The invention relates to a novel long-circulating
liposome composition and an application method thereof. The long-circulating
liposome composition is mainly prepared from
phospholipid,
cholesterol, an electronegative material and a long-circulating material serving as main raw materials, wherein
tocopheryl acetate succinate or
cholesterol succinate is used as the electronegative material particularly, and
tocopheryl acetate polyethylene glycol succinate (TPGS) is used as the long-circulating material particularly, so that the stability of combining the long-circulating
liposome composition and medicaments is improved; the long-circulating liposome composition can be used as a carrier of anti-tumor medicaments such as
paclitaxel,
docetaxel and 10-hydroxycamptothecine, and simultaneously, the tolerance is improved; and when the long-circulating liposome composition is used as the medicinal carrier, the circulating time of the carried medicaments
in vivo is longer than that of various carriers sold on the market obviously, and the long-circulating liposome composition has the advantages of low cost and suitability for wide popularization and application.