987 results about "Gel matrix" patented technology

A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.

A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic/hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.

Embodiments of a hair conditioning composition include a silicone polymer comprising one or more quaternary groups, at least one silicone block comprising greater than 200 siloxane units, at least one polyalkylene oxide structural unit, and at least one terminal ester group. The silicone polymer has a viscosity of up to 100,000 mPa·s. The silicone polymer is a pre-emulsified dispersion with a particle size of less than about 1 micron. The hair conditioning composition includes a gel matrix including a cationic surfactant, a high melting point fatty compound, and an aqueous carrier.

An iontophoresis device includes an active electrode element operable to provide an electrical potential; an electrolyte reservoir comprising an electrolyte composition; an inner active agent reservoir comprising a gel matrix and distributed in said gel matrix, a first positively charged active agent; an inner ion selective membrane deposed between said electrolyte reservoir and said inner active agent reservoir; and an outermost ion selective membrane having an outer surface, the outer surface being against the biological interface, wherein, the gel matrix comprises a hydrophilic polycarboxylated polymer having net negative charges.

A formulation of phenyloin suitable for topical application to a wound comprises a reservoir of phenyloin entrapped within a stabilising matrix, and an amount of dissolved phenyloin, wherein the dissolved phenyloin is in chemical equilibrium with the phenyloin entrapped within the stabilised matrix. The stabilised matrix may comprise a gel matrix, especially a gel matrix in which the polymer of the gel forms ion-pairs with the phenyloin. Also described are methods of treating a wound in diabetic and non-diabetic patients using a formulation according to the invention.

Contamination between an active agent solution in an active agent reservoir and an electrolyte solution in an electrolyte solution reservoir may be reduced in an iontophoresis device, thus helping to suppress the generation of gas and helping to reduce changes in pH upon energization. A gel matrix that transforms into a liquid state upon thermal excitation and/or mechanical excitation may be used in one or more reservoirs in the iontophoresis device.

The present invention is directed to an indulgent edible composition that provides an orally pleasurable eating experience similar to chocolate as the chocolate melts in the oral cavity comprising (a) a starch that when combined with water in a weight ratio of 5:95 starch to water, has a viscosity at 22° C. of about 0.03 Pa-s to about 2 Pa-s at a shear rate of 10 sec⁻¹; (b) a protein-containing component that will substantially hydrate in water and will not coagulate; (c) a sweetener that when substantially hydrated is at least 90% free of crystals in said edible composition; (d) a fat-containing component that melts at a temperature of about 45° C. or less; (e) a hydrocolloid gelling agent that facilitates the formation of a gel matrix that will break down at a temperature of about 45° C. or less; and (f) an edible surfactant that is food-grade and has a HLB value of about 0 to about 12, wherein the edible composition has a total moisture content from about 10% to about 50% moisture by weight of the composition.

The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt, solvate, ester, and/or prodrug thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient. The present invention also provides methods of making and using the controlled-release compositions.

Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo.

The invention relates to a method for preparing an aquogel matrix, in particular to a method for preparing the aquogel matrix for ultraviolet light three-dimensional (3D) printing and belongs to the technical field of preparation of biological materials. An alkenyl group is ingrafted on a chitosan molecular chain, a sulfydryl group is ingrafted on polyvinyl alcohol, and mixing is performed to obtain the aquogel matrix for ultraviolet light 3D printing. According to the aquogel matrix, sulfydryl-alkene 'click' reaction characteristic is fully utilized, gel forming is rapidly achieved under ultraviolet irradiation, inhibition of oxygen in air or a system can be fully overcome, 3D printing efficiency is greatly increased, cytocompatibility of the aquogel matrix is good, enough supporting environment is provided for cell growth, and cell adhesion, growth and proliferation can be facilitated. The preparation method is simple and low in costs, and industrial production is easy.

A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.