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Near infrared laser-driven mitochondrial targeting fluorescent polymer and preparation method and application thereof

A fluorescent polymer and laser-driven technology, applied in photodynamic therapy, chemical instruments and methods, medical preparations of non-active ingredients, etc., can solve the problems of short lifespan and small diffusion range of photosensitizers

Active Publication Date: 2017-08-11
深圳市丰用实业集团有限公司
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AI Technical Summary

Problems solved by technology

However, the traditional photosensitizers have short lifetime, small diffusion range, easy aggregation-induced quenching effect, and most of the excitation light is ultraviolet light or visible light with shallow tissue permeability.

Method used

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  • Near infrared laser-driven mitochondrial targeting fluorescent polymer and preparation method and application thereof
  • Near infrared laser-driven mitochondrial targeting fluorescent polymer and preparation method and application thereof
  • Near infrared laser-driven mitochondrial targeting fluorescent polymer and preparation method and application thereof

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Embodiment

[0068] A near-infrared laser-driven mitochondria-targeting fluorescent polymer, the compound name is poly(2Z,2'Z)-3,3'-(2,5-bis(diphenylamino)-1,4-phenyl) Bis(2-(3,5-bis(trifluoromethyl)phenyl)acrylonitrile-co(N-(2-hydroxypropyl)methacrylamide)-co(2-aminoethyl methacrylate) ) polymer (PAIE-TPP), emits red fluorescence under the irradiation of an ultraviolet lamp with a wavelength of 365nm, and the molecular structural formula of the compound PAIE-TPP is:

[0069]

[0070] Its preparation method, the steps are as follows:

[0071] 1) In a 100mL round bottom flask, mix 0.3300g (1.130mmol) of 1,4-dibromo-2,5-diformylbenzene, 0.5718g (2.260mmol of 3,5-bis(trifluoromethyl)benzene with Mix 20mL absolute ethanol evenly to obtain a mixed solution;

[0072] 2) Dissolve 6.0g (16.70mmol) NaOH in 10mL absolute ethanol to obtain NaOH-ethanol solution;

[0073]3) Using a constant pressure low liquid funnel, under N 2 Under protection, NaOH-ethanol solution was added dropwise to the m...

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Abstract

Disclosed is a near infrared laser-driven mitochondrial targeting fluorescent polymer and a preparation method and application thereof. A nano-scale photosensitizer, which is prepared from a polymer of poly-(2Z, 2'Z)-3,3'-(2, 5-bis(diphenylamino)-1, 4-phenyl) bis(2-(3, 5-bis(trifluoromethyl) phenyl) acrylonitrile-copolymer (N-(2-hydroxypropyl) methacrylamide)-copolymer (2-dimethylamino ethyl methacrylate) and an inorganic upconversion nano-scale particle of ytterbium and thulium codoped sodium yttrium fluoride in aqueous solution; when irradiated by laser of a wavelength of 980 nm, the nano-scale photosensitizer can produce reactive oxygen to effectively kill cells. The invention provides a novel and effective nano-scale photosensitive material for research and application of photodynamic therapy of tumor cells in the future.

Description

technical field [0001] The invention relates to a photodynamic therapy technology based on a fluorescent photosensitizer, in particular to a method for preparing a nano photosensitizer driven by a near-infrared laser, highly aggregated, and targeted to mitochondria, which is an organic fluorescent polymer-coated inorganic upconversion nanoparticle. Background technique [0002] Photodynamic therapy, also known as photosensitization therapy and photochemotherapy, is a new technology for tumor treatment that was formed in the late 1970s. Photodynamic therapy is to irradiate the laser with a specific wavelength to excite the photosensitizer absorbed by the tissue, and the photosensitizer in the excited state transfers energy to the surrounding oxygen to generate highly active singlet oxygen, singlet oxygen and adjacent oxygen. Oxidation reaction of biomacromolecules occurs, resulting in cytotoxicity, which in turn leads to cell damage and even death. At present, it has been of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/58C08F220/34C08F8/40C09K11/02C09K11/06C09K11/85A61K41/00A61K9/51A61K47/32A61P35/00
CPCA61K9/5138A61K41/0057C08F8/40C08F220/58C09K11/02C09K11/06C09K11/7773C09K2211/1425C08F220/34
Inventor 吕宏光高辉关月
Owner 深圳市丰用实业集团有限公司
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