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1095results about How to "Early detection" patented technology

Method and apparatus for detection of vulnerable atherosclerotic plaque

Methods for the detection of inflammation associated with vulnerable atherosclerotic plaque to prevent heart attack and stroke are disclosed. The methods are also applicable to detection of infection, cancer, wounds or auto-immune disease in the body. Certain embodiments of the new methods provide a way of predicting the level of vulnerability of an atherosclerotic plaque to rupture or thrombus formation by assessing via fiber optic NIR spectrophotometry the status of two or more parameters associated with inflamed atherosclerotic plaque in a vessel of a living patient. From these measurements such conditions as low pH, hypoxia, low glucose, oxidative stress or compounds abundant in vulnerable plaque such as oxidized LDL cholesterol and oxidized metabolites of NO, significant active macrophage population, thin plaque cap, as well as senescence and / or apoptosis of smooth muscle or endothelial cells are determined with the assistance of a suitably programmed microprocessor. By considering together the status of some or all of these conditions with respect to successive sites along a vessel wall, particular plaques which are at significant risk of rupturing or thrombosing can be distinguished from “normal” vessel wall and from “intermediate” and relatively stable or “lower risk” plaques. Sites having more of the indicator conditions would be considered most in need of prompt intervention, and certain combinations of parameter levels would be suggestive of relatively stable plaque.Also disclosed is a multi-parameter catheter and analytical processing assembly for use in the methods.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

System and Method for Real-Time Diagnosis, Treatment, and Therapeutic Drug Monitoring

Systems and methods for diagnosing and / or treating diseases as well as monitoring disease treatment. For diagnosis, the present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. In certain embodiments, nanoparticle-based assemblies include a payload for simultaneous diagnosis and treatment of disease. In further embodiments, a therapeutic drug and therapeutic drug marker are administered to a patient to monitor disease treatment. Bodily fluid samples are analyzed using sensor technology to detect the presence of surrogate and / or therapeutic drug markers to provide an efficient and accurate means for diagnosing a disease and / or monitoring disease treatment.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment

Systems and methods for diagnosing and / or treating conditions, diseases, or disorders. The present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. Such nanoparticle-based assemblies combine nanotechnology and sensor technology to provide an efficient and accurate means for diagnosing a condition, disease, or disorder as well as for focused treatment regimens.
Owner:FLORIDA UNIV OF A FLORIDA

Data transport acceleration and management within a network communication system

Improved data transport and management within a network communication system may be achieved by utilizing a transmit timer incorporated within the sender device and exploiting host-level statistics for a plurality of connections between a sender and receiver. The period of the transmit timer may be periodically adjusted based on a ratio of the smoothed round-trip time and the smoothed congestion window, thereby reducing or eliminating bursty data transmission commonly associated with conventional TCP architectures. For applications having a plurality of connections between a sender and a receiver that share a common channel, such as web applications, the congestion window and smoothed round trip time estimates for all active connections may be used to initialize new connections and allocate bandwidth among existing connections. This aspect of the present invention may reduce the destructive interference that may occur as different connections compete with one another to maximize the bandwidth of each connection without regard to other connections serving the same application. Error recovery may also be improved by incorporating a short timer and a long timer that are configured to reduce the size of the congestion window and the corresponding transmission rate in response to a second packet loss with a predefined time period in order to increase resilience to random packet loss.
Owner:OPTIMORPHIX INC

Detecting coagulum formation

Techniques for detecting coagulum formation on an ablation electrode make use of an ablation electrode that is connected to a radio-frequency (RF) generator capable of applying a small amount of RF energy that is not cell destructive. The temperature at the ablation electrode can be precisely measured using a thermosensor incorporated within the ablation electrode. Before and after actual ablation, a low, non-cell destructing (non-ablating) amount of RF energy is generated at the ablation electrode. If no coagulum has formed during actual ablation, the temperature increase during this test application will be similar before and after the ablation attempt. If coagulum has formed during the actual ablation, however, the temperature increase during the test application after ablation will be significantly higher.
Owner:MEDTRONIC INC

Positioning catheters using impedance measurement

The invention relates to a method for determining the position of a catheter in a blood vessel relative to a change in the vascular cross section, comprising the steps: providing a catheter that includes at least two electrodes which can be brought into electrically conductive contact with the surrounding blood while the catheter is being positioned in the blood vessel, wherein the two electrodes are installed on the catheter along the longitudinal axis at a defined distance from each other; advancing the catheter in the vessel to be treated, toward the change in the vascular cross section; and measuring the impedance across the two electrodes while the catheter is being advanced; and to a catheter for use in a method of this type.
Owner:BIOTRONIK SE & CO KG

Modular adaptive optical subsystem for integration with a fundus camera body and CCD camera unit and improved fundus camera employing same

A modular fundus camera including an adaptive optical module that detachably interfaces to a fundus camera body and image capture subsystem. The fundus camera body directs light produced from a first light source into the human eye and that collects and collimates retinal reflections. The adaptive optical module includes a wavefront sensor, controller and phase-compensating optical element. The wavefront sensor measures phase aberrations in the retinal reflections and operates in a closed-loop fashion with the controller to control the phase-compensating optical element to compensate for such phase aberrations to produce phase-compensated retinal reflections for output to the image capture subsystem.
Owner:ADAPTIVE OPTICS ASSOC
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