The invention provides a method for prognosis judgment of colon
cancer. The method comprises the step of detecting the
amino acid sequence of a polypeptide, wherein the
amino acid sequence is the sequence shown in SEQ NO.1 or a sequence with 99% of display content identical with the display content of the sequence shown in SEQ NO.1. A novel marker, namely HOXB-AS3 polypeptide, for prognosis evaluation and judgment of colon
cancer is also provided.
Clinical study proves that low expression or expression failure of the HOXB-AS3 polypeptide in colon
cancer tissue is positively related to
poor prognosis of colon cancer patients, and patients with low HOXB-AS3 polypeptide level in colon cancer tissue have higher death rate and shorter lifetime. Therefore, by using the HOXB-AS3 polypeptide as the biomarker, the positive
coincidence rate is effectively increased when the kit is clinically applied to prognosis judgment of colon cancer. Furthermore, by detecting the level of the HOXB-AS3 polypeptide in a biological sample tissue slice, generation,
malignancy grade and metastatic potential of colon cancer can be judged easily.