103 results about "Ethanol Injection" patented technology

Method and surgical instrument for treating prostate tissue including a surgical instrument having a main body, a needle deployment port, a needle, first and second handles and a lockout release mechanism to limit needle extension. Additionally, a kit includes the surgical instrument, together with a cystoscope, and optionally a syringe and reservoir of ethanol. The method includes needle-less injection and visualizing the ethanol injection by delivering both an echogenic agent and ethanol either by needle or needle-less injection or by providing an ultrasonically visible marker near the tip of the ethanol delivery cannula. The method also includes extending the needle transversely of the instrument housing using a link assembly.

Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management microprocessor system controls injection of the anti-knock agent so as to control knock and minimize that amount of the anti-knock agent that is used in a drive cycle. It is preferred that the anti-knock agent is ethanol. The use of ethanol can be further minimized by injection in a non-uniform manner within a cylinder. The ethanol injection suppresses knock so that higher compression ratio and / or engine downsizing from increased turbocharging or supercharging can be used to increase the efficiency of the engine.

Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. A fuel management microprocessor system controls injection of the anti-knock agent so as to control knock and minimize that amount of the anti-knock agent that is used in a drive cycle. It is preferred that the anti-knock agent is ethanol. The use of ethanol can be further minimized by injection in a non-uniform manner within a cylinder. The ethanol injection suppresses knock so that higher compression ratio and / or engine downsizing from increased turbocharging or supercharging can be used to increase the efficiency of the engine.

Method and surgical instrument for treating prostate tissue including a surgical instrument having a main body, a needle deployment port, a needle, first and second handles and a lockout release mechanism to limit needle extension. Additionally, a kit includes the surgical instrument, together with a cystoscope, and optionally a syringe and reservoir of ethanol. The method includes needle-less injection and visualizing the ethanol injection by delivering both an echogenic agent and ethanol either by needle or needle-less injection or by providing an ultrasonically visible marker near the tip of the ethanol delivery cannula. The method also includes extending the needle transversely of the instrument housing using a link assembly.

Fuel tank system for a direct ethanol injection octane boosted gasoline engine. The system includes a gasoline engine and a main fuel tank that contains a mix of gasoline and gasoline E85. A smaller secondary tank is provided to contain ethanol or E85. An injector directly injects in a separately controlled fashion ethanol or E85 into a cylinder of the engine to boost octane. A control module controls the relative amounts of gasoline and ethanol used and structure is provided for fueling the main and secondary fuel tanks.

The invention belongs to the new technical field of a drug preparation and in particular relates to a precursor liposome containing a glycyrrhetinic acid and a method for preparing the same. The precursor liposome containing the glycyrrhetinic acid consists of glycyrrhetinic acid, phospholipids, cholesterol, a surfactant and a water-soluble material; a suspension solution of the glycyrrhetinic acid liposome is prepared by an ethanol injection method or a thin-film dispersion method; and solid liposome powder is prepared by a freeze drying method or a spray drying method. The precursor liposome has simple process and good repeatability, is suitable for industrialized production; through drug administration by intravenous injection, the precursor liposome has long-circulating function, can remarkably reduce the toxicity of drug and achieve the function of prolonging the drug effect; and through oral administration, a solid preparation of the liposome can increase absorption and improve bioavailability by three to five times.

Fuel tank system for a direct ethanol injection octane boosted gasoline engine. The system includes a gasoline engine and a main fuel tank that contains a mix of gasoline and gasoline E85. A smaller secondary tank is provided to contain ethanol or E85. An injector directly injects in a separately controlled fashion ethanol or E85 into a cylinder of the engine to boost octane. A control module controls the relative amounts of gasoline and ethanol used and structure is provided for fueling the main and secondary fuel tanks.

The invention provides a preparation method of a vitamin E nano liposome, belonging to the functional health food technology field. The vitamin E is used as core material and lecithin, cholesterol and Tween 80 are used as wall material and vitamin E common liposome is prepared using an ethanol injection method and then subjected to ultra-high pressure homogeneity, thus transparent or semi-transparent vitamin E nano liposome with average diameter of les than 100nm and encapsulation rate of higher than 90% is obtained. The preparation method is suitable for continuous production and solves problem of saled vitamin E in aspects of stability, water dispersibility and oral absorbency and is widely applied on preparation method of functional water based food.

A fuel tank system for gasoline or flexible gasoline / ethanol powered vehicles that use independently controlled direct ethanol injection to provide a large on-demand octane boost is disclosed. The on-demand octane boost is used when needed to prevent knock. The ethanol can be in the form of 100% ethanol or E85 (a 85% ethanol, 15% gasoline mixture) and is stored in a second tank that is separate from the tank that which contains the primary fuel. The primary fuel can be gasoline, E85, ethanol or a mix of these fuels. The fuel tank system enables convenient, quick, flexible and minimal cost refueling of the separate fuel tank. A range of fueling options is available to provide the driver with the maximum freedom to choose fuels depending upon price and availability. Valves may be utilized to direct the flow in fuel to the various tanks.

The invention discloses a hydroxypropyl-beta-cyclodextrin inclusion liposome of zedoary turmeric oil and a preparation method thereof. The liposome is prepared by the following steps of: preparing a hydroxypropyl-beta-cyclodextrin inclusion of the zedoary turmeric oil from the zedoary turmeric oil and hydroxypropyl-beta-cyclodextrin through an inclusion process; and preparing the hydroxypropyl-beta-cyclodextrin inclusion liposome of the zedoary turmeric oil from the hydroxypropyl-beta-cyclodextrin inclusion, phospholipid and cholesterol through an ethanol injection method. Experimental results show that: the hydroxypropyl-beta-cyclodextrin inclusion liposome of the zedoary turmeric oil has the advantages of good sustained release and long action, high loading rate, particularly no untoward effect such as hemolysis, and higher safety.

The invention discloses a preparation method of tea polyphenol nano-liposomes by combination of an ethanol injection method and dynamic high-pressure microfluidization-enzymolysis. Tea polyphenol, lecithin, tween-80 and a phosphate buffer solution are adopted as raw materials. The tea polyphenol nano-liposomes are prepared by utilization of an ethanol injection-dynamic high-pressure microfluidization-enzymolysis method. According to the prepared tea polyphenol nano-liposomes, the average particle size is 67.4 nm plus or minus 3.0 nm, the zeta potential is -6.07 mV plus or minus 0.59 mV, the distribution coefficient is 0.220 plus or minus 0.010, and the encapsulation efficiency is 79.7% plus or minus 5.4%. The prepared tea polyphenol nano-liposomes show good slow-release property. Only 30.3% plus or minus 2.9% of the tea polyphenol is released after 24 h. In a small-intestine simulation environment where pH is 7.4, the tea polyphenol nano-liposomes show good stability.

The invention provides a lavender essential oil nanometer liposome which is prepared from the following components in percentage by weight: 1-30% of lavender essential oil, 30-75% of lecithin, 3-20% of cholesterol, 5-40% of Tween 80 and the balance of an anti-oxidant. In the lavender essential oil nanometer liposome, the content of the lavender essential oil accounts for 1-30% of solid substances, the average particle diameter is smaller than 200 nm, and the encapsulation rate can reach 90-98%. The invention further provides a preparation method of the lavender essential oil nanometer liposome. The lavender essential oil nanometer liposome is prepared according to an ethanol injection-filtration film extrusion technology, so that the stability of the lavender essential oil is enhanced, the solubility of the lavender essential oil nanometer liposome is improved, bioactive ingredients in the lavender essential oil are effectively protected, the absorption effect and bioavailability of the lavender essential oil are improved, the quality of the lavender essential oil is improved, and the application rage of the lavender essential oil nanometer liposome is enlarged.

The invention belongs to the technical field of medicine and relates to irinotecan liposome and a preparation method thereof. The method can control ethanol content in liposome during a preparation process and ensure no substantial influence of residual ethanol on liposome property in the preparation process. The invention employs improved ethanol injection method to prepare irinotecan liposome, and a membrane material comprises phospholipid or / and other components. The method comprises steps of: preparing a hydrating medium at 45-75 DEG C and insulating for standby; dissolving lipid phase with ethanol, including absolute ethyl alcohol, in a volume less than 10% of a final volume of a preparation at 45-75 DEG C; adding the hydrating medium into the lipid phase at a certain speed; stirring and dispersing to reduce grain size and obtain a blank liposome; and loading according to a gradient method. The invention can effectively control residual ethanol amount during the preparation process, and physical and chemical properties of the liposome have no significant change.

The invention provides a novel Irinotecan carrier which is circulating nano liposome and a novel preparation method thereof which is an ethanol injection-ammonium sulfate active medicament-loading method. The preparation process comprises: a, dissolving a lipid material for forming the liposome in ethanol to prepare solution; b, dissolving a polyethylene glycol compound in solution of ammonium sulfate to prepare a hydration medium; c, injecting solution obtained by the step a into the hydration medium obtained by the step b with stirring in a water bath, stirring at a constant temperature for a certain period under a condition of introducing N2 to form circulating blank liposome; d, dialyzing the blank liposome obtained by the step c in physiological saline; and e, adding solution of Irinotecan into the blank liposome, regulating the pH value of an external phase, and performing incubation and medicament loading at a certain temperature to obtain the Irinotecan circulating nano liposome. The process is simple, the particle size is 80 to 150 nanometers, the coating rate is over 95 percent, the sterile preparation can be obtained easily, and an industrialization requirement is met.

The invention discloses an application of a transdermal enhancer with phospholipid and Vitamin E tocopherol acid polyethylene glycol succinate (TPGS) micelle as medicines or functional compositions of cosmetics. A cuticle of a skin epidermis has a multi-layer compact film structure and consists of cuticle cells and lipid compositions among the cuticle cells, the cuticle cells and the lipid compositions together form a compact barrier to prevent influences from the external factors such as the medicines, and therefore, transdermal absorption of the cosmetic compositions needs to overcome the barrier function of the cuticle. According to the application disclosed by the invention, an ethanol injection method is adopted on the phospholipid and the TPGS with a certain proportion to prepare a water soluble micelle, and the water soluble micelle is frozen and dried to prepare a phospholipid-TPGS water soluble powder; the phospholipid-TPGS water soluble powder is self assembled into nano-micelle with the average grain diameter being about 25nm after being dissolving into water and can enter the internals of skin cuticle cells to mutually react with keratin, so that the compact degree of the cuticle cells is lowered, and meanwhile, the phospholipid carried by the nano-micelle can form a lipid channel; and the stability of the micelle is very good, and the micelle has better transdermal promotion effect on various functional compositions of the cosmetics.

The invention discloses sunitinib malate liposome and a preparation method thereof, belonging to the technical field of medicines. A prescription for the sunitinib malate liposome in the invention is as follows: drugs and lipid substances used for constructing a bilayer membrane of the liposome are prepared by using an improved ethanol injection method. In the invention, influence of the content of ethanol in the preparation prescription on an entrapment rate, particle size distribution, stability and an antineoplastic effect of the liposome is also investigated. According to results of investigation, liposome which is obtained through drug loaded preparation by using a gradient method has an entrapment rate greater than 90%; when the content of ethanol is controlled to be no more than 10%, related parameters of the liposome hardly change, thereby providing reference for control of the content of ethanol in preparation and industrial production of the sunitinib liposome.

The invention discloses verapamil liposome and a preparation method of the verapamil liposome, belonging to the technical field of medicine. The verapamil liposome is composed of verapamil, phospholipid, cholesterol, chitosan, cationic lipid and antioxidant, etc., all of which are in certain weight percentage. The verapamil liposome is prepared by adopting ammonium sulphate gradients method, film hydration method, ethanol injection method and reverse phase evaporation method. The invention adopts chitosan or derivatives of the chitosan to modify the surface of the liposome, and applies the chitosan to ophthalmic preparation, which can further increase corneal retention of the liposome and can remarkably improve the corneal penetration amount of the drug, with obvious advantages compared with ordinary liposome. With high entrapment efficiency, good stability, good biocompatibility, biological adhesiveness and biodegradability, the prepared liposome can realize sustained release and long-acting administration, particularly suitable for administration on ocular region, and can better play the ocular effects of anti-glaucoma and anti-cataract of verapamil.

The invention relates to a TPGS modified docetaxel liposome nano-drug delivery system, a preparation method and an application thereof. The TPGS modified docetaxel liposome nano-drug delivery system uses phospholipid and cholesterol as membrane materials, Surfactant TPGS modified liposomes and docetaxel (DTX) as anticancer drug were prepared by membrane dispersion ethanol injection ultrasonic dispersion reverse evaporation and freeze drying. The particle size of nano-doxetaxel liposomes modified by TPGS is 80-200 nm, the zeta potential is 0+30 mV or 0-30 mV, the encapsulation efficiency is 75-99%, with a drug loading of 3-15%. The in vitro cell experiment and in vivo pharmacodynamic experiment of the TPGS modified docetaxel liposome nano-drug delivery system prepared by the invention showthat the nano-drug delivery system can inhibit P. Overexpression of gp, decrease of drug efflux, increase of drug enrichment in tumor cells, increase of cytotoxicity and apoptosis rate, increase of tumor therapeutic effect and reversal of multidrug resistance.

The invention relates to liposome of extract of cordyceps and a method for preparing the same. The main composition of the extract is polysaccharide. The liposome of the cordyceps is prepared by using phospholipid and cholesterol as membrane materials, and the prepared liposome of the cordyceps can be further prepared into dosage forms of tablet, injection, oral agent, capsule, granule, freeze-dried powder and the like. The method for preparing the liposome of the cordyceps can adopt a reverse evaporation method, a film ultrasound method and an ethanol injection method, the encapsulation rate of the methods can reach more than 40 percent, and the in vitro burst rate is low. The preparing process improves the stability of the drug. After the polysaccharide of the cordyceps is coated with the liposome, the polysaccharide of the cordyceps can be absorbed and used better in human body; and through the slow release effect of the liposome, the effective blood drug level of the drug can be maintained for a longer time.

The invention relates to synthesis of a KGM (Konjac Glucomannan)-g(grafted)-AH (Alicyclic Amine) material and preparation of drug loaded nano micelle thereof, and belongs to the technical field of biological materials and slow release. The synthesis of the KGM-g-AH material comprises the following steps: firstly carrying out oxidization ring opening on KGM by using periodate, thus obtaining DAK (Dialdehyde KGM); then enabling the DAK to react with alicyclic amine, thus obtaining amphipathic KGM-g-AH. A grafted copolymer can be assembled to form nano micelle through an ethanol injection method; the nano micelle has pH (Potential of Hydrogen) sensitivity; in a neutral environment of normal tissues and blood, the nano micelle is relatively stable; in a weak acid environment of tumor tissues, imine bonds of molecules of the nano micelle are in reversible breakage, loaded drugs can be rapidly released, and the loaded drugs can be gathered in tumor cells, so that site-specific delivery of the drugs on the tumor tissues is realized. The prepared KGM-g-AH drug-loaded nano micelle is stable in structure, simple to synthesise, high in drug loading capacity, good in biocompatibility and low in cytotoxicity, has pH sensitivity and has a wide application prospect in the field of drug controlled release.

The invention belongs to the technical field of medicines and relates to a compound low-molecular heparin sodium liposome gel and a preparation method and application thereof. The compound low-molecular heparin sodium liposome gel comprises low-molecular heparin sodium, asiaticoside, lipid components, a membrane softening agent and gel matrix components, wherein the low-molecular heparin sodium and asiaticoside are pharmacological active ingredients, and based on the total gel of 100g, the content of the low-molecular heparin sodium is 5000-35000IU, and the content of the asiaticoside is 0.1-2.5g. The preparation method comprises the following steps of: (1) preparing a compound low-molecular heparin sodium liposome by employing an ethanol injection-ultrasonic method or ethanol injection-high pressure homogenizer method; (2) preparing a blank gel; (3) adding the compound low-molecular heparin sodium liposome into the blank gel, uniformly stirring, and obtaining the compound low-molecular heparin sodium liposome gel. The gel is mainly used for treating skin injury and scar.

The invention discloses an artemether nanoliposome, and a preparation method and an application thereof. The artemether nanoliposome is prepared from the following raw materials in parts by weight: 1 part of artemether, 2 parts of cholesterol and 8-10 parts of egg yolk lecithin. The preparation method comprises a film dispersion-sonication-film filtering method and an ethanol injection-sonication method. The artemether nanoliposome is applied to the preparation of artemether targeting preparation drugs. The encapsulation rate of the artemether nanoliposome is 61.33-63.86%, the average particle size is 161.65-162.73nm, and the poly dispersition index (PDI) is 0.2678-0.4463. The artemether nanoliposome has good stability when being stored at 4 DEG C.

The invention discloses a preparation method of purple sweet potato anthocyanin nano-liposome. According to the preparation method, homogenization treatment is performed by combining an ethanol injection method and a dynamic high-pressure microjet method to prepare the purple sweet potato anthocyanin nano-liposome, so that purple sweet potato anthocyanin is successfully entrapped in the nano-liposome, and the stability of the purple sweet potato anthocyanin in the storage and application fields is improved; a freeze-drying protective additive is added for freeze drying to obtain freeze-dried powder of the purple sweet potato anthocyanin liposome. The prepared purple sweet potato anthocyanin nano-liposome has the advantages of high entrapment rate, small particle size, high thermal stability and high light stability. Moreover, the preparation process is simple, is low in cost, and is easy to realize industrial production. The entrapment rate of the anthocyanin liposome prepared by the method is up to 70 percent, the nano-liposome is 60 to 80 nm in particle size, and the prepared purple sweet potato anthocyanin nano-liposome is small in particle size, is easy for human body to absorb, and has higher bioavailability.

The invention relates to an adjusting method of an ethanol-gasoline dual fuel injector with adjustable ratio. The method specifically comprises the steps that step 1, the operating condition of an engine is determined according to an electronic accelerograph signal of the engine and a rotation speed signal of the engine, and the ethanol volume needed is determined; step 2, according to the determined working condition of the engine and the ethanol volume needed in step 1, moving direction of an ethanol injection piston (11) is controlled, and the ethanol injection piston moves in the up-and-down direction along a push rod chamber of the ethanol injection piston (4-1); step 3, after the moving direction of the ethanol injection piston (11) is determined according to step 2, the precise position of the ethanol injection piston (11) in an ethanol injection piston chamber (33) is controlled, so that target ethanol volume is achieved. According to the method, accurate injection and accuratecontrol of ethanol-gasoline ratio of the dual fuel injector are achieved.

The present invention relates to a composition with repair and anti-aging effects, and a preparation method and application thereof. The composition comprises the following components in percentage byweight: humectant 10-50%, thickener 0.1-1%, squalane 0.1-10%, ubiquinone 0.01-3%, lecithin 1-20%, cholesterol 1-15%, ceramide 0.1-5%, cypress essential oil 0.01-0.3%, carnosine 0.1-3%, sodium hyaluronate 0.01-0.5%, and deionized water as the balance. The preparation method comprises the steps of: dissolving fat-soluble components of the composition in ethanol, preparing a liposome by using an ethanol injection method, and mixing water-soluble components of the composition with the liposome to obtain the composition with repairing and anti-aging effects. The composition is easily absorbed by skin and has significant repairing and anti-aging benefits.

The present invention discloses a breast cancer treatment triptolide liposome preparation and a preparation method thereof, wherein the breast cancer treatment triptolide liposome preparation is a liposome preparation prepared from a breast cancer treatment traditional Chinese medicine active effective component triptolide. The preparation method comprises: adopting an ethanol injection method to prepare liposomes to obtain the breast cancer (breast cancer and triple-negative breast cancer) treatment triptolide liposome preparation. According to the breast cancer treatment triptolide liposome preparation, in vivo animal anti-cancer pharmacological experiment results show that: significant growth inhibition effects are provided for breast cancer and triple-negative breast cancer, and anti-cancer activity of the breast cancer treatment triptolide liposome preparation is respectively and significantly higher than anti-cancer activities of chemotherapy drugs such as paclitaxel and cisplatin. In addition, the triptolide liposome preparation provides a higher anti-cancer effect than the triptolide non-liposome preparation.

The invention relates to the technical field of healthcare food, and particularly discloses a chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome and a preparation method ofthe chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome. The preparation method adopts soybean lecithin and cholesterol as film materials, adopts an ethanol injection methodto prepare the osmanthus phenylethanoid glycosides lipidosome, and utilizes the chitosan to modify the lipidosome, thereby obtaining the chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome. The embedding rate of the chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome prepared by the invention is 35.04 to 88.10 percent, and a particle size is 74.14 to 116.47 nm. The stability of the sweet-scented osmanthus phenylethanoid glycosides is improved, and the sweet-scented osmanthus phenylethanoid glycosides has a sustained release effect.