactam can achieve better results.

The invention relates to a tetramethylpyrazine phosphate liposome drug and a preparation method; wherein, the drug is characterized in that: the effective efficacy components and weight accounts of the liposome drug are as following: a mixture 200 to330 with a weight ratio 4 to 1 of egg yolk lecithin and sheep cerebral lecithin, a mixture 170 to 280 with a weight ratio 3 to 1of stigmasterol and campestrol, reduction glutathione 2.5 to 10, tetramethylpyrazine phosphate 15 to 25, a mixture 720 to 1200 with a weight ratio 1 : 0.01 to 0.05 : 0.02 to 0.07 of tert-butyl alcohol, ethanol, acetone, amixture 140 to 160 with a weight ratio 4:05 to 1 of polyethylene glycol-2000 and tween 801, and hydroxyl propyl methyl cellulose 100 to 120. The invention also provides the preparation method for theliposome drugs. The invention has the advantages of adopting the provided drugs, enabling to decrease the drug dosage by two third and once a day, and improving the efficacy above fifteen percent.

The invention discloses a solanesol ramification of reductive sensibility of tumor tissue. The ramification structure is shown in the prediction. While serving as a micelle for carrying medicine, the solanesol ramification is characterized in that (1) the nano-scale grain size is smaller than 1000 nm, and the granulometric distribution is even and stable; (2) by means of the hydrophilic shell of polyethylene glycol and the nano-scale grain size, the long circulation of nano particles and passive targeting of EPR are achieved; (3) in the effect of the active targeting capable of reducing sensibility, the reductive material GSH which is richly contained in tumour cytoplasm can be utilized to achieve triggered-type drug release in tumor tissue portions; (4) the solanesol ramification has an excellent ability of loading hydrophobic anti-cancer drugs, a high drug loading capacity and great stability;(5) since the solanesol ramification has a great tumor targeting, medicine is more released in tumor tissue and less released in normal tissue, therefore the toxic and side effect performed on the normal tissue is decreased;(6) since the hydrophobic solanesol has an effect of inhibiting tumor cells and sensibilization of anti-cancer medicine, the inhibiting effect of tumor cells in anti-cancer medicine is enhanced.

The present invention discloses a diversified low -carbon hydrocarbon adsorption and absorbing evaluation device and method. Its devices include gas supply systems, dual -channel switching system I, adsorption and absorbing system, dual -channel switching system II, chromatography analysis system, tail gas emissions system, relieving inhalation absorbing absorbing systemSystems, adsorbent discharge and analysis systems, adsorbent online feeding systems and blowing conveyor gas source systems; the present invention uses advanced dual -channel switching systems, gas supply systems, high temperature inert gas relieving adsorption systems and adsorbent analysis systems.The pressurization of various sample gas and adsorbents, long cycle, and dual -channel adsorption and absorbing evaluation have the characteristics of simple operation and online reading results, and have good expansion and market prospects.

The present invention relates to medicine composition of alprostadil and Chuanhuning / Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning / Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.

The invention provides an application of pH (potential of hydrogen) sensitive polyethylene glycol derivative and small molecule drug conjugate in a formula (I) and polymer micelle thereof as an inflammatory targeting delivery system and a preparation method of the pH sensitive polyethylene glycol derivative and small molecule drug conjugate. A portion B includes a small molecule drug D with inflammatory disease treating activity, and a portion A includes a polyethylene glycol derivative carrier system. The pH sensitive polyethylene glycol derivative and small molecule drug conjugate polymer micelle has good inflammatory targeting property, the concentration of the drug in the portion B at a low-pH inflammatory site can be remarkably increased, or staying time of the drug at the low-pH inflammatory site can be prolonged, or the anti-inflammatory effect of the drug can be enhanced.