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990 results about "Gel matrix" patented technology
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Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
InactiveUS6589549B2Improve stabilityPowder deliveryPeptide/protein ingredientsActive agentEngineering
A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bioactive agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and / or controlled. In addition, a second agent may be loaded in some of the microparticles and / or the gel matrix.
Owner:BTG INT LTD
Sol-gel matrices for direct colorimetric detection of analytes
InactiveUS6022748AEasily associated with transducing deviceRobust and stableMaterial nanotechnologyBiological testingAnalyteBiopolymer
The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.
Owner:SANDIA +1
Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
InactiveUS20020076441A1Improve stabilityPowder deliveryPeptide/protein ingredientsActive agentPharmaceutical drug
A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bioactive agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and / or controlled. In addition, a second agent may be loaded in some of the microparticles and / or the gel matrix.
Owner:BTG INT LTD
Self-Assembling Cell Aggregates and Methods of Making Engineered Tissue Using the Same
Owner:MUSC FOUND FOR RES DEV +1
Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
InactiveUS7018645B1Good curative effectMinimize side effectsPowder deliveryPeptide/protein ingredientsPolymer scienceErosion rate
A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic / hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.
Owner:BTG INT LTD
Immobilized bioactive hydrogel matrices as surface coatings
InactiveUS7303814B2Improves tissue integrationImprove intimate contactSurgerySkeletal disorderHydrogel matrixMedical device
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.
Owner:PIONEER SURGICAL TECH INC
Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
InactiveUS7135190B2Improve gelationGood drug release propertiesPowder deliveryGogglesPolymer scienceErosion rate
A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic / hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.
Owner:BTG INT LTD
Shear gel compositions
InactiveUS6673371B2Extended stayPowder deliveryCosmetic preparationsThickened fluidsPolymer chemistry
Owner:UNILEVER HOME & PERSONAL CARE USA DIV OF CONOPCO IN C
Marker device for X-ray, ultrasound and MR imaging
InactiveUS20060293581A1Sharp contrastEasily introduced into tissueUltrasonic/sonic/infrasonic diagnosticsPowder deliveryDiagnostic Radiology ModalityMicrosphere
An imaging marker comprised of glass and iron-containing aluminum microspheres in a gel matrix which shows uniformly good contrast with MR, US and X-Ray imaging. The marker is small and can be easily introduced into tissue through a 12-gauge biopsy needle. The concentration of glass microspheres and the size dictate the contrast for US imaging. The contrast seen in MRI resulting from susceptibility losses is dictated by the number of iron-containing aluminum microspheres; while the artifact of the marker also depends on its shape, orientation and echo time. By optimizing the size, iron concentration and gel binding, an implantable tissue marker is created which is clearly visible with all three imaging modalities.
Owner:SUNNYBROOK & WOMENS COLLEGE HEALTH SCI CENT
Hair Conditioning Compositions Comprising Low Viscosity Emulsified Silicone Polymers
ActiveUS20150093420A1Improved conditioning benefitLow viscosityCosmetic preparationsHair cosmeticsStructural unitSURFACTANT BLEND
Embodiments of a hair conditioning composition include a silicone polymer comprising one or more quaternary groups, at least one silicone block comprising greater than 200 siloxane units, at least one polyalkylene oxide structural unit, and at least one terminal ester group. The silicone polymer has a viscosity of up to 100,000 mPa·s. The silicone polymer is a pre-emulsified dispersion with a particle size of less than about 1 micron. The hair conditioning composition includes a gel matrix including a cationic surfactant, a high melting point fatty compound, and an aqueous carrier.
Owner:THE PROCTER & GAMBLE COMPANY
Self-gelling alginate systems and uses thereof
Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate / gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate / gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.
Owner:FMC BIOPOLYMER AS
Medicament incorporation matrix
ActiveUS20060165751A1Increased durabilityIncrease tenacityImpression capsOther blood circulation devicesHydrophilic monomerMeth-
A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.
Owner:SURMODICS INC
Self-gelling alginate systems and uses thereof
ActiveUS20060159823A1Improve survivabilityBiocideOrganic active ingredientsLipid formationCITRATE ESTER
Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate / gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate / gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.
Owner:FMC BIOPOLYMER AS
Iontophoretic device and method of delivery of active agents to biological interface
InactiveUS20070083185A1Increase loadImproved release characteristicElectrotherapyMedical devicesActive agentElectrolyte composition
An iontophoresis device includes an active electrode element operable to provide an electrical potential; an electrolyte reservoir comprising an electrolyte composition; an inner active agent reservoir comprising a gel matrix and distributed in said gel matrix, a first positively charged active agent; an inner ion selective membrane deposed between said electrolyte reservoir and said inner active agent reservoir; and an outermost ion selective membrane having an outer surface, the outer surface being against the biological interface, wherein, the gel matrix comprises a hydrophilic polycarboxylated polymer having net negative charges.
Owner:TITI ELLEBEAU INC
Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
Owner:OCUGEN INC
Self-assembling cell aggregates and methods of making engineered tissue using the same
A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.
Owner:MUSC FOUND FOR RES DEV +1
Tissue mimicking elastography phantoms
ActiveUS7462488B2Enhanced ultrasound backscatterImprove stabilityMaterial analysis using sonic/ultrasonic/infrasonic wavesWeather/light/corrosion resistanceSonificationResonance
Tissue mimicking materials for elastography phantoms have elastic, ultrasound, and magnetic resonance characteristics that are characteristic of human soft tissues and well suited for the calibration and performance assessment of elastography imaging systems. In one embodiment, the material is formed from a base material containing an oil dispersed within a gel matrix and at least one inclusion formed from a gel. In another embodiment, the material is formed from a gel-forming material suffused throughout an open-cell reticulated mesh matrix.
Owner:WISCONSIN ALUMNI RES FOUND
Phenytoin Formulations, and Uses Thereof in Wound Healing
InactiveUS20090022779A1Promote wound healingCut woundOrganic active ingredientsPowder deliveryWound healingPhenylbutyrate
A formulation of phenyloin suitable for topical application to a wound comprises a reservoir of phenyloin entrapped within a stabilising matrix, and an amount of dissolved phenyloin, wherein the dissolved phenyloin is in chemical equilibrium with the phenyloin entrapped within the stabilised matrix. The stabilised matrix may comprise a gel matrix, especially a gel matrix in which the polymer of the gel forms ion-pairs with the phenyloin. Also described are methods of treating a wound in diabetic and non-diabetic patients using a formulation according to the invention.
Owner:ROYAL COLLEGE OF SURGEONS & IRELAND
Iontophoresis device
InactiveUS20070088332A1Reduce pollutionSlow changeElectrotherapyPharmaceutical delivery mechanismActive agentLiquid state
Contamination between an active agent solution in an active agent reservoir and an electrolyte solution in an electrolyte solution reservoir may be reduced in an iontophoresis device, thus helping to suppress the generation of gas and helping to reduce changes in pH upon energization. A gel matrix that transforms into a liquid state upon thermal excitation and / or mechanical excitation may be used in one or more reservoirs in the iontophoresis device.
Owner:TITI ELLEBEAU INC
Electro-Blotting Devices, Systems, and Kits, And Methods For Their Use
ActiveUS20060278531A1Rapid and efficientLess bubbleSludge treatmentVolume/mass flow measurementElectricityElectrophoresis
The invention provides a dry electroblotting system for dry blotting gels, in which the system includes an electroblotting transfer stack that comprises an analysis gel and a blotting membrane, an anode, a body of anodic gel matrix juxtaposed with the anode between the anode and the transfer stack, a cathode, and a body of cathodic gel matrix juxtaposed with the cathode between the cathode and the transfer stack, in which the anodic gel matrix and the cathodic gel matrix each comprise an ion source for electrophoretic transfer. The dry electroblotting system does not use any liquid buffers that are added to the system just before electroblotting (such as when the transfer stack is being assembled). The anode, the cathode, or both can be separate from a power supply and provided as part of a disposable electrode assembly that also includes a body of gel matrix that includes ions for electrophoretic transfer.
Owner:LIFE TECH ISRAEL
Indulgent edible composition
ActiveUS20080026111A1Increase moisture contentReduce heat densityConfectionerySweetmeatsBiotechnologyFood grade
The present invention is directed to an indulgent edible composition that provides an orally pleasurable eating experience similar to chocolate as the chocolate melts in the oral cavity comprising (a) a starch that when combined with water in a weight ratio of 5:95 starch to water, has a viscosity at 22° C. of about 0.03 Pa-s to about 2 Pa-s at a shear rate of 10 sec−1; (b) a protein-containing component that will substantially hydrate in water and will not coagulate; (c) a sweetener that when substantially hydrated is at least 90% free of crystals in said edible composition; (d) a fat-containing component that melts at a temperature of about 45° C. or less; (e) a hydrocolloid gelling agent that facilitates the formation of a gel matrix that will break down at a temperature of about 45° C. or less; and (f) an edible surfactant that is food-grade and has a HLB value of about 0 to about 12, wherein the edible composition has a total moisture content from about 10% to about 50% moisture by weight of the composition.
Owner:MARS INC
Thermo-sensitive in-situ gel pharmaceutical composition
InactiveCN102125516APharmaceutical delivery mechanismMacromolecular non-active ingredientsAdjuvantPharmaceutical drug
The invention relates to an in-situ gel pharmaceutical composition, and in particular relates to a thermo-sensitive in-situ gel pharmaceutical composition, and a method for administering the pharmaceutical composition to treat and / or prevent diseases in mammals, particularly human beings. The pharmaceutical composition comprises drugs, chitosan, auxiliary gel matrix materials and pharmaceutically acceptable adjuvants. The pharmaceutical composition is superior in biocompatibility and biodegradability. The pharmaceutical composition provided by the invention has a simple preparation method, a transparent appearance and good stability, and is non-irritant and non-toxic to the mucosa.
Owner:PEKING UNIV
Gel type solid-liquid electronic cigarette cartridge and manufacturing method thereof
The invention discloses a gel type solid-liquid electronic cigarette cartridge. The gel type solid-liquid electronic cigarette cartridge comprises a metal shell, wherein one end of the metal shell is open, and the open end of the metal shell is sealed through a metal foil film. The gel type solid-liquid electronic cigarette cartridge is characterized in that the metal shell is filled with tobacco gel, the tobacco gel is formed by evenly mixing and stirring basic tobacco, basic gel and tobacco flavors and fragrances, the basic tobacco is the mixture formed by one of tobacco shreds, reconstituted tobacco and tobacco waste or a mixture of the tobacco shreds, the reconstituted tobacco and the tobacco waste, and the basic gel is formed by stirring and dissolving gel base materials and a fogging agent. The gel type solid-liquid electronic cigarette cartridge has the advantages of being not prone to spilling and convenient to store.
Owner:HUBEI CHINA TOBACCO IND
Hair Care Composition Comprising Metathesized Unsaturated Polyol Esters
A hair care composition having from about 0.05% to about 15% of one or more oligomers derived from unsaturated polyol esters. The hair care composition further includes a gel matrix phase. The gel matrix has from about 0.1% to about 20% of one or more high melting point fatty compounds, from about 0.1% to about 10% of a cationic surfactant system, and at least about 20% of an aqueous carrier, by weight of said hair care composition. The present invention may further comprise a deposition polymer.
Owner:THE PROCTER & GAMBLE COMPANY
Controlled-release formulations, method of manufacture, and use thereof
Owner:SUN PHARMA IND INC
Ex Vivo Culture, Proliferation and Expansion of Intestinal Epithelium
ActiveUS20100047853A1Induce pluripotencyAlter differentiationGastrointestinal cellsMicrobiological testing/measurementAir liquid interfaceMammal
Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Aroma-releasing polymeric gel matrix
A translucent-to-clear, plasticized PVC thermoplastic polymeric matrix gel composition comprising (i) a high loading of fragrance composition and / or odor counteractant(s)—preferably greater than about 85%; (ii) from about 4% to about 25% of a plastisol with a Shore hardness of from about 60 to about 95 that is liquid at room temperature; and, optionally, (iii) an evaporation / firmness controlling agent. The high loading of fragrance and / or odor counteractants in the polymeric matrix gel composition of the invention provides a desired aroma to an environment in a persistent manner over an extended period of time.
Owner:WHITEHEAD KENNETH R +1
Gel formation to reduce hematocrit sensitivity in electrochemical test
InactiveUS20080149480A1Reduce inaccuracyReduce sensitivityImmobilised enzymesBioreactor/fermenter combinationsSpecific volumeElectrochemistry
Devices for determining the concentration of a constituent in a physiological sample that comprise gel matrices to filter red blood cells are provided. Examples of such devices include a biosensor comprising, on a support substrate, a sample reception region for receiving a blood sample; at least one electrode; and a reaction reagent system that is located in a gel matrix. The gel matrix disclosed herein is sufficient to prevent at least some of the red cells in the blood sample from contacting the electrode, and thus reduce the hematocrit sensitivity in the measurement.
Owner:NIPRO DIAGNOSTICS INC
Method for preparing aquogel matrix for ultraviolet light three-dimensional (3D) printing
InactiveCN104861216AOvercome polymerization inhibitionImprove printing efficiencyCell adhesionPolyvinyl alcohol
The invention relates to a method for preparing an aquogel matrix, in particular to a method for preparing the aquogel matrix for ultraviolet light three-dimensional (3D) printing and belongs to the technical field of preparation of biological materials. An alkenyl group is ingrafted on a chitosan molecular chain, a sulfydryl group is ingrafted on polyvinyl alcohol, and mixing is performed to obtain the aquogel matrix for ultraviolet light 3D printing. According to the aquogel matrix, sulfydryl-alkene 'click' reaction characteristic is fully utilized, gel forming is rapidly achieved under ultraviolet irradiation, inhibition of oxygen in air or a system can be fully overcome, 3D printing efficiency is greatly increased, cytocompatibility of the aquogel matrix is good, enough supporting environment is provided for cell growth, and cell adhesion, growth and proliferation can be facilitated. The preparation method is simple and low in costs, and industrial production is easy.
Owner:WUHAN TEXTILE UNIV
Medicament incorporation matrix
InactiveUS7056533B2Increased durabilityIncrease tenacityAntibacterial agentsOrganic active ingredientsHydrophilic monomerMeth-
A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.
Owner:SURMODICS INC
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